Butyrate elicits a metabolic switch in human colon cancer cells by targeting the pyruvate dehydrogenase complex

International Journal of Cancer

Volumn 128, Issue 11, 2011, Pages 2591-2601

  Blouin, Jean Marc ^a   Penot, Graziella ^a   Collinet, Martine ^a   Nacfer, Magali ^a   Forest, Claude ^a   Laurent Puig, Pierre ^a   Coumoul, Xavier ^a   Barouki, Robert ^a   Benelli, Chantal ^a   Bortoli, Sylvie ^a  

^a INSERM   (France)

Author keywords

butyrate; colon cancer cells; glutamine; metabolism; pyruvate dehydrogenase kinase

Indexed keywords

ACETYL COENZYME A; BUTYRIC ACID; CARBON DIOXIDE; FATTY ACID; GLUCOSE; GLUTAMINE; HISTONE; LACTIC ACID; LIPID; PYRUVATE DEHYDROGENASE; PYRUVATE DEHYDROGENASE KINASE; PYRUVATE DEHYDROGENASE KINASE 4;

AMINO ACID METABOLISM; ANTINEOPLASTIC ACTIVITY; ARTICLE; CELL METABOLISM; CELL STRAIN CACO 2; CLINICAL ARTICLE; COLON CANCER; CONTROLLED STUDY; DRUG TARGETING; ENZYME INACTIVATION; FATTY ACID OXIDATION; FATTY ACID SYNTHESIS; FEMALE; GENE EXPRESSION REGULATION; GLUCOSE OXIDATION; GLUCOSE UTILIZATION; GLYCOLYSIS; HISTONE ACETYLATION; HUMAN; HUMAN CELL; HUMAN TISSUE; MALE; METABOLIC REGULATION; PHENOTYPE; PRIORITY JOURNAL; PROMOTER REGION;

ADENOCARCINOMA; BLOTTING, WESTERN; BUTYRATES; CELL DIFFERENTIATION; CELL PROLIFERATION; CHROMATIN IMMUNOPRECIPITATION; COLONIC NEOPLASMS; GLUCOSE; GLUTAMINE; GLYCOLYSIS; HISTONE DEACETYLASES; HISTONES; HUMANS; OXIDATION-REDUCTION; PROTEIN-SERINE-THREONINE KINASES; PYRUVATE DEHYDROGENASE COMPLEX; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; TUMOR CELLS, CULTURED;

EID: 79953309326     PISSN: 00207136     EISSN: 10970215     Source Type: Journal    
DOI: 10.1002/ijc.25599     Document Type: Article

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