메뉴 건너뛰기




Volumn 25, Issue 6, 2015, Pages 629-642

Products for the treatment of inflammatory bowel disease: A patent review (2013-2014)

Author keywords

Colitis; Crohn's disease; Functional foods; Inflammatory bowel disease; Intestinal anti inflammatory compounds; MAb; Natural products; Prebiotic; Probiotic

Indexed keywords

ALGINIC ACID; ALPHA5 INTEGRIN; ALPHA5 INTEGRIN ANTAGONIST; ALPHA7 RECEPTOR BINDING CHOLINERGIC AGONIST; ANTIINFLAMMATORY AGENT; ANTISENSE OLIGONUCLEOTIDE; BIOLOGICAL PRODUCT; CHOLINERGIC RECEPTOR STIMULATING AGENT; GUANYLATE CYCLASE C AGONIST; GUANYLATE CYCLASE INHIBITOR; HISTONE ACETYLTRANSFERASE; HYALURONIC ACID; LACTOCEPIN; SECO A 2, 19 DINOR 1,25 DIHYDROXYVITAMIN D3; SHORT CHAIN FATTY ACID; UNCLASSIFIED DRUG; VITAMIN D DERIVATIVE; WS 727713;

EID: 84930199714     PISSN: 13543776     EISSN: 17447674     Source Type: Journal    
DOI: 10.1517/13543776.2015.1041921     Document Type: Review
Times cited : (8)

References (129)
  • 1
    • 84908231842 scopus 로고    scopus 로고
    • New tools and approaches for improved management of inflammatory bowel diseases
    • Ghosh S, Pariente B, Mould DR, et al. New tools and approaches for improved management of inflammatory bowel diseases. J Crohns Colitis 2014;8(10):1246-53
    • (2014) J Crohns Colitis , vol.8 , Issue.10 , pp. 1246-1253
    • Ghosh, S.1    Pariente, B.2    Mould, D.R.3
  • 2
    • 84893788912 scopus 로고    scopus 로고
    • Advances in the medical management of paediatric IBD
    • Aloi M, Nuti F, Stronati L, et al. Advances in the medical management of paediatric IBD. Nat Rev Gastroenterol Hepatol 2014;11(2):99-108
    • (2014) Nat Rev Gastroenterol Hepatol , vol.11 , Issue.2 , pp. 99-108
    • Aloi, M.1    Nuti, F.2    Stronati, L.3
  • 3
    • 79959271087 scopus 로고    scopus 로고
    • Intestinal homeostasis and its breakdown in inflammatory bowel disease
    • Maloy KJ, Powrie F. Intestinal homeostasis and its breakdown in inflammatory bowel disease. Nature 2011;474(7351):298-306
    • (2011) Nature , vol.474 , Issue.7351 , pp. 298-306
    • Maloy, K.J.1    Powrie, F.2
  • 4
    • 0035978533 scopus 로고    scopus 로고
    • A frameshift mutation in NOD2 associated with susceptibility to Crohn's disease
    • Ogura Y, Bonen DK, Inohara N, et al. A frameshift mutation in NOD2 associated with susceptibility to Crohn's disease. Nature 2001;411(6837):603-6
    • (2001) Nature , vol.411 , Issue.6837 , pp. 603-606
    • Ogura, Y.1    Bonen, D.K.2    Inohara, N.3
  • 5
    • 84880790074 scopus 로고    scopus 로고
    • A clinical review of recent findings in the epidemiology of inflammatory bowel disease
    • Ponder A, Long MD. A clinical review of recent findings in the epidemiology of inflammatory bowel disease. Clin Epidemiol 2013;5:237-47
    • (2013) Clin Epidemiol , vol.5 , pp. 237-247
    • Ponder, A.1    Long, M.D.2
  • 6
    • 84927956527 scopus 로고    scopus 로고
    • Vedolizumab in the treatment of Crohn's disease
    • [Epub ahead of print]
    • Gisbert JP, Domenech E. Vedolizumab in the treatment of Crohn's disease. Gastroenterol Hepatol 2015. [Epub ahead of print]
    • (2015) Gastroenterol Hepatol
    • Gisbert, J.P.1    Domenech, E.2
  • 7
    • 80655133081 scopus 로고    scopus 로고
    • Early use of immunosuppressives or TNF antagonists for the treatment of Crohn's disease: Time for a change
    • Ordas I, Feagan BG, Sandborn WJ. Early use of immunosuppressives or TNF antagonists for the treatment of Crohn's disease: time for a change. Gut 2011;60(12):1754-63
    • (2011) Gut , vol.60 , Issue.12 , pp. 1754-1763
    • Ordas, I.1    Feagan, B.G.2    Sandborn, W.J.3
  • 8
    • 84871600935 scopus 로고    scopus 로고
    • Current status of monoclonal antibody therapy for the treatment of inflammatory bowel disease: An update
    • Denmark VK, Mayer L. Current status of monoclonal antibody therapy for the treatment of inflammatory bowel disease: an update. Expert Rev Clin Immunol 2013;9(1):77-92
    • (2013) Expert Rev Clin Immunol , vol.9 , Issue.1 , pp. 77-92
    • Denmark, V.K.1    Mayer, L.2
  • 9
    • 84908296732 scopus 로고    scopus 로고
    • Development of drugs to target interactions between leukocytes and endothelial cells and treatment algorithms for inflammatory bowel diseases
    • Danese S, Panes J. Development of drugs to target interactions between leukocytes and endothelial cells and treatment algorithms for inflammatory bowel diseases. Gastroenterology 2014;147(5):981-9
    • (2014) Gastroenterology , vol.147 , Issue.5 , pp. 981-989
    • Danese, S.1    Panes, J.2
  • 10
    • 84903275253 scopus 로고    scopus 로고
    • Inflammatory bowel disease: Clinical aspects and treatments
    • Fakhoury M, Negrulj R, Mooranian A, et al. Inflammatory bowel disease: clinical aspects and treatments. J Inflamm Res 2014;7:113-20
    • (2014) J Inflamm Res , vol.7 , pp. 113-120
    • Fakhoury, M.1    Negrulj, R.2    Mooranian, A.3
  • 11
    • 84930224278 scopus 로고    scopus 로고
    • Biological therapy for ulcerative colitis
    • Epub ahead of print
    • Arora Z, Shen B. Biological therapy for ulcerative colitis. Gastroenterol Rep (Oxf) 2014; Epub ahead of print
    • (2014) Gastroenterol Rep
    • Arora, Z.1    Shen, B.2
