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Volumn 24, Issue 5, 2012, Pages 373-382

Translational research in immune senescence: Assessing the relevance of current models

Author keywords

Aging; Immune senescence; Translational research

Indexed keywords

ACUTE DISEASE; ATHEROSCLEROSIS; B LYMPHOCYTE; CD8+ T LYMPHOCYTE; CELL AGING; DEATH; DEMENTIA; DISABILITY; DISEASE COURSE; DISEASE MODEL; FIBROBLAST; GERIATRIC DISORDER; HUMAN; IMMUNE RESPONSE; IMMUNIZATION; IMMUNOPATHOLOGY; LYMPHOCYTE DIFFERENTIATION; NERVE CELL; NONHUMAN; PHENOTYPE; PREMATURE AGING; REVIEW; TRANSLATIONAL RESEARCH; VIRAL CLEARANCE; VIRUS INFECTION;

EID: 84868212804     PISSN: 10445323     EISSN: 10963618     Source Type: Journal    
DOI: 10.1016/j.smim.2012.04.007     Document Type: Review
Times cited : (37)

References (89)
  • 1
    • 84883491082 scopus 로고    scopus 로고
    • cdc.gov.
    • cdc.gov.; 2011. http://www.cdc.gov/mmwr/preview/mmwrhtml/mm5816a2.htm.
    • (2011)
  • 2
    • 84883491159 scopus 로고    scopus 로고
    • census.gov.
    • census.gov.; 2011. http://www.census.gov/compendia/statab/cats/births_deaths_marriages_divorces/life_expectancy.html.
    • (2011)
  • 3
    • 84883490913 scopus 로고    scopus 로고
    • census.gov.
    • census.gov.; 2011. http://www.census.gov/hhes/www/disability/disability.html.
    • (2011)
  • 5
    • 79953159005 scopus 로고    scopus 로고
    • Are senescence and exhaustion intertwined or unrelated processes that compromise immunity
    • Akbar A.N., Henson S.M. Are senescence and exhaustion intertwined or unrelated processes that compromise immunity. Nature Reviews Immunology 2011, 11:289-295.
    • (2011) Nature Reviews Immunology , vol.11 , pp. 289-295
    • Akbar, A.N.1    Henson, S.M.2
  • 6
    • 46249132015 scopus 로고    scopus 로고
    • Ageing and life-long maintenance of T-cell subsets in the face of latent persistent infections
    • Nikolich-Zugich J. Ageing and life-long maintenance of T-cell subsets in the face of latent persistent infections. Nature Reviews Immunology 2008, 8:512-522.
    • (2008) Nature Reviews Immunology , vol.8 , pp. 512-522
    • Nikolich-Zugich, J.1
  • 7
    • 67649660551 scopus 로고    scopus 로고
    • Redefining chronic viral infection
    • Virgin H.W., Wherry E.J., Ahmed R. Redefining chronic viral infection. Cell 2009, 138:30-50.
    • (2009) Cell , vol.138 , pp. 30-50
    • Virgin, H.W.1    Wherry, E.J.2    Ahmed, R.3
  • 8
    • 79955948087 scopus 로고    scopus 로고
    • Expansions of NK-like alphabetaT cells with chronologic aging: novel lymphocyte effectors that compensate for functional deficits of conventional NK cells and T cells
    • Vallejo A.N., Mueller R.G., Hamel D.L., Way A., Dvergsten J.A., Griffin P., et al. Expansions of NK-like alphabetaT cells with chronologic aging: novel lymphocyte effectors that compensate for functional deficits of conventional NK cells and T cells. Ageing Research Reviews 2011, 10:354-361.
    • (2011) Ageing Research Reviews , vol.10 , pp. 354-361
    • Vallejo, A.N.1    Mueller, R.G.2    Hamel, D.L.3    Way, A.4    Dvergsten, J.A.5    Griffin, P.6
  • 9
    • 67649407892 scopus 로고    scopus 로고
    • CD28(-) T cells: their role in the age-associated decline of immune function
    • Weng N.P., Akbar A.N., Goronzy J. CD28(-) T cells: their role in the age-associated decline of immune function. Trends in Immunology 2009, 30:306-312.
