메뉴 건너뛰기




Volumn 5, Issue , 2015, Pages

The role of cyclooxygenase-2, interleukin-1β and fibroblast growth factor-2 in the activation of matrix metalloproteinase-1 in sheared-chondrocytes and articular cartilage

Author keywords

[No Author keywords available]

Indexed keywords

15-DEOXY-DELTA(12,14)-PROSTAGLANDIN J2; 15-DEOXYPROSTAGLANDIN J2; CYCLOOXYGENASE 2; FIBROBLAST GROWTH FACTOR 2; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1BETA; INTERSTITIAL COLLAGENASE; MITOGEN ACTIVATED PROTEIN KINASE P38; PHOSPHATIDYLINOSITOL 3 KINASE; PROSTAGLANDIN D2; PROSTAGLANDIN E2; PROTEIN KINASE B; STRESS ACTIVATED PROTEIN KINASE;

EID: 84930208800     PISSN: None     EISSN: 20452322     Source Type: Journal    
DOI: 10.1038/srep10412     Document Type: Article
Times cited : (28)

References (52)
  • 1
    • 5444243033 scopus 로고    scopus 로고
    • The mechanobiology of articular cartilage development and degeneration
    • Carter, D.R. et al. The mechanobiology of articular cartilage development and degeneration. Clin. Orthop. Relat. Res. 427, S69-77 (2004).
    • (2004) Clin. Orthop. Relat. Res. , vol.427 , pp. S69-77
    • Carter, D.R.1
  • 2
    • 78650846194 scopus 로고    scopus 로고
    • Prolonged application of high fuid shear to chondrocytes recapitulates gene expression profles associated with osteoarthritis
    • Zhu, F., Wang, P., Lee, N.H., Goldring, M.B. & Konstantopoulos, K. Prolonged application of high fuid shear to chondrocytes recapitulates gene expression profles associated with osteoarthritis. PLoS One 5, e15174 (2010).
    • (2010) PLoS One , vol.5 , pp. e15174
    • Zhu, F.1    Wang, P.2    Lee, N.H.3    Goldring, M.B.4    Konstantopoulos, K.5
  • 3
    • 84890482110 scopus 로고    scopus 로고
    • Fluid shear stress-induced osteoarthritis: Roles of cyclooxygenase-2 and its metabolic products in inducing the expression of proinfammatory cytokines and matrix metalloproteinases
    • Wang, P. et al. Fluid shear stress-induced osteoarthritis: roles of cyclooxygenase-2 and its metabolic products in inducing the expression of proinfammatory cytokines and matrix metalloproteinases. FASEB J. 27, 4664-77 (2013).
    • (2013) FASEB J. , vol.27 , pp. 4664-4677
    • Wang, P.1
  • 4
    • 4944257679 scopus 로고    scopus 로고
    • PGE2 induces the gene expression of bone matrix metalloproteinase-1 in mouse osteoblasts by cAMP-PKA signaling pathway
    • Kim, C.H., Park, Y.G., Noh, S.H. & Kim, Y.K. PGE2 induces the gene expression of bone matrix metalloproteinase-1 in mouse osteoblasts by cAMP-PKA signaling pathway. Int J. Biochem. Cell Biol. 37, 375-85 (2005).
    • (2005) Int J. Biochem. Cell Biol. , vol.37 , pp. 375-385
    • Kim, C.H.1    Park, Y.G.2    Noh, S.H.3    Kim, Y.K.4
  • 5
    • 3042719893 scopus 로고    scopus 로고
    • Cox-2 inhibition abrogates Chlamydia pneumoniae-induced PGE2 and MMP-1 expression
    • Rupp, J. et al. Cox-2 inhibition abrogates Chlamydia pneumoniae-induced PGE2 and MMP-1 expression. Biochem. Biophys. Res. Commun. 320, 738-44 (2004).
