-
1
-
-
0030989287
-
A role for the Wnt gene family in hematopoiesis: expansion of multilineage progenitor cells
-
Austin, T.W., G.P. Solar, F.C. Ziegler, L. Liem, and W. Matthews. 1997. A role for the Wnt gene family in hematopoiesis: expansion of multilineage progenitor cells. Blood. 89:3624-3635.
-
(1997)
Blood
, vol.89
, pp. 3624-3635
-
-
Austin, T.W.1
Solar, G.P.2
Ziegler, F.C.3
Liem, L.4
Matthews, W.5
-
2
-
-
33747488399
-
PML inhibits HIF-1alpha translation and neoangiogenesis through repression of mTOR
-
Bernardi, R., I. Guernah, D. Jin, S. Grisendi, A. Alimonti, J. Teruya-Feldstein, C. Cordon-Cardo, M.C. Simon, S. Rafii, and P.P. Pandolfi. 2006. PML inhibits HIF-1alpha translation and neoangiogenesis through repression of mTOR. Nature. 442:779-785. http://dx.doi.org/10.1038/nature05029
-
(2006)
Nature
, vol.442
, pp. 779-785
-
-
Bernardi, R.1
Guernah, I.2
Jin, D.3
Grisendi, S.4
Alimonti, A.5
Teruya-Feldstein, J.6
Cordon-Cardo, C.7
Simon, M.C.8
Rafii, S.9
Pandolfi, P.P.10
-
3
-
-
0038454621
-
Persistence of malignant hematopoietic progenitors in chronic myelogenous leukemia patients in complete cytogenetic remission following imatinib mesylate treatment
-
Bhatia, R., M. Holtz, N. Niu, R. Gray, D.S. Snyder, C.L. Sawyers, D.A. Arber, M.L. Slovak, and S.J. Forman. 2003. Persistence of malignant hematopoietic progenitors in chronic myelogenous leukemia patients in complete cytogenetic remission following imatinib mesylate treatment. Blood. 101:4701-4707. http://dx.doi .org/10.1182/blood-2002-09-2780
-
(2003)
Blood
, vol.101
, pp. 4701-4707
-
-
Bhatia, R.1
Holtz, M.2
Niu, N.3
Gray, R.4
Snyder, D.S.5
Sawyers, C.L.6
Arber, D.A.7
Slovak, M.L.8
Forman, S.J.9
-
4
-
-
0033582929
-
Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor
-
Brunet, A., A. Bonni, M.J. Zigmond, M.Z. Lin, P. Juo, L.S. Hu, M.J. Anderson, K.C. Arden, J. Blenis, and M.E. Greenberg. 1999. Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor. Cell. 96:857-868. http://dx.doi.org/10.1016/S0092-8674(00)80595-4
-
(1999)
Cell
, vol.96
, pp. 857-868
-
-
Brunet, A.1
Bonni, A.2
Zigmond, M.J.3
Lin, M.Z.4
Juo, P.5
Hu, L.S.6
Anderson, M.J.7
Arden, K.C.8
Blenis, J.9
Greenberg, M.E.10
-
5
-
-
77955443001
-
Critical roles for mTORC2- and rapamycin-insensitive mTORC1-complexes in growth and survival of BCR-ABL-expressing leukemic cells
-
Carayol, N., E. Vakana, A. Sassano, S. Kaur, D.J. Goussetis, H. Glaser, B.J. Druker, N.J. Donato, J.K. Altman, S. Barr, and L.C. Platanias. 2010. Critical roles for mTORC2- and rapamycin-insensitive mTORC1-complexes in growth and survival of BCR-ABL-expressing leukemic cells. Proc. Natl. Acad. Sci. USA. 107:12469-12474. http://dx.doi.org/10.1073/pnas.1005114107
-
(2010)
Proc. Natl. Acad. Sci. USA.
