메뉴 건너뛰기




Volumn 119, Issue 18, 2012, Pages 4264-4271

BCR-ABL1 doubling times more reliably assess the dynamics of CML relapse compared with the BCR-ABL1 fold rise: Implications for monitoring and management

Author keywords

[No Author keywords available]

Indexed keywords

BCR ABL PROTEIN; BCR ABL1 PROTEIN; IMATINIB; UNCLASSIFIED DRUG;

EID: 84860752177     PISSN: 00064971     EISSN: 15280020     Source Type: Journal    
DOI: 10.1182/blood-2011-11-393041     Document Type: Article
Times cited : (43)

References (50)
  • 1
    • 73349122639 scopus 로고    scopus 로고
    • Chronic myeloid leukemia: An update of concepts and management recommendations of European LeukemiaNet
    • Baccarani M, Cortes J, Pane F, et al. Chronic myeloid leukemia: An update of concepts and management recommendations of European LeukemiaNet. J Clin Oncol. 2009;27(35):6041-6051.
    • (2009) J Clin Oncol. , vol.27 , Issue.35 , pp. 6041-6051
    • Baccarani, M.1    Cortes, J.2    Pane, F.3
  • 3
    • 33644516935 scopus 로고    scopus 로고
    • The role of serial BCR-ABL transcript monitoring in predicting the emergence of BCR-ABL kinase mutations in imatinib-treated patients with chronic myeloid leukemia
    • Wang L, Knight K, Lucas C, Clark RE. The role of serial BCR-ABL transcript monitoring in predicting the emergence of BCR-ABL kinase mutations in imatinib-treated patients with chronic myeloid leukemia. Haematologica. 2006;91(2):235-239.
    • (2006) Haematologica. , vol.91 , Issue.2 , pp. 235-239
    • Wang, L.1    Knight, K.2    Lucas, C.3    Clark, R.E.4
  • 4
    • 35948937212 scopus 로고    scopus 로고
    • A half-log increase in BCR-ABL RNA predicts a higher risk of relapse in patients with chronic myeloid leukemia with an imatinib-induced complete cytogenetic response
    • DOI 10.1158/1078-0432.CCR-07-1112
    • Press RD, Galderisi C, Yang R, et al. A half-log increase in BCR-ABL RNA predicts a higher risk of relapse in patients with chronic myeloid leukemia with an imatinib-induced complete cytogenetic response. Clin Cancer Res. 2007;13(20): 6136-6143. (Pubitemid 350075073)
    • (2007) Clinical Cancer Research , vol.13 , Issue.20 , pp. 6136-6143
    • Press, R.D.1    Galderisi, C.2    Yang, R.3    Rempfer, C.4    Willis, S.G.5    Mauro, M.J.6    Druker, B.J.7    Deininger, M.W.N.8
  • 5
    • 64149123286 scopus 로고    scopus 로고
    • Does a rise in the BCR-ABL1 transcript level identify chronic phase CML patients responding to imatinib who have a high risk of cytogenetic relapse?
    • Marin D, Khorashad JS, Foroni L, et al. Does a rise in the BCR-ABL1 transcript level identify chronic phase CML patients responding to imatinib who have a high risk of cytogenetic relapse? Br J Haematol. 2009;145(3):373-375.
    • (2009) Br J Haematol. , vol.145 , Issue.3 , pp. 373-375
    • Marin, D.1    Khorashad, J.S.2    Foroni, L.3
  • 6
    • 77952467377 scopus 로고    scopus 로고
    • Adherence is the critical factor for achieving molecular responses in patients with chronic myeloid leukemia who achieve complete cytogenetic responses on imatinib
    • Marin D, Bazeos A, Mahon F-X, et al. Adherence is the critical factor for achieving molecular responses in patients with chronic myeloid leukemia who achieve complete cytogenetic responses on imatinib. J Clin Oncol. 2010;28(14): 2381-2388.