    • (2004) Biochem. Biophys. Res. Commun. , vol.320 , pp. 738-744
    • Rupp, J.1
  • 6
    • 64349099334 scopus 로고    scopus 로고
    • 15-Deoxy-Delta12, 14-prostaglandin J2 upregulates the expression of heme oxygenase-1 and subsequently matrix metalloproteinase-1 in human breast cancer cells: Possible roles of iron and ROS
    • Kim, D.H. et al. 15-Deoxy-Delta12, 14-prostaglandin J2 upregulates the expression of heme oxygenase-1 and subsequently matrix metalloproteinase-1 in human breast cancer cells: possible roles of iron and ROS. Carcinogenesis 30, 645-54 (2009).
    • (2009) Carcinogenesis , vol.30 , pp. 645-654
    • Kim, D.H.1
  • 7
    • 17144444084 scopus 로고    scopus 로고
    • Prostaglandin-J(2) upregulates expression of matrix metalloproteinase-1 independently of activation of peroxisome proliferator-activated receptor-gamma
    • Jozkowicz, A. et al. Prostaglandin-J(2) upregulates expression of matrix metalloproteinase-1 independently of activation of peroxisome proliferator-activated receptor-gamma. Acta Biochim. Pol. 50, 677-89 (2003).
    • (2003) Acta Biochim. Pol. , vol.50 , pp. 677-689
    • Jozkowicz, A.1
  • 8
    • 55849114042 scopus 로고    scopus 로고
    • Inhibition of interleukin-1beta-induced matrix metalloproteinases 1 and 13 production in human osteoarthritic chondrocytes by prostaglandin D2
    • Zayed, N. et al. Inhibition of interleukin-1beta-induced matrix metalloproteinases 1 and 13 production in human osteoarthritic chondrocytes by prostaglandin D2. Arthritis Rheum 58, 3530-40 (2008).
    • (2008) Arthritis Rheum , vol.58 , pp. 3530-3540
    • Zayed, N.1
  • 9
    • 0036151348 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor gamma activators inhibit MMP-1 production in human synovial fbroblasts likely by reducing the binding of the activator protein 1
    • Fahmi, H. et al. Peroxisome proliferator-activated receptor gamma activators inhibit MMP-1 production in human synovial fbroblasts likely by reducing the binding of the activator protein 1. Osteoarthritis Cartilage 10, 100-8 (2002).
    • (2002) Osteoarthritis Cartilage , vol.10 , pp. 100-108
    • Fahmi, H.1
  • 10
    • 57349183076 scopus 로고    scopus 로고
    • The interleukin 1beta pathway in the pathogenesis of osteoarthritis
    • Daheshia, M. & Yao, J.Q. The interleukin 1beta pathway in the pathogenesis of osteoarthritis. J. Rheumatol. 35, 2306-12 (2008).
    • (2008) J. Rheumatol. , vol.35 , pp. 2306-2312
    • Daheshia, M.1    Yao, J.Q.2
  • 11
    • 84893062912 scopus 로고    scopus 로고
    • Preclinical evidence for the antihyperalgesic activity of CDP-choline in oxaliplatin-induced neuropathic pain
    • Kanat, D., Bagdas, D., Ozboluk, H.Y. & Gurun, M.S. Preclinical evidence for the antihyperalgesic activity of CDP-choline in oxaliplatin-induced neuropathic pain. J. BUON 18, 1012-8 (2013).
    • (2013) J. BUON , vol.18 , pp. 1012-1018
    • Kanat, D.1    Bagdas, D.2    Ozboluk, H.Y.3    Gurun, M.S.4
  • 12
    • 80051781277 scopus 로고    scopus 로고
    • Efect of a Herbal-Leucine mix on the IL-1beta-induced cartilage degradation and infammatory gene expression in human chondrocytes
    • Akhtar, N., Miller, M.J. & Haqqi, T.M. Efect of a Herbal-Leucine mix on the IL-1beta-induced cartilage degradation and infammatory gene expression in human chondrocytes. BMC Complement Altern. Med. 11, 66 (2011).
    • (2011) BMC Complement Altern. Med. , vol.11 , pp. 66
    • Akhtar, N.1    Miller, M.J.2    Haqqi, T.M.3
  • 13
    • 67650070760 scopus 로고    scopus 로고
    • Fibroblast growth factor 2: A new key player in osteoarthritis
    • Gavrilovic, J. Fibroblast growth factor 2: A new key player in osteoarthritis. Arthritis Rheum 60, 1869-72 (2009).
