The CYP2E1 inhibitor DDC up-regulates MMP-1 expression in hepatic stellate cells via an ERK1/2- and Akt-dependent mechanism

Bioscience Reports

Volumn 33, Issue 3, 2013, Pages 439-450

  Liu, Tianhui ^a   Wang, Ping ^a   Cong, Min ^a   Xu, Youqing ^a   Jia, Jidong ^a   You, Hong ^a  

^a CAPITAL MEDICAL UNIVERSITY   (China)

Author keywords

Collagen; Cytochrome P450 2E1; Diethyldithiocarbamate; Matrix metalloproteinase 1; Mitogen activated protein kinases; Reactive oxygen species

Indexed keywords

CATALASE; COLLAGEN TYPE 1; CYTOCHROME P450 2E1; DIETHYLDITHIOCARBAMIC ACID; ENZYME PRECURSOR; HYDROGEN PEROXIDE; INTERSTITIAL COLLAGENASE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; PROTEIN KINASE B; REACTIVE OXYGEN METABOLITE; SYNAPTOPHYSIN; COLLAGEN; CYTOCHROME P450 2E1 INHIBITOR; ENZYME INHIBITOR; MITOGEN ACTIVATED PROTEIN KINASE P38;

ARTICLE; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME ACTIVITY; HUMAN; HUMAN CELL; PROTEIN EXPRESSION; STELLATE CELL; UPREGULATION; ANTAGONISTS AND INHIBITORS; CELL LINE; COCULTURE; DRUG EFFECTS; GENETICS; LIVER CELL; METABOLISM;

CELL LINE; COCULTURE TECHNIQUES; COLLAGEN; CYTOCHROME P-450 CYP2E1 INHIBITORS; DITIOCARB; ENZYME INHIBITORS; HEPATIC STELLATE CELLS; HEPATOCYTES; HUMANS; MATRIX METALLOPROTEINASE 1; MITOGEN-ACTIVATED PROTEIN KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASE 3; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PROTO-ONCOGENE PROTEINS C-AKT; REACTIVE OXYGEN SPECIES; UP-REGULATION;

EID: 84879637980     PISSN: 01448463     EISSN: 15734935     Source Type: Journal    
DOI: 10.1042/BSR20130033     Document Type: Article

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