    • (2010) J Clin Oncol. , vol.28 , Issue.14 , pp. 2381-2388
    • Marin, D.1    Bazeos, A.2    Mahon, F.-X.3
  • 7
    • 84860731850 scopus 로고    scopus 로고
    • NCCN Clinical Practice Guidelines in Oncology: Chronic Myelogenous Leukemia Version 2.2012.. Accessed July 11, 2011
    • O'Brien S. NCCN Clinical Practice Guidelines in Oncology: Chronic Myelogenous Leukemia, Version 2.2012. http://wwwnccnorg/professionals/physician. Accessed July 11, 2011.
    • O'Brien, S.1
  • 8
    • 70350509806 scopus 로고    scopus 로고
    • Determining the rise in BCR-ABL RNA that optimally predicts a kinase domain mutation in patients with chronic myeloid leukemia on imatinib
    • Press RD, Willis SG, Laudadio J, Mauro MJ, Deininger MW. Determining the rise in BCR-ABL RNA that optimally predicts a kinase domain mutation in patients with chronic myeloid leukemia on imatinib. Blood. 2009;114(13):2598-2605.
    • (2009) Blood. , vol.114 , Issue.13 , pp. 2598-2605
    • Press, R.D.1    Willis, S.G.2    Laudadio, J.3    Mauro, M.J.4    Deininger, M.W.5
  • 9
    • 0029925863 scopus 로고    scopus 로고
    • Kinetics of increasing BCR-ABL transcript numbers in chronic myeloid leukemia patients who relapse after bone marrow transplantation
    • Lin F, van Rhee F, Goldman JM, Cross NC. Kinetics of increasing BCR-ABL transcript numbers in chronic myeloid leukemia patients who relapse after bone marrow transplantation. Blood. 1996; 87(10):4473-4478. (Pubitemid 26152290)
    • (1996) Blood , vol.87 , Issue.10 , pp. 4473-4478
    • Lin, F.1    Van Rhee, F.2    Goldman, J.M.3    Cross, N.C.P.4
  • 10
    • 0032411451 scopus 로고    scopus 로고
    • Tumor doubling time: A selection factor for pulmonary resection of metastatic melanoma
    • DOI 10.1002/(SICI)1096-9098(199812)69:4<206::AID-JSO3>3.0.CO;2-N
    • Ollila DW, Stern SL, Morton DL. Tumor doubling time: A selection factor for pulmonary resection of metastatic melanoma. J Surg Oncol. 1998;69(4): 206-211. (Pubitemid 29024563)
    • (1998) Journal of Surgical Oncology , vol.69 , Issue.4 , pp. 206-211
    • Ollila, D.W.1    Stern, S.L.2    Morton, D.L.3
  • 12
    • 14144253034 scopus 로고    scopus 로고
    • CA 125 half-life breakpoint between a "good" and "poor" prognosis in patients with ovarian cancer
    • DOI 10.1016/j.ijgo.2004.12.028
    • Mano A, Godinho I, Falcao AC. CA 125 half-life breakpoint between a "good" and "poor" prognosis in patients with ovarian cancer. Int J Gynaecol Obstet. 2005;88(3):333-335. (Pubitemid 40283618)
    • (2005) International Journal of Gynecology and Obstetrics , vol.88 , Issue.3 , pp. 333-335
    • Mano, A.1    Godinho, I.2    Falcao, A.C.3
  • 13
    • 77749301511 scopus 로고    scopus 로고
    • Calcitonin and carcinoembryonic antigen doubling times as prognostic factors in medullary thyroid carcinoma: A structured meta-analysis
    • Meijer JA, le Cessie S, van den Hout WB, et al. Calcitonin and carcinoembryonic antigen doubling times as prognostic factors in medullary thyroid carcinoma: A structured meta-analysis. Clin Endocrinol (Oxf). 2010;72(4):534-542.