    • (2009) Arthritis Rheum , vol.60 , pp. 1869-1872
    • Gavrilovic, J.1
  • 14
    • 0031001097 scopus 로고    scopus 로고
    • Fibroblast growth factor receptor signaling activates the human interstitial collagenase promoter via the bipartite Ets-AP1 element
    • Newberry, E.P., Willis, D., Latif, T., Boudreaux, J.M. & Towler, D.A. Fibroblast growth factor receptor signaling activates the human interstitial collagenase promoter via the bipartite Ets-AP1 element. Mol. Endocrinol. 11, 1129-44 (1997).
    • (1997) Mol. Endocrinol. , vol.11 , pp. 1129-1144
    • Newberry, E.P.1    Willis, D.2    Latif, T.3    Boudreaux, J.M.4    Towler, D.A.5
  • 15
    • 33745415858 scopus 로고    scopus 로고
    • Matrix metalloproteinases MMP-3 and MMP-1 levels in sera and synovial fuids in patients with rheumatoid arthritis and osteoarthritis
    • Mahmoud, R.K., El-Ansary, A.K., El-Eishi, H.H., Kamal, H.M. & El-Saeed, N.H. Matrix metalloproteinases MMP-3 and MMP-1 levels in sera and synovial fuids in patients with rheumatoid arthritis and osteoarthritis. Ital. J. Biochem. 54, 248-57 (2005).
    • (2005) Ital. J. Biochem. , vol.54 , pp. 248-257
    • Mahmoud, R.K.1    El-Ansary, A.K.2    El-Eishi, H.H.3    Kamal, H.M.4    El-Saeed, N.H.5
  • 16
    • 84883311019 scopus 로고    scopus 로고
    • Subchondral cyst development and MMP-1 expression during progression of osteoarthritis: An immunohistochemical study
    • Kaspiris, A. et al. Subchondral cyst development and MMP-1 expression during progression of osteoarthritis: an immunohistochemical study. Orthop Traumatol Surg. Res. 99, 523-9 (2013).
    • (2013) Orthop Traumatol Surg. Res. , vol.99 , pp. 523-529
    • Kaspiris, A.1
  • 17
    • 17644414532 scopus 로고    scopus 로고
    • MMP protein and activity levels in synovial fuid from patients with joint injury, infammatory arthritis, and osteoarthritis
    • Tchetverikov, I. et al. MMP protein and activity levels in synovial fuid from patients with joint injury, infammatory arthritis, and osteoarthritis. Ann. Rheum. Dis. 64, 694-8 (2005).
    • (2005) Ann. Rheum. Dis. , vol.64 , pp. 694-698
    • Tchetverikov, I.1
  • 18
    • 0035076487 scopus 로고    scopus 로고
    • Matrix metalloproteinase and proinfammatory cytokine production by chondrocytes of human osteoarthritic cartilage: Associations with degenerative changes
    • Tetlow, L.C., Adlam, D.J. & Woolley, D.E. Matrix metalloproteinase and proinfammatory cytokine production by chondrocytes of human osteoarthritic cartilage: associations with degenerative changes. Arthritis Rheum. 44, 585-94 (2001).
    • (2001) Arthritis Rheum. , vol.44 , pp. 585-594
    • Tetlow, L.C.1    Adlam, D.J.2    Woolley, D.E.3
  • 19
    • 0344012451 scopus 로고    scopus 로고
    • CITED2-mediated regulation of MMP-1 and MMP-13 in human chondrocytes under fow shear
    • Yokota, H., Goldring, M.B. & Sun, H.B. CITED2-mediated regulation of MMP-1 and MMP-13 in human chondrocytes under fow shear. J. Biol. Chem. 278, 47275-80 (2003).
