Malaria antifolate resistance with contrasting Plasmodium falciparum dihydrofolate reductase (DHFR) polymorphisms in humans and Anopheles mosquitoes

Proceedings of the National Academy of Sciences of the United States of America

Volumn 108, Issue 46, 2011, Pages 18796-18801

  Mharakurwa, Sungano ^a,b   Kumwenda, Taida ^a   Mkulama, Mtawa A P ^a   Musapa, Mulenga ^a   Chishimba, Sandra ^a   Shiff, Clive J ^b   Sullivan, David J ^b   Thuma, Philip E ^a,b   Liu, Kun ^b   Agre, Peter ^b  

^a Malaria Institute at Macha   (Zambia)

^b JOHNS HOPKINS BLOOMBERG SCHOOL OF PUBLIC HEALTH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALANINE; ARGININE; ASPARTIC ACID; ATOVAQUONE PLUS PROGUANIL; CYCLOGUANIL; CYSTEINE; DIHYDROFOLATE REDUCTASE; DNA; FOLIC ACID ANTAGONIST; ISOLEUCINE; PYRIMETHAMINE; PYRIMETHAMINE PLUS SULFADOXINE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; SERINE; THREONINE; VALINE;

ADOLESCENT; ADULT; AGED; ALLELE; AMINO ACID SUBSTITUTION; ANOPHELES; ANOPHELES ARABIENSIS; ANTIMALARIAL DRUG RESISTANCE; ARTICLE; BLOOD; BLOOD SAMPLING; BLOOD SMEAR; CHILD; CLINICAL TRIAL; COMPUTER MODEL; CONTROLLED STUDY; ENZYME BINDING; ENZYME METABOLISM; GENE FREQUENCY; HUMAN; INFANT; MAJOR CLINICAL STUDY; MALARIA FALCIPARUM; MIDGUT; MUTANT; NEWBORN; NONHUMAN; PARASITE; PARASITE VECTOR; PLASMODIUM FALCIPARUM; POLYMERASE CHAIN REACTION; PRESCHOOL CHILD; PRIORITY JOURNAL; PROSPECTIVE STUDY; PROTEIN ANALYSIS; PROTEIN STABILITY; SCHOOL CHILD; SINGLE NUCLEOTIDE POLYMORPHISM; ZAMBIA;

ALLELES; ANIMALS; ANOPHELES; BASE SEQUENCE; DNA RESTRICTION ENZYMES; DRUG RESISTANCE; FOLIC ACID ANTAGONISTS; HUMANS; MALARIA; MOLECULAR SEQUENCE DATA; MUTATION; PLASMODIUM FALCIPARUM; POLYMERASE CHAIN REACTION; POLYMORPHISM, GENETIC; SEQUENCE ANALYSIS, DNA; SEQUENCE HOMOLOGY, NUCLEIC ACID; TETRAHYDROFOLATE DEHYDROGENASE; ZAMBIA;

ANOPHELES (GENUS); ANOPHELES ARABIENSIS; PLASMODIUM FALCIPARUM;

EID: 81755172877     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1116162108     Document Type: Article

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