    • (2009) Trends in Immunology , vol.30 , pp. 306-312
    • Weng, N.P.1    Akbar, A.N.2    Goronzy, J.3
  • 11
    • 77949881221 scopus 로고    scopus 로고
    • The senescence-associated secretory phenotype: the dark side of tumor suppression
    • Coppe J.P., Desprez P.Y., Krtolica A., Campisi J. The senescence-associated secretory phenotype: the dark side of tumor suppression. Annual Review of Pathology 2010, 5:99-118.
    • (2010) Annual Review of Pathology , vol.5 , pp. 99-118
    • Coppe, J.P.1    Desprez, P.Y.2    Krtolica, A.3    Campisi, J.4
  • 13
    • 80054682555 scopus 로고    scopus 로고
    • Tumor suppressor and aging biomarker p16(INK4a) induces cellular senescence without the associated inflammatory secretory phenotype
    • Coppe J.P., Rodier F., Patil C.K., Freund A., Desprez P.Y., Campisi J. Tumor suppressor and aging biomarker p16(INK4a) induces cellular senescence without the associated inflammatory secretory phenotype. Journal of Biological Chemistry 2011, 286:36396-36403.
    • (2011) Journal of Biological Chemistry , vol.286 , pp. 36396-36403
    • Coppe, J.P.1    Rodier, F.2    Patil, C.K.3    Freund, A.4    Desprez, P.Y.5    Campisi, J.6
  • 14
    • 31544458154 scopus 로고    scopus 로고
    • Age-related changes in cell surface and senescence markers in the spleen of DBA/2 mice: a flow cytometric analysis
    • Connoy A.C., Trader M., High K.P. Age-related changes in cell surface and senescence markers in the spleen of DBA/2 mice: a flow cytometric analysis. Experimental Gerontology 2006, 41:225-229.
    • (2006) Experimental Gerontology , vol.41 , pp. 225-229
    • Connoy, A.C.1    Trader, M.2    High, K.P.3
  • 15
    • 67651180787 scopus 로고    scopus 로고
    • Expression of p16(INK4a) in peripheral blood T-cells is a biomarker of human aging
    • Liu Y., Sanoff H.K., Cho H., Burd C.E., Torrice C., Ibrahim J.G., et al. Expression of p16(INK4a) in peripheral blood T-cells is a biomarker of human aging. Aging Cell 2009, 8:439-448.
    • (2009) Aging Cell , vol.8 , pp. 439-448
    • Liu, Y.1    Sanoff, H.K.2    Cho, H.3    Burd, C.E.4    Torrice, C.5    Ibrahim, J.G.6
  • 16
    • 78049441699 scopus 로고    scopus 로고
    • Lifestyle impacts on the aging-associated expression of biomarkers of DNA damage and telomere dysfunction in human blood
    • Song Z., von Figura G., Liu Y., Kraus J.M., Torrice C., Dillon P., et al. Lifestyle impacts on the aging-associated expression of biomarkers of DNA damage and telomere dysfunction in human blood. Aging Cell 2010, 9:607-615.
    • (2010) Aging Cell , vol.9 , pp. 607-615
    • Song, Z.1    von Figura, G.2    Liu, Y.3    Kraus, J.M.4    Torrice, C.5    Dillon, P.6
  • 21
  • 22
    • 80053516103 scopus 로고    scopus 로고
    • Functional CD8 T cell memory responding to persistent latent infection is maintained for life
    • Lang A., Nikolich-Zugich J. Functional CD8 T cell memory responding to persistent latent infection is maintained for life. Journal of Immunology 2011, 187:3759-3768.
    • (2011) Journal of Immunology , vol.187 , pp. 3759-3768
    • Lang, A.1    Nikolich-Zugich, J.2
  • 25
  • 27
    • 84857727992 scopus 로고    scopus 로고
    • Reversal of functional defects in highly differentiated young and old CD8 T cells by PDL blockade
    • April
    • Henson S.M., Macaulay R., Franzese O., Akbar A.N. Reversal of functional defects in highly differentiated young and old CD8 T cells by PDL blockade. Immunology 2012, 135:355-363. April.