    • (2003) J. Biol. Chem. , vol.278 , pp. 47275-47280
    • Yokota, H.1    Goldring, M.B.2    Sun, H.B.3
  • 20
    • 79959336476 scopus 로고    scopus 로고
    • Phosphorylated c-Jun and Fra-1 induce matrix metalloproteinase-1 and thereby regulate invasion activity of 143B osteosarcoma cells
    • Kimura, R., Ishikawa, C., Rokkaku, T., Janknecht, R. & Mori, N. Phosphorylated c-Jun and Fra-1 induce matrix metalloproteinase-1 and thereby regulate invasion activity of 143B osteosarcoma cells. Biochim. Biophys. Acta 1813, 1543-53 (2011).
    • (2011) Biochim. Biophys. Acta , vol.1813 , pp. 1543-1553
    • Kimura, R.1    Ishikawa, C.2    Rokkaku, T.3    Janknecht, R.4    Mori, N.5
  • 21
    • 0035008915 scopus 로고    scopus 로고
    • Inhibition of transcription factor NF-kappaB reduces matrix metalloproteinase-1,-3 and-9 production by vascular smooth muscle cells
    • Bond, M., Chase, A.J., Baker, A.H. & Newby, A.C. Inhibition of transcription factor NF-kappaB reduces matrix metalloproteinase-1,-3 and-9 production by vascular smooth muscle cells. Cardiovasc Res. 50, 556-65 (2001).
    • (2001) Cardiovasc Res. , vol.50 , pp. 556-565
    • Bond, M.1    Chase, A.J.2    Baker, A.H.3    Newby, A.C.4
  • 22
    • 77952657476 scopus 로고    scopus 로고
    • Prostaglandin E2 induces interleukin-6 expression in human chondrocytes via cAMP/protein kinase A-and phosphatidylinositol 3-kinase-dependent NF-kappaB activation
    • Wang, P., Zhu, F. & Konstantopoulos, K. Prostaglandin E2 induces interleukin-6 expression in human chondrocytes via cAMP/protein kinase A-and phosphatidylinositol 3-kinase-dependent NF-kappaB activation. Am. J. Physiol. Cell Physiol. 298, C1445-56 (2010).
    • (2010) Am. J. Physiol. Cell Physiol. , vol.298 , pp. C1445-C1456
    • Wang, P.1    Zhu, F.2    Konstantopoulos, K.3
  • 23
    • 84930202806 scopus 로고    scopus 로고
    • Prostaglandin D2 enhances interleukin-1beta-induced cyclooxygenase-2 expression in osteoarthritic cartilage
    • Zayed, N. et al. Prostaglandin D2 enhances interleukin-1beta-induced cyclooxygenase-2 expression in osteoarthritic cartilage. Journal of Translational Medicine 8((Suppl 1) P61 (2010).
    • (2010) Journal of Translational Medicine , vol.8 , pp. P61
    • Zayed, N.1
  • 24
    • 28044432798 scopus 로고    scopus 로고
    • Repetitive mechanical stretching modulates IL-1beta induced COX-2, MMP-1 expression, and PGE2 production in human patellar tendon fbroblasts
    • Yang, G., Im, H.J. & Wang, J.H. Repetitive mechanical stretching modulates IL-1beta induced COX-2, MMP-1 expression, and PGE2 production in human patellar tendon fbroblasts. Gene 363, 166-72 (2005).
    • (2005) Gene , vol.363 , pp. 166-172
    • Yang, G.1    Im, H.J.2    Wang, J.H.3
  • 25
    • 84895524336 scopus 로고    scopus 로고
    • Decreased PGE(2) content reduces MMP-1 activity and consequently increases collagen density in human varicose vein
    • Gomez, I. et al. Decreased PGE(2) content reduces MMP-1 activity and consequently increases collagen density in human varicose vein. PLoS One 9, e88021 (2014).
    • (2014) PLoS One , vol.9 , pp. e88021
    • Gomez, I.1
  • 26
    • 84879637980 scopus 로고    scopus 로고
    • The CYP2E1 inhibitor DDC up-regulates MMP-1 expression in hepatic stellate cells via an ERK1/2-and Akt-dependent mechanism
    • Liu, T. et al. The CYP2E1 inhibitor DDC up-regulates MMP-1 expression in hepatic stellate cells via an ERK1/2-and Akt-dependent mechanism. Biosci. Rep. 33, 439-50 (2013).
