Memory T-cell homeostasis and senescence during aging

Advances in Experimental Medicine and Biology

Volumn 684, Issue , 2010, Pages 189-197

  Henson, Sian M ^a   Akbar, Arne N ^b  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

CD27 ANTIGEN; CD28 ANTIGEN; CD45RA ANTIGEN; CD45RB ANTIGEN; CD45RO ANTIGEN; CHEMOKINE RECEPTOR CCR7; CYTOTOXIC T LYMPHOCYTE ANTIGEN 4; FAS ANTIGEN; L SELECTIN; LYMPHOCYTE FUNCTION ASSOCIATED ANTIGEN 1; NATURAL KILLER CELL LECTIN LIKE RECEPTOR; NATURAL KILLER CELL LECTIN LIKE RECEPTOR SUBFAMILY G1; PHOSPHATASE; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE; PHOSPHATIDYLINOSITOL 4,5 BISPHOSPHATE; PROGRAMMED DEATH 1 RECEPTOR; PROTEIN BCL 2; PROTEIN KINASE B; PROTEIN TYROSINE PHOSPHATASE SHP; SH2 DOMAIN CONTAINING INOSITOL PHOSPHATASE; TELOMERASE; TELOMERASE REVERSE TRANSCRIPTASE; UNCLASSIFIED DRUG;

AGING; ANTIGEN EXPRESSION; ANTIGEN FUNCTION; ANTIGEN RECOGNITION; ARTICLE; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CELL LOSS; CYTOMEGALOVIRUS INFECTION; HERPES SIMPLEX; HERPES ZOSTER; HOMEOSTASIS; HUMAN; INFLUENZA; LYMPHOCYTE DIFFERENTIATION; LYMPHOCYTE FUNCTION; MEMORY T LYMPHOCYTE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; SENESCENCE; TELOMERE; VIRUS CELL INTERACTION; CELL AGING; CELL DIFFERENTIATION; IMMUNOLOGICAL MEMORY; IMMUNOLOGY; LYMPHOPOIESIS; METABOLISM; PHYSIOLOGY; T LYMPHOCYTE;

AGING; CELL AGING; CELL DIFFERENTIATION; HOMEOSTASIS; HUMANS; IMMUNOLOGIC MEMORY; LYMPHOPOIESIS; T-LYMPHOCYTES; TELOMERASE; TELOMERE;

EID: 77956862589     PISSN: 00652598     EISSN: None     Source Type: Book Series    
DOI: 10.1007/978-1-4419-6451-9_15     Document Type: Article

References (93)

1. LaCroix AZ, Lipson S, Miles TP et al. Prospective study of pneumonia hospitalizations and mortality of US older people: The role of chronic conditions, health behaviors, and nutritional status. Public Health Rep 1989; 104: 350-360 (Pubitemid 19207539)
2. Gorse GJ, Thrupp LD, Nudleman KL et al. Bacterial meningitis in the elderly. Arch Intern Med 1984; 144: 1603-1607 (Pubitemid 14054482)
3. Chattopadhyay B, Al-Zahawi M. Septicaemia and its unacceptably high mortality in the elderly. J Infect 1983; 7: 134-138 (Pubitemid 13002226)
4. Ackermann RJ, Monroe PW. Bacteremic urinary tract infection in older people. J Am Geriatr Soc 1996; 44: 927-933 (Pubitemid 26287148)
5. Barker WH, Mullooly JP. Impact of epidemic type A influenza in a defined adult population. Am J Epidemiol 1980; 112: 798-811
6. Sprenger MJ, Mulder PG, Beyer WE et al. Impact of influenza on mortality in relation to age and underlying disease, 1967-1989. Int J Epidemiol 1993; 22: 334-340
7. Yoshikawa TT. Perspective: Aging and infectious diseases: Past, present, and future. J Infect Dis 1997; 176: 1053-1057 (Pubitemid 27411050)
8. Berger R, Florent G, Just M. Decrease of the lymphoproliferative response to varicella-zoster virus antigen in the aged. Infect Immun 1981; 32: 24-27 (Pubitemid 11156896)
9. Scott BJ, Powers DC, Johnson JE et al. Seroepidemiological evidence of Epstein-Barr virus reactivation in a veterans' nursing home. Serodiagn Immunother Infect Dis 1994; 87-92 (Pubitemid 24176546)