  • 12
    • 34247504544 scopus 로고    scopus 로고
    • Risks and benefits of biologic therapy for inflammatory bowel diseases
    • D'Haens G. Risks and benefits of biologic therapy for inflammatory bowel diseases. Gut 2007;56(5):725-32
    • (2007) Gut , vol.56 , Issue.5 , pp. 725-732
    • D'haens, G.1
  • 13
    • 84930224279 scopus 로고    scopus 로고
    • Formulations and uses of 2-hydroxy-5- phenylazobenzoic acid derivatives for the treatment of males
    • Ltd. US8497256B2
    • Forbes W, Borte E, Johnson L, et al. Formulations and uses of 2-hydroxy-5- phenylazobenzoic acid derivatives for the treatment of males. Salix Pharmaceuticals, Ltd. US8497256B2; 2013
    • (2013) Salix Pharmaceuticals
    • Forbes, W.1    Borte, E.2    Johnson, L.3
  • 14
    • 84930224280 scopus 로고    scopus 로고
    • Methods for treatment for ulcerative colitis in mammals
    • LLC. USPTO8476233
    • Pravda J. Methods for treatment for ulcerative colitis in mammals. Therapeutic Research, LLC. USPTO8476233; 2013
    • (2013) Therapeutic Research
    • Pravda, J.1
  • 15
    • 84930224281 scopus 로고    scopus 로고
    • Preparations of pharmaceuticals containing 5-Amino salicylic acid and phospholipids for treatment of inflammatory bowel disease
    • JPO2014015478
    • Lichtenberger LM. Preparations of pharmaceuticals containing 5-Amino salicylic acid and phospholipids for treatment of inflammatory bowel disease. Board Of Regents Of The University Of Texas System. JPO2014015478; 2014
    • (2014) Board of Regents of the University of Texas System
    • Lichtenberger, L.M.1
  • 17
    • 84930224283 scopus 로고    scopus 로고
    • Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders
    • Inc. USPTO8569246
    • Shailubhai K. Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders. Synergy Pharmaceuticals Inc. USPTO8569246; 2013
    • (2013) Synergy Pharmaceuticals
    • Shailubhai, K.1
  • 18
    • 84876460077 scopus 로고    scopus 로고
    • Pharmacology and clinical potential of guanylyl cyclase C agonists in the treatment of ulcerative colitis
    • Pitari GM. Pharmacology and clinical potential of guanylyl cyclase C agonists in the treatment of ulcerative colitis. Drug Des Devel Ther 2013;7:351-60
    • (2013) Drug des Devel Ther , vol.7 , pp. 351-360
    • Pitari, G.M.1
  • 19
    • 0033000111 scopus 로고    scopus 로고
    • Guanylin regulatory peptides: Structures, biological activities mediated by cyclic GMP and pathobiology
    • Forte LR. Guanylin regulatory peptides: structures, biological activities mediated by cyclic GMP and pathobiology. Regul Pept 1999;81(1-3):25-39
    • (1999) Regul Pept , vol.81 , Issue.1-3 , pp. 25-39
    • Forte, L.R.1
  • 20
    • 34547868470 scopus 로고    scopus 로고
    • Linaclotide, a new direction in the treatment of irritable bowel syndrome and chronic constipation
    • Harris LA, Crowell MD. Linaclotide, a new direction in the treatment of irritable bowel syndrome and chronic constipation. Curr Opin Mol Ther 2007;9(4):403-10
    • (2007) Curr Opin Mol Ther , vol.9 , Issue.4 , pp. 403-410
    • Harris, L.A.1    Crowell, M.D.2
  • 21
    • 0023198769 scopus 로고
    • Small and large intestinal guanylate cyclase activity in children: Effect of age and stimulation by Escherichia coli heatstable enterotoxin
    • Guarino A, Cohen MB, Giannella RA. Small and large intestinal guanylate cyclase activity in children: effect of age and stimulation by Escherichia coli heatstable enterotoxin. Pediatr Res 1987;21(6):551-5
    • (1987) Pediatr Res , vol.21 , Issue.6 , pp. 551-555
    • Guarino, A.1    Cohen, M.B.2    Giannella, R.A.3
  • 22
    • 0021339268 scopus 로고
    • A simple, sensitive, and specific assay for the heat-stable enterotoxin of Escherichia coli
    • Waldman SA, O'Hanley P, Falkow S, et al. A simple, sensitive, and specific assay for the heat-stable enterotoxin of Escherichia coli. J Infect Dis 1984;149(1):83-9
    • (1984) J Infect Dis , vol.149 , Issue.1 , pp. 83-89
    • Waldman, S.A.1    O'hanley, P.2    Falkow, S.3
  • 23
    • 79551650331 scopus 로고    scopus 로고
    • Loss of guanylyl cyclase C (GCC) signaling leads to dysfunctional intestinal barrier
    • Han X, Mann E, Gilbert S, et al. Loss of guanylyl cyclase C (GCC) signaling leads to dysfunctional intestinal barrier. PLoS One 2011;6(1):e16139
    • (2011) PLoS One , vol.6 , Issue.1 , pp. e16139
    • Han, X.1    Mann, E.2    Gilbert, S.3
  • 24
    • 84863180511 scopus 로고    scopus 로고
    • GUCY2C opposes systemic genotoxic tumorigenesis by regulating AKT-dependent intestinal barrier integrity
    • Lin JE, Snook AE, Li P, et al. GUCY2C opposes systemic genotoxic tumorigenesis by regulating AKT-dependent intestinal barrier integrity. PLoS One 2012;7(2):e31686
    • (2012) PLoS One , vol.7 , Issue.2 , pp. e31686
    • Lin, J.E.1    Snook, A.E.2    Li, P.3
  • 26
    • 0034789792 scopus 로고    scopus 로고
    • Antigen-specific immunomodulation via altered peptide ligands
    • Bielekova B, Martin R. Antigen-specific immunomodulation via altered peptide ligands. J Mol Med (Berl) 2001;79(10):552-65
    • (2001) J Mol Med Berl , vol.79 , Issue.10 , pp. 552-565
    • Bielekova, B.1    Martin, R.2
  • 28