    • (2013) Biosci. Rep. , vol.33 , pp. 439-450
    • Liu, T.1
  • 27
    • 33748028803 scopus 로고    scopus 로고
    • Role of focal adhesion kinase and phosphatidylinositol 3'-kinase in integrin fbronectin receptor-mediated, matrix metalloproteinase-1-dependent invasion by metastatic prostate cancer cells
    • Zeng, Z.Z. et al. Role of focal adhesion kinase and phosphatidylinositol 3'-kinase in integrin fbronectin receptor-mediated, matrix metalloproteinase-1-dependent invasion by metastatic prostate cancer cells. Cancer Res. 66, 8091-9 (2006).
    • (2006) Cancer Res. , vol.66 , pp. 8091-8099
    • Zeng, Z.Z.1
  • 28
    • 47249135425 scopus 로고    scopus 로고
    • Synergistic collagenase expression and cartilage collagenolysis are phosphatidylinositol 3-kinase/Akt signaling-dependent
    • Litherland, G.J. et al. Synergistic collagenase expression and cartilage collagenolysis are phosphatidylinositol 3-kinase/Akt signaling-dependent. J. Biol. Chem. 283, 14221-9 (2008).
    • (2008) J. Biol. Chem. , vol.283 , pp. 14221-14229
    • Litherland, G.J.1
  • 29
    • 0032432798 scopus 로고    scopus 로고
    • Enhancement of fbroblast collagenase-1 (MMP-1) gene expression by tumor promoter okadaic acid is mediated by stress-activated protein kinases Jun N-terminal kinase and p38
    • Westermarck, J., Holmstrom, T., Ahonen, M., Eriksson, J.E. & Kahari, V.M. Enhancement of fbroblast collagenase-1 (MMP-1) gene expression by tumor promoter okadaic acid is mediated by stress-activated protein kinases Jun N-terminal kinase and p38. Matrix Biol. 17, 547-57 (1998).
    • (1998) Matrix Biol. , vol.17 , pp. 547-557
    • Westermarck, J.1    Holmstrom, T.2    Ahonen, M.3    Eriksson, J.E.4    Kahari, V.M.5
  • 30
    • 0033981730 scopus 로고    scopus 로고
    • Expression of collagenase-3 (MMP-13) and collagenase-1 (MMP-1) by transformed keratinocytes is dependent on the activity of p38 mitogen-activated protein kinase
    • Johansson, N. et al. Expression of collagenase-3 (MMP-13) and collagenase-1 (MMP-1) by transformed keratinocytes is dependent on the activity of p38 mitogen-activated protein kinase. J. Cell Sci. 113 (Pt 2), 227-35 (2000).
    • (2000) J. Cell Sci. , vol.113 , pp. 227-235
    • Johansson, N.1
  • 31
    • 2342450078 scopus 로고    scopus 로고
    • C-Jun NH2-terminal kinase pathway is involved in constitutive matrix metalloproteinase-1 expression in a hepatocellular carcinoma-derived cell line
    • Sugioka, Y. et al. c-Jun NH2-terminal kinase pathway is involved in constitutive matrix metalloproteinase-1 expression in a hepatocellular carcinoma-derived cell line. Int. J. Cancer 109, 867-74 (2004).
    • (2004) Int. J. Cancer , vol.109 , pp. 867-874
    • Sugioka, Y.1
  • 32
    • 77953405498 scopus 로고    scopus 로고
    • Mycobacterium tuberculosis upregulates microglial matrix metalloproteinase-1 and-3 expression and secretion via NF-kappaB-and Activator Protein-1-dependent monocyte networks
    • Green, J.A. et al. Mycobacterium tuberculosis upregulates microglial matrix metalloproteinase-1 and-3 expression and secretion via NF-kappaB-and Activator Protein-1-dependent monocyte networks. J. Immunol. 184, 6492-503 (2013).
