Enhanced immune reconstitution by sex steroid ablation following allogeneic hemopoietic stein cell transplantation

Journal of Immunology

Volumn 178, Issue 11, 2007, Pages 7483-7484

  Goldberg, Gabrielle L ^a,b   Alpdogan, Önder ^b   Muriglan, Stephanie J ^b   Hammett, Maree V ^a   Milton, Morag K ^a   Eng, Jeffrey M ^b   Hubbard, Vanessa M ^b   Kochman, Adam ^b   Willis, Lucy M ^b   Greenberg, Andrew S ^b   Tjoe, Kartono H ^b   Sutherland, Jayne S ^a   Chidgey, Ann ^a   Van Den Brink, Marcel R M ^b   Boyd, Richard L ^a  

^a MONASH UNIVERSITY   (Australia)

^b MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

INTERLEUKIN 7; SEX HORMONE;

ALLOGENEIC STEM CELL TRANSPLANTATION; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; B LYMPHOCYTE; CONTROLLED STUDY; DENDRITIC CELL; GRAFT VERSUS HOST REACTION; GRAFT VERSUS LEUKEMIA EFFECT; IMMUNE RECONSTITUTION INFLAMMATORY SYNDROME; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; T LYMPHOCYTE; THYMUS ATROPHY; ALLOTRANSPLANTATION; ANIMAL; BAGG ALBINO MOUSE; BONE MARROW TRANSPLANTATION; C3H MOUSE; C57BL MOUSE; CBA MOUSE; GENETICS; HEMATOPOIETIC STEM CELL TRANSPLANTATION; IMMUNOLOGY; LYMPHOCYTE COUNT; MOUSE MUTANT; MULTIMODALITY CANCER THERAPY; ORCHIECTOMY; SPLEEN; T LYMPHOCYTE SUBPOPULATION; THYMUS; TRANSPLANTATION;

ANIMALS; B-LYMPHOCYTE SUBSETS; BONE MARROW TRANSPLANTATION; COMBINED MODALITY THERAPY; DENDRITIC CELLS; GRAFT VS HOST DISEASE; GRAFT VS TUMOR EFFECT; HEMATOPOIETIC STEM CELL TRANSPLANTATION; INTERLEUKIN-7; LYMPHOCYTE COUNT; MALE; MICE; MICE, INBRED BALB C; MICE, INBRED C3H; MICE, INBRED C57BL; MICE, INBRED CBA; MICE, KNOCKOUT; ORCHIECTOMY; SPLEEN; T-LYMPHOCYTE SUBSETS; THYMUS GLAND; TRANSPLANTATION, HOMOLOGOUS;

EID: 34249821626     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (78)

