Mycobacterium tuberculosis upregulates microglial matrix metalloproteinase-1 and -3 expression and secretion via NF-κB- and activator protein-1-dependent monocyte networks

Journal of Immunology

Volumn 184, Issue 11, 2010, Pages 6492-6503

  Green, Justin A ^a   Elkington, Paul T ^a   Pennington, Caroline J ^c   Roncaroli, Federico ^a   Dholakia, Shruti ^a   Moores, Rachel C ^a   Bullen, Anwen ^a   Porter, Joanna C ^b   Agranoff, Dan ^a   Edwards, Dylan R ^c   Friedland, Jon S ^a  

^a IMPERIAL COLLEGE LONDON   (United Kingdom)

^b UNIVERSITY COLLEGE LONDON   (United Kingdom)

^c UNIVERSITY OF EAST ANGLIA   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

DEXAMETHASONE; GELATINASE B; HETERODIMER; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1BETA; INTERSTITIAL COLLAGENASE; PROTEIN C JUN; PROTEIN SUBUNIT; STROMELYSIN; TISSUE INHIBITOR OF METALLOPROTEINASE 2; TISSUE INHIBITOR OF METALLOPROTEINASE 3; TISSUE INHIBITOR OF METALLOPROTEINASE 4; TRANSCRIPTION FACTOR AP 1; TRANSCRIPTION FACTOR FOSB; TUMOR NECROSIS FACTOR ALPHA; ANTIINFLAMMATORY AGENT;

ARTICLE; BACTERIAL GENE; BRAIN; CELL CULTURE; CENTRAL NERVOUS SYSTEM TUBERCULOSIS; CULTURE MEDIUM; GENE EXPRESSION; GRANULOMA; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOREACTIVITY; IN VITRO STUDY; MICROGLIA; MONOCYTE; MORTALITY; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; PROTEIN SECRETION; SECRETION; STEROID THERAPY; SURFACE ENHANCED LASER DESORPTION IONIZATION TIME OF FLIGHT MASS SPECTROMETRY; SURFACE PROPERTY; UPREGULATION; CONFOCAL MICROSCOPY; ENZYME LINKED IMMUNOSORBENT ASSAY; FLUORESCENT ANTIBODY TECHNIQUE; GENE EXPRESSION PROFILING; GENETICS; IMMUNOLOGY; MASS SPECTROMETRY; METABOLISM; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION;

ANTI-INFLAMMATORY AGENTS; DEXAMETHASONE; ENZYME-LINKED IMMUNOSORBENT ASSAY; FLUORESCENT ANTIBODY TECHNIQUE; GENE EXPRESSION; GENE EXPRESSION PROFILING; HUMANS; MATRIX METALLOPROTEINASE 1; MATRIX METALLOPROTEINASE 3; MICROGLIA; MICROSCOPY, CONFOCAL; MONOCYTES; MYCOBACTERIUM TUBERCULOSIS; NF-KAPPA B; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; SPECTROMETRY, MASS, MATRIX-ASSISTED LASER DESORPTION-IONIZATION; TRANSCRIPTION FACTOR AP-1; TUBERCULOSIS, CENTRAL NERVOUS SYSTEM; UP-REGULATION;

EID: 77953405498     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.0903811     Document Type: Article

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