    • (2012) Immunology , vol.135 , pp. 355-363
    • Henson, S.M.1    Macaulay, R.2    Franzese, O.3    Akbar, A.N.4
  • 28
    • 84883490878 scopus 로고    scopus 로고
    • Cellular aging and senescence characteristics of human T-lymphocytes. Biogerontology, [Epub ahead of print].
    • Onyema OO, Njemini R, Bautmans I, Renmans W, De WM, Mets T. Cellular aging and senescence characteristics of human T-lymphocytes. Biogerontology, [Epub ahead of print].
    • Onyema, O.O..1    Njemini, R.2    Bautmans, I.3    Renmans, W.4    De, W.M.5    Mets, T.6
  • 29
    • 84864017351 scopus 로고    scopus 로고
    • Role of CD8 T cell replicative senescence in human aging and in HIV-mediated immunosenescence
    • Dock J.N., Effros R.B. Role of CD8 T cell replicative senescence in human aging and in HIV-mediated immunosenescence. Aging and Disease 2011, 2:382-397.
    • (2011) Aging and Disease , vol.2 , pp. 382-397
    • Dock, J.N.1    Effros, R.B.2
  • 30
    • 84883491189 scopus 로고    scopus 로고
    • The role of the T cell in age-related inflammation. Age (Dordrecht), [Epub ahead of print].
    • Macaulay R, Akbar AN, Henson SM. The role of the T cell in age-related inflammation. Age (Dordrecht), [Epub ahead of print].
    • Macaulay, R.1    Akbar, A.N.2    Henson, S.M.3
  • 33
    • 0035202615 scopus 로고    scopus 로고
    • Value of immunological markers in predicting responsiveness to influenza vaccination in elderly individuals
    • Goronzy J.J., Fulbright J.W., Crowson C.S., Poland G.A., O'Fallon W.M., Weyand C.M. Value of immunological markers in predicting responsiveness to influenza vaccination in elderly individuals. Journal of Virology 2001, 75:12182-12187.
    • (2001) Journal of Virology , vol.75 , pp. 12182-12187
    • Goronzy, J.J.1    Fulbright, J.W.2    Crowson, C.S.3    Poland, G.A.4    O'Fallon, W.M.5    Weyand, C.M.6
  • 34
    • 0036604275 scopus 로고    scopus 로고
    • Lack of antibody production following immunization in old age: association with CD8(+)CD28(-) T cell clonal expansions and an imbalance in the production of Th1 and Th2 cytokines
    • Saurwein-Teissl M., Lung T.L., Marx F., Gschosser C., Asch E., Blasko I., et al. Lack of antibody production following immunization in old age: association with CD8(+)CD28(-) T cell clonal expansions and an imbalance in the production of Th1 and Th2 cytokines. Journal of Immunology 2002, 168:5893-5899.
    • (2002) Journal of Immunology , vol.168 , pp. 5893-5899
    • Saurwein-Teissl, M.1    Lung, T.L.2    Marx, F.3    Gschosser, C.4    Asch, E.5    Blasko, I.6
  • 35
    • 34347405728 scopus 로고    scopus 로고
    • Lower GrB+ CD62Lhigh CD8 TCM effector lymphocyte response to influenza virus in older adults is associated with increased CD28null CD8 T lymphocytes
    • Xie D., McElhaney J.E. Lower GrB+ CD62Lhigh CD8 TCM effector lymphocyte response to influenza virus in older adults is associated with increased CD28null CD8 T lymphocytes. Mechanisms of Ageing and Development 2007, 128:392-400.
    • (2007) Mechanisms of Ageing and Development , vol.128 , pp. 392-400
    • Xie, D.1    McElhaney, J.E.2
  • 36
    • 0242317690 scopus 로고    scopus 로고
    • Association between cytomegalovirus infection, enhanced proinflammatory response and low level of anti-hemagglutinins during the anti-influenza vaccination-an impact of immunosenescence
    • Trzonkowski P., Myśliwska J., Szmit E., Wieckiewicz J., Lukaszuk K., Brydak L.B., et al. Association between cytomegalovirus infection, enhanced proinflammatory response and low level of anti-hemagglutinins during the anti-influenza vaccination-an impact of immunosenescence. Vaccine 2003, 21:3826-3836.