1. Parkman, R., and K. I. Weinberg. 1997. Immunological reconstitution following bone marrow transplantation. Immunol. Rev. 157: 73-78.
2. Aspinall, R., and D. Andrew. 2000. Thymic atrophy in the mouse is a soluble problem of the thymic environment. Vaccine 18: 1629-1637.
3. Greenstein, B. D., F. T. Fitzpatrick, I. M. Adcock, M. D. Kendall, and M. J. Wheeler. 1986. Reappearance of the thymus in old rats after orchidectomy: inhibition of regeneration by testosterone. J. Endocrinol. 110: 417-422.
4. Windmill, K. F., B. J. Meade, and V. W. Lee. 1993. Effect of prepubertal gonadectomy and sex steroid treatment on the growth and lymphocyte populations of the rat thymus. Reprod. Fertil. Dev. 5: 73-81.
5. Nabarra, B., and I. Andrianarison. 1996. Ultrastructural study of thymic microenvironment involution in aging mice. Exp. Gerontol. 31: 489-506.
6. Fitzpatrick, F. T., M. D. Kendall, M. J. Wheeler, I. M. Adcock, and B. D. Greenstein. 1985. Reappearance of thymus of ageing rats after orchidectomy. J. Endocrinol. 106: R17-R19.
7. Marchetti, B., V. Guarcello, M. C. Morale, G. Bartoloni, F. Raiti, G. Palumbo, Jr., Z. Farinella, S. Cordaro, and U. Scapagnini. 1989. Luteinizing hormone-releasing hormone (LHRH) agonist restoration of age-associated decline of thymus weight, thymic LHRH receptors, and thymocyte proliferative capacity. Endocrinology 125: 1037-1045.
8. Scollay, R. G., E. C. Butcher, and I. L. Weissman. 1980. Thymus cell migration: quantitative aspects of cellular traffic from the thymus to the periphery in mice. Eur. J. Immunol. 10: 210-218.
9. Berzins, S. P., R. L. Boyd, and J. F. Miller. 1998. The role of the thymus and recent thymic migrants in the maintenance of the adult peripheral lymphocyte pool. J. Exp. Med. 187: 1839-1848.
10. Steffens, C. M., L. Al-Harthi, S. Shott, R. Yogev, and A. Landay. 2000. Evaluation of thymopoiesis using T cell receptor excision circles (TRECs): differential correlation between adult and pediatric TRECs and naive phenotypes. Clin. Immunol. 97: 95-101.
11. Sempowski, G. D., M. E. Gooding, H. X. Liao, P. T. Le, and B. F. Haynes. 2002. T cell receptor excision circle assessment of thymopoiesis in aging mice. Mol. Immunol. 38: 841-848.
12. + T cells from young and aged mice. J. Immunol. 145: 1295-1302.
13. Kurashima, C., M. Utsuyama, M. Kasai, S. A. Ishijima, A. Konno, and K. Hirokawa. 1995. The role of thymus in the aging of Th cell subpopulations and age-associated alteration of cytokine production by these cells. Int. Immunol. 7: 97-104.
14. + T cell subsets in human peripheral blood. Mech. Ageing Dev. 63: 57-68.
15. Mosley, R. L., M. M. Koker, and R. A. Miller. 1998. Idiosyncratic alterations of TCR size distributions affecting both CD4 and CD8 T cell subsets in aging mice. Cell. Immunol. 189: 10-18.
16. LeMaoult, J., I. Messaoudi, J. S. Manavalan, H. Potvin, D. Nikolich-Zugich, R. Dyall, P. Szabo, M. E. Weksler, and J. Nikolich-Zugich. 2000. Age-related dysregulation in CD8 T cell homeostasis: kinetics of a diversity loss. J. Immunol. 165: 2367-2373.
17. + T cells from old CBA/RIJ mice. Mech. Ageing Dev. 53: 141-155.
18. Flurkey, K., R. A. Miller, and D. E. Harrison. 1992. Cellular determinants of age-related decrements in the T-cell mitogen response of B6CBAF1 mice. J. Gerontol. 47: B115-B120.
19. Kirschmann, D. A., and D. M. Murasko. 1992. Splenic and inguinal lymph node T cells of aged mice respond differently to polyclonal and antigen-specific stimuli. Cell. Immunol. 139: 426-437.
20. Hu, A., D. Ehleiter, A. Ben-Yehuda, R. Schwab, C. Russo, P. Szabo, and M. E. Weksler. 1993. Effect of age on the expressed B cell repertoire: role of B cell subsets. Int. Immunol. 5: 1035-1039.
21. LeMaoult, J., J. S. Manavalan, R. Dyall, P. Szabo, J. Nikolic-Zugic, and M. E. Weksler. 1999. Cellular basis of B cell clonal populations in old mice. J. Immunol. 162: 6384-6391.
22. Weksler, M. E., C. Russo, and G. W. Siskind. 1989. Peripheral T cells select the B-cell repertoire in old mice. Immunol Rev. 110: 173-185.