10. Nagami PH, Yoshikawa TT. Tuberculosis in the geriatric patient. J Am Geriatr Soc 1983; 31: 356-363 (Pubitemid 13062329)
11. McVoy MA, Adler SP. Immunologic evidence for frequent age-related cytomegalovirus reactivation in seropositive immunocompetent individuals. J Infect Dis 1989; 160: 1-10 (Pubitemid 19162986)
12. Zhang Y, Cosyns M, Levin MJ et al. Cytokine production in varicella zoster virus-stimulated limiting dilution lymphocyte cultures. Clin Exp Immunol 1994; 98: 128-133 (Pubitemid 24315463)
13. Douek DC, McFarland RD, Keiser PH et al. Changes in thymic function with age and during the treatment of HIV infection. Nature 1998; 396: 690-695 (Pubitemid 29003949)
14. Linton PJ, Dorshkind K. Age-related changes in lymphocyte development and function. Nat Immunol 2004; 5: 133-139 (Pubitemid 38208354)
15. Messaoudi I, Lemaoult J, Guevara-Patino JA et al. Age-related CD8 T cell clonal expansions constrict CD8 T cell repertoire and have the potential to impair immune defense. J Exp Med 2004; 200: 1347-1358 (Pubitemid 39552575)
16. Akbar AN, Fletcher JM. Memory T cell homeostasis and senescence during aging. Curr Opin Immunol 2005; 17: 480-485 (Pubitemid 41207950)
17. Goronzy JJ, Fulbright JW, Crowson CS et al. Value of immunological markers in predicting responsiveness to influenza vaccination in elderly individuals. J Virol 2001; 75: 12182-12187 (Pubitemid 33115891)
18. Olsson J, Wikby A, Johansson B et al. Age-related change in peripheral blood T-lymphocyte subpopulations and cytomegalovirus infection in the very old: The Swedish longitudinal OCTO immune study. Mech Ageing Dev 2000; 121: 187-201 (Pubitemid 32115413)
19. Ouyang Q, Wagner WM, Voehringer D et al. Age-associated accumulation of CMV-specific CD8+ T cells expressing the inhibitory killer cell lectin-like receptor G1 (KLRG1). Exp Gerontol 2003; 38: 911-920 (Pubitemid 36952673)
20. Ouyang Q, Wagner WM, Walter S et al. An age-related increase in the number of CD8+ T cells carrying receptors for an immunodominant Epstein-Barr virus (EBV) epitope is counteracted by a decreased frequency of their antigen-specific responsiveness. Mech Ageing Dev 2003; 124: 477-485 (Pubitemid 36519208)
21. Effros RB, Boucher N, Porter V et al. Decline in CD28+ T cells in centenarians and in long-term T cell cultures: A possible cause for both in vivo and in vitro immunosenescence. Exp Gerontol 1994; 29: 601-609 (Pubitemid 24382608)
22. Goronzy JJ, Lee WW, Weyand CM. Aging and T-cell diversity. Exp Gerontol 2007; 42: 400-406 (Pubitemid 46561179)
23. Czesnikiewicz-Guzik M, Lee WW, Cui D et al. T cell subset-specific susceptibility to aging. Clin Immunol 2008; 127: 107-118
24. Amyes E, Hatton C, Montamat-Sicotte D et al. Characterization of the CD4+ T cell response to Epstein-Barr virus during primary and persistent infection. J Exp Med 2003; 198: 903-911 (Pubitemid 37152927)
25. Fletcher JM, Vukmanovic-Stejic M, Dunne PJ et al. Cytomegalovirus- specific CD4+ T cells in healthy carriers are continuously driven to replicative exhaustion. J Immunol 2005; 175: 8218-8225 (Pubitemid 41798386)
26. Appay V, Dunbar PR, Callan M et al. Memory CD8+ T cells vary in differentiation phenotype in different persistent virus infections. Nat Med 2002; 8: 379-385 (Pubitemid 34407033)