    • (2010) Clin Endocrinol (Oxf). , vol.72 , Issue.4 , pp. 534-542
    • Meijer, J.A.1    Le Cessie, S.2    Van Den Hout, W.B.3
  • 14
    • 4644341516 scopus 로고    scopus 로고
    • Discontinuation of imatinib therapy after achieving a molecular response [3]
    • DOI 10.1182/blood-2004-04-1335
    • Cortes J, O'Brien S, Kantarjian H. Discontinuation of imatinib therapy after achieving a molecular response. Blood. 2004;104(7):2204-2205. (Pubitemid 39297882)
    • (2004) Blood , vol.104 , Issue.7 , pp. 2204-2205
    • Cortes, J.1    O'Brien, S.2    Kantarjian, H.3
  • 17
    • 67049087117 scopus 로고    scopus 로고
    • Prevalence, determinants, and outcomes of nonadherence to imatinib therapy in patients with chronic myeloid leukemia: The ADAGIO study
    • Noens L, van Lierde MA, De Bock R, et al. Prevalence, determinants, and outcomes of nonadherence to imatinib therapy in patients with chronic myeloid leukemia: The ADAGIO study. Blood. 2009;113(22):5401-5411.
    • (2009) Blood. , vol.113 , Issue.22 , pp. 5401-5411
    • Noens, L.1    Van Lierde, M.A.2    De Bock, R.3
  • 18
    • 79953823237 scopus 로고    scopus 로고
    • Poor adherence is the main reason for loss of CCyR and imatinib failure for chronic myeloid leukemia patients on long-term therapy
    • Ibrahim AR, Eliasson L, Apperley JF, et al. Poor adherence is the main reason for loss of CCyR and imatinib failure for chronic myeloid leukemia patients on long-term therapy. Blood. 2011; 117(14):3733-3736.
    • (2011) Blood. , vol.117 , Issue.14 , pp. 3733-3736
    • Ibrahim, A.R.1    Eliasson, L.2    Apperley, J.F.3
  • 20
    • 58149160055 scopus 로고    scopus 로고
    • Impact of early dose intensity on cytogenetic and molecular responses in chronic-phase CML patients receiving 600 mg/day of imatinib as initial therapy
    • Hughes TP, Branford S, White DL, et al. Impact of early dose intensity on cytogenetic and molecular responses in chronic-phase CML patients receiving 600 mg/day of imatinib as initial therapy. Blood. 2008;112(10):3965-3973.
    • (2008) Blood. , vol.112 , Issue.10 , pp. 3965-3973
    • Hughes, T.P.1    Branford, S.2    White, D.L.3
  • 21
    • 79952037284 scopus 로고    scopus 로고
    • Selective escalation of imatinib therapy and early switching to nilotinib in de novo chronic phase CML patients: Interim results from the TIDEL-II trial [abstract]
    • Yeung DT, Osborn M, White DL, et al. Selective escalation of imatinib therapy and early switching to nilotinib in de novo chronic phase CML patients: Interim results from the TIDEL-II trial [abstract]. Blood (ASH Annual Meeting Abstracts). 2010;116(21):209.
    • (2010) Blood (ASH Annual Meeting Abstracts). , vol.116 , Issue.21 , pp. 209
    • Yeung, D.T.1    Osborn, M.2    White, D.L.3
  • 22
    • 77958012952 scopus 로고    scopus 로고
    • Patients with chronic myeloid leukemia who maintain a complete molecular response after stopping imatinib treatment have evidence of persistent leukemia by DNA PCR
    • Ross DM, Branford S, Seymour JF, et al. Patients with chronic myeloid leukemia who maintain a complete molecular response after stopping imatinib treatment have evidence of persistent leukemia by DNA PCR. Leukemia. 2010;24(10):1719-1724.
    • (2010) Leukemia. , vol.24 , Issue.10 , pp. 1719-1724
    • Ross, D.M.1    Branford, S.2    Seymour, J.F.3
  • 23
    • 75749105885 scopus 로고    scopus 로고
    • Phase III, randomized, open-label study of daily imatinib mesylate 400 mg versus 800 mg in patients with newly diagnosed, previously untreated chronic myeloid leukemia in chronic phase using molecular end points: Tyrosine kinase inhibitor optimization and selectivity study
    • Cortes JE, Baccarani M, Guilhot F, et al. Phase III, randomized, open-label study of daily imatinib mesylate 400 mg versus 800 mg in patients with newly diagnosed, previously untreated chronic myeloid leukemia in chronic phase using molecular end points: Tyrosine kinase inhibitor optimization and selectivity study. J Clin Oncol. 2010; 28(3):424-430.