23. Weksler, M. E. 2000. Changes in the B-cell repertoire with age. Vaccine 18: 1624-1628.
24. Nicoletti, C., X. Yang, and J. Cerny. 1993. Repertoire diversity of antibody response to bacterial antigens in aged mice. III. Phosphorylcholine antibody from young and aged mice differ in structure and protective activity against infection with Streptococcus pneumoniae. J. Immunol. 150: 543-549.
25. Donek, D. C., R. D. McFarland, P. H. Keiser, E. A. Gage, J. M. Massey, B. F. Haynes, M. A. Polis, A. T. Haase, M. B. Feinberg, J. L. Sullivan, et al. 1998. Changes in thymic function with age and during the treatment of HIV infection. Nature 396: 690-695.
26. + T-lymphocyte regeneration after intensive chemotherapy. N. Engl. J. Med. 332: 143-149.
27. Sutherland, J. S., G. L. Goldberg, M. V. Hammett, A. P. Uldrich, S. P. Berzins, T. S. Heng, B. R. Blazar, J. L. Millar, M. A. Malin, A. P. Chidgey, and R. L. Boyd. 2005. Activation of thymic regeneration in mice and humans following androgen blockade. J. Immunol. 175: 2741-2753.
28. Heng, T. S., G. L. Goldberg, D. H. Gray, J. S. Sutherland, A. P. Chidgey, and R. L. Boyd. 2005. Effects of castration on thymocyte development in two different models of thymic involution. J. Immunol. 175: 2982-2993.
29. Utsuyama, M., K. Hirokawa, C. Mancini, R. Brunelli, G. Leter, and G. Doria. 1995. Differential effects of gonadectomy on thymic stromal cells in promoting T cell differentiation in mice. Mech. Ageing Dev. 81: 107-117.
30. Moron, G., B. Maletto, A. Ropolo, and M. C. Pistoresi-Palencia. 2000. Changes in the development of experimental autoimmune prostatitis (EAP) by castration in aged rats. Dev. Comp. Immunol. 24: 673-682.
31. Ellis, T. M., M. T. Moser, P. T. Le, R. C. Flanigan, and E. D. Kwon. 2001. Alterations in peripheral B cells and B cell progenitors following androgen ablation in mice. Int. Immunol. 13: 553-558.
32. Alpdogan, O., C. Schmaltz, S. J. Muriglan, B. J. Kappel, M. A. Perales, J. A. Rotolo, J. A. Halm, B. E. Rich, and M. R. van den Brink. 2001. Administration of interleukin-7 after allogeneic bone marrow transplantation improves immune reconstitution without aggravating graft-versus-host disease. Blood 98: 2256-2265.
33. Cooke, K. R., L. Kobzik, T. R. Martin, J. Brewer, J. Delmonte, Jr., J. M. Crawford, and J. L. Ferrara. 1996. An experimental model of idiopathic pneumonia syndrome after bone marrow transplantation: I. The roles of minor H antigens and endotoxin. Blood 88: 3230-3239.
34. Gray, D. H., A. P. Chidgey, and R. L. Boyd. 2002. Analysis of thymic stromal cell populations using flow cytometry. J. Immunol. Methods 260: 15-28.
35. Thurmond, T. S., F. G. Murante, J. E. Staples, A. E. Silverstone, K. S. Korach, and T. A. Gasiewicz. 2000. Role of estrogen receptor α in hematopoietic stem cell development and B lymphocyte maturation in the male mouse. Endocrinology 141: 2309-2318.
36. Medina, K. L., K. P. Garrett, L. F. Thompson, M. I. Rossi, K. J. Payne, and P. W. Kincade. 2001. Identification of very early lymphoid precursors in bone marrow and their regulation by estrogen. Nat. Immunol. 2: 718-724.
37. Kouro, T., K. L. Medina, K. Oritani, and P. W. Kincade. 2001. Characteristics of early murine B-lymphocyte precursors and their direct sensitivity to negative regulators. Blood 97: 2708-2715.
38. Morelli, A. E., H. Hackstein, and A. W. Thomson. 2001. Potential of tolerogenic dendritic cells for transplantation. Semin. Immunol. 13: 323-335.
39. Gabor, M. J., D. I. Godfrey, and R. Scollay. 1997. Recent thymic emigrants are distinct from most medullary thymocytes. Eur. J. Immunol. 27: 2010-2015.
40. Boursalian, T. E., J. Golob, D. M. Soper, C. J. Cooper, and P. J. Fink. 2004. Continued maturation of thymic emigrants in the periphery. Nat. Immunol. 5: 418-425.
41. Bolotin, E., M. Smogorzewska, S. Smith, M. Widmer, and K. Weinberg. 1996. Enhancement of thymopoiesis after bone marrow transplant by in vivo interleukin-7. Blood 88: 1887-1894.