27. Plunkett FJ, Franzese O, Belaramani LL et al. The impact of telomere erosion on memory CD8+ T cells in patients with X-linked lymphoproliferative syndrome. Mech Ageing Dev 2005; 126: 855-865 (Pubitemid 40909782)
28. Effros RB, Dagarag M, Spaulding C et al. The role of CD8+ T-cell replicative senescence in human aging. Immunol Rev 2005; 205: 147-157 (Pubitemid 40780183)
29. Waller EC, McKinney N, Hicks R et al. Differential costimulation through CD137 (4-1BB) restores proliferation of human virus-specific "effector memory" (CD28(-) CD45RA(HI)) CD8(+) T cells. Blood 2007; 110: 4360-4366 (Pubitemid 351377801)
30. Plunkett FJ, Franzese O, Finney HM et al. The loss of telomerase activity in highly differentiated CD8+CD28-CD27-T cells is associated with decreased Akt (Ser473) phosphorylation. J Immunol 2007; 178: 7710-7719 (Pubitemid 46898042)
31. Voehringer D, Koschella M, Pircher H. Lack of proliferative capacity of human effector and memory T cells expressing killer cell lectinlike receptor G1 (KLRG1). Blood 2002; 100: 3698-3702 (Pubitemid 35303941)
32. Voehringer D, Blaser C, Brawand P et al. Viral infections induce abundant numbers of senescent CD8 T cells. J Immunol 2001; 167: 4838-4843 (Pubitemid 33009711)
33. Ito M, Maruyama T, Saito N et al. Killer cell lectin-like receptor G1 binds three members of the classical cadherin family to inhibit NK cell cytotoxicity. J Exp Med 2006; 203: 289-295 (Pubitemid 43290837)
34. Wakikawa A, Utsuyama M, Hirokawa K. Altered expression of various receptors on T cells in young and old mice after mitogenic stimulation: A flow cytometric analysis. Mech Ageing Dev 1997; 94: 113-122 (Pubitemid 27216100)
35. Leng Q, Bentwich Z, Borkow G. CTLA-4 upregulation during aging. Mech Ageing Dev 2002; 123: 1419-1421 (Pubitemid 35247438)
36. Fann M, Chiu WK, Wood WH, 3rd et al. Gene expression characteristics of CD28null memory phenotype CD8+ T cells and its implication in T-cell aging. Immunol Rev 2005; 205: 190-206 (Pubitemid 40780186)
37. Day CL, Kaufmann DE, Kiepiela P et al. PD-1 expression on HIV-specific T cells is associated with T-cell exhaustion and disease progression. Nature 2006; 443: 350-354 (Pubitemid 44435155)
38. Barber DL, Wherry EJ, Masopust D et al. Restoring function in exhausted CD8 T cells during chronic viral infection. Nature 2006; 439: 682-687 (Pubitemid 43237609)
39. Keir ME, Butte MJ, Freeman GJ et al. PD-1 and its ligands in tolerance and immunity. Annu Rev Immunol 2008; 26: 677-704 (Pubitemid 351600389)
40. Geginat J, Lanzavecchia A, Sallusto F. Proliferation and differentiation potential of human CD8+ memory T-cell subsets in response to antigen or homeostatic cytokines. Blood 2003; 101: 4260-4266 (Pubitemid 36857786)
41. Dunne PJ, Belaramani L, Fletcher JM et al. Quiescence and functional reprogramming of Epstein-Barr virus (EBV)-specific CD8+ T cells during persistent infection. Blood 2005; 106: 558-565 (Pubitemid 40981251)
42. Dunne PJ, Faint JM, Gudgeon NH et al. Epstein-Barr virus-specific CD8(+) T cells that re-express CD45RA are apoptosis-resistant memory cells that retain replicative potential. Blood 2002; 100: 933-940 (Pubitemid 34832620)