    • (2003) Vaccine , vol.21 , pp. 3826-3836
    • Trzonkowski, P.1    Myśliwska, J.2    Szmit, E.3    Wieckiewicz, J.4    Lukaszuk, K.5    Brydak, L.B.6
  • 37
    • 33846111415 scopus 로고    scopus 로고
    • Inflammaging and anti-inflammaging: a systemic perspective on aging and longevity emerged from studies in humans
    • Franceschi C., Capri M., Monti D., Giunta S., Olivieri F., Sevini F., et al. Inflammaging and anti-inflammaging: a systemic perspective on aging and longevity emerged from studies in humans. Mechanisms of Ageing and Development 2007, 128:92-105.
    • (2007) Mechanisms of Ageing and Development , vol.128 , pp. 92-105
    • Franceschi, C.1    Capri, M.2    Monti, D.3    Giunta, S.4    Olivieri, F.5    Sevini, F.6
  • 40
    • 0033502284 scopus 로고    scopus 로고
    • Elderly humans show prolonged in vivo inflammatory activity during pneumococcal infections
    • Bruunsgaard H., Skinhoj P., Qvist J., Pedersen B.K. Elderly humans show prolonged in vivo inflammatory activity during pneumococcal infections. Journal of Infectious Diseases 1999, 180:551-554.
    • (1999) Journal of Infectious Diseases , vol.180 , pp. 551-554
    • Bruunsgaard, H.1    Skinhoj, P.2    Qvist, J.3    Pedersen, B.K.4
  • 43
    • 84868203671 scopus 로고    scopus 로고
    • Old cells under attack
    • Ageing Peeper D.S. Old cells under attack. Nature 2011, 479:186-187.
    • (2011) Nature , vol.479 , pp. 186-187
    • Ageing, P.D.S.1
  • 44
    • 79953086335 scopus 로고    scopus 로고
    • Expression of p16(INK4a) prevents cancer and promotes aging in lymphocytes
    • Liu Y., Johnson S.M., Fedoriw Y., Rogers A.B., Yuan H., Krishnamurthy J., et al. Expression of p16(INK4a) prevents cancer and promotes aging in lymphocytes. Blood 2011, 117:3257-3267.
    • (2011) Blood , vol.117 , pp. 3257-3267
    • Liu, Y.1    Johnson, S.M.2    Fedoriw, Y.3    Rogers, A.B.4    Yuan, H.5    Krishnamurthy, J.6
  • 45
    • 0037271852 scopus 로고    scopus 로고
    • A road less travelled: large animal models in immunological research
    • Hein W.R., Griebel P.J. A road less travelled: large animal models in immunological research. Nature Reviews Immunology 2003, 3:79-84.
    • (2003) Nature Reviews Immunology , vol.3 , pp. 79-84
    • Hein, W.R.1    Griebel, P.J.2
  • 46
    • 0005457558 scopus 로고    scopus 로고
    • First human trial of a DNA-based vaccine for treatment of human immunodeficiency virus type 1 infection: safety and host response
    • MacGregor R.R., Boyer J.D., Ugen K.E., Lacy K.E., Gluckman S.J., Bagarazzi M.L., et al. First human trial of a DNA-based vaccine for treatment of human immunodeficiency virus type 1 infection: safety and host response. Journal of Infectious Diseases 1998, 178:92-100.
    • (1998) Journal of Infectious Diseases , vol.178 , pp. 92-100
    • MacGregor, R.R.1    Boyer, J.D.2    Ugen, K.E.3    Lacy, K.E.4    Gluckman, S.J.5    Bagarazzi, M.L.6
  • 47
    • 1342303482 scopus 로고    scopus 로고
    • Of mice and not men: differences between mouse and human immunology
    • Mestas J., Hughes C.C. Of mice and not men: differences between mouse and human immunology. Journal of Immunology 2004, 172:2731-2738.
    • (2004) Journal of Immunology , vol.172 , pp. 2731-2738
    • Mestas, J.1    Hughes, C.C.2
  • 48
    • 68249118173 scopus 로고    scopus 로고
    • Evolutionary dynamics of human Toll-like receptors and their different contributions to host defense
    • Barreiro L.B., Ben-Ali M., Quach H., Laval G., Patin E., Pickrell J.K., et al. Evolutionary dynamics of human Toll-like receptors and their different contributions to host defense. PLoS Genetics 2009, 5:e1000562.