    • 84862983459 scopus 로고    scopus 로고
    • Zonulin, regulation of tight junctions, and autoimmune diseases
    • Fasano A. Zonulin, regulation of tight junctions, and autoimmune diseases. Ann N Y Acad Sci 2012;1258:25-33
    • (2012) Ann N y Acad Sci , vol.1258 , pp. 25-33
    • Fasano, A.1
  • 29
    • 84906253214 scopus 로고    scopus 로고
    • The role of Haptoglobin and its related protein Zonulin in inflammatory bowel disease
    • Vanuytsel T, Vermeire S, Cleynen I. The role of Haptoglobin and its related protein, Zonulin, in inflammatory bowel disease. Tissue Barriers 2013;1(5):e27321
    • (2013) Tissue Barriers , vol.1 , Issue.5 , pp. e27321
    • Vanuytsel, T.1    Vermeire, S.2    Cleynen, I.3
  • 30
    • 58249085436 scopus 로고    scopus 로고
    • Reducing small intestinal permeability attenuates colitis in the IL10 genedeficient mouse
    • Arrieta MC, Madsen K, Doyle J, et al. Reducing small intestinal permeability attenuates colitis in the IL10 genedeficient mouse. Gut 2009;58(1):41-8
    • (2009) Gut , vol.58 , Issue.1 , pp. 41-48
    • Arrieta, M.C.1    Madsen, K.2    Doyle, J.3
  • 32
    • 33746040501 scopus 로고    scopus 로고
    • Hyaluronan fragments: An informationrich system
    • Stern R, Asari AA, Sugahara KN. Hyaluronan fragments: an informationrich system. Eur J Cell Biol 2006;85(8):699-715
    • (2006) Eur J Cell Biol , vol.85 , Issue.8 , pp. 699-715
    • Stern, R.1    Asari, A.A.2    Sugahara, K.N.3
  • 34
    • 0036259277 scopus 로고    scopus 로고
    • Alpha 4 integrin antagonists
    • Jackson DY. Alpha 4 integrin antagonists. Curr Pharm Des 2002;8(14):1229-53
    • (2002) Curr Pharm des , vol.8 , Issue.14 , pp. 1229-1253
    • Jackson, D.Y.1
  • 36
    • 84902332541 scopus 로고    scopus 로고
    • Dynamic interactions between TIP60 and p300 regulate FOXP3 function through a structural switch defined by a single lysine on TIP60
    • Xiao Y, Nagai Y, Deng G, et al. Dynamic interactions between TIP60 and p300 regulate FOXP3 function through a structural switch defined by a single lysine on TIP60. Cell Rep 2014;7(5):1471-80
    • (2014) Cell Rep , vol.7 , Issue.5 , pp. 1471-1480
    • Xiao, Y.1    Nagai, Y.2    Deng, G.3
  • 42
    • 84930224290 scopus 로고    scopus 로고
    • Pharma Inc; UEDA Keiko c/o Astellas Pharma Inc. et al. Compound WS727713. Telsar Pharma Inc. JPO2014040456
    • Takanao O; Hirotsugu c/o Astellas Pharma Inc; UEDA, Keiko c/o Astellas Pharma Inc. et al. Compound WS727713. Telsar Pharma Inc. JPO2014040456; 2014
    • (2014) Hirotsugu C/o Astellas
    • Takanao, O.1
  • 46
    • 80055029175 scopus 로고    scopus 로고
    • Functional foods and dietary supplements: Products at the interface between pharma and nutrition
    • Eussen SR, Verhagen H, Klungel OH, et al. Functional foods and dietary supplements: products at the interface between pharma and nutrition. Eur J Pharmacol 2011;668(Suppl 1):S2-9
    • (2011) Eur J Pharmacol , vol.668 , pp. S2-9
    • Eussen, S.R.1    Verhagen, H.2    Klungel, O.H.3
  • 47
    • 0036741363 scopus 로고    scopus 로고
    • Functional food concept and its application to prebiotics
    • Roberfroid M. Functional food concept and its application to prebiotics. Dig Liver Dis 2002;34(Suppl 2):S105-10
    • (2002) Dig Liver Dis , vol.34 , pp. S105-S110
    • Roberfroid, M.1
  • 48
    • 0005420377 scopus 로고    scopus 로고
    • Scientific concepts of functional foods in Europe. Consensus document
    • Diplock AT, Ashwell M, Bomet F, et al. Scientific concepts of functional foods in Europe. Consensus document. Br J Nutr 1999;81(Suppl 1):S1-27
    • (1999) Br J Nutr , vol.81 , pp. S1-27
    • Diplock, A.T.1    Ashwell, M.2    Bomet, F.3
  • 49
    • 66149121918 scopus 로고    scopus 로고
    • Prebiotics in chronic intestinal inflammation
    • Looijer-van Langen MA, Dieleman LA. Prebiotics in chronic intestinal inflammation. Inflamm Bowel Dis 2009;15(3):454-62
    • (2009) Inflamm Bowel Dis , vol.15 , Issue.3 , pp. 454-462
    • Langen Ma, L.1    Dieleman, L.A.2
  • 50
    • 84925230968 scopus 로고    scopus 로고
    • Probiotic bacteria lactobacillus and bifidobacterium attenuate inflammation in dextran sulfate sodium-induced experimental colitis in mice
    • Toumi R, Soufli I, Rafa H, et al. Probiotic bacteria lactobacillus and bifidobacterium attenuate inflammation in dextran sulfate sodium-induced experimental colitis in mice. Int J Immunopathol Pharmacol 2014;27(4):615-27
    • (2014) Int J Immunopathol Pharmacol , vol.27 , Issue.4 , pp. 615-627
    • Toumi, R.1    Soufli, I.2    Rafa, H.3
  • 51
    • 84928530576 scopus 로고    scopus 로고
    • Bifidobacterium longum subsp infantis BB-02 attenuates acute murine experimental model of inflammatory bowel disease
    • Elian SD, Souza EL, Vieira AT, et al. Bifidobacterium longum subsp. infantis BB-02 attenuates acute murine experimental model of inflammatory bowel disease. Benef Microbes 2015;6(3):277-86
    • (2015) Benef Microbes , vol.6 , Issue.3 , pp. 277-286
    • Elian, S.D.1    Souza, E.L.2    Vieira, A.T.3
  • 52
    • 84889247257 scopus 로고    scopus 로고
    • Probiotic yogurt Affects Pro- and Anti-inflammatory Factors in Patients with Inflammatory Bowel Disease
