The stapled AKAP disruptor peptide STAD-2 displays antimalarial activity through a PKA-independent mechanism

PLoS ONE

Volumn 10, Issue 5, 2015, Pages

  Flaherty, Briana R ^a   Wang, Yuxiao ^a   Trope, Edward C ^a   Ho, Tienhuei G ^a   Muralidharan, Vasant ^a   Kennedy, Eileen J ^a   Peterson, David S ^a  

^a NONE

Author keywords

[No Author keywords available]

Indexed keywords

ANTIPARASITIC AGENT; CYCLIC AMP DEPENDENT PROTEIN KINASE; CYCLIC AMP DEPENDENT PROTEIN KINASE ANCHORING PROTEIN; FUROSEMIDE; STAD 2; UNCLASSIFIED DRUG; ANTIMALARIAL AGENT; PEPTIDE; PROTOZOAL PROTEIN;

ANTIMALARIAL ACTIVITY; ARTICLE; BINDING AFFINITY; CELL MEMBRANE PERMEABILITY; CONCENTRATION RESPONSE; CRYSTAL STRUCTURE; DNA CONTENT; ENZYME ACTIVITY; ERYTHROCYTE; HUMAN; HUMAN CELL; IC50; IN VITRO STUDY; PARASITE VIABILITY; PLASMODIUM FALCIPARUM; PROTEIN BINDING; PROTEIN LOCALIZATION; PROTEIN PROTEIN INTERACTION; CHEMISTRY; DRUG EFFECTS; METABOLISM; MOLECULAR DOCKING; MOLECULAR MODEL; PARASITOLOGY; SIGNAL TRANSDUCTION;

PLASMODIUM FALCIPARUM;

A KINASE ANCHOR PROTEINS; ANTIMALARIALS; CYCLIC AMP-DEPENDENT PROTEIN KINASES; ERYTHROCYTES; HUMANS; MODELS, MOLECULAR; MOLECULAR DOCKING SIMULATION; PEPTIDES; PLASMODIUM FALCIPARUM; PROTOZOAN PROTEINS; SIGNAL TRANSDUCTION;

EID: 84930226446     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0129239     Document Type: Article

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