43. Wills MR, Okecha G, Weekes MP et al. Identification of naive or antigen-experienced human CD8(+) T cells by expression of costimulation and chemokine receptors: Analysis of the human cytomegalovirus-specific CD8(+) T cell response. J Immunol 2002; 168: 5455-5464 (Pubitemid 34556123)
44. Grubeck-Loebenstein B, Wick G. The aging of the immune system. Adv Immunol 2002; 80: 243-284 (Pubitemid 34625625)
45. Faint JM, Annels NE, Curnow SJ et al. Memory T cells constitute a subset of the human CD8+CD45RA+ pool with distinct phenotypic and migratory characteristics. J Immunol 2001; 167: 212-220 (Pubitemid 32567780)
46. Wright WE, Shay JW. Telomere dynamics in cancer progression and prevention: Fundamental differences in human and mouse telomere biology. Nat Med 2000; 6: 849-851 (Pubitemid 30644735)
47. Hodes RJ, Hathcock KS, Weng NP. Telomeres in T and B cells. Nat Rev Immunol 2002; 2: 699-706 (Pubitemid 37328727)
48. Blackburn EH. Switching and signaling at the telomere. Cell 2001; 106: 661-673 (Pubitemid 32900658)
49. Ducray C, Pommier JP, Martins L et al. Telomere dynamics, end-to-end fusions and telomerase activation during the human fibroblast immortalization process. Oncogene 1999; 18: 4211-4223 (Pubitemid 29377852)
50. d'Adda di Fagagna F, Reaper PM, Clay-Farrace L et al. A DNA damage checkpoint response in telomere-initiated senescence. Nature 2003; 426: 194-198 (Pubitemid 37442589)
51. Blackburn EH. Telomeres and telomerase: Their mechanisms of action and the effects of altering their functions. FEBS Lett 2005; 579: 859-862 (Pubitemid 40361854)
52. Fritsch RD, Shen X, Sims GP et al. Stepwise differentiation of CD4 memory T cells defined by expression of CCR7 and CD27. J Immunol 2005; 175: 6489-6497 (Pubitemid 41598891)
53. Liu K, Hodes RJ, Weng N. Cutting edge: Telomerase activation in human T lymphocytes does not require increase in telomerase reverse transcriptase (hTERT) protein but is associated with hTERT phosphorylation and nuclear translocation. J Immunol 2001; 166: 4826-4830 (Pubitemid 32280689)
54. Plunkett FJ, Soares MV, Annels N et al. The flow cytometric analysis of telomere length in antigen-specific CD8+ T cells during acute Epstein-Barr virus infection. Blood 2001; 97: 700-707 (Pubitemid 32113403)
55. Bodnar AG, Kim NW, Effros RB et al. Mechanism of telomerase induction during T cell activation. Exp Cell Res 1996; 228: 58-64 (Pubitemid 26349713)
56. Weng NP, Levine BL, June CH et al. Regulated expression of telomerase activity in human T lymphocyte development and activation. J Exp Med 1996; 183: 2471-2479 (Pubitemid 26192356)
57. Liu K, Schoonmaker MM, Levine BL et al. Constitutive and regulated expression of telomerase reverse transcriptase (hTERT) in human lymphocytes. Proc Natl Acad Sci U S A 1999; 96: 5147-5152 (Pubitemid 29214550)
58. Kang SS, Kwon T, Kwon DY et al. Akt protein kinase enhances human telomerase activity through phosphorylation of telomerase reverse transcriptase subunit. J Biol Chem 1999; 274: 13085-13090
59. Simpson L, Parsons R. PTEN: Life as a tumor suppressor. Exp Cell Res 2001; 264: 29-41 (Pubitemid 32989079)
