Large-scale meta-analysis of interleukin-1 beta and interleukin-1 receptor antagonist polymorphisms on risk of radiographic hip and knee osteoarthritis and severity of knee osteoarthritis

Osteoarthritis and Cartilage

Volumn 19, Issue 3, 2011, Pages 265-271

  Kerkhof, H J M ^a,b   Doherty, M ^c   Arden, N K ^d,e   Abramson, S B ^f   Attur, M ^f   Bos, S D ^b,g   Cooper, C ^d,e   Dennison, E M ^d   Doherty, S A ^c   Evangelou, E ^h   Hart, D J ⁱ   Hofman, A ^a   Javaid, K ^e   Kerna, I ^j   Kisand, K ^j   Kloppenburg, M ^g   Krasnokutsky, S ^f   Maciewicz, R A ^k   Meulenbelt, I ^b,g   Muir, K R ^l   Rivadeneira, F ^a,b   Samuels, J ^f   Sezgin, M ^m   Slagboom, E ^b,g   Smith, A J P ⁿ   Spector, T D ⁱ   Tamm, A ^j   Uitterlinden, A G ^a,b   Wheeler, M ^c   Zhai, G ⁱ   Zhang, W ^c   van Meurs, J B J ^a,b   Valdes, A M ⁱ   more..

^a ERASMUS MEDICAL CENTER   (Netherlands)

^b Netherlands Genomics Initiative   (Netherlands)

^c NOTTINGHAM CITY HOSPITAL   (United Kingdom)

^d UNIVERSITY OF SOUTHAMPTON   (United Kingdom)

^e UNIVERSITY OF OXFORD   (United Kingdom)

^f NEW YORK UNIVERSITY SCHOOL OF MEDICINE   (United States)

^g LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

^h UNIVERSITY OF IOANNINA   (Greece)

ⁱ ST THOMAS HOSPITAL   (United Kingdom)

^j UNIVERSITY OF TARTU   (Estonia)

^k ASTRAZENECA   (United Kingdom)

^l UNIVERSITY OF WARWICK   (United Kingdom)

^m MERSIN UNIVERSITY   (Turkey)

ⁿ UNIVERSITY COLLEGE LONDON   (United Kingdom)

more..

Author keywords

Association; Genetic; IL 1; Interleukin; Osteoarthritis; Polymorphism

Indexed keywords

INTERLEUKIN 1 RECEPTOR BLOCKING AGENT; INTERLEUKIN 1BETA;

ARTICLE; CONTROLLED STUDY; DISEASE SEVERITY; DNA POLYMORPHISM; GENETIC RISK; GENETIC VARIABILITY; HAPLOTYPE; HIP OSTEOARTHRITIS; HUMAN; KNEE OSTEOARTHRITIS; MAJOR CLINICAL STUDY; META ANALYSIS; PRIORITY JOURNAL; RADIOGRAPHY;

EID: 79951858462     PISSN: 10634584     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.joca.2010.12.003     Document Type: Article

References (32)