    • (2010) J Clin Oncol. , vol.28 , Issue.3 , pp. 424-430
    • Cortes, J.E.1    Baccarani, M.2    Guilhot, F.3
  • 24
    • 54049139246 scopus 로고    scopus 로고
    • Desirable performance characteristics for BCR-ABL measurement on an international reporting scale to allow consistent interpretation of individual patient response and comparison of response rates between clinical trials
    • Branford S, Fletcher L, Cross NCP, et al. Desirable performance characteristics for BCR-ABL measurement on an international reporting scale to allow consistent interpretation of individual patient response and comparison of response rates between clinical trials. Blood. 2008;112(8):3330-3338.
    • (2008) Blood. , vol.112 , Issue.8 , pp. 3330-3338
    • Branford, S.1    Fletcher, L.2    Cross, N.C.P.3
  • 25
    • 0032748325 scopus 로고    scopus 로고
    • Monitoring chronic myeloid leukaemia therapy by real-time quantitative PCR in blood is a reliable alternative to bone marrow cytogenetics
    • Branford S, Hughes TP, Rudzki Z. Monitoring chronic myeloid leukaemia therapy by real-time quantitative PCR in blood is a reliable alternative to bone marrow cytogenetics. Br J Haematol. 1999;107(3):587-599.
    • (1999) Br J Haematol. , vol.107 , Issue.3 , pp. 587-599
    • Branford, S.1    Hughes, T.P.2    Rudzki, Z.3
  • 26
    • 0036566540 scopus 로고    scopus 로고
    • High frequency of point mutations clustered within the adenosine triphosphate-binding region of BCR/ABL in patients with chronic myeloid leukemia or Ph-positive acute lymphoblastic leukemia who develop imatinib (STI571) resistance
    • DOI 10.1182/blood.V99.9.3472
    • Branford S, Rudzki Z, Walsh S, et al. High frequency of point mutations clustered within the adenosine triphosphate-binding region of BCR/ABL in patients with chronic myeloid leukemia or Ph-positive acute lymphoblastic leukemia who develop imatinib (STI571) resistance. Blood. 2002;99(9):3472-3475. (Pubitemid 34525335)
    • (2002) Blood , vol.99 , Issue.9 , pp. 3472-3475
    • Branford, S.1    Rudzki, Z.2    Walsh, S.3    Grigg, A.4    Arthur, C.5    Taylor, K.6    Herrmann, R.7    Lynch, K.P.8    Hughes, T.P.9
  • 27
    • 77958595179 scopus 로고    scopus 로고
    • Longterm prognostic significance of early molecular response to imatinib in newly diagnosed chronic myeloid leukemia: An analysis from the International Randomized Study of Interferon and STI571 (IRIS)
    • Hughes TP, Hochhaus A, Branford S, et al. Longterm prognostic significance of early molecular response to imatinib in newly diagnosed chronic myeloid leukemia: An analysis from the International Randomized Study of Interferon and STI571 (IRIS). Blood. 2010;116(19):3758-3765.
    • (2010) Blood. , vol.116 , Issue.19 , pp. 3758-3765
    • Hughes, T.P.1    Hochhaus, A.2    Branford, S.3
  • 28
    • 78049528573 scopus 로고    scopus 로고
    • Discontinuation of imatinib in patients with chronic myeloid leukaemia who have maintained complete molecular remission for at least 2 years: The prospective, multicentre Stop Imatinib (STIM) trial
    • Mahon FX, Rea D, Guilhot J, et al. Discontinuation of imatinib in patients with chronic myeloid leukaemia who have maintained complete molecular remission for at least 2 years: The prospective, multicentre Stop Imatinib (STIM) trial. Lancet Oncol. 2010;11(11):1029-1035.
    • (2010) Lancet Oncol. , vol.11 , Issue.11 , pp. 1029-1035
    • Mahon, F.X.1    Rea, D.2    Guilhot, J.3
  • 29
    • 84860729243 scopus 로고    scopus 로고
    • Discontinuation of imatinib therapy in chronic myeloid leukemia patients with sustained complete molecular response4.5 (CMR4.5) [abstract]
    • Goh H-G, Choi S-Y, Bang J-He, et al. Discontinuation of imatinib therapy in chronic myeloid leukemia patients with sustained complete molecular response4.5 (CMR4.5) [abstract]. Blood (ASH Annual Meeting Abstracts). 2011;118(21):2763.