    • (2009) PLoS Genetics , vol.5
    • Barreiro, L.B.1    Ben-Ali, M.2    Quach, H.3    Laval, G.4    Patin, E.5    Pickrell, J.K.6
  • 50
    • 75649139205 scopus 로고    scopus 로고
    • Murine responses to endotoxin: another dirty little secret
    • Munford R.S. Murine responses to endotoxin: another dirty little secret. Journal of Infectious Diseases 2010, 201:175-177.
    • (2010) Journal of Infectious Diseases , vol.201 , pp. 175-177
    • Munford, R.S.1
  • 51
    • 0025029030 scopus 로고
    • Hypervariable ultra-long telomeres in mice
    • Kipling D., Cooke H.J. Hypervariable ultra-long telomeres in mice. Nature 1990, 347:400-402.
    • (1990) Nature , vol.347 , pp. 400-402
    • Kipling, D.1    Cooke, H.J.2
  • 52
    • 0033859430 scopus 로고    scopus 로고
    • Loss of CD28 expression on CD8(+) T cells is induced by IL-2 receptor gamma chain signalling cytokines and type I IFN, and increases susceptibility to activation-induced apoptosis
    • Borthwick N.J., Lowdell M., Salmon M., Akbar A.N. Loss of CD28 expression on CD8(+) T cells is induced by IL-2 receptor gamma chain signalling cytokines and type I IFN, and increases susceptibility to activation-induced apoptosis. International Immunology 2000, 12:1005-1013.
    • (2000) International Immunology , vol.12 , pp. 1005-1013
    • Borthwick, N.J.1    Lowdell, M.2    Salmon, M.3    Akbar, A.N.4
  • 56
    • 0036867423 scopus 로고    scopus 로고
    • Divergent telomerase and CD28 expression patterns in human CD4 and CD8 T cells following repeated encounters with the same antigenic stimulus
    • Valenzuela H.F., Effros R.B. Divergent telomerase and CD28 expression patterns in human CD4 and CD8 T cells following repeated encounters with the same antigenic stimulus. Clinical Immunology 2002, 105:117-125.
    • (2002) Clinical Immunology , vol.105 , pp. 117-125
    • Valenzuela, H.F.1    Effros, R.B.2
  • 58
    • 34147157752 scopus 로고    scopus 로고
    • CD8 T cell clonal expansions & aging: a heterogeneous phenomenon with a common outcome
    • Clambey E.T., Kappler J.W., Marrack P. CD8 T cell clonal expansions & aging: a heterogeneous phenomenon with a common outcome. Experimental Gerontology 2007, 42:407-411.
    • (2007) Experimental Gerontology , vol.42 , pp. 407-411
    • Clambey, E.T.1    Kappler, J.W.2    Marrack, P.3
  • 59
    • 78649813010 scopus 로고    scopus 로고
    • Nonmalignant clonal expansions of memory CD8+ T cells that arise with age vary in their capacity to mount recall responses to infection
    • Kohlmeier J.E., Connor L.M., Roberts A.D., Cookenham T., Martin K., Woodland D.L. Nonmalignant clonal expansions of memory CD8+ T cells that arise with age vary in their capacity to mount recall responses to infection. Journal of Immunology 2010, 185:3456-3462.
    • (2010) Journal of Immunology , vol.185 , pp. 3456-3462
    • Kohlmeier, J.E.1    Connor, L.M.2    Roberts, A.D.3    Cookenham, T.4    Martin, K.5    Woodland, D.L.6
  • 60
    • 44449158272 scopus 로고    scopus 로고
    • Age-related dysregulation of CD8+ T cell memory specific for a persistent virus is independent of viral replication
    • Lang A., Brien J.D., Messaoudi I., Nikolich-Zugich J. Age-related dysregulation of CD8+ T cell memory specific for a persistent virus is independent of viral replication. Journal of Immunology 2008, 180:4848-4857.