1. Dieppe P.A., Lohmander L.S. Pathogenesis and management of pain in osteoarthritis. Lancet 2005, 365:965-973.
2. Benito M.J., Veale D.J., FitzGerald O., van den Berg W.B., Bresnihan B. Synovial tissue inflammation in early and late osteoarthritis. Ann Rheum Dis 2005, 64:1263-1267.
3. Goldring M.B., Berenbaum F. The regulation of chondrocyte function by proinflammatory mediators: prostaglandins and nitric oxide. Clin Orthop Relat Res 2004, 427. Suppl:S37-46.
4. Valdes A.M., Spector T.D. The clinical relevance of genetic susceptibility to osteoarthritis. Best Pract Res Clin Rheumatol 2010, 24:3-14.
5. Attur M., Wang H.Y., Byers Kraus V., Bukowski J.F., Aziz N., Krasnokutsky S., et al. Radiographic severity of knee osteoarthritis is conditional on interleukin-1 receptor antagonist gene variations. Ann Rheum Dis 2010, 69:856-861.
6. Chapman K., Loughlin J. Association of the interleukin-1 gene cluster with osteoarthritis of the hip: comment on the article by Meulenbelt et al and the letter by Smith, et al. Arthritis Rheum 2006, 54:3722-3723.
7. Kanoh T., Hasegawa Y., Masui T., Yamaguchi J., Ishiguro N., Hamajima N. Interleukin-1beta gene polymorphism associated with radiographic signs of osteoarthritis of the knee. J Orthop Sci. 2008, 13:97-100.
8. Limer K.L., Tosh K., Bujac S.R., McConnell R., Doherty S., Nyberg F., et al. Attempt to replicate published genetic associations in a large, well-defined osteoarthritis case-control population (the GOAL study). Osteoarthritis & Cartilage 2009, 17:782-789.
9. Loughlin J., Dowling B., Mustafa Z., Chapman K. Association of the interleukin-1 gene cluster on chromosome 2q13 with knee osteoarthritis. Arthritis Rheum 2002, 46:1519-1527.
10. Meulenbelt I., Seymour A.B., Nieuwland M., Huizinga T.W., van Duijn C.M., Slagboom P.E. Association of the interleukin-1 gene cluster with radiographic signs of osteoarthritis of the hip. Arthritis Rheum 2004, 50:1179-1186.
11. Ni H., Shi D., Dai J., Qin J., Xu Y., Zhu L., et al. Genetic polymorphisms of interleukin-1beta (-511C/T) and interleukin-1 receptor antagonist (86-bpVNTR) in susceptibility to knee osteoarthritis in a Chinese Han population. Rheumatol Int 2009, 29:1301-1305.
12. Ruzickova S., Senolt L., Gatterova J., Vencovsky J., Pavelka K. The lack of correlation between the increased frequency of allele IL-1RN*2 of interleukin-1 receptor antagonist gene in Czech patients with knee osteoarthritis and the markers of cartilage degradation. Folia Biol (Praha) 2008, 54:115-120.
13. Sezgin M., Erdal M.E., Altintas Z.M., Ankarali H.C., Barlas I.O., Turkmen E., et al. Lack of association polymorphisms of the IL1RN, IL1A, and IL1B genes with knee osteoarthritis in Turkish patients. Clin Invest Med 2007, 30:E86-E92.
14. Smith A.J., Elson C.J., Perry M.J., Bidwell J.L. Accuracy of haplotype association studies is enhanced by increasing number of polymorphic loci examined: comment on the article by Meulenbelt et al. Arthritis Rheum 2005, 52:675. author reply-6.
15. Smith A.J., Keen L.J., Billingham M.J., Perry M.J., Elson C.J., Kirwan J.R., et al. Extended haplotypes and linkage disequilibrium in the IL1R1-IL1A-IL1B-IL1RN gene cluster: association with knee osteoarthritis. Genes Immun 2004, 5:451-460.
16. Moxley G., Meulenbelt I., Chapman K., van Diujn C.M., Slagboom P.E., Neale M.C., et al. Interleukin-1 region meta-analysis with osteoarthritis phenotypes. Osteoarthritis & Cartilage 2010, 18:200-207.
17. Hart D.J., Spector T.D. Cigarette smoking and risk of osteoarthritis in women in the general population: the Chingford study. Ann Rheum Dis 1993, 52:93-96.
18. Hart D.J., Spector T.D. The relationship of obesity, fat distribution and osteoarthritis in women in the general population: the Chingford Study. J Rheumatol 1993, 20:331-335.
19. Spector T.D., Williams F.M. The UK Adult Twin Registry (TwinsUK). Twin Res Hum Genet. 2006, 9:899-906.
20. Abdin-Mohamed M., Jameson K., Dennison E.M., Cooper C., Arden N.K. Hertfordshire Cohort Study G. Volumetric bone mineral density of the tibia is not increased in subjects with radiographic knee osteoarthritis. Osteoarthritis & Cartilage 2009, 17:174-177.
21. Hofman A., Breteler M.M., van Duijn C.M., Janssen H.L., Krestin G.P., Kuipers E.J., et al. The Rotterdam Study: 2010 objectives and design update. Eur J Epidemiol 2009, 24:553-572.
22. Riyazi N., Meulenbelt I., Kroon H.M., Ronday K.H., Hellio le Graverand M.P., Rosendaal F.R., et al. Evidence for familial aggregation of hand, hip, and spine but not knee osteoarthritis in siblings with multiple joint involvement: the GARP study. Ann Rheum Dis 2005, 64:438-443.
23. Tamm A., Lintrop M., Veske K., Hansen U., Tamm A. Prevalence of patello- and tibiofemoral osteoarthritis in Elva, Southern Estonia. J Rheumatol 2008, 35:543-544.
24. Valdes A.M., Spector T.D., Doherty S., Wheeler M., Hart D.J., Doherty M. Association of the DVWA and GDF5 polymorphisms with osteoarthritis in UK populations. Ann Rheum Dis 2009, 68:1916-1920.
25. Richards J.B., Rivadeneira F., Inouye M., Pastinen T.M., Soranzo N., Wilson S.G., et al. Bone mineral density, osteoporosis, and osteoporotic fractures: a genome-wide association study. Lancet 2008, 371:1505-1512.
26. Kerkhof H.J., Lories R.J., Meulenbelt I., Jonsdottir I., Valdes A.M., Arp P., et al. A genome-wide association study identifies an osteoarthritis susceptibility locus on chromosome 7q22. Arthritis Rheum 2010, 62:499-510.
27. Richards J.B., Kavvoura F.K., Rivadeneira F., Styrkarsdottir U., Estrada K., Halldorsson B.V., et al. Collaborative meta-analysis: associations of 150 candidate genes with osteoporosis and osteoporotic fracture. Ann Intern Med 2009, 151:528-537.
28. Purcell S., Neale B., Todd-Brown K., Thomas L., Ferreira M.A., Bender D., et al. PLINK: a tool set for whole-genome association and population-based linkage analyses. Am J Hum Genet 2007, 81:559-575.
29. Barrett J.C., Fry B., Maller J., Daly M.J. Haploview: analysis and visualization of LD and haplotype maps. Bioinformatics 2005, 21:263-265.
30. Cochran W.G. The combination of estimates from different experiments. Biometrics 1954, 101-129.
31. Higgins J.P., Tompson S.G. Quantifying heterogeneity in a meta-analysis. Stat Med 2002, 21:1539-1558.
32. Engels E.A., Schmid C.H., Terrin N., Olkin I., Lau J. Heterogeneity and statistical significance in meta-analysis: an empirical study of 125 meta-analyses. Stat Med 2000, 19:1707-1728.