Cytokine production by T lymphocytes from young and aged mice

Journal of Immunology

Volumn 156, Issue 10, 1996, Pages 3621-3630

  Engwerda, Christian R ^a,c   Fox, Barbara S ^a,d   Handwerger, Barry S ^a,b  

^a UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

^b BALTIMORE VA MEDICAL CENTER   (United States)

^c LONDON SCHOOL OF HYGIENE AND TROPICAL MEDICINE   (United Kingdom)

^d ImmuLogic Pharmaceutical Corporation   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD28 ANTIGEN; CD3 ANTIGEN; CD4 ANTIGEN; CD8 ANTIGEN; GAMMA INTERFERON; HERMES ANTIGEN; INTERLEUKIN 2; INTERLEUKIN 4;

ANIMAL CELL; ANTIGEN EXPRESSION; ARTICLE; IMMUNOREGULATION; INTERFERON PRODUCTION; LYMPHOCYTE PROLIFERATION; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN SYNTHESIS; SIGNAL TRANSDUCTION; T LYMPHOCYTE ACTIVATION;

AGING; ANIMALS; ANTIGENS, CD44; CD4-POSITIVE T-LYMPHOCYTES; CD8-POSITIVE T-LYMPHOCYTES; CYTOKINES; IMMUNOPHENOTYPING; INTERLEUKIN-2; INTERLEUKIN-4; MALE; MICE; MICE, INBRED C57BL; MICE, INBRED CBA; SPLEEN; T-LYMPHOCYTE SUBSETS;

EID: 0029871836     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (57)