    • (2008) Journal of Immunology , vol.180 , pp. 4848-4857
    • Lang, A.1    Brien, J.D.2    Messaoudi, I.3    Nikolich-Zugich, J.4
  • 61
    • 33747789572 scopus 로고    scopus 로고
    • Age-related CD8+ T cell clonal expansions express elevated levels of CD122 and CD127 and display defects in perceiving homeostatic signals
    • Messaoudi I., Warner J., Nikolich-Zugich J. Age-related CD8+ T cell clonal expansions express elevated levels of CD122 and CD127 and display defects in perceiving homeostatic signals. Journal of Immunology 2006, 177:2784-2792.
    • (2006) Journal of Immunology , vol.177 , pp. 2784-2792
    • Messaoudi, I.1    Warner, J.2    Nikolich-Zugich, J.3
  • 62
    • 29644443961 scopus 로고    scopus 로고
    • Molecular, cellular, and antigen requirements for development of age-associated T cell clonal expansions in vivo
    • Messaoudi I., Warner J., Nikolich-Zugich D., Fischer M., Nikolich-Zugich J. Molecular, cellular, and antigen requirements for development of age-associated T cell clonal expansions in vivo. Journal of Immunology 2006, 176:301-308.
    • (2006) Journal of Immunology , vol.176 , pp. 301-308
    • Messaoudi, I.1    Warner, J.2    Nikolich-Zugich, D.3    Fischer, M.4    Nikolich-Zugich, J.5
  • 67
    • 0025675862 scopus 로고
    • Involvement of lipoproteins in suppression of interleukin 2-dependent cell proliferation by sera from aged humans
    • Ohtsuka Y., Kobayashi K., Hirano T., Furukawa S., Nagano S., Takahashi T. Involvement of lipoproteins in suppression of interleukin 2-dependent cell proliferation by sera from aged humans. Gerontology 1990, 36:268-275.
    • (1990) Gerontology , vol.36 , pp. 268-275
    • Ohtsuka, Y.1    Kobayashi, K.2    Hirano, T.3    Furukawa, S.4    Nagano, S.5    Takahashi, T.6
  • 68
    • 0018876110 scopus 로고
    • Correlations between membrane viscosity, serum cholesterol, lymphocyte activation and aging in man
    • Rivnay B., Bergman S., Shinitzky M., Globerson A. Correlations between membrane viscosity, serum cholesterol, lymphocyte activation and aging in man. Mechanisms of Ageing and Development 1980, 12:119-126.
    • (1980) Mechanisms of Ageing and Development , vol.12 , pp. 119-126
    • Rivnay, B.1    Bergman, S.2    Shinitzky, M.3    Globerson, A.4
  • 71
    • 0024561193 scopus 로고
    • Dendritic cells and T cells transfer sensitization for delayed-type hypersensitivity after skin painting with contact sensitizer
    • Macatonia S.E., Knight S.C. Dendritic cells and T cells transfer sensitization for delayed-type hypersensitivity after skin painting with contact sensitizer. Immunology 1989, 66:96-99.
    • (1989) Immunology , vol.66 , pp. 96-99
    • Macatonia, S.E.1    Knight, S.C.2
  • 73
    • 77953637386 scopus 로고    scopus 로고
    • Loss of naive T cells and repertoire constriction predict poor response to vaccination in old primates
    • Cicin-Sain L., Smyk-Pearson S., Currier N., Byrd L., Koudelka C., Robinson T., et al. Loss of naive T cells and repertoire constriction predict poor response to vaccination in old primates. Journal of Immunology 2010, 184:6739-6745.
    • (2010) Journal of Immunology , vol.184 , pp. 6739-6745
    • Cicin-Sain, L.1    Smyk-Pearson, S.2    Currier, N.3    Byrd, L.4    Koudelka, C.5    Robinson, T.6
  • 75
    • 0142214639 scopus 로고    scopus 로고
    • Phenotypic and functional T-cell aging in rhesus macaques (Macaca mulatta): differential behavior of CD4 and CD8 subsets
    • Jankovic V., Messaoudi I., Nikolich-Zugich J. Phenotypic and functional T-cell aging in rhesus macaques (Macaca mulatta): differential behavior of CD4 and CD8 subsets. Blood 2003, 102:3244-3251.
    • (2003) Blood , vol.102 , pp. 3244-3251
    • Jankovic, V.1    Messaoudi, I.2    Nikolich-Zugich, J.3
  • 77
    • 79958069078 scopus 로고    scopus 로고
    • The development of small primate models for aging research
    • Austad S.N., Fischer K.E. The development of small primate models for aging research. ILAR Journal 2011, 52:78-88.