, vol.107
, pp. 12469-12474
-
-
Carayol, N.1
Vakana, E.2
Sassano, A.3
Kaur, S.4
Goussetis, D.J.5
Glaser, H.6
Druker, B.J.7
Donato, N.J.8
Altman, J.K.9
Barr, S.10
Platanias, L.C.11
-
6
-
-
67649861052
-
Loss of the Alox5 gene impairs leukemia stem cells and prevents chronic myeloid leukemia
-
Chen, Y., Y. Hu, H. Zhang, C. Peng, and S. Li. 2009. Loss of the Alox5 gene impairs leukemia stem cells and prevents chronic myeloid leukemia. Nat. Genet. 41:783-792. http://dx.doi.org/10.1038/ng.389
-
(2009)
Nat. Genet.
, vol.41
, pp. 783-792
-
-
Chen, Y.1
Hu, Y.2
Zhang, H.3
Peng, C.4
Li, S.5
-
7
-
-
79960505838
-
A tumor suppressor function of the Msr1 gene in leukemia stem cells of chronic myeloid leukemia
-
Chen, Y., C. Sullivan, C. Peng, Y. Shan, Y. Hu, D. Li, and S. Li. 2011. A tumor suppressor function of the Msr1 gene in leukemia stem cells of chronic myeloid leukemia. Blood. 118:390-400. http://dx.doi.org/10.1182/blood-2010-11-316760
-
(2011)
Blood
, vol.118
, pp. 390-400
-
-
Chen, Y.1
Sullivan, C.2
Peng, C.3
Shan, Y.4
Hu, Y.5
Li, D.6
Li, S.7
-
8
-
-
0029947186
-
Effects of a selective inhibitor of the Abl tyrosine kinase on the growth of Bcr-Abl positive cells
-
Druker, B.J., S. Tamura, E. Buchdunger, S. Ohno, G.M. Segal, S. Fanning, J. Zimmermann, and N.B. Lydon. 1996. Effects of a selective inhibitor of the Abl tyrosine kinase on the growth of Bcr-Abl positive cells. Nat. Med. 2:561-566. http://dx.doi.org/10.1038/nm0596-561
-
(1996)
Nat. Med.
, vol.2
, pp. 561-566
-
-
Druker, B.J.1
Tamura, S.2
Buchdunger, E.3
Ohno, S.4
Segal, G.M.5
Fanning, S.6
Zimmermann, J.7
Lydon, N.B.8
-
9
-
-
79956305728
-
BCL6 enables Ph+ acute lymphoblastic leukaemia cells to survive BCR-ABL1 kinase inhibition
-
Duy, C., C. Hurtz, S. Shojaee, L. Cerchietti, H. Geng, S. Swaminathan, L. Klemm, S.M. Kweon, R. Nahar, M. Braig, et al. 2011. BCL6 enables Ph+ acute lymphoblastic leukaemia cells to survive BCR-ABL1 kinase inhibition. Nature. 473:384-388. http://dx.doi.org/10.1038/nature09883
-
(2011)
Nature
, vol.473
, pp. 384-388
-
-
Duy, C.1
Hurtz, C.2
Shojaee, S.3
Cerchietti, L.4
Geng, H.5
Swaminathan, S.6
Klemm, L.7
Kweon, S.M.8
Nahar, R.9
Braig, M.10
-
10
-
-
7644244868
-
FoxO3a and BCR-ABL regulate cyclin D2 transcription through a STAT5/BCL6-dependent mechanism
-
Fernández de Mattos, S., A. Essafi, I. Soeiro, A.M. Pietersen, K.U. Birkenkamp, C.S. Edwards, A. Martino, B.H. Nelson, J.M. Francis, M.C. Jones, et al. 2004. FoxO3a and BCR-ABL regulate cyclin D2 transcription through a STAT5/BCL6-dependent mechanism. Mol. Cell. Biol. 24:10058-10071. http://dx.doi.org/10.1128/MCB.24.22.10058-10071.2004
-
(2004)
Mol. Cell. Biol.
