Fluid shear promotes chondrosarcoma cell invasion by activating matrix metalloproteinase 12 via IGF-2 and VEGF signaling pathways

Oncogene

Volumn 34, Issue 35, 2015, Pages 4558-4569

  Wang, P ^a,b   Chen, S H ^b,c   Hung, W C ^b,c   Paul, C ^b   Zhu, F ^b   Guan, P P ^a,b   Huso, D L ^d   Kontrogianni Konstantopoulos, A ^e   Konstantopoulos, K ^b,c,f  

^a NORTHEASTERN UNIVERSITY   (China)

^b Johns Hopkins University   (United States)

^c JOHNS HOPKINS UNIVERSITY   (United States)

^d JOHNS HOPKINS UNIVERSITY   (United States)

^e UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

^f Johns Hopkins University   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MACROPHAGE ELASTASE; MITOGEN ACTIVATED PROTEIN KINASE P38; PHOSPHATIDYLINOSITOL 3 KINASE; SOMATOMEDIN; STRESS ACTIVATED PROTEIN KINASE; VASCULOTROPIN; VASCULOTROPIN B; VASCULOTROPIN D; MMP12 PROTEIN, HUMAN; SOMATOMEDIN B; VEGFB PROTEIN, HUMAN; VEGFD PROTEIN, HUMAN;

APOPTOSIS; ARTICLE; BIOENGINEERING; CARTILAGE CELL; CELL CYCLE G2 PHASE; CELL FUNCTION; CELL INVASION; CELL MIGRATION; CHONDROSARCOMA; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME ACTIVITY; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; IN VIVO STUDY; INTRACELLULAR SIGNALING; M PHASE CELL CYCLE CHECKPOINT; MALIGNANT TRANSFORMATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; SHEAR STRESS; TUMOR CELL; UPREGULATION; ANIMAL; BIOMECHANICS; BONE TUMOR; CANCER TRANSPLANTATION; CELL MOTION; ENZYME INDUCTION; ENZYMOLOGY; GENE EXPRESSION REGULATION; KNOCKOUT MOUSE; LUNG TUMOR; METABOLISM; NONOBESE DIABETIC MOUSE; PATHOLOGY; PHYSIOLOGY; SCID MOUSE; SECONDARY; SIGNAL TRANSDUCTION; TUMOR CELL LINE; TUMOR INVASION;

ANIMALS; BIOMECHANICAL PHENOMENA; BONE NEOPLASMS; CELL LINE, TUMOR; CELL MOVEMENT; CHONDROSARCOMA; ENZYME ACTIVATION; ENZYME INDUCTION; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; INSULIN-LIKE GROWTH FACTOR II; LUNG NEOPLASMS; MAP KINASE SIGNALING SYSTEM; MATRIX METALLOPROTEINASE 12; MICE, INBRED NOD; MICE, KNOCKOUT; MICE, SCID; NEOPLASM INVASIVENESS; NEOPLASM TRANSPLANTATION; VASCULAR ENDOTHELIAL GROWTH FACTOR B; VASCULAR ENDOTHELIAL GROWTH FACTOR D;

EID: 84940600736     PISSN: 09509232     EISSN: 14765594     Source Type: Journal    
DOI: 10.1038/onc.2014.397     Document Type: Article

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