    • Shadnoush M, Shaker Hosseini R, Mehrabi Y, et al. Probiotic yogurt Affects Pro- and Anti-inflammatory Factors in Patients with Inflammatory Bowel Disease. Iran J Pharm Res 2013;12(4):929-36
    • (2013) Iran J Pharm Res , vol.12 , Issue.4 , pp. 929-936
    • Shadnoush, M.1    Shaker Hosseini, R.2    Mehrabi, Y.3
  • 53
    • 34547921265 scopus 로고    scopus 로고
    • Anti-inflammatory effects of probiotic yogurt in inflammatory bowel disease patients
    • Lorea Baroja M, Kirjavainen PV, Hekmat S, et al. Anti-inflammatory effects of probiotic yogurt in inflammatory bowel disease patients. Clin Exp Immunol 2007;149(3):470-9
    • (2007) Clin Exp Immunol , vol.149 , Issue.3 , pp. 470-479
    • Lorea Baroja, M.1    Kirjavainen, P.V.2    Hekmat, S.3
  • 54
    • 84878012036 scopus 로고    scopus 로고
    • Nutritional protective mechanisms against gut inflammation
    • Viladomiu M, Hontecillas R, Yuan L, et al. Nutritional protective mechanisms against gut inflammation. J Nutr Biochem 2013;24(6):929-39
    • (2013) J Nutr Biochem , vol.24 , Issue.6 , pp. 929-939
    • Viladomiu, M.1    Hontecillas, R.2    Yuan, L.3
  • 55
    • 84909641363 scopus 로고    scopus 로고
    • Intestinal microbiota, probiotics and prebiotics in inflammatory bowel disease
    • Orel R, Kamhi Trop T. Intestinal microbiota, probiotics and prebiotics in inflammatory bowel disease. World J Gastroenterol 2014;20(33):11505-24
    • (2014) World J Gastroenterol , vol.20 , Issue.33 , pp. 11505-11524
    • Orel, R.1    Kamhi Trop, T.2
  • 57
    • 0029013322 scopus 로고
    • Dietary modulation of the human colonic microbiota: Introducing the concept of prebiotics
    • Gibson GR, Roberfroid MB. Dietary modulation of the human colonic microbiota: introducing the concept of prebiotics. J Nutr 1995;125(6):1401-12
    • (1995) J Nutr , vol.125 , Issue.6 , pp. 1401-1412
    • Gibson, G.R.1    Roberfroid, M.B.2
  • 58
    • 0000679638 scopus 로고    scopus 로고
    • Fructo-oligosaccharide malabsorption: Benefit for gastrointestinal functions
    • Roberfroid MB. Fructo-oligosaccharide malabsorption: benefit for gastrointestinal functions. Curr Opin Gastroenterol 2000;16(2):173-7
    • (2000) Curr Opin Gastroenterol , vol.16 , Issue.2 , pp. 173-177
    • Roberfroid, M.B.1
  • 59
    • 84912102518 scopus 로고    scopus 로고
    • Intestinal microbiota in health and disease: Role of bifidobacteria in gut homeostasis
    • Tojo R, Suarez A, Clemente MG, et al. Intestinal microbiota in health and disease: role of bifidobacteria in gut homeostasis. World J Gastroenterol 2014;20(41):15163-76
    • (2014) World J Gastroenterol , vol.20 , Issue.41 , pp. 15163-15176
    • Tojo, R.1    Suarez, A.2    Clemente, M.G.3
  • 60
    • 84896708204 scopus 로고    scopus 로고
    • Acetylation and carboxymethylation of the polysaccharide from Ganoderma atrum and their antioxidant and immunomodulating activities
    • Chen Y, Zhang H, Wang Y, et al. Acetylation and carboxymethylation of the polysaccharide from Ganoderma atrum and their antioxidant and immunomodulating activities. Food Chem 2014;156:279-88
    • (2014) Food Chem , vol.156 , pp. 279-288
    • Chen, Y.1    Zhang, H.2    Wang, Y.3
  • 61
    • 84927910670 scopus 로고    scopus 로고
    • Modulating the microbiota in inflammatory bowel diseases: Prebiotics, probiotics or faecal transplantation?
    • Verbeke KA, Boesmans L, Boets E. Modulating the microbiota in inflammatory bowel diseases: prebiotics, probiotics or faecal transplantation? Proc Nutr Soc 2014;73(4):490-7
    • (2014) Proc Nutr Soc , vol.73 , Issue.4 , pp. 490-497
    • Verbeke, K.A.1    Boesmans, L.2    Boets, E.3
  • 62
    • 84883184463 scopus 로고    scopus 로고
    • Gut microbial flora, prebiotics, and probiotics in IBD: Their current usage and utility
    • Scaldaferri F, Gerardi V, Lopetuso LR, et al. Gut microbial flora, prebiotics, and probiotics in IBD: their current usage and utility. Biomed Res Int 2013;2013:435268
    • (2013) Biomed Res Int , vol.2013 , pp. 435268
    • Scaldaferri, F.1    Gerardi, V.2    Lopetuso, L.R.3
  • 63
    • 84883412154 scopus 로고    scopus 로고
    • Recent progress on the role of gut microbiota in the pathogenesis of inflammatory bowel disease
    • Yu CG, Huang Q. Recent progress on the role of gut microbiota in the pathogenesis of inflammatory bowel disease. J Dig Dis 2013;14(10):513-17
    • (2013) J Dig Dis , vol.14 , Issue.10 , pp. 513-517
    • Yu, C.G.1    Huang, Q.2
  • 64
    • 84884650652 scopus 로고    scopus 로고
    • Diet, microbes, and host genetics: The perfect storm in inflammatory bowel diseases
    • Leone V, Chang EB, Devkota S. Diet, microbes, and host genetics: the perfect storm in inflammatory bowel diseases. J Gastroenterol 2013;48(3):315-21
    • (2013) J Gastroenterol , vol.48 , Issue.3 , pp. 315-321
    • Leone, V.1    Chang, E.B.2    Devkota, S.3
  • 65
    • 84889090313 scopus 로고    scopus 로고
    • Diet, the human gut microbiota, and IBD
    • Wu GD, Bushmanc FD, Lewis JD. Diet, the human gut microbiota, and IBD. Anaerobe 2013;24:117-20
    • (2013) Anaerobe , vol.24 , pp. 117-120
    • Wu, G.D.1    Bushmanc, F.D.2    Lewis, J.D.3
  • 66
    • 33845276869 scopus 로고    scopus 로고
    • Short-chain fatty acids: Ready for prime time?