, vol.24
, pp. 10058-10071
-
-
Fernández de Mattos, S.1
Essafi, A.2
Soeiro, I.3
Pietersen, A.M.4
Birkenkamp, K.U.5
Edwards, C.S.6
Martino, A.7
Nelson, B.H.8
Francis, J.M.9
Jones, M.C.10
-
11
-
-
0036090222
-
Primitive, quiescent Philadelphia-positive stem cells from patients with chronic myeloid leukemia are insensitive to STI571 in vitro
-
Graham, S.M., H.G. Jørgensen, E. Allan, C. Pearson, M.J. Alcorn, L. Richmond, and T.L. Holyoake. 2002. Primitive, quiescent, Philadelphia-positive stem cells from patients with chronic myeloid leukemia are insensitive to STI571 in vitro. Blood. 99:319-325. http://dx.doi.org/10.1182/blood.V99.1.319
-
(2002)
Blood
, vol.99
, pp. 319-325
-
-
Graham, S.M.1
Jørgensen, H.G.2
Allan, E.3
Pearson, C.4
Alcorn, M.J.5
Richmond, L.6
Holyoake, T.L.7
-
12
-
-
80055108071
-
BCL6-mediated repression of p53 is critical for leukemia stem cell survival in chronic myeloid leukemia
-
Hurtz, C., K. Hatzi, L. Cerchietti, M. Braig, E. Park, Y.-M. Kim, S. Herzog, P. Ramezani-Rad, H. Jumaa, M.C. Müller, et al. 2011. BCL6-mediated repression of p53 is critical for leukemia stem cell survival in chronic myeloid leukemia. J. Exp. Med. 208:2163-2174.
-
(2011)
J. Exp. Med.
, vol.208
, pp. 2163-2174
-
-
Hurtz, C.1
Hatzi, K.2
Cerchietti, L.3
Braig, M.4
Park, E.5
Kim, Y.-M.6
Herzog, S.7
Ramezani-Rad, P.8
Jumaa, H.9
Müller, M.C.10
-
13
-
-
0000506439
-
P210 and P190(BCR/ABL) induce the tyrosine phosphorylation and DNA binding activity of multiple specific STAT family members
-
Ilaria, R.L. Jr., and R.A. Van Etten. 1996. P210 and P190(BCR/ABL) induce the tyrosine phosphorylation and DNA binding activity of multiple specific STAT family members. J. Biol. Chem. 271:31704-31710. http://dx.doi.org/10.1074/jbc.271.49.31704
-
(1996)
J. Biol. Chem.
, vol.271
, pp. 31704-31710
-
-
Ilaria Jr., R.L.1
Van Etten, R.A.2
-
14
-
-
44349166602
-
PML targeting eradicates quiescent leukaemiainitiating cells
-
Ito, K., R. Bernardi, A. Morotti, S. Matsuoka, G. Saglio, Y. Ikeda, J. Rosenblatt, D.E. Avigan, J. Teruya-Feldstein, and P.P. Pandolfi. 2008. PML targeting eradicates quiescent leukaemiainitiating cells. Nature. 453:1072-1078. http://dx.doi.org/10.1038/nature07016
-
(2008)
Nature
, vol.453
, pp. 1072-1078
-
-
Ito, K.1
Bernardi, R.2
Morotti, A.3
Matsuoka, S.4
Saglio, G.5
Ikeda, Y.6
Rosenblatt, J.7
Avigan, D.E.8
Teruya-Feldstein, J.9
Pandolfi, P.P.10
-
15
-
-
0037458609
-
A member of Forkhead transcription factor FKHRL1 is a downstream effector of STI571-induced cell cycle arrest in BCR-ABL-expressing cells
-
Komatsu, N., T. Watanabe, M. Uchida, M. Mori, K. Kirito, S. Kikuchi, Q. Liu, T. Tauchi, K. Miyazawa, H. Endo, et al. 2003. A member of Forkhead transcription factor FKHRL1 is a downstream effector of STI571-induced cell cycle arrest in BCR-ABL-expressing cells. J. Biol. Chem. 278:6411-6419. http://dx.doi.org/10.1074/jbc.M211562200
