GUCY2C opposes systemic genotoxic tumorigenesis by regulating AKT-dependent intestinal barrier integrity

PLoS ONE

Volumn 7, Issue 2, 2012, Pages

  Lin, Jieru Egeria ^a   Snook, Adam Eugene ^a   Li, Peng ^a   Stoecker, Brian Arthur ^a   Kim, Gilbert Won ^a   Magee, Michael Sullivan ^a   Garcia, Alex Vladimir Mejia ^a   Valentino, Michael Anthony ^a   Hyslop, Terry ^b   Schulz, Stephanie ^a   Waldman, Scott Arthur ^a  

^a THOMAS JEFFERSON UNIVERSITY   (United States)

^b THOMAS JEFFERSON UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CLAUDIN 4; GAP JUNCTION PROTEIN; GUANYLYL CYCLASE C; OCCLUDIN; PROTEIN KINASE B; UNCLASSIFIED DRUG; ATRIAL NATRIURETIC FACTOR RECEPTOR; CLAUDIN; ENTEROTOXIN RECEPTOR; LIGAND; MEMBRANE PROTEIN; MUTAGENIC AGENT; RECEPTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CARCINOGENESIS; COLITIS; CONTROLLED STUDY; DISEASE EXACERBATION; DNA DAMAGE; FEMALE; GENE SILENCING; GENOTOXICITY; IN VITRO STUDY; INTESTINAL BARRIER INTEGRITY; INTESTINE MUCOSA PERMEABILITY; MALE; MOUSE; NONHUMAN; OXIDATION; PERMEABILITY BARRIER; PROTEIN FUNCTION; ANIMAL; CELL STRAIN CACO 2; DRUG ANTAGONISM; GENETICS; GENOTYPE; HUMAN; INTESTINE; INTESTINE MUCOSA; METABOLISM; PERMEABILITY; TRANSGENIC MOUSE;

MUS;

ANIMALS; CACO-2 CELLS; CLAUDINS; COLITIS; DNA DAMAGE; FEMALE; GENOTYPE; HUMANS; INTESTINAL MUCOSA; INTESTINES; LIGANDS; MALE; MEMBRANE PROTEINS; MICE; MICE, TRANSGENIC; MUTAGENS; PERMEABILITY; PROTO-ONCOGENE PROTEINS C-AKT; RECEPTORS, GUANYLATE CYCLASE-COUPLED; RECEPTORS, PEPTIDE;

EID: 84863180511     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0031686     Document Type: Article

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