Biological and phenotypic alterations of T cells in aging

Immunology of Aging

Volumn , Issue , 2014, Pages 177-182

  Massoud, Ahmad ^a   Massoud, Amir Hossein ^b,c  

^a TEHRAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^b MCGILL UNIVERSITY   (Canada)

^c MCGILL UNIVERSITY   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 84930268348     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1007/978-3-642-39495-9_11     Document Type: Chapter

References (46)

1. Alam I, Larbi A, Pawelec G (2012) Nutritional status influences peripheral immune cell phenotypes in healthy men in rural Pakistan. Immun Ageing 9(1):16
2. Alvarado C, Alvarez P, Puerto M et al (2006) Dietary supplementation with antioxidants improves functions and decreases oxidative stress of leukocytes from prematurely aging mice. Nutrition 22(7-8):767-777
3. Behzad H, Huckriede AL, Haynes L et al (2012) GLA-SE, a synthetic toll-like receptor 4 agonist, enhances T-cell responses to influenza vaccine in older adults. J Infect Dis 205(3):466-473
4. Chen BJ, Cui X, Sempowski GD et al (2003) Growth hormone accelerates immune recovery following allogeneic T-cell-depleted bone marrow transplantation in mice. Exp Hematol 31(10):953-958
5. Chen BJ, Deoliveira D, Spasojevic I et al (2010) Growth hormone mitigates against lethal irradiation and enhances hematologic and immune recovery in mice and nonhuman primates. PLoS One 5(6):e11056
6. Chidgey AP, Boyd RL (2006) Stemming the tide of thymic aging. Nat Immunol 7(10):1013-1016
7. Chou JP, Effros RB (2013) T cell replicative senescence in human aging. Curr Pharm Des 19(9):1680-1698
8. Curtsinger JM, Schmidt CS, Mondino A et al (1999) Inflammatory cytokines provide a third signal for activation of naive CD4+ and CD8+ T cells. J Immunol 162(6):3256-3262
9. Douziech N, Seres I, Larbi A et al (2002) Modulation of human lymphocyte proliferative response with aging. Exp Gerontol 37(2-3):369-387
10. Eaton SM, Maue AC, Swain SL et al (2008) Bone marrow precursor cells from aged mice generate CD4 T cells that function well in primary and memory responses. J Immunol 181(7):4825-4831
11. Effros RB (2003) Genetic alterations in the ageing immune system: impact on infection and cancer. Mech Ageing Dev 124(1):71-77
12. Engwerda CR, Fox BS, Handwerger BS (1996) Cytokine production by T lymphocytes from young and aged mice. J Immunol 156(10):3621-3630
13. Goldberg GL, Sutherland JS, Hammet MV et al (2005) Sex steroid ablation enhances lymphoid recovery following autologous hematopoietic stem cell transplantation. Transplantation 80(11):1604-1613
14. Goldberg GL, Alpdogan O, Muriglan SJ et al (2007) Enhanced immune reconstitution by sex steroid ablation following allogeneic hemopoietic stem cell transplantation. J Immunol 178(11):7473-7484
15. Haynes L, Swain SL (2006) Why aging T cells fail: implications for vaccination. Immunity 24(6):663-666
16. Haynes L, Linton PJ, Eaton SM et al (1999) Interleukin 2, but not other common gamma chain-binding cytokines, can reverse the defect in generation of CD4 effector T cells from naive T cells of aged mice. J Exp Med 190(7):1013-1024
17. Haynes L, Eaton SM, Burns EM et al (2003) CD4 T cell memory derived from young naive cells functions well into old age, but memory generated from aged naive cells functions poorly. Proc Natl Acad Sci U S A 100(25):15053-15058
18. Haynes L, Eaton SM, Burns EM et al (2004) Inflammatory cytokines overcome age-related defects in CD4 T cell responses in vivo. J Immunol 172(9):5194-5199
19. Heng TS, Chidgey AP, Boyd RL (2010) Getting back at nature: understanding thymic development and overcoming its atrophy. Curr Opin Pharmacol 10(4):425-433
20. Henson SM, Akbar AN (2010) Memory T-cell homeostasis and senescence during aging. Adv Exp Med Biol 684:189-197