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 6411-6419
-
-
Komatsu, N.1
Watanabe, T.2
Uchida, M.3
Mori, M.4
Kirito, K.5
Kikuchi, S.6
Liu, Q.7
Tauchi, T.8
Miyazawa, K.9
Endo, H.10
-
16
-
-
78049496814
-
mTOR activation induces tumor suppressors that inhibit leukemogenesis and deplete hematopoietic stem cells after Pten deletion
-
Lee, J.Y., D. Nakada, O.H. Yilmaz, Z. Tothova, N.M. Joseph, M.S. Lim, D.G. Gilliland, and S.J. Morrison. 2010. mTOR activation induces tumor suppressors that inhibit leukemogenesis and deplete hematopoietic stem cells after Pten deletion. Cell Stem Cell. 7:593-605. http://dx.doi.org/10.1016/j.stem.2010.09.015
-
(2010)
Cell Stem Cell
, vol.7
, pp. 593-605
-
-
Lee, J.Y.1
Nakada, D.2
Yilmaz, O.H.3
Tothova, Z.4
Joseph, N.M.5
Lim, M.S.6
Gilliland, D.G.7
Morrison, S.J.8
-
17
-
-
78049528573
-
Intergroupe Français des Leucémies Myéloïdes hroniques, Discontinuation of imatinib in patients with chronic myeloid leukaemia who have maintained complete molecular remission for at least 2 years: the prospective, multicentre Stop Imatinib (STIM) trial
-
Mahon, F.X., D. Réa, J. Guilhot, F. Guilhot, F. Huguet, F. Nicolini, L. Legros, A. Charbonnier, A. Guerci, B. Varet, et al; Intergroupe Français des Leucémies Myéloïdes Chroniques. 2010. Discontinuation of imatinib in patients with chronic myeloid leukaemia who have maintained complete molecular remission for at least 2 years: the prospective, multicentre Stop Imatinib (STIM) trial. Lancet Oncol. 11:1029-1035. http://dx.doi.org/10.1016/S1470-2045(10)70233-3
-
(2010)
Lancet Oncol
, vol.11
, pp. 1029-1035
-
-
Mahon, F.X.1
Réa, D.2
Guilhot, J.3
Guilhot, F.4
Huguet, F.5
Nicolini, F.6
Legros, L.7
Charbonnier, A.8
Guerci, A.9
Varet, B.10
-
18
-
-
76249087423
-
TGFbeta-FOXO signalling maintains leukaemiainitiating cells in chronic myeloid leukaemia
-
Naka, K., T. Hoshii, T. Muraguchi, Y. Tadokoro, T. Ooshio, Y. Kondo, S. Nakao, N. Motoyama, and A. Hirao. 2010. TGFbeta-FOXO signalling maintains leukaemiainitiating cells in chronic myeloid leukaemia. Nature. 463:676-680. http://dx.doi.org/10.1038/nature08734
-
(2010)
Nature
, vol.463
, pp. 676-680
-
-
Naka, K.1
Hoshii, T.2
Muraguchi, T.3
Tadokoro, Y.4
Ooshio, T.5
Kondo, Y.6
Nakao, S.7
Motoyama, N.8
Hirao, A.9
-
19
-
-
18244432009
-
Jak2 deficiency defines an essential developmental checkpoint in definitive hematopoiesis
-
Neubauer, H., A. Cumano, M. Müller, H. Wu, U. Huffstadt, and K. Pfeffer. 1998. Jak2 deficiency defines an essential developmental checkpoint in definitive hematopoiesis. Cell. 93:397-409. http://dx.doi.org/10.1016/S0092-8674(00)81168-X
-
(1998)
Cell
, vol.93
, pp. 397-409
-
-
Neubauer, H.1
Cumano, A.2
Müller, M.3
Wu, H.4
Huffstadt, U.5
Pfeffer, K.6
-
20
-
-
27644569730
