Prolonged Application of High Fluid Shear to Chondrocytes Recapitulates Gene Expression Profiles Associated with Osteoarthritis

PLoS ONE

Volumn 5, Issue 12, 2010, Pages

  Zhu, Fei ^a   Wang, Pu ^a   Lee, Norman H ^b   Goldring, Mary B ^c   Konstantopoulos, Konstantinos ^a  

^a Johns Hopkins University   (United States)

^b GEORGE WASHINGTON UNIVERSITY MEDICAL CENTER   (United States)

^c HOSPITAL FOR SPECIAL SURGERY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLOOXYGENASE 2; PROSTAGLANDIN D SYNTHASE; REACTIVE OXYGEN METABOLITE;

APOPTOSIS; ARTICLE; CARTILAGE CELL; CONTROLLED STUDY; DISEASE COURSE; DNA MICROARRAY; DOWN REGULATION; GENE EXPRESSION PROFILING; GENE FUNCTION; GENETIC REGULATION; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; INFLAMMATION; MICROARRAY ANALYSIS; NUCLEOTIDE SEQUENCE; OSTEOARTHRITIS; PATHOGENESIS; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SHEAR STRESS; UPREGULATION; ARTICULAR CARTILAGE; CARTILAGE; CELL LINE; CLUSTER ANALYSIS; CYTOLOGY; GENE EXPRESSION REGULATION; MECHANICAL STRESS; METABOLISM; SHEAR STRENGTH; TENSILE STRENGTH;

CARTILAGE; CARTILAGE, ARTICULAR; CELL LINE; CHONDROCYTES; CLUSTER ANALYSIS; DISEASE PROGRESSION; DOWN-REGULATION; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; HUMANS; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; OSTEOARTHRITIS; SHEAR STRENGTH; STRESS, MECHANICAL; TENSILE STRENGTH;

EID: 78650846194     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0015174     Document Type: Article

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