42. Faltynek, C. R., S. Wang, D. Miller, E. Young, L. Tiberio, K. Kross, M. Kelley, and E. Kloszewski. 1992. Administration of human recombinant IL-7 to normal and irradiated mice increases the numbers of lymphocytes and some immature cells of the myeloid lineage. J. Immunol. 149: 1276-1282.
43. Morrissey, P. J., P. Conlon, S. Braddy, D. E. Williams, A. E. Namen, and D. Y. Mochizuki. 1991. Administration of IL-7 to mice with cyclophosphamide- induced lymphopenia accelerates lymphocyte repopulation. J. Immunol. 146: 1547-1552.
44. Alpdogan, O., S. J. Muriglan, J. M. Eng, L. M. Willis, A. S. Greenberg, B. J. Kappel, and M. R. van den Brink. 2003. IL-7 enhances peripheral T cell reconstitution after allogeneic hematopoietic stem cell transplantation. J. Clin. Invest. 112: 1095-1107.
45. Shull, M. M., I. Ormsby, A. B. Kier, S. Pawlowski, R. J. Diebold, M. Yin, R. Allen, C. Sidman, G. Proetzel, D. Calvin, et al. 1992. Targeted disruption of the mouse transforming growth factor-β1 gene results in multifocal inflammatory disease. Nature 359: 693-699.
46. von Freeden-Jeffry, U., P. Vieira, L. A. Lucian, T. McNeil, S. E. Burdach, and R. Murray. 1995. Lymphopenia in interleukin (IL)-7 gene-deleted mice identifies IL-7 as a nonredundant cytokine. J. Exp. Med. 181: 1519-1526.
47. Storek, J., A. Joseph, G. Espino, M. A. Dawson, D. C. Douek, K. M. Sullivan, M. E. Flowers, P. Martin, G. Mathioudakis, R. A. Nash, et al. 2001. Immunity of patients surviving 20 to 30 years after allogeneic or syngeneic bone marrow transplantation. Blood 98: 3505-3512.
48. Lewin, S. R., G. Heller, L. Zhang, E. Rodrigues, E. Skulsky, M. R. van den Brink, T. N. Small, N. A. Kernan, R. J. O'Reilly, D. D. Ho, and J. W. Young. 2002. Direct evidence for new T-cell generation by patients after either T-cell-depleted or unmodified allogeneic hematopoietic stem cell transplantations. Blood 100: 2235-2242.
49. Storek, J., T. Gooley, R. P. Witherspoon, K. M. Sullivan, and R. Storb. 1997. Infectious morbidity in long-term survivors of allogeneic marrow transplantation is associated with low CD4 T cell counts. Am. J. Hematol. 54: 131-138.
50. Siena, S., R. Schiavo, P. Pedrazzoli, and C. Carlo-Stella. 2000. Therapeutic relevance of CD34 cell dose in blood cell transplantation for cancer therapy. J. Clin. Oncol. 18: 1360-1377.
51. + peripheral blood progenitor cell dose on hematopoietic recovery. Biol. Blood Marrow Transplant. 4: 84-92.
52. + cell dose predicts survival, posttransplant morbidity, and rate of hematologic recovery after allogeneic marrow transplants for hematologic malignancies. Blood 88: 3223-3229.
53. + cell immunomagnetic selection in breast cancer patients: effect on hematopoietic progenitor content and hematologic recovery after high-dose chemotherapy and autotransplantation. Transfusion 38: 1063-1070.
54. Mackall, C. L., F. T. Hakim, and R. E. Gress. 1997. Restoration of T-cell homeostasis after T-cell depletion. Semin. Immunol. 9: 339-346.
55. Mackall, C. L., and R. E. Gress. 1997. Thymic aging and T-cell regeneration. Immunol. Rev. 160: 91-102.
56. Almeida, A. R., J. A. Borghans, and A. A. Freitas. 2001. T cell homeostasis: thymus regeneration and peripheral T cell restoration in mice with a reduced fraction of competent precursors. J. Exp. Med. 194: 591-599.
57. Small, T. N., C. A. Keever, S. Weiner-Fedus, G. Heller, R. J. O'Reilly, and N. Flomenberg. 1990. B-cell differentiation following autologous, conventional, or T-cell depleted bone marrow transplantation: a recapitulation of normal B-cell ontogeny. Blood 76: 1647-1656.
58. Jenkinson, E. J., P. Jhittay, R. Kingston, and J. J. Owen. 1985. Studies of the role of the thymic environment in the induction of tolerance to MHC antigens. Transplantation 39: 331-333.
59. Matzinger, P., and S. Guerder. 1989. Does T-cell tolerance require a dedicated antigen-presenting cell? Nature 338: 74-76.
60. Tomita, Y., A. Khan, and M. Sykes. 1994. Role of intrathymic clonal deletion and peripheral anergy in transplantation tolerance induced by bone marrow transplantation in mice conditioned with a nonmyeloablative regimen. J. Immunol. 153: 1087-1098.