60. Andjelkovic M, Alessi DR, Meier R et al. Role of translocation in the activation and function of protein kinase B. J Biol Chem 1997; 272: 31515-31524 (Pubitemid 28013293)
61. Lemmon MA, Ferguson KM. Signal-dependent membrane targeting by pleckstrin homology (PH) domains. Biochem J 2000; 350 Pt 1: 1-18
62. Carver DJ, Aman MJ, Ravichandran KS. SHIP inhibits Akt activation in B cells through regulation of Akt membrane localization. Blood 2000; 96: 1449-1456 (Pubitemid 30658476)
63. Cuevas B, Lu Y, Watt S et al. SHP-1 regulates Lck-induced phosphatidylinositol 3-kinase phosphorylation and activity. J Biol Chem 1999; 274: 27583-27589
64. Lu Y, Yu Q, Liu JH et al. Src family protein-tyrosine kinases alter the function of PTEN to regulate phosphatidylinositol 3-kinase/AKT cascades. J Biol Chem 2003; 278: 40057-40066 (Pubitemid 37248572)
65. Wu CJ, O'Rourke DM, Feng GS et al. The tyrosine phosphatase SHP-2 is required for mediating phosphatidylinositol 3-kinase/Akt activation by growth factors. Oncogene 2001; 20: 6018-6025 (Pubitemid 32955044)
66. Zhang SQ, Tsiaras WG, Araki T et al. Receptor-specific regulation of phosphatidylinositol 3'-kinase activation by the protein tyrosine phosphatase Shp2. Mol Cell Biol 2002; 22: 4062-4072 (Pubitemid 34556577)
67. Parry RV, Chemnitz JM, Frauwirth KA et al. CTLA-4 and PD-1 receptors inhibit T-cell activation by distinct mechanisms. Mol Cell Biol 2005; 25: 9543-9553 (Pubitemid 41507854)
68. Tessmer MS, Fugere C, Stevenaert F et al. KLRG1 binds cadherins and preferentially associates with SHIP-1. Int Immunol 2007; 19: 391-400 (Pubitemid 46523387)
69. Lichterfeld M, Mou D, Cung TD et al. Telomerase activity of HIV-1-specific CD8+ T cells: Constitutive upregulation in controllers and selective increase by blockade of PD ligand 1 in progressors. Blood 2008; 112(9):3679-3687
70. Wallace DL, Berard M, Soares MV et al. Prolonged exposure of naive CD8+ T cells to interleukin-7 or interleukin-15 stimulates proliferation without differentiation or loss of telomere length. Immunology 2006; 119: 243-253 (Pubitemid 44401643)
71. Li Y, Zhi W, Wareski P et al. IL-15 activates telomerase and minimizes telomere loss and may preserve the replicative life span of memory CD8+ T cells in vitro. J Immunol 2005; 174: 4019-4024 (Pubitemid 40395977)
72. Weng NP, Liu K, Catalfamo M et al. IL-15 is a growth factor and an activator of CD8 memory T cells. Ann N Y Acad Sci 2002; 975: 46-56 (Pubitemid 36131113)
73. Soares MV, Borthwick NJ, Maini MK et al. IL-7-dependent extrathymic expansion of CD45RA+ T cells enables preservation of a naive repertoire. J Immunol 1998; 161: 5909-59017
74. Reed JR, Vukmanovic-Stejic M, Fletcher JM et al. Telomere erosion in memory T cells induced by telomerase inhibition at the site of antigenic challenge in vivo. J Exp Med 2004; 199: 1433-1443 (Pubitemid 38685734)
75. Wikby A, Johansson B, Olsson J et al. Expansions of peripheral blood CD8 T-lymphocyte subpopulations and an association with cytomegalovirus seropositivity in the elderly: The Swedish NONA immune study. Exp Gerontol 2002; 37: 445-453 (Pubitemid 34073563)
76. Pawelec G, Akbar A, Caruso C et al. Human immunosenescence: Is it infectious? Immunol Rev 2005; 205: 257-268 (Pubitemid 40780191)