    • (2013) J. Immunol. , vol.184 , pp. 6492-6503
    • Green, J.A.1
  • 33
    • 0346435097 scopus 로고    scopus 로고
    • Molecular basis for the direct inhibition of AP-1 DNA binding by 15-deoxy-Delta 12, 14-prostaglandin J2
    • Perez-Sala, D., Cernuda-Morollon, E. & Canada, F.J. Molecular basis for the direct inhibition of AP-1 DNA binding by 15-deoxy-Delta 12, 14-prostaglandin J2. J. Biol. Chem. 278, 51251-60 (2003).
    • (2003) J. Biol. Chem. , vol.278 , pp. 51251-51260
    • Perez-Sala, D.1    Cernuda-Morollon, E.2    Canada, F.J.3
  • 34
    • 38349141806 scopus 로고    scopus 로고
    • MMP-1, IL-1beta, and COX-2 mRNA expression is modulated by static load in rabbit fexor tendons
    • Asundi, K.R. & Rempel, D.M. MMP-1, IL-1beta, and COX-2 mRNA expression is modulated by static load in rabbit fexor tendons. Ann. Biomed. Eng. 36, 237-43 (2008).
    • (2008) Ann. Biomed. Eng. , vol.36 , pp. 237-243
    • Asundi, K.R.1    Rempel, D.M.2
  • 35
    • 84905001803 scopus 로고    scopus 로고
    • Aggravation of Alzheimer's disease due to the COX-2-mediated reciprocal regulation of IL-1beta and Abeta between glial and neuron cells
    • Wang, P. et al. Aggravation of Alzheimer's disease due to the COX-2-mediated reciprocal regulation of IL-1beta and Abeta between glial and neuron cells. Aging Cell, 605-15 (2014).
    • (2014) Aging Cell , pp. 605-615
    • Wang, P.1
  • 36
    • 36849094930 scopus 로고    scopus 로고
    • Selective cyclooxygenase-2 inhibition suppresses basic fbroblast growth factor expression in human esophageal adenocarcinoma
    • Baguma-Nibasheka, M. et al. Selective cyclooxygenase-2 inhibition suppresses basic fbroblast growth factor expression in human esophageal adenocarcinoma. Mol. Carcinog 46, 971-80 (2007).
    • (2007) Mol. Carcinog , vol.46 , pp. 971-980
    • Baguma-Nibasheka, M.1
  • 37
    • 0344872675 scopus 로고    scopus 로고
    • Hypoxia induces myocyte-dependent COX-2 regulation in endothelial cells: Role of VEGF
    • Wu, G. et al. Hypoxia induces myocyte-dependent COX-2 regulation in endothelial cells: role of VEGF. Am. J. Physiol. Heart Circ. Physiol. 285, H2420-9 (2003).
    • (2003) Am. J. Physiol. Heart Circ. Physiol. , vol.285 , pp. H2420-H2429
    • Wu, G.1
  • 38
    • 79952327710 scopus 로고    scopus 로고
    • IL-1beta stimulates COX-2 dependent PGE(2) synthesis and CGRP release in rat trigeminal ganglia cells
    • Neeb, L. et al. IL-1beta stimulates COX-2 dependent PGE(2) synthesis and CGRP release in rat trigeminal ganglia cells. PLoS One 6, e17360 (2011).
    • (2011) PLoS One , vol.6 , pp. e17360
    • Neeb, L.1
  • 39
    • 84863777207 scopus 로고    scopus 로고
    • Correlation between plasma and synovial fuid basic fbroblast growth factor with radiographic severity in primary knee osteoarthritis
    • Honsawek, S. et al. Correlation between plasma and synovial fuid basic fbroblast growth factor with radiographic severity in primary knee osteoarthritis. Int. Orthop. 36, 981-5 (2012).
    • (2012) Int. Orthop. , vol.36 , pp. 981-985
    • Honsawek, S.1
  • 40
    • 79951858462 scopus 로고    scopus 로고
    • Large-scale meta-analysis of interleukin-1 beta and interleukin-1 receptor antagonist polymorphisms on risk of radiographic hip and knee osteoarthritis and severity of knee osteoarthritis
    • Kerkhof, H.J. et al. Large-scale meta-analysis of interleukin-1 beta and interleukin-1 receptor antagonist polymorphisms on risk of radiographic hip and knee osteoarthritis and severity of knee osteoarthritis. Osteoarthritis Cartilage 19, 265-71 (2011).