21. High KP, Akbar AN, Nikolich-Zugich J (2012) Translational research in immune senescence: assessing the relevance of current models. Semin Immunol 24(5):373-382
22. Hobbs MV, Ernst DN, Torbett BE et al (1991) Cell proliferation and cytokine production by CD4+ cells from old mice. J Cell Biochem 46(4):312-320
23. Holland AM, van den Brink MR (2009) Rejuvenation of the aging T cell compartment. Curr Opin Immunol 21(4):454-459
24. Hosaka N, Nose M, Kyogoku M et al (1996) Thymus transplantation, a critical factor for correction of autoimmune disease in aging MRL/+mice. Proc Natl Acad Sci U S A 93(16):8558-8562
25. Kapasi ZF, Murali-Krishna K, McRae ML et al (2002) Defective generation but normal maintenance of memory T cells in old mice. Eur J Immunol 32(6):1567-1573
26. Kaszubowska L (2008) Telomere shortening and ageing of the immune system. J Physiol Pharmacol 59(Suppl 9):169-186
27. Kilpatrick RD, Rickabaugh T, Hultin LE et al (2008) Homeostasis of the naive CD4+ T cell compartment during aging. J Immunol 180(3):1499-1507
28. Klinman NR, Kline GH (1997) The B-cell biology of aging. Immunol Rev 160:103-114
29. Kwon TK, Nagel JE, Buchholz MA et al (1996) Characterization of the murine cyclin-dependent kinase inhibitor gene p27Kip1. Gene 180(1-2):113-120
30. Lee N, Shin MS, Kang I (2012) T-cell biology in aging, with a focus on lung disease. J Gerontol A Biol Sci Med Sci 67(3):254-263
31. Linton PJ, Dorshkind K (2004) Age-related changes in lymphocyte development and function. Nat Immunol 5(2):133-139
32. Lustyik G, O'Leary JJ (1989) Aging and the mobilization of intracellular calcium by phytohemagglutinin in human T cells. J Gerontol 44(2):B30-B36
33. Maue AC, Eaton SM, Lanthier PA et al (2009) Proinflammatory adjuvants enhance the cognate helper activity of aged CD4 T cells. J Immunol 182(10):6129-6135
34. McLeod JD (2000) Apoptotic capability in ageing T cells. Mech Ageing Dev 121(1-3):151-159
35. Minematsu T, Yamamoto Y, Nagase T et al (2011) Aging enhances maceration-induced ultrastructural alteration of the epidermis and impairment of skin barrier function. J Dermatol Sci 62(3):160-168
36. Noble JM, Ford GA, Thomas TH (1999) Effect of aging on CD11b and CD69 surface expression by vesicular insertion in human polymorphonuclear leucocytes. Clin Sci (Lond) 97(3):323-329
37. Pae M, Meydani SN, Wu D (2012) The role of nutrition in enhancing immunity in aging. Ageing Dis 3(1): 91-129
38. Ponnappan U (2002) Ubiquitin-proteasome pathway is compromised in CD45RO + and CD45RA + T lymphocyte subsets during aging. Exp Gerontol 37(2-3): 359-367
39. Santiago AF, Alves AC, Oliveira RP et al (2011) Aging correlates with reduction in regulatory-type cytokines and T cells in the gut mucosa. Immunobiology 216(10):1085-1093
40. Sempowski GD, Gooding ME, Liao HX et al (2002) T cell receptor excision circle assessment of thymopoiesis in aging mice. Mol Immunol 38(11): 841-848
41. Strasser A, Sonnek U, Niedermuller H (1997) Agerelated changes in plasma IgM level after SRBCstimulation in the rat. Arch Gerontol Geriatr 25(3): 277-284
42. Tamura T, Kunimatsu T, Yee ST et al (2000) Molecular mechanism of the impairment in activation signal transduction in CD4(+) T cells from old mice. Int Immunol 12(8):1205-1215
43. von Freeden-Jeffry U, Solvason N, Howard M et al (1997) The earliest T lineage-committed cells depend on IL-7 for Bcl-2 expression and normal cell cycle progression. Immunity 7(1):147-154
44. Weinberger B, Grubeck-Loebenstein B (2012) Vaccines for the elderly. Clin Microbiol Infect 18(Suppl 5): 100-108
45. Welniak LA, Sun R, Murphy WJ (2002) The role of growth hormone in T-cell development and reconstitution. J Leukoc Biol 71(3):381-387
46. Zhou X, McElhaney JE (2011) Age-related changes in memory and effector T cells responding to influenza A/H3N2 and pandemic A/H1N1 strains in humans. Vaccine 29(11):2169-2177