77. Annels NE, Callan MF, Tan L et al. Changing patterns of dominant TCR usage with maturation of an EBV-specific cytotoxic T cell response. J Immunol 2000; 165: 4831-4841
78. Davenport MP, Fazou C, McMichael AJ et al. Clonal selection, clonal senescence, and clonal succession: The evolution of the T cell response to infection with a persistent virus. J Immunol 2002; 168: 3309-3317 (Pubitemid 34250393)
79. Karrer U, Sierro S, Wagner M et al. Memory inflation: Continuous accumulation of antiviral CD8+ T cells over time. J Immunol 2003; 170: 2022-2029 (Pubitemid 36197423)
80. Ouyang Q, Wagner WM, Wikby A et al. Large numbers of dysfunctional CD8+ T lymphocytes bearing receptors for a single dominant CMV epitope in the very old. J Clin Immunol 2003; 23: 247-257 (Pubitemid 36870667)
81. Khan N, Shariff N, Cobbold M et al. Cytomegalovirus seropositivity drives the CD8 T cell repertoire toward greater clonality in healthy elderly individuals. J Immunol 2002; 169: 1984-1992 (Pubitemid 34857662)
82. Ely KH, Roberts AD, Kohlmeier JE et al. Aging and CD8+ T cell immunity to respiratory virus infections. Exp Gerontol 2007; 42: 427-431 (Pubitemid 46561180)
83. Arvin AM. Humoral and cellular immunity to varicella-zoster virus: An overview. J Infect Dis 2008; 197 Suppl 2: S58-S60 (Pubitemid 351590147)
84. Akbar AN, Beverley PC, Salmon M. Will telomere erosion lead to a loss of T-cell memory? Nat Rev Immunol 2004; 4: 737-743 (Pubitemid 39223079)
85. Caplin B, Sweny P, Burroughs A et al. Antiviral treatment after solid organ transplantation. Lancet 2005; 366: 806-807; author reply 7 (Pubitemid 41557377)
86. Sallusto F, Geginat J, Lanzavecchia A. Central memory and effector memory T cell subsets: Function, generation, and maintenance. Annu Rev Immunol 2004; 22: 745-763 (Pubitemid 38680440)
87. Akbar AN, Terry L, Timms A et al. Loss of CD45R and gain of UCHL1 reactivity is a feature of primed T cells. J Immunol 1988; 140: 2171-2178 (Pubitemid 18098471)
88. Hamann D, Baars PA, Rep MH et al. Phenotypic and functional separation of memory and effector human CD8+ T cells. J Exp Med 1997; 186: 1407-1418 (Pubitemid 27479800)
89. Salmon M, Pilling D, Borthwick NJ et al. The progressive differentiation of primed T cells is associated with an increasing susceptibility to apoptosis. Eur J Immunol 1994; 24: 892-899 (Pubitemid 24093785)
90. Akbar AN, Salmon M, Savill J et al. A possible role for bcl-2 in regulating T-cell memory-a 'balancing act' between cell death and survival. Immunol Today 1993; 14: 526-532 (Pubitemid 23316710)
91. Baars PA, Ribeiro Do Couto LM, Leusen JH et al. Cytolytic mechanisms and expression of activation-regulating receptors on effector-type CD8+CD45RA+CD27-human T cells. J Immunol 2000; 165: 1910-1917 (Pubitemid 30648744)
92. Kaufmann DE, Kavanagh DG, Pereyra F et al. Upregulation of CTLA-4 by HIV-specific CD4+ T cells correlates with disease progression and defines a reversible immune dysfunction. Nat Immunol 2007; 8: 1246-1254 (Pubitemid 350011764)
93. Sauce D, Almeida JR, Larsen M et al. PD-1 expression on human CD8 T cells depends on both state of differentiation and activation status. AIDS 2007; 21: 2005-2013. (Pubitemid 47462149)