Shear-induced interleukin-6 synthesis in chondrocytes: Roles of E prostanoid (EP) 2 and EP3 in cAMP/protein kinase A- and PI3-K/Akt-dependent NF-κB activation

Journal of Biological Chemistry

Volumn 285, Issue 32, 2010, Pages 24793-24804

  Wang, Pu ^a   Zhu, Fei ^a   Lee, Norman H ^c   Konstantopoulos, Konstantinos ^a,b  

^a Johns Hopkins University   (United States)

^b JOHNS HOPKINS UNIVERSITY   (United States)

^c GEORGE WASHINGTON UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BODY FLUIDS; CARTILAGE; CELL CULTURE; CELL DEATH; FETAL MONITORING; FLOW OF FLUIDS; GENETIC ENGINEERING; LIGAMENTS; PHOSPHORYLATION; SIGNALING; STRESSES; TENSILE STRAIN;

APOPTOSIS; ARTIFICIAL CARTILAGES; CHONDROCYTE CELLS; CHONDROCYTES; CYCLOOXYGENASE 2; DOWN-REGULATION; ECTOPIC EXPRESSIONS; ELEVATED LEVEL; FLUID FLOW; FLUID SHEAR STRESS; HYDROSTATIC STRESS; IL-6 EXPRESSION; IN-VITRO; IN-VIVO; INFLAMMATORY MEDIATORS; INHIBITORY EFFECT; INTERLEUKIN-6; INTRACELLULAR CAMP; KINASE A; MATRIX; MODEL SYSTEM; PHOSPHATIDYLINOSITOL 3-KINASE; PROTEIN KINASE A; SIGNALING NETWORKS; SIGNALING PATHWAYS; THERAPEUTIC STRATEGY; UP-REGULATION;

IMMUNOLOGY;

CYCLIC AMP; CYCLIC AMP DEPENDENT PROTEIN KINASE; CYCLOOXYGENASE 2; E PROSTANOID 2; E PROSTANOID 3; INTERLEUKIN 6; PHOSPHATIDYLINOSITOL 3 KINASE; PROSTAGLANDIN E2; PROSTANOID; PROTEIN KINASE B; TRANSCRIPTION FACTOR RELA; UNCLASSIFIED DRUG; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; PROSTAGLANDIN E RECEPTOR; PROSTAGLANDIN E RECEPTOR 2; PROSTAGLANDIN E RECEPTOR 3; PTGER2 PROTEIN, HUMAN; PTGER3 PROTEIN, HUMAN;

ARTICLE; ARTICULAR CARTILAGE; BIOREACTOR; CARTILAGE CELL; CONTROLLED STUDY; CYTOKINE PRODUCTION; DOWN REGULATION; GENE EXPRESSION; HUMAN; HUMAN CELL; MECHANICAL STRESS; NUCLEOTIDE SEQUENCE; OSTEOARTHRITIS; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; SHEAR STRESS; SIGNAL TRANSDUCTION; TISSUE ENGINEERING; TRANSACTIVATION; UPREGULATION; BIOLOGICAL MODEL; CELL CULTURE; CELL NUCLEUS; CHEMISTRY; CYTOLOGY; METABOLISM; REPORTER GENE;

CELL NUCLEUS; CELLS, CULTURED; CHONDROCYTES; CYCLIC AMP; CYCLIC AMP-DEPENDENT PROTEIN KINASES; DINOPROSTONE; GENES, REPORTER; HUMANS; INTERLEUKIN-6; MODELS, BIOLOGICAL; NF-KAPPA B; RECEPTORS, PROSTAGLANDIN E; RECEPTORS, PROSTAGLANDIN E, EP2 SUBTYPE; RECEPTORS, PROSTAGLANDIN E, EP3 SUBTYPE; SIGNAL TRANSDUCTION; STRESS, MECHANICAL;

EID: 77955289199     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M110.110320     Document Type: Article

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