    • Roy CC, Kien CL, Bouthillier L, et al. Short-chain fatty acids: ready for prime time? Nutr Clin Pract 2006;21(4):351-66
    • (2006) Nutr Clin Pract , vol.21 , Issue.4 , pp. 351-366
    • Roy, C.C.1    Kien, C.L.2    Bouthillier, L.3
  • 67
    • 70450233538 scopus 로고    scopus 로고
    • Activation of the AMP activated protein kinase by short-chain fatty acids is the main mechanism underlying the beneficial effect of a high fiber diet on the metabolic syndrome
    • Hu GX, Chen GR, Xu H, et al. Activation of the AMP activated protein kinase by short-chain fatty acids is the main mechanism underlying the beneficial effect of a high fiber diet on the metabolic syndrome. Med Hypotheses 2010;74(1):123-6
    • (2010) Med Hypotheses , vol.74 , Issue.1 , pp. 123-126
    • Hu, G.X.1    Chen, G.R.2    Xu, H.3
  • 68
    • 84883139076 scopus 로고    scopus 로고
    • The role of short-chain fatty acids in the interplay between diet, gut microbiota, and host energy metabolism
    • den Besten G, van Eunen K, Groen AK, et al. The role of short-chain fatty acids in the interplay between diet, gut microbiota, and host energy metabolism. J Lipid Res 2013;54(9):2325-40
    • (2013) J Lipid Res , vol.54 , Issue.9 , pp. 2325-2340
    • Den Besten, G.1    Van Eunen, K.2    Groen, A.K.3
  • 69
    • 79955579989 scopus 로고    scopus 로고
    • The microbiome and butyrate regulate energy metabolism and autophagy in the mammalian colon
    • Donohoe DR, Garge N, Zhang X, et al. The microbiome and butyrate regulate energy metabolism and autophagy in the mammalian colon. Cell Metab 2011;13(5):517-26
    • (2011) Cell Metab , vol.13 , Issue.5 , pp. 517-526
    • Donohoe, D.R.1    Garge, N.2    Zhang, X.3
  • 70
    • 79953309326 scopus 로고    scopus 로고
    • Butyrate elicits a metabolic switch in human colon cancer cells by targeting the pyruvate dehydrogenase complex
    • Blouin JM, Penot G, Collinet M, et al. Butyrate elicits a metabolic switch in human colon cancer cells by targeting the pyruvate dehydrogenase complex. Int J Cancer 2011;128(11):2591-601
    • (2011) Int J Cancer , vol.128 , Issue.11 , pp. 2591-2601
    • Blouin, J.M.1    Penot, G.2    Collinet, M.3
  • 71
    • 78650618692 scopus 로고    scopus 로고
    • G-protein-coupled receptor for shortchain fatty acids suppresses colon cancer
    • Tang Y, Chen Y, Jiang H, et al. G-protein-coupled receptor for shortchain fatty acids suppresses colon cancer. Int J Cancer 2011;128(4):847-56
    • (2011) Int J Cancer , vol.128 , Issue.4 , pp. 847-856
    • Tang, Y.1    Chen, Y.2    Jiang, H.3
  • 72
    • 37149022209 scopus 로고    scopus 로고
    • Review article: The role of butyrate on colonic function
    • Hamer HM, Jonkers D, Venema K, et al. Review article: the role of butyrate on colonic function. Aliment Pharmacol Ther 2008;27(2):104-19
    • (2008) Aliment Pharmacol Ther , vol.27 , Issue.2 , pp. 104-119
    • Hamer, H.M.1    Jonkers, D.2    Venema, K.3
  • 73
    • 0025321505 scopus 로고
    • Energy contributions of volatile fatty acids from the gastrointestinal tract in various species
    • Bergman EN. Energy contributions of volatile fatty acids from the gastrointestinal tract in various species. Physiol Rev 1990;70(2):567-90
    • (1990) Physiol Rev , vol.70 , Issue.2 , pp. 567-590
    • Bergman, E.N.1
  • 74
    • 0019940133 scopus 로고
    • Utilization of nutrients by isolated epithelial cells of the rat colon
    • Roediger WE. Utilization of nutrients by isolated epithelial cells of the rat colon. Gastroenterology 1982;83(2):424-9
    • (1982) Gastroenterology , vol.83 , Issue.2 , pp. 424-429
    • Roediger, W.E.1
  • 75
    • 80051471073 scopus 로고    scopus 로고
    • Suppressive effect of short-chain fatty acids on production of proinflammatory mediators by neutrophils
    • Vinolo MA, Rodrigues HG, Hatanaka E, et al. Suppressive effect of short-chain fatty acids on production of proinflammatory mediators by neutrophils. J Nutr Biochem 2011;22(9):849-55
    • (2011) J Nutr Biochem , vol.22 , Issue.9 , pp. 849-855
    • Vinolo, M.A.1    Rodrigues, H.G.2    Hatanaka, E.3
  • 76
    • 84885301788 scopus 로고    scopus 로고
    • Pathobiology and potential therapeutic value of intestinal short-chain fatty acids in gut inflammation and obesity
    • Soldavini J, Kaunitz JD. Pathobiology and potential therapeutic value of intestinal short-chain fatty acids in gut inflammation and obesity. Dig Dis Sci 2013;58(10):2756-66
    • (2013) Dig Dis Sci , vol.58 , Issue.10 , pp. 2756-2766
    • Soldavini, J.1    Kaunitz, J.D.2
  • 77
    • 84923087600 scopus 로고    scopus 로고
    • Intestinal microbiota the explosive mixture at the origin of inflammatory bowel disease?