-
The tumor suppressor PP2A is functionally inactivated in blast crisis CML through the inhibitory activity of the BCR/ABL-regulated SET protein
-
Neviani, P., R. Santhanam, R. Trotta, M. Notari, B.W. Blaser, S. Liu, H. Mao, J.S. Chang, A. Galietta, A. Uttam, et al. 2005. The tumor suppressor PP2A is functionally inactivated in blast crisis CML through the inhibitory activity of the BCR/ABL-regulated SET protein. Cancer Cell. 8:355-368. http://dx.doi.org/10.1016/j.ccr.2005.10.015
-
(2005)
Cancer Cell
, vol.8
, pp. 355-368
-
-
Neviani, P.1
Santhanam, R.2
Trotta, R.3
Notari, M.4
Blaser, B.W.5
Liu, S.6
Mao, H.7
Chang, J.S.8
Galietta, A.9
Uttam, A.10
-
21
-
-
34648832173
-
FTY720, a new alternative for treating blast crisis chronic myelogenous leukemia and Philadelphia chromosome-positive acute lymphocytic leukemia
-
Neviani, P., R. Santhanam, J.J. Oaks, A.M. Eiring, M. Notari, B.W. Blaser, S. Liu, R. Trotta, N. Muthusamy, C. Gambacorti-Passerini, et al. 2007. FTY720, a new alternative for treating blast crisis chronic myelogenous leukemia and Philadelphia chromosome-positive acute lymphocytic leukemia. J. Clin. Invest. 117:2408-2421. http://dx.doi.org/10.1172/JCI31095
-
(2007)
J. Clin. Invest.
, vol.117
, pp. 2408-2421
-
-
Neviani, P.1
Santhanam, R.2
Oaks, J.J.3
Eiring, A.M.4
Notari, M.5
Blaser, B.W.6
Liu, S.7
Trotta, R.8
Muthusamy, N.9
Gambacorti-Passerini, C.10
-
22
-
-
77449117864
-
PTEN is a tumor suppressor in CML stem cells and BCR-ABL-induced leukemias in mice
-
Peng, C., Y. Chen, Z. Yang, H. Zhang, L. Osterby, A.G. Rosmarin, and S. Li. 2010. PTEN is a tumor suppressor in CML stem cells and BCR-ABL-induced leukemias in mice. Blood. 115:626-635. http://dx.doi.org/10.1182/blood-2009-06-228130
-
(2010)
Blood
, vol.115
, pp. 626-635
-
-
Peng, C.1
Chen, Y.2
Yang, Z.3
Zhang, H.4
Osterby, L.5
Rosmarin, A.G.6
Li, S.7
-
23
-
-
0015694748
-
Letter: A new consistent chromosomal abnormality in chronic myelogenous leukaemia identified by quinacrine fluorescence and Giemsa staining
-
Rowley, J.D. 1973. Letter: A new consistent chromosomal abnormality in chronic myelogenous leukaemia identified by quinacrine fluorescence and Giemsa staining. Nature. 243:290-293. http://dx.doi.org/10.1038/243290a0
-
(1973)
Nature
, vol.243
, pp. 290-293
-
-
Rowley, J.D.1
-
24
-
-
64949147229
-
Jak2 inhibition deactivates Lyn kinase through the SETPP2A-SHP1 pathway, causing apoptosis in drug-resistant cells from chronic myelogenous leukemia patients
-
Samanta, A.K., S.N. Chakraborty, Y. Wang, H. Kantarjian, X. Sun, J. Hood, D. Perrotti, and R.B. Arlinghaus. 2009. Jak2 inhibition deactivates Lyn kinase through the SETPP2A-SHP1 pathway, causing apoptosis in drug-resistant cells from chronic myelogenous leukemia patients. Oncogene. 28:1669-1681. http://dx.doi.org/10.1038/onc.2009.7
-
(2009)