    • (2011) ILAR Journal , vol.52 , pp. 78-88
    • Austad, S.N.1    Fischer, K.E.2
  • 80
    • 58149301590 scopus 로고    scopus 로고
    • From bench to bedside and back: the SENIEUR protocol and the efficacy of influenza vaccination in the elderly
    • Trzonkowski P., Mysliwska J., Pawelec G., Mysliwski A. From bench to bedside and back: the SENIEUR protocol and the efficacy of influenza vaccination in the elderly. Biogerontology 2009, 10:83-94.
    • (2009) Biogerontology , vol.10 , pp. 83-94
    • Trzonkowski, P.1    Mysliwska, J.2    Pawelec, G.3    Mysliwski, A.4
  • 82
    • 15044359591 scopus 로고    scopus 로고
    • Insights into severe sepsis in older patients: from epidemiology to evidence-based management
    • Girard T.D., Opal S.M., Ely E.W. Insights into severe sepsis in older patients: from epidemiology to evidence-based management. Clinical Infectious Diseases 2005, 40:719-727.
    • (2005) Clinical Infectious Diseases , vol.40 , pp. 719-727
    • Girard, T.D.1    Opal, S.M.2    Ely, E.W.3
  • 83
    • 48449089561 scopus 로고    scopus 로고
    • From bedside to bench: summary from the American Geriatrics Society/National Institute on Aging Research Conference on Comorbidity and Multiple Morbidity in Older Adults
    • Boyd C.M., Ritchie C.S., Tipton E.F., Studenski S.A., Wieland D. From bedside to bench: summary from the American Geriatrics Society/National Institute on Aging Research Conference on Comorbidity and Multiple Morbidity in Older Adults. Aging Clinical and Experimental Research 2008, 20:181-188.
    • (2008) Aging Clinical and Experimental Research , vol.20 , pp. 181-188
    • Boyd, C.M.1    Ritchie, C.S.2    Tipton, E.F.3    Studenski, S.A.4    Wieland, D.5
  • 86
    • 30944462935 scopus 로고    scopus 로고
    • Intraindividual variability and the effect of acute illness on immune senescence markers
    • High K.P., Trader M., Pahor M., Loeb M. Intraindividual variability and the effect of acute illness on immune senescence markers. Journal of the American Geriatrics Society 2005, 53:1761-1766.
    • (2005) Journal of the American Geriatrics Society , vol.53 , pp. 1761-1766
    • High, K.P.1    Trader, M.2    Pahor, M.3    Loeb, M.4
  • 87
    • 57449096122 scopus 로고    scopus 로고
    • A prescription for human immunology
    • Davis M.M. A prescription for human immunology. Immunity 2008, 29:835-838.
    • (2008) Immunity , vol.29 , pp. 835-838
    • Davis, M.M.1
  • 88
    • 84859492402 scopus 로고    scopus 로고
    • Molecular links between cellular senescence, longevity and age-related diseases-a systems biology perspective
    • Tacutu R., Budovsky A., Yanai H., Fraifeld V.E. Molecular links between cellular senescence, longevity and age-related diseases-a systems biology perspective. Aging (Albany, NY) 2011, 3:1178-1191.
    • (2011) Aging (Albany, NY) , vol.3 , pp. 1178-1191
    • Tacutu, R.1    Budovsky, A.2    Yanai, H.3    Fraifeld, V.E.4
  • 89
    • 80054778535 scopus 로고    scopus 로고
    • NK-like T cells and plasma cytokines, but not anti-viral serology, define immune fingerprints of resilience and mild disability in exceptional aging
    • Vallejo A.N., Hamel D.L., Mueller R.G., Ives D.G., Michel J.J., Boudreau R.M., et al. NK-like T cells and plasma cytokines, but not anti-viral serology, define immune fingerprints of resilience and mild disability in exceptional aging. PLoS One 2011, 6:e26558.
    • (2011) PLoS One , vol.6
    • Vallejo, A.N.1    Hamel, D.L.2    Mueller, R.G.3    Ives, D.G.4    Michel, J.J.5    Boudreau, R.M.6


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