    • Bringiotti R, Ierardi E, Lovero R, et al. Intestinal microbiota: the explosive mixture at the origin of inflammatory bowel disease? World J Gastrointest Pathophysiol 2014;5(4):550-9
    • (2014) World J Gastrointest Pathophysiol , vol.5 , Issue.4 , pp. 550-559
    • Bringiotti, R.1    Ierardi, E.2    Lovero, R.3
  • 80
    • 51349098875 scopus 로고    scopus 로고
    • Adjuvant fermented wheat germ extract (Avemar) nutraceutical improves survival of highrisk skin melanoma patients: A randomized, pilot, phase II clinical study with a 7-year follow-up
    • Demidov LV, Manziuk LV, Kharkevitch GY, et al. Adjuvant fermented wheat germ extract (Avemar) nutraceutical improves survival of highrisk skin melanoma patients: a randomized, pilot, phase II clinical study with a 7-year follow-up. Cancer Biother Radiopharm 2008;23(4):477-82
    • (2008) Cancer Biother Radiopharm , vol.23 , Issue.4 , pp. 477-482
    • Demidov, L.V.1    Manziuk, L.V.2    Kharkevitch, G.Y.3
  • 81
    • 33746586489 scopus 로고    scopus 로고
    • Effect of Avemar-A fermented wheat germ extract-on rheumatoid arthritis Preliminary data
    • Balint G, Apathy A, Gaal M, et al. Effect of Avemar-A fermented wheat germ extract-on rheumatoid arthritis. Preliminary data. Clin Exp Rheumatol 2006;24(3):325-8
    • (2006) Clin Exp Rheumatol , vol.24 , Issue.3 , pp. 325-328
    • Balint, G.1    Apathy, A.2    Gaal, M.3
  • 82
    • 33644643901 scopus 로고    scopus 로고
    • Fermented wheat germ extract in the supportive therapy of colorectal cancer
    • Farkas E. Fermented wheat germ extract in the supportive therapy of colorectal cancer. Orv Hetil 2005;146(37):1925-31
    • (2005) Orv Hetil , vol.146 , Issue.37 , pp. 1925-1931
    • Farkas, E.1
  • 83
    • 0041475739 scopus 로고    scopus 로고
    • A medical nutriment has supportive value in the treatment of colorectal cancer
    • Jakab F, Shoenfeld Y, Balogh A, et al. A medical nutriment has supportive value in the treatment of colorectal cancer. Br J Cancer 2003;89(3):465-9
    • (2003) Br J Cancer , vol.89 , Issue.3 , pp. 465-469
    • Jakab, F.1    Shoenfeld, Y.2    Balogh, A.3
  • 84
    • 0034004550 scopus 로고    scopus 로고
    • First clinical data of a natural immunomodulator in colorectal cancer
    • Jakab F, Mayer A, Hoffmann A, et al. First clinical data of a natural immunomodulator in colorectal cancer. Hepatogastroenterology 2000;47(32):393-5
    • (2000) Hepatogastroenterology , vol.47 , Issue.32 , pp. 393-395
    • Jakab, F.1    Mayer, A.2    Hoffmann, A.3
  • 85
    • 85013605171 scopus 로고    scopus 로고
    • A multicentric prospective open trial on the quality of life and oxidative stress in patients affected by advanced head and neck cancer treated with a new benzoquinone-rich product derived from fermented wheat germ (Avemar
    • Sukkar S, Cella F, Rovera G, et al. A multicentric prospective open trial on the quality of life and oxidative stress in patients affected by advanced head and neck cancer treated with a new benzoquinone-rich product derived from fermented wheat germ (Avemar). Mediterr J Nutr Metab 2008;1(1):37-42
    • (2008) Mediterr J Nutr Metab , vol.1 , Issue.1 , pp. 37-42
    • Sukkar, S.1    Cella, F.2    Rovera, G.3
  • 89
    • 73749083065 scopus 로고    scopus 로고
    • Fermented milk containing Bifidobacterium lactis DN-173 improves gastrointestinal well-being and digestive symptoms in women reporting minor digestive symptoms: A randomised, double-blind, parallel, controlled study
    • Guyonnet D, Schlumberger A, Mhamdi L, et al. Fermented milk containing Bifidobacterium lactis DN-173 improves gastrointestinal well-being and digestive symptoms in women reporting minor digestive symptoms: a randomised, double-blind, parallel, controlled study. Br J Nutr 2009;102(11):1654-62
    • (2009) Br J Nutr , vol.102 , Issue.11 , pp. 1654-1662
    • Guyonnet, D.1    Schlumberger, A.2    Mhamdi, L.3
  • 90
    • 78149262230 scopus 로고    scopus 로고
    • Bifidobacterium animalis subsp lactis fermented milk product reduces inflammation by altering a niche for colitogenic microbes
    • Veiga P, Gallini CA, Beal C, et al. Bifidobacterium animalis subsp. lactis fermented milk product reduces inflammation by altering a niche for colitogenic microbes. Proc Natl Acad Sci USA 2010;107(42):18132-7
    • (2010) Proc Natl Acad Sci USA , vol.107 , Issue.42 , pp. 18132-18137
    • Veiga, P.1    Gallini, C.A.2    Beal, C.3
  • 92
    • 84888315007 scopus 로고    scopus 로고
    • Profermin is efficacious in patients with active ulcerative colitis-A randomized controlled trial
    • Krag A, Munkholm P, Israelsen H, et al. Profermin is efficacious in patients with active ulcerative colitis-A randomized controlled trial. Inflamm Bowel Dis 2013;19(12):2584-92
    • (2013) Inflamm Bowel Dis , vol.19 , Issue.12 , pp. 2584-2592
    • Krag, A.1    Munkholm, P.2    Israelsen, H.3
  • 93
    • 84866177353 scopus 로고    scopus 로고
    • Safety and efficacy of Profermin(R) to induce remission in ulcerative colitis
    • Krag A, Israelsen H, von Ryberg B, et al. Safety and efficacy of Profermin(R) to induce remission in ulcerative colitis. World J Gastroenterol 2012;18(15):1773-80
    • (2012) World J Gastroenterol , vol.18 , Issue.15 , pp. 1773-1780
    • Krag, A.1    Israelsen, H.2    Von Ryberg, B.3
  • 96
    • 84873252459 scopus 로고    scopus 로고
    • Protective effects of galacturonic acid-rich vinegar brewed from Japanese pear in a dextran sodium sulfate-induced acute colitis model
    • Wakuda T, Azuma K, Saimoto H, et al. Protective effects of galacturonic acid-rich vinegar brewed from Japanese pear in a dextran sodium sulfate-induced acute colitis model. J Funct Foods 2013;5(1):516-23
    • (2013) J Funct Foods , vol.5 , Issue.1 , pp. 516-523
    • Wakuda, T.1    Azuma, K.2    Saimoto, H.3
  • 97
    • 85006189045 scopus 로고    scopus 로고
    • Vedolizumab for inflammatory bowel disease: Changing the game or more of the same?