    • (2011) Osteoarthritis Cartilage , vol.19 , pp. 265-271
    • Kerkhof, H.J.1
  • 41
    • 0043210529 scopus 로고    scopus 로고
    • Shear-induced cyclooxygenase-2 via a JNK2/c-Jun-dependent pathway regulates prostaglandin receptor expression in chondrocytic cells
    • Abulencia, J.P. et al. Shear-induced cyclooxygenase-2 via a JNK2/c-Jun-dependent pathway regulates prostaglandin receptor expression in chondrocytic cells. J Biol Chem 278, 28388-94 (2003).
    • (2003) J Biol Chem , vol.278 , pp. 28388-28394
    • Abulencia, J.P.1
  • 42
    • 80855139771 scopus 로고    scopus 로고
    • Interleukin-6 synthesis in human chondrocytes is regulated via the antagonistic actions of prostaglandin (PG) E2 and 15-deoxy-Delta(12, 14)-PGJ2
    • Wang, P., Zhu, F. & Konstantopoulos, K. Interleukin-6 synthesis in human chondrocytes is regulated via the antagonistic actions of prostaglandin (PG)E2 and 15-deoxy-Delta(12, 14)-PGJ2. PLoS One 6, e27630 (2011).
    • (2011) PLoS One , vol.6 , pp. e27630
    • Wang, P.1    Zhu, F.2    Konstantopoulos, K.3
  • 43
    • 84866392795 scopus 로고    scopus 로고
    • The antagonistic actions of endogenous interleukin-1beta and 15-deoxy-Delta12, 14-prostaglandin J2 regulate the temporal synthesis of matrix metalloproteinase-9 in sheared chondrocytes
    • Wang, P., Zhu, F. & Konstantopoulos, K. The antagonistic actions of endogenous interleukin-1beta and 15-deoxy-Delta12, 14-prostaglandin J2 regulate the temporal synthesis of matrix metalloproteinase-9 in sheared chondrocytes. J. Biol. Chem. 287, 31877-93 (2012).
    • (2012) J. Biol. Chem. , vol.287 , pp. 31877-31893
    • Wang, P.1    Zhu, F.2    Konstantopoulos, K.3
  • 44
    • 77955289199 scopus 로고    scopus 로고
    • Shear-induced interleukin-6 synthesis in chondrocytes: Roles of e prostanoid (EP) 2 and EP3 in cAMP/protein kinase A-and PI3-K/Akt-dependent NF-kappaB activation
    • Wang, P., Zhu, F., Lee, N.H. & Konstantopoulos, K. Shear-induced interleukin-6 synthesis in chondrocytes: roles of E prostanoid (EP) 2 and EP3 in cAMP/protein kinase A-and PI3-K/Akt-dependent NF-kappaB activation. J. Biol. Chem. 285, 24793-804 (2010).
    • (2010) J. Biol. Chem. , vol.285 , pp. 24793-24804
    • Wang, P.1    Zhu, F.2    Lee, N.H.3    Konstantopoulos, K.4
  • 45
    • 80053900365 scopus 로고    scopus 로고
    • Response of chondrocytes to shear stress: Antagonistic efects of the binding partners Toll-like receptor 4 and caveolin-1
    • Wang, P., Zhu, F., Tong, Z. & Konstantopoulos, K. Response of chondrocytes to shear stress: antagonistic efects of the binding partners Toll-like receptor 4 and caveolin-1. FASEB J. 25, 3401-15 (2011).
    • (2011) FASEB J. , vol.25 , pp. 3401-3415
    • Wang, P.1    Zhu, F.2    Tong, Z.3    Konstantopoulos, K.4
  • 46
    • 78650666914 scopus 로고    scopus 로고
    • GDF5 defciency in mice is associated with instability-driven joint damage, gait and subchondral bone changes
    • Daans, M., Luyten, F.P. & Lories, R.J. GDF5 defciency in mice is associated with instability-driven joint damage, gait and subchondral bone changes. Ann. Rheum. Dis. 70, 208-13 (2011).