61. Duncan, S. R., N. G. Capetanakis, B. R. Lawson, and A. N. Theofilopoulos. 2002. Thymic dendritic cells traffic to thymi of allogeneic recipients and prolong graft survival. J. Clin. Invest. 109: 755-764.
62. Garrovillo, M., A. Ali, and S. F. Oluwole. 1999. Indirect allorecognition in acquired thymic tolerance: induction of donor-specific tolerance to rat cardiac allografts by allopeptide-pulsed host dendritic cells. Transplantation 68: 1827-1834.
63. Ali, A., M. Garrovillo, M. X. Jin, M. A. Hardy, and S. F. Oluwole. 2000. Major histocompatibility complex class I peptide-pulsed host dendritic cells induce antigen-specific acquired thymic tolerance to islet cells. Transplantation 69: 221-226.
64. Garrovillo, M., A. Ali, H. A. Depaz, R. Gopinathan, O. O. Oluwole, M. A. Hardy, and S. F. Oluwole. 2001. Induction of transplant tolerance with immunodominant allopeptide-pulsed host lymphoid and myeloid dendritic cells. Am. J. Transplant. 1: 129-137.
65. Oluwole, S. F., N. C. Chowdhury, M. X. Jin, and M. A. Hardy. 1993. Induction of transplantation tolerance to rat cardiac allografts by intrathymic inoculation of allogeneic soluble peptides. Transplantation 56: 1523-1527.
66. Girasole, G., R. L. Jilka, G. Passeri, S. Boswell, G. Boder, D. C. Williams, and S. C. Manolagas. 1992. 17β-Estradiol inhibits interleukin-6 production by bone marrow-derived stromal cells and osteoblasts in vitro: a potential mechanism for the antiosteoporotic effect of estrogens. J. Clin. Invest. 89: 883-891.
67. Smithson, G., K. Medina, I. Ponting, and P. W. Kincade. 1995. Estrogen suppresses stromal cell-dependent lymphopoiesis in culture. J. Immunol. 155: 3409-3417.
68. 1 maintains hematopoietic immaturity by a reversible negative control of cell cycle and induces CD34 antigen up-modulation. J. Cell Sci. 113(Pt. 3): 383-390.
69. Fan, X., G. Valdimarsdottir, J. Larsson, A. Brun, M. Magnusson, S. E. Jacobsen, P. ten Dijke, and S. Karlsson. 2002. Transient disruption of autocrine TGF-β signaling leads to enhanced survival and proliferation potential in single primitive human hemopoietic progenitor cells. J. Immunol. 168: 755-762.
70. Erben, R. G., J. Eberle, and M. Stangassinger. 2001. B lymphopoiesis is upregulated after orchiectomy and is correlated with estradiol but not testosterone serum levels in aged male rats. Horm. Metab. Res. 33: 491-498.
71. Wilson, C. A., S. A. Mrose, and D. W. Thomas. 1995. Enhanced production of B lymphocytes after castration. Blood 85: 1535-1539.
72. Masuzawa, T., C. Miyaura, Y. Onoe, K. Kusano, H. Ohta, S. Nozawa, and T. Suda. 1994. Estrogen deficiency stimulates B lymphopoiesis in mouse bone marrow. J. Clin. Invest. 94: 1090-1097.
73. Olsen, N. J., X. Gu, and W. J. Kovacs. 2001. Bone marrow stromal cells mediate androgenic suppression of B lymphocyte development. J. Clin. Invest. 108: 1697-1704.
74. Olsen, N. J., G. Olson, S. M. Viselli, X. Gu, and W. J. Kovacs. 2001. Androgen receptors in thymic epithelium modulate thymus size and thymocyte development. Endocrinology 142: 1278-1283.
75. Andrew, D., and R. Aspinall. 2002. Age-associated thymic atrophy is linked to a decline in IL-7 production. Exp. Gerontol. 37: 455-463.
76. Ortman, C. L., K. A. Dittmar, P. L. Witte, and P. T. Le. 2002. Molecular characterization of the mouse involuted thymus: aberrations in expression of transcription regulators in thymocyte and epithelial compartments. Int. Immunol. 14: 813-822.
77. Andrew, D., and R. Aspinall. 2001. IL-7 and not stem cell factor reverses both the increase in apoptosis and the decline in thymopoiesis seen in aged mice. J. Immunol. 166: 1524-1530.
78. Sempowski, G. D., L. P. Hale, J. S. Sundy, J. M. Massey, R. A. Koup, D. C. Douek, D. D. Patel, and B. F. Haynes. 2000. Leukemia inhibitory factor, oncostatin M, IL-6, and stem cell factor mRNA expression in human thymus increases with age and is associated with thymic atrophy. J. Immunol. 164: 2180-2187.