    • Raine T. Vedolizumab for inflammatory bowel disease: changing the game, or more of the same? United European Gastroenterol J 2014;2(5):333-44
    • (2014) United European Gastroenterol J , vol.2 , Issue.5 , pp. 333-344
    • Raine, T.1
  • 98
    • 84910132089 scopus 로고    scopus 로고
    • Predictors of response to anti-tumor necrosis factor therapy in ulcerative colitis
    • Zampeli E, Gizis M, Siakavellas SI, et al. Predictors of response to anti-tumor necrosis factor therapy in ulcerative colitis. World J Gastrointest Pathophysiol 2014;5(3):293-303
    • (2014) World J Gastrointest Pathophysiol , vol.5 , Issue.3 , pp. 293-303
    • Zampeli, E.1    Gizis, M.2    Siakavellas, S.I.3
  • 99
    • 84860557456 scopus 로고    scopus 로고
    • New therapies for inflammatory bowel disease: From the bench to the bedside
    • Danese S. New therapies for inflammatory bowel disease: from the bench to the bedside. Gut 2012;61(6):918-32
    • (2012) Gut , vol.61 , Issue.6 , pp. 918-932
    • Danese, S.1
  • 100
    • 84925485488 scopus 로고    scopus 로고
    • Vedolizumab: A review of its use in adult patients with moderately to severely active ulcerative colitis or Crohn's disease
    • Garnock-Jones KP. Vedolizumab: a review of its use in adult patients with moderately to severely active ulcerative colitis or Crohn's disease. BioDrugs 2015;29(1):57-67
    • (2015) BioDrugs , vol.29 , Issue.1 , pp. 57-67
    • Garnock-Jones, K.P.1
  • 101
    • 84880035682 scopus 로고    scopus 로고
    • Efficacy, safety and tolerability of vidofludimus in patients with inflammatory bowel disease: The ENTRANCE study
    • Herrlinger KR, Diculescu M, Fellermann K, et al. Efficacy, safety and tolerability of vidofludimus in patients with inflammatory bowel disease: the ENTRANCE study. J Crohns Colitis 2013;7(8):636-43
    • (2013) J Crohns Colitis , vol.7 , Issue.8 , pp. 636-643
    • Herrlinger, K.R.1    Diculescu, M.2    Fellermann, K.3
  • 103
    • 84872277296 scopus 로고    scopus 로고
    • Blocking IL-25 signalling protects against gut inflammation in a type-2 model of colitis by suppressing nuocyte and NKT derived IL-13
    • Camelo A, Barlow JL, Drynan LF, et al. Blocking IL-25 signalling protects against gut inflammation in a type-2 model of colitis by suppressing nuocyte and NKT derived IL-13. J Gastroenterol 2012;47(11):1198-211
    • (2012) J Gastroenterol , vol.47 , Issue.11 , pp. 1198-1211
    • Camelo, A.1    Barlow, J.L.2    Drynan, L.F.3
  • 104
    • 83455238462 scopus 로고    scopus 로고
    • Interleukin-25: Key regulator of inflammatory and autoimmune diseases
    • Saadoun D, Terrier B, Cacoub P. Interleukin-25: key regulator of inflammatory and autoimmune diseases. Curr Pharm Des 2011;17(34):3781-5
    • (2011) Curr Pharm des , vol.17 , Issue.34 , pp. 3781-3785
    • Saadoun, D.1    Terrier, B.2    Cacoub, P.3
  • 105
    • 78649704149 scopus 로고    scopus 로고
    • Interleukin-25: A two-edged sword in the control of immune-inflammatory responses
    • Monteleone G, Pallone F, Macdonald TT. Interleukin-25: a two-edged sword in the control of immune-inflammatory responses. Cytokine Growth Factor Rev 2010;21(6):471-5
    • (2010) Cytokine Growth Factor Rev , vol.21 , Issue.6 , pp. 471-475
    • Monteleone, G.1    Pallone, F.2    Macdonald, T.T.3
  • 107
    • 84862172053 scopus 로고    scopus 로고
    • Functional requirements for inhibitory signal transmission by the immunomodulatory receptor CD300a
    • DeBell KE, Simhadri VR, Mariano JL, et al. Functional requirements for inhibitory signal transmission by the immunomodulatory receptor CD300a. BMC Immunol 2012;13:23
    • (2012) BMC Immunol , vol.13 , pp. 23
    • Debell, K.E.1    Simhadri, V.R.2    Mariano, J.L.3
  • 108
    • 84903204012 scopus 로고    scopus 로고
    • PPARbeta/delta activation of CD300a controls intestinal immunity
    • Tanaka T, Tahara-Hanaoka S, Nabekura T, et al. PPARbeta/delta activation of CD300a controls intestinal immunity. Sci Rep 2014;4:5412
    • (2014) Sci Rep , vol.4 , pp. 5412
    • Tanaka, T.1    Tahara-Hanaoka, S.2    Nabekura, T.3
  • 110
    • 0035063548 scopus 로고    scopus 로고
    • Role of interferon alpha in promoting T helper cell type 1 responses in the small intestine in coeliac disease
    • Monteleone G, Pender SL, Alstead E, et al. Role of interferon alpha in promoting T helper cell type 1 responses in the small intestine in coeliac disease. Gut 2001;48(3):425-9
    • (2001) Gut , vol.48 , Issue.3 , pp. 425-429
    • Monteleone, G.1    Pender, S.L.2    Alstead, E.3
  • 111
    • 0028576989 scopus 로고
    • Interferon expression in Crohn's disease patients: Increased interferongamma and -Alpha mRNA in the intestinal lamina propria mononuclear cells
    • Fais S, Capobianchi MR, Silvestri M, et al. Interferon expression in Crohn's disease patients: increased interferongamma and -Alpha mRNA in the intestinal lamina propria mononuclear cells. J Interferon Res 1994;14(5):235-8
    • (1994) J Interferon Res , vol.14 , Issue.5 , pp. 235-238
    • Fais, S.1    Capobianchi, M.R.2    Silvestri, M.3
  • 112
    • 84883417081 scopus 로고    scopus 로고
    • Type i IFNs regulate effector and regulatory T cell accumulation and anti-inflammatory cytokine production during T cellmediated colitis
    • Kole A, He J, Rivollier A, et al. Type I IFNs regulate effector and regulatory T cell accumulation and anti-inflammatory cytokine production during T cellmediated colitis. J Immunol 2013;191(5):2771-9
    • (2013) J Immunol , vol.191 , Issue.5 , pp. 2771-2779
    • Kole, A.1    He, J.2    Rivollier, A.3
  • 113
    • 84902584152 scopus 로고    scopus 로고
    • The role of type i interferons in intestinal infection homeostasis and inflammation
    • Cho H, Kelsall BL. The role of type I interferons in intestinal infection, homeostasis, and inflammation. Immunol Rev 2014;260(1):145-67
    • (2014) Immunol Rev , vol.260 , Issue.1 , pp. 145-167
    • Cho, H.1    Kelsall, B.L.2