    • (2011) Ann. Rheum. Dis. , vol.70 , pp. 208-213
    • Daans, M.1    Luyten, F.P.2    Lories, R.J.3
  • 47
    • 84940600736 scopus 로고    scopus 로고
    • Fluid Shear Promotes Chondrosarcoma Cell Invasion by Activating Matrix Metalloproteinase-12 via IGF-2-and VEGF-Signaling Pathways
    • press
    • Wang, P. et al. Fluid Shear Promotes Chondrosarcoma Cell Invasion by Activating Matrix Metalloproteinase-12 via IGF-2-and VEGF-Signaling Pathways. Oncogene In press (2014).
    • (2014) Oncogene
    • Wang, P.1
  • 48
    • 84894477196 scopus 로고    scopus 로고
    • Interleukin-1beta and cyclic AMP mediate the invasion of sheared chondrosarcoma cells via a matrix metalloproteinase-1-dependent mechanism
    • Wang, P. et al. Interleukin-1beta and cyclic AMP mediate the invasion of sheared chondrosarcoma cells via a matrix metalloproteinase-1-dependent mechanism. Biochim Biophys. Acta. 1843, 923-33 (2014).
    • (2014) Biochim Biophys. Acta. , vol.1843 , pp. 923-933
    • Wang, P.1
  • 49
    • 0030810727 scopus 로고    scopus 로고
    • Cell-type specifc regulation of human interstitial collagenase-1 gene expression by interleukin-1 beta (IL-1 beta) in human fbroblasts and BC-8701 breast cancer cells
    • Rutter, J.L., Benbow, U., Coon, C.I. & Brinckerhof, C.E. Cell-type specifc regulation of human interstitial collagenase-1 gene expression by interleukin-1 beta (IL-1 beta) in human fbroblasts and BC-8701 breast cancer cells. J. Cell Biochem. 66, 322-36 (1997).
    • (1997) J. Cell Biochem. , vol.66 , pp. 322-336
    • Rutter, J.L.1    Benbow, U.2    Coon, C.I.3    Brinckerhof, C.E.4
  • 50
    • 77952657476 scopus 로고    scopus 로고
    • Prostaglandin E2 induces interleukin-6 expression in human chondrocytes via cAMP/protein kinase A-and phosphatidylinositol 3-kinase-dependent NF-{kappa}B activation
    • Wang, P., Zhu, F. & Konstantopoulos, K. Prostaglandin E2 induces interleukin-6 expression in human chondrocytes via cAMP/protein kinase A-and phosphatidylinositol 3-kinase-dependent NF-{kappa}B activation. Am. J. Physiol. Cell Physiol. 298, C1445-1456 (2010).
    • (2010) Am. J. Physiol. Cell Physiol. , vol.298 , pp. C1445-1456
    • Wang, P.1    Zhu, F.2    Konstantopoulos, K.3
  • 51
    • 80855139771 scopus 로고    scopus 로고
    • Interleukin-6 Synthesis in Human Chondrocytes is Regulated via the Antagonistic Actions of Prostaglandin (PG)E2 and 15-Δ12, 14-PGJ2
    • Wang, P., Zhu, F. & Konstantopoulos, K. Interleukin-6 Synthesis in Human Chondrocytes Is Regulated via the Antagonistic Actions of Prostaglandin (PG)E2 and 15-Δ12, 14-PGJ2. PLoS ONE 6, e27630 (2011).
    • (2011) PLoS ONE , vol.6 , pp. e27630
    • Wang, P.1    Zhu, F.2    Konstantopoulos, K.3
  • 52
    • 80053900365 scopus 로고    scopus 로고
    • Response of chondrocytes to shear stress: Antagonistic efects of the binding partners Toll-like receptor 4 and caveolin-1
    • Wang, P., Zhu, F., Tong, Z. & Konstantopoulos, K. Response of chondrocytes to shear stress: antagonistic efects of the binding partners Toll-like receptor 4 and caveolin-1. The FASEB Journal 25, 3401-3415 (2011).
    • (2011) The FASEB Journal , vol.25 , pp. 3401-3415
    • Wang, P.1    Zhu, F.2    Tong, Z.3    Konstantopoulos, K.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.