1. Thoman, M. L., and W. O. Weigle. 1989 The cellular and subcellular bases of immunosenescence. Adv. Immunol. 46:221.
2. Miller, R. A. 1989. The cell biology of aging- immunologic models. J. Gerontol. 44:B4.
3. Budd, R. C., J.-C Cerottini, C Horvath, C. Bron, T. Pedrazzini, R. C. Howe, and H R. MacDonald 1987 Distinction of virgin and memory T lymphocytes. Stable acquisition of the Pgp-1 glycoprotein concomitant with anugenic stimulation. J. Immunol. 138.3120.
4. high T lymphocytes accumulate with age in mice and respond poorly to concanavalin A. Eur. J. Immunol. 19-977.
5. + T cells from young and aged mice. J Immunol. 145:1295.
6. Flurkey, K., M. Stadecker, and R. A. Miller. 1992. Memory T lymphocyte hyporesponsiveness to noncognate stimuli: a key factor in age-related immunodeficiency. Eur. J. Immunol. 22.931.
7. + cells from old mice. J. Cell. Biochem. 46:312.
8. + T cells from young and old mice. J. Immunol. 150:3602.
9. + T cells correlates with shifts in the frequencies of cell subsets defined by membrane CD44, CD45RB, 3G11, and MEL-14 expression. J. Immunol. 151:575.
10. + T cells. Eur. J. Immunol. 21:273.
11. Swam, S. L., D. T. McKenzie, A. D. Weinberg, and W. Hancock 1988. Characterization of T helper 1 and 2 cell subsets in normal mice. Helper T cells responsible for IL-4 and IL-5 production are present as precursors that require priming before they develop into lymphokine-secreting cells. J Immunol 141: 3445.
12. + T cells identified by expression of Pgp-1. J. Immunol. 138:3583.
13. + T cells. J. Immunol. 144:3288.
14. Bottomly, K., M. Luqman, L Greenbaum, S. Carding, J. West, T. Pasqualini, and D B Murphy 1989 A monoclonal antibody to murine CD45R distinguishes CD4 T cell populations that produce different cytokines. Eur. J Immunol 19:617.
15. Mosmann, T. R., and R. L Coffmann. 1989. Th1 and Th2 cells, different patterns of lymphokine secretion lead to different functional properties. Annu Rev. Immunol. 7:145.
16. Swam, S. L., and L. M. Bradley. 1992. Helper T cell memory: more questions than answers. Semm. Immunol. 4:59.
17. + T cells from aged mice display functional and phenotypic characteristics of memory cells. Int Immunol. 6:1227.
18. Kubo, M., and B. Cinader. 1990. Polymorphism of age-related changes in interleukin (IL) production: differential changes of T helper subpopulations, synthesizing IL-2, EL-3, and IL-4. Eur. J. Immunol 20:1289.
19. Philosophe, B., and R. A. Miller. 1990. Diminished calcium signal generation in subsets of T lymphocytes that predominate in old mice. J. Gerontol. Biol Sci. 45:887
20. Engwerda, C. R., B. S. Handwerger, and B. S. Fox. 1994. Aged T cells are hyporesponsive to costimulation mediated by CD28. J. Immunol. 152:3740.
21. Liu, Y., and P. S Linsley. 1992. Costimulation and T cell growth. Curr. Opin. Immunol. 4:265.
22. Linsley, P. S., and J. A. Ledbetter. 1993. The role of CD28 receptor during T cell responses to antigen. Annu. Rev. Immunol. 11.191
23. Gross, J. A., E. Callas, and J. P Allison. 1992. Identification and distribution of the costimulatory receptor CD28 in the mouse. J. Immunol. 149:380.
24. Linsley, P. S., E. A. Clark, and J. A. Ledbetter. 1990. T cell antigen CD28 mediates adhesion with B cells by interacting with activation antigen B7/BB1. Proc. Natl. Acad Sci. USA 87:5031.
25. Azuma, M., D Ito, H Yagita, K Okumura, J H. Phillips, L. L. Lanier, and C. Somoza. 1993. B70 antigen is a second ligand for CTLA-4 and CD28. Nature 366.76.
26. Hathcock, K. S., G Laszlo, H. B. Dickler, J. Bradshaw, P. Linsley, and R. H. Hodes. 1993 Identification of an alternative CTLA-4 ligand costimulatory for T cell activation. Science 262 905.
27. Freeman, G J , F. Borriello, R J. Hodes, H. Reiser, K S. Hathcock, G. Laszlo, A. J McKnight, J. Kim, L. Du, D. B. Lombard, S. Gray, L. M. Nadler, and A H. Sharpe. 1993. Uncovering of functional alternative CTLA-4 counter-receptor in B7-deficient mice. Science 262:907.
28. Freeman, G. J., J. G. Gribben, V. A Boussiotis, J. W. Ng, V. A. Restivo, L. A Lombard, G. S. Gray, and L. M. Nadler 1993. Cloning of B7-2: a CTLA-4 counter-receptor that costimulates human T cell proliferation. Science 262:909.
29. Linsley, P. S., W. Brady, M. Urnes, L S. Grosmaire, N. K Damle, and J A Ledbetter. 1991. CTLA-4 is a second receptor for the B cell activation antigen B7. J. Exp. Med 174.561.
30. Linsley, P. S., J. L. Greene, P. Tan, J Bradshaw, J. A. Ledbetter, C Anasetti, and N. K. Damle. 1992. Coexpression and functional cooperation of CTLA-4 and CD28 on actuated T lymphocytes. J Exp. Med 176:1595.
31. McArthur, J. G., and D H. Raulet. 1993. CD28-induced costimulation of T helper type 2 cells mediated by induction of responsiveness to interleukin-4. J. Exp. Med. 178:1645
