A-kinase anchoring proteins: Protein kinase A and beyond

Current Opinion in Cell Biology

Volumn 12, Issue 2, 2000, Pages 217-221

  Edwards, Amelia S ^a   Scott, John D ^a  

^a OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIC AMP DEPENDENT PROTEIN KINASE; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; PHOSPHATASE;

ENZYME LOCALIZATION; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION; PROTEIN TARGETING; REVIEW; SECOND MESSENGER; SIGNAL TRANSDUCTION;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ANIMALS; CAENORHABDITIS ELEGANS PROTEINS; CARRIER PROTEINS; CYCLIC AMP-DEPENDENT PROTEIN KINASES; CYTOSKELETAL PROTEINS; DROSOPHILA PROTEINS; MEMBRANE PROTEINS; PROTEINS; SEMINAL PLASMA PROTEINS;

EID: 0034057087     PISSN: 09550674     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0955-0674(99)00085-X     Document Type: Review

References (40)

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4. Newlon M.G., Roy M., Morikis D., Hausken Z.E., Coghlan V., Scott J.D., Jennings P.A. The molecular basis for protein kinase A anchoring revealed by solution NMR. Nat Struct Biol. 6:1999;222-227. Solving the three-dimensional structure of the AKAP biding site on RII provides a structural framework for the mechanism of PKA-AKAP interactions and confirms much of the early data from a variety of laboratories that mapped anchoring determinants.
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35. Harada H., Becknell B., Wilm M., Mann M., Huang L.J., Taylor S.S., Scott J.D., Korsmeyer S.J. Phosphorylation and inactivation of BAD by mitochondria-anchored protein kinase A. Mol Cell. 3:1999;413-422. This paper provides the first evidence that PKA may be a BAD kinase that initiates anti-apoptotic events by allowing recruitment of 14-3-3. Functional evidence with anchoring inhibitor peptides implicates a targeted pool of PKA in mediating mitochondrial apoptotic events.
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37. Gao T., Yatani A., Dell'Acqua M.L., Sako H., Green S.A., Dascal N., Scott J.D., Hosey M.M. cAMP-dependent regulation of cardiac L-type Ca2+ channels requires membrane targeting of PKA and phosphorylation of channel subunits. Neuron. 19:1997;185-196.
38. Davare M.A., Dong F., Rubin C.S., Hell J.W. The A-kinase anchor protein MAP2B and cAMP-dependent protein kinase are associated with class C L-type calcium channels in neurons. J Biol Chem. 274:1999;30280-30287.
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