Oncogene
, vol.28
, pp. 1669-1681
-
-
Samanta, A.K.1
Chakraborty, S.N.2
Wang, Y.3
Kantarjian, H.4
Sun, X.5
Hood, J.6
Perrotti, D.7
Arlinghaus, R.B.8
-
25
-
-
0032475861
-
Negative regulation of PKB/Aktdependent cell survival by the tumor suppressor PTEN
-
Stambolic, V., A. Suzuki, J.L. de la Pompa, G.M. Brothers, C. Mirtsos, T. Sasaki, J. Ruland, J.M. Penninger, D.P. Siderovski, and T.W. Mak. 1998. Negative regulation of PKB/Aktdependent cell survival by the tumor suppressor PTEN. Cell. 95:29-39. http://dx.doi.org/10.1016/S0092-8674(00)81780-8
-
(1998)
Cell
, vol.95
, pp. 29-39
-
-
Stambolic, V.1
Suzuki, A.2
de la Pompa, J.L.3
Brothers, G.M.4
Mirtsos, C.5
Sasaki, T.6
Ruland, J.7
Penninger, J.M.8
Siderovski, D.P.9
Mak, T.W.10
-
26
-
-
33846419112
-
FoxOs are critical mediators of hematopoietic stem cell resistance to physiologic oxidative stress
-
Tothova, Z., R. Kollipara, B.J. Huntly, B.H. Lee, D.H. Castrillon, D.E. Cullen, E.P. McDowell, S. Lazo-Kallanian, I.R. Williams, C. Sears, et al. 2007. FoxOs are critical mediators of hematopoietic stem cell resistance to physiologic oxidative stress. Cell. 128:325-339. http://dx.doi.org/10.1016/j.cell.2007.01.003
-
(2007)
Cell
, vol.128
, pp. 325-339
-
-
Tothova, Z.1
Kollipara, R.2
Huntly, B.J.3
Lee, B.H.4
Castrillon, D.H.5
Cullen, D.E.6
McDowell, E.P.7
Lazo-Kallanian, S.8
Williams, I.R.9
Sears, C.10
-
27
-
-
0037126385
-
Jak2 is involved in c-Myc induction by Bcr-Abl
-
Xie, S., H. Lin, T. Sun, and R.B. Arlinghaus. 2002. Jak2 is involved in c-Myc induction by Bcr-Abl. Oncogene. 21:7137-7146. http://dx.doi.org/10.1038/sj.onc.1205942
-
(2002)
Oncogene
, vol.21
, pp. 7137-7146
-
-
Xie, S.1
Lin, H.2
Sun, T.3
Arlinghaus, R.B.4
-
28
-
-
33646376411
-
Pten dependence distinguishes haematopoietic stem cells from leukaemia-initiating cells
-
Yilmaz, O.H., R. Valdez, B.K. Theisen, W. Guo, D.O. Ferguson, H. Wu, and S.J. Morrison. 2006. Pten dependence distinguishes haematopoietic stem cells from leukaemia-initiating cells. Nature. 441:475-482. http://dx.doi.org/10.1038/nature04703
-
(2006)
Nature
, vol.441
, pp. 475-482
-
-
Yilmaz, O.H.1
Valdez, R.2
Theisen, B.K.3
Guo, W.4
Ferguson, D.O.5
Wu, H.6
Morrison, S.J.7
-
29
-
-
58149156479
-
AHI-1 interacts with BCRABL and modulates BCR-ABL transforming activity and imatinib response of CML stem/progenitor cells
-
Zhou, L.L., Y. Zhao, A. Ringrose, D. DeGeer, E. Kennah, A.E. Lin, G. Sheng, X.J. Li, A. Turhan, and X. Jiang. 2008. AHI-1 interacts with BCRABL and modulates BCR-ABL transforming activity and imatinib response of CML stem/ progenitor cells. J. Exp. Med. 205:2657-2671. http://dx.doi.org/10.1084/jem.20072316
-
(2008)
J. Exp. Med.
, vol.205
, pp. 2657-2671
-
-
Zhou, L.L.1
Zhao, Y.2
Ringrose, A.3
DeGeer, D.4
Kennah, E.5
Lin, A.E.6
Sheng, G.7
Li, X.J.8
Turhan, A.9
Jiang, X.10
|