  • 115
    • 84881260209 scopus 로고    scopus 로고
    • Smad7 antisense oligonucleotide-based therapy for inflammatory bowel diseases
    • Zorzi F, Angelucci E, Sedda S, et al. Smad7 antisense oligonucleotide-based therapy for inflammatory bowel diseases. Dig Liver Dis 2013;45(7):552-5
    • (2013) Dig Liver Dis , vol.45 , Issue.7 , pp. 552-555
    • Zorzi, F.1    Angelucci, E.2    Sedda, S.3
  • 116
  • 117
    • 84859439270 scopus 로고    scopus 로고
    • Phase i clinical trial of Smad7 knockdown using antisense oligonucleotide in patients with active Crohn's disease
    • Monteleone G, Fantini MC, Onali S, et al. Phase I clinical trial of Smad7 knockdown using antisense oligonucleotide in patients with active Crohn's disease. Mol Ther 2012;20(4):870-6
    • (2012) Mol Ther , vol.20 , Issue.4 , pp. 870-876
    • Monteleone, G.1    Fantini, M.C.2    Onali, S.3
  • 119
    • 44449127592 scopus 로고    scopus 로고
    • The epidermal growth factor receptor family: Biology driving targeted therapeutics
    • Wieduwilt MJ, Moasser MM. The epidermal growth factor receptor family: biology driving targeted therapeutics. Cell Mol Life Sci 2008;65(10):1566-84
    • (2008) Cell Mol Life Sci , vol.65 , Issue.10 , pp. 1566-1584
    • Wieduwilt, M.J.1    Moasser, M.M.2
  • 120
    • 84873957232 scopus 로고    scopus 로고
    • Neuregulin-4 is a survival factor for colon epithelial cells both in culture and in vivo
    • Bernard JK, McCann SP, Bhardwaj V, et al. Neuregulin-4 is a survival factor for colon epithelial cells both in culture and in vivo. J Biol Chem 2012;287(47):39850-8
    • (2012) J Biol Chem , vol.287 , Issue.47 , pp. 39850-39858
    • Bernard, J.K.1    McCann, S.P.2    Bhardwaj, V.3
  • 121
    • 84922454995 scopus 로고    scopus 로고
    • The ErbB4 ligand neuregulin-4 protects against experimental necrotizing enterocolitis
    • McElroy SJ, Castle SL, Bernard JK, et al. The ErbB4 ligand neuregulin-4 protects against experimental necrotizing enterocolitis. Am J Pathol 2014;184(10):2768-78
    • (2014) Am J Pathol , vol.184 , Issue.10 , pp. 2768-2778
    • McElroy, S.J.1    Castle, S.L.2    Bernard, J.K.3
  • 123
    • 0035167691 scopus 로고    scopus 로고
    • Enhanced secretion of IFN-gamma by activated Th1 cells occurs via reverse signaling through TNF-related activationinduced cytokine
    • Chen NJ, Huang MW, Hsieh SL. Enhanced secretion of IFN-gamma by activated Th1 cells occurs via reverse signaling through TNF-related activationinduced cytokine. J Immunol 2001;166(1):270-6
    • (2001) J Immunol , vol.166 , Issue.1 , pp. 270-276
    • Chen, N.J.1    Huang, M.W.2    Hsieh, S.L.3
  • 124
    • 84902550294 scopus 로고    scopus 로고
    • Of worms mice and man: An overview of experimental and clinical helminth-based therapy for inflammatory bowel disease
    • Heylen M, Ruyssers NE, Gielis EM, et al. Of worms, mice and man: an overview of experimental and clinical helminth-based therapy for inflammatory bowel disease. Pharmacol Ther 2014;143(2):153-67
    • (2014) Pharmacol Ther , vol.143 , Issue.2 , pp. 153-167
    • Heylen, M.1    Ruyssers, N.E.2    Gielis, E.M.3
  • 125
    • 0025924547 scopus 로고
    • Egg deposition is the major stimulus for the production of Th2 cytokines in murine schistosomiasis mansoni
    • Grzych JM, Pearce E, Cheever A, et al. Egg deposition is the major stimulus for the production of Th2 cytokines in murine schistosomiasis mansoni. J Immunol 1991;146(4):1322-7
    • (1991) J Immunol , vol.146 , Issue.4 , pp. 1322-1327
    • Grzych, J.M.1    Pearce, E.2    Cheever, A.3
  • 126
    • 0028069831 scopus 로고
    • IL-12 inhibits Th2 cytokine responses induced by eggs of Schistosoma mansoni
    • Oswald IP, Caspar P, Jankovic D, et al. IL-12 inhibits Th2 cytokine responses induced by eggs of Schistosoma mansoni. J Immunol 1994;153(4):1707-13
    • (1994) J Immunol , vol.153 , Issue.4 , pp. 1707-1713
    • Oswald, I.P.1    Caspar, P.2    Jankovic, D.3
  • 127
    • 84930197975 scopus 로고    scopus 로고
    • Suzhou Sciscape Biomedicine Science & Technology Co. Ltd., Chenggang Zhang, Junhuai LI, Yang Xu, Yonghong Wu, Weiguang Li, Yanchun Zhang, Yan Gao, Zhihui Li, Institute Of Radiation Medicine, Academy Of Military Medical Sciences, People's Liberation Army Of China. EP2730287A1
    • Zhang C, Li Y, Xu Y, et al. Use of salmonella flagellin derivative in preparation of drug for preventing and treating inflammatory bowel diseases. Suzhou Sciscape Biomedicine Science & Technology Co. Ltd., Chenggang Zhang, Junhuai LI, Yang Xu, Yonghong Wu, Weiguang Li, Yanchun Zhang, Yan Gao, Zhihui Li, Institute Of Radiation Medicine, Academy Of Military Medical Sciences, People's Liberation Army Of China. EP2730287A1; 2013
    • (2013) Use of Salmonella Flagellin Derivative in Preparation of Drug for Preventing and Treating Inflammatory Bowel Diseases
    • Zhang, C.1    Li, Y.2    Xu, Y.3
  • 128
    • 0035424901 scopus 로고    scopus 로고
    • Decreased expression of Toll-like receptor-4 and MD-2 correlates with intestinal epithelial cell protection against dysregulated proinflammatory gene expression in response to bacterial lipopolysaccharide
    • Abreu MT, Vora P, Faure E, et al. Decreased expression of Toll-like receptor-4 and MD-2 correlates with intestinal epithelial cell protection against dysregulated proinflammatory gene expression in response to bacterial lipopolysaccharide. J Immunol 2001;167(3):1609-16
    • (2001) J Immunol , vol.167 , Issue.3 , pp. 1609-1616
    • Abreu, M.T.1    Vora, P.2    Faure, E.3
  • 129
    • 2342646956 scopus 로고    scopus 로고
    • Bacterial flagellin is a dominant antigen in Crohn disease
    • Lodes MJ, Cong Y, Elson CO, et al. Bacterial flagellin is a dominant antigen in Crohn disease. J Clin Invest 2004;113(9):1296-306
    • (2004) J Clin Invest , vol.113 , Issue.9 , pp. 1296-1306
    • Lodes, M.J.1    Cong, Y.2    Elson, C.O.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.