    • (2011) Blood (ASH Annual Meeting Abstracts). , vol.118 , Issue.21 , pp. 2763
    • Goh, H.-G.1    Choi, S.-Y.2    Bang, J.-He.3
  • 30
    • 75649091203 scopus 로고    scopus 로고
    • Strikingly different molecular relapse kinetics in NPM1c, PML-RARA, RUNX1-RUNX1T1, and CBFB-MYH11 acute myeloid leukemias
    • Ommen HB, Schnittger S, Jovanovic JV, et al. Strikingly different molecular relapse kinetics in NPM1c, PML-RARA, RUNX1-RUNX1T1, and CBFB-MYH11 acute myeloid leukemias. Blood. 2010;115(2):198-205.
    • (2010) Blood. , vol.115 , Issue.2 , pp. 198-205
    • Ommen, H.B.1    Schnittger, S.2    Jovanovic, J.V.3
  • 32
    • 10744232328 scopus 로고    scopus 로고
    • Detection of BCR-ABL mutations in patients with CML treated with imatinib is virtually always accompanied by clinical resistance, and mutations in the ATP phosphate-binding loop (P-loop) are associated with a poor prognosis
    • DOI 10.1182/blood-2002-09-2896
    • Branford S, Rudzki Z, Walsh S, et al. Detection of BCR-ABL mutations in patients with CML treated with imatinib is virtually always accompanied by clinical resistance, and mutations in the ATP phosphate-binding loop (P-loop) are associated with a poor prognosis. Blood. 2003;102(1):276-283. (Pubitemid 36759665)
    • (2003) Blood , vol.102 , Issue.1 , pp. 276-283
    • Branford, S.1    Rudzki, Z.2    Walsh, S.3    Parkinson, I.4    Grigg, A.5    Szer, J.6    Taylor, K.7    Herrmann, R.8    Seymour, J.F.9    Arthur, C.10    Joske, D.11    Lynch, K.12    Hughes, T.13
  • 35
    • 54349089682 scopus 로고    scopus 로고
    • Finding of kinase domain mutations in patients with chronic phase chronic myeloid leukemia responding to imatinib may identify those at high risk of disease progression
    • Khorashad JS, de Lavallade H, Apperley JF, et al. Finding of kinase domain mutations in patients with chronic phase chronic myeloid leukemia responding to imatinib may identify those at high risk of disease progression. J Clin Oncol. 2008; 26(29):4806-4813.
    • (2008) J Clin Oncol. , vol.26 , Issue.29 , pp. 4806-4813
    • Khorashad, J.S.1    De Lavallade, H.2    Apperley, J.F.3
  • 36
    • 73949111062 scopus 로고    scopus 로고
    • Epidemiologic study on survival of chronic myeloid leukemia and Ph(-) acute lymphoblastic leukemia patients with BCR-ABL T315I mutation
    • Nicolini FE, Mauro MJ, Martinelli G, et al. Epidemiologic study on survival of chronic myeloid leukemia and Ph(-) acute lymphoblastic leukemia patients with BCR-ABL T315I mutation. Blood. 2009;114(26):5271-5278.
    • (2009) Blood. , vol.114 , Issue.26 , pp. 5271-5278
    • Nicolini, F.E.1    Mauro, M.J.2    Martinelli, G.3
  • 38
    • 47249123747 scopus 로고    scopus 로고
    • Characteristics and outcomes of patients with chronic myeloid leukemia and T315I mutation following failure of imatinib mesylate therapy
    • Jabbour E, Kantarjian H, Jones D, et al. Characteristics and outcomes of patients with chronic myeloid leukemia and T315I mutation following failure of imatinib mesylate therapy. Blood. 2008; 112(1):53-55.