32. Seder, R. A , R N. Germain, P. S. Linsley, and W. E. Paul. 1994. CD28-mediated costimulation of interleukin-2 (IL-2) production plays a critical role in T cell priming for IL-4 and interferon-γ production J. Exp. Med. 179:299
33. Kuchoo, V. K., M. D Das, J. A. Brown, A. M. Ranger, S S. Zamvil, R. A. Sobel, H. L. Weiner, N. Nabavi, and L. H. Glimcher. 1995. B7-1 and B7-2 costimulatory molecules activate differentially the Th1/Th2 development pathways: application to autoimmune disease therapy. Cell 80.707.
34. Thompson, C B. 1995. Distinct roles for the costimulatory ligands B7-1 and B7-2 in T helper cell differentiation. Cell 80:979.
35. Holter, W., O. Majdic, F. S. Kalthoff, and A. Knapp. 1992. Regulation of interleukin-4 production in human mononuclear cells. Eur. J. Immunol. 22:2765.
36. de Boer, M., A. Kasran, J. Kwekkeboom, H. Walter, P. Vandenberghe, and J L. Ceuppens. 1993. Ligation of B7 with CD28/CTLA-4 on T cells results in CD40 ligand expression, interleukin-4 secretion, and efficient help for antibody production by B cells. Eur. J. Immunol. 23:3120.
37. Freeman, G. J., V. A. Boussiotis, A. Anumanthan, G. M. Bernstein, X.-Y. Ke, P. D. Rennert, G. S Sray, J. G. Gribben, and L. M. Nadler. 1995. B7-1 and B7-2 do not deliver identical costimulatory signals, since B7-2 but not B7-1 preferentially costimulates the initial production of IL-4. Immunity 2:523.
38. Gross, J. A., T. St. John, and J. P Allison. 1990. The murine homologue of the T lymphocyte antigen CD28: molecular cloning and cell surface expression. J. Immunol. 144:3201
39. Leo, O , M. Foo, D. H. Sachs, L. E. Samelson, and J. A. Bluestone. 1987. Identification of a monoclonal antibody specific for a T3 polypeptide. Proc Natl. Acad. Sci. USA 84:1374.
40. Ceredig, R., J. W. Lowenthal, M Nabholz, and H. R. MacDonald. 1985. Expression of interleukin-2 receptors as a differentiation marker on intrathymic stem cells. Nature 314:98.
41. Sarmiento, M., A. L. Glasebrook, and F. W Fitch. 1980 IgG or IgM monoclonal antibodies reactive with different determinants on the molecular complex bearing Lyt-2 antigen block T cell-mediated cytolysis in the absence of complement. J. Immunol. 125:2665.
42. Marshak-Rothstein, A., P. Fink, T. Gridley, D H. Raulet, M. J. Bevan, and M. L. Gefter. 1979. Properties and applications of monoclonal antibodies directed against determinants of the Thy-1 locus. J Immunol. 122 2491.
43. Lane, P , W. Gerhard, S. Hubele, A Lanzavecchia, and F McConnell 1993. Expression and functional properties of mouse BB1/B7 using a fusion protein between mouse CTLA-4 and human γl. Immunology 80:56.
44. Julius, M. H., E. Simpson, and L. A. Henenberg 1973. A rapid method for the isolation of functional thymus-derived lymphocytes. Eur. J Immunol. 3:645
45. Gillis, S., M. M. Ferm, W. Ou, and K. A. Smith. 1978. T cell growth factor: parameters of production and a quantitative microassay for activity. J. Immunol. 120 2027.
46. Hu-Li, J., J. Ohara, C. Watson, W. Tsang, and W. E. Paul 1989. Derivation of a T cell line that is highly responsive to IL-4 and IL-2 (CT 4R) and of an IL-2 hyporesponsive mutant of that line (CT.4S) J. Immunol. 142:800.
47. Curry, R. C., P. A. Keiner, and G. L. Spitalny. 1978. A sensitive immunochemical assay for biologically active MuIFN-γ. J. Immunol. Methods 104:137
48. Mosmann, T. R., and T. A. T. Fong. 1989. Specific assays for cytokine production by T cells. J. Immunol. Methods 116.151.
49. Svetic, A., F. D. Finkelman, Y. C. Jian, C. W. Dieffenbach, D. E. Scott, K. F. McCarthy, A. D. Steinberg, and W. C. Gause 1991. Cytokine gene expression after in vivo primary immunization with goat antibody to mouse IgD antibody. J. Immunol. 147.2391
50. Chomczynski, P., and N. Sacchi. 1987. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal. Biochem. 162: 156.
51. Sambrook, J., E. F. Fritsch, and T. Maniatis 1989 Molecular Cloning: A Laboratory Manual, 2nd Ed. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY.
52. De Maeyer, E , and J. De Maeyer-Guignard. 1992. Interferon-γ. Curr. Opin. Immunol 4:321
53. + T cell response to antigen. Memory cells are less dependent on accessory cell costimulation and can respond to many antigen-presenting cell types including resting B cells. J Immunol. 152:2675.
54. + T cells. Immunol. Rev. 123:209.
55. Gajewski, T. F., and F. W. Fitch. 1988. Antiproliferative effect of IFN-γ in immune regulation. I. IFN-γ inhibits the proliferation of Th2 but not Th1 murine helper T lymphocyte clones, J. Immunol. 140:4245.
56. Chen, L., S. Ashe, W. A. Brady, I. Hellstrom, K. E. Hellstrom, J. A. Ledbetter, P. McGowan, and P. S Linsley. 1992. Costimulation of antitumor immunity by the B7 counterreceptor for the T lymphocyte molecules CD28 and CTLA-4. Cell 71:1093.
57. - T cells by B7-transfected melanoma cells. Science 259:368.