    • (2008) Blood. , vol.112 , Issue.1 , pp. 53-55
    • Jabbour, E.1    Kantarjian, H.2    Jones, D.3
  • 39
    • 34249676964 scopus 로고    scopus 로고
    • Chronic myeloid leukaemia as a model of disease evolution in human cancer
    • DOI 10.1038/nrc2147, PII NRC2147
    • Melo JV, Barnes DJ. Chronic myeloid leukaemia as a model of disease evolution in human cancer. Nat Rev Cancer. 2007;7(6):441-453. (Pubitemid 46823444)
    • (2007) Nature Reviews Cancer , vol.7 , Issue.6 , pp. 441-453
    • Melo, J.V.1    Barnes, D.J.2
  • 40
    • 84856708602 scopus 로고    scopus 로고
    • Dynamics of the emergence of dasatinib and nilotinib resistance in imatinib-resistant CML patients
    • Gruber FX, Ernst T, Porkka K, et al. Dynamics of the emergence of dasatinib and nilotinib resistance in imatinib-resistant CML patients. Leukemia. 2012;26(1):172-177.
    • (2012) Leukemia. , vol.26 , Issue.1 , pp. 172-177
    • Gruber, F.X.1    Ernst, T.2    Porkka, K.3
  • 45
    • 73949105873 scopus 로고    scopus 로고
    • Dasatinib treatment of chronic-phase chronic myeloid leukemia: Analysis of responses according to preexisting BCR-ABL mutations
    • Muller MC, Cortes JE, Kim D-W, et al. Dasatinib treatment of chronic-phase chronic myeloid leukemia: Analysis of responses according to preexisting BCR-ABL mutations. Blood. 2009;114(24): 4944-4953.
    • (2009) Blood. , vol.114 , Issue.24 , pp. 4944-4953
    • Muller, M.C.1    Cortes, J.E.2    Kim, D.-W.3
  • 46
    • 70249105789 scopus 로고    scopus 로고
    • Impact of baseline BCR-ABL mutations on response to nilotinib in patients with chronic myeloid leukemia in chronic phase
    • Hughes T, Saglio G, Branford S, et al. Impact of baseline BCR-ABL mutations on response to nilotinib in patients with chronic myeloid leukemia in chronic phase. J Clin Oncol. 2009;27(25):4204-4210.
    • (2009) J Clin Oncol. , vol.27 , Issue.25 , pp. 4204-4210
    • Hughes, T.1    Saglio, G.2    Branford, S.3
  • 47
    • 55949104933 scopus 로고    scopus 로고
    • Targets and tactics: The relative importance of HbA, fasting and postprandial plasma glucose levels to glycaemic control in type 2 diabetes
    • Woo V, Shestakova MV, Orskov C, Ceriello A. Targets and tactics: The relative importance of HbA, fasting and postprandial plasma glucose levels to glycaemic control in type 2 diabetes. Int J Clin Pract. 2008;62(12):1935-1942.
    • (2008) Int J Clin Pract. , vol.62 , Issue.12 , pp. 1935-1942
    • Woo, V.1    Shestakova, M.V.2    Orskov, C.3    Ceriello, A.4
  • 48
    • 70450277223 scopus 로고    scopus 로고
    • Harmonization of molecular monitoring of CML therapy in Europe
    • Muller MC, Cross NCP, Erben P, et al. Harmonization of molecular monitoring of CML therapy in Europe. Leukemia. 2009;23(11):1957-1963.
    • (2009) Leukemia. , vol.23 , Issue.11 , pp. 1957-1963
    • Muller, M.C.1    Cross, N.C.P.2    Erben, P.3
  • 49
    • 33750327903 scopus 로고    scopus 로고
    • Rationale for the recommendations for harmonizing current methodology for detecting BCR-ABL transcripts in patients with chronic myeloid leukaemia
    • DOI 10.1038/sj.leu.2404388, PII 2404388
    • Branford S, Cross NCP, Hochhaus A, et al. Rationale for the recommendations for harmonizing current methodology for detecting BCR-ABL transcripts in patients with chronic myeloid leukaemia. Leukemia. 2006;20(11):1925-1930. (Pubitemid 44614879)
    • (2006) Leukemia , vol.20 , Issue.11 , pp. 1925-1930
    • Branford, S.1    Cross, N.C.P.2    Hochhaus, A.3    Radich, J.4    Saglio, G.5    Kaeda, J.6    Goldman, J.7    Hughes, T.8


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.