Adjuvant fermented wheat germ extract (Avemar™) nutraceutical improves survival of high-risk skin melanoma patients: A randomized, pilot, phase II clinical study with a 7-year follow-up

Cancer Biotherapy and Radiopharmaceuticals

Volumn 23, Issue 4, 2008, Pages 477-482

  Demidov, Lev V ^a,b   Manziuk, Ljudmila V ^a   Kharkevitch, Galina Y ^a   Pirogova, Nina A ^a   Artamonova, Elena V ^a  

^a N N BLOKHIN RUSSIAN CANCER RESEARCH CENTER   (Russian Federation)

^b INSTITUTE OF BIOMEDICAL CHEMISTRY   (Russian Federation)

Author keywords

Avemar; Dacarbazine (DTIC); Fermented wheat germ extract; Melanoma; Nutraceutical

Indexed keywords

AVEMAR; DACARBAZINE; FERMENTED WHEAT GERM EXTRACT; FLUOROURACIL; NUTRACEUTICAL; UNCLASSIFIED DRUG;

ADJUVANT THERAPY; ADOLESCENT; ADULT; AGED; ARTICLE; CANCER SURVIVAL; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; DIARRHEA; FATIGUE; FEMALE; FEVER; FOLLOW UP; HIGH RISK PATIENT; HUMAN; INFECTION; LEUKOPENIA; MAJOR CLINICAL STUDY; MALE; MELANOMA; NAUSEA; OVERALL SURVIVAL; PHASE 2 CLINICAL TRIAL; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; SURVIVAL TIME; THROMBOCYTOPENIA; TREATMENT OUTCOME; VOMITING; WHEAT;

ADOLESCENT; ADULT; AGED; CHEMOTHERAPY, ADJUVANT; DACARBAZINE; DIETARY SUPPLEMENTS; DRUG THERAPY, COMBINATION; FEMALE; FERMENTATION; FOLLOW-UP STUDIES; HUMANS; KAPLAN-MEIERS ESTIMATE; MALE; MELANOMA; MIDDLE AGED; PILOT PROJECTS; PLANT EXTRACTS; SKIN NEOPLASMS; TREATMENT OUTCOME; TRITICUM;

EID: 51349098875     PISSN: 10849785     EISSN: None     Source Type: Journal    
DOI: 10.1089/cbr.2008.0486     Document Type: Article

References (23)

1. Miller AJ, Mihm MC. Melanoma. N Engl J Med 2006;355:51.
2. Balch CM, Soong S-J, Gershenwald JE, et al. Prognostic factors analysis of 17,600 melanoma patients: Validation of the American Joint Committee on Cancer melanoma staging system. J Clin Oncol 2001;19:3622.
3. Tsao H, Atkins MB, Sober AJ. Management of cutaneous melanoma. N Engl J Med 2004;351:998.
4. Batliwalla FM, Bateman BA, Serrano D, et al. A 15-year follow-up of AJCC stage III malignant melanoma patients treated postsurgically with Newcastle disease virus (NDV) oncolysate and determination of alterations in the CD8 T-cell repertoire. Mol Med 1998;4:783.
5. National Cancer Institute. Complementary and alternative medicine, 2008. Online document at: www.cancer.gov/cancertopics/pdg/NDV/HealthProfessional/page8 Accessed August 12, 2008.
6. Nichelatti M, Hidvegi M. Experimental and clinical results with Avemar (a dried extract from fermented wheat germ) in animal cancer models and in cancer patients. Nogyogyaszati Onkologia 2002;7:40.
7. Garami M, Schuler D, Babosa M, et al. Fermented wheat germ extract reduces chemotherapy induced febrile neutropenia in pediatric cancer patients. J Pediatr Hematol Oncol 2004;26:631.
8. Heimbach JT, Sebestyen G, Semjen G, et al. Safety studies regarding a standardized extract of fermented wheat germ. Int J Toxicol 2007;26:253.
9. Boros LG, Nichelatti M, Shoenfeld Y. Fermented wheat germ extract (Avemar) in the treatment of cancer and autoimmune diseases. Ann N Y Acad Sci 2005;1051:529.
10. Pfeifer B. Avemar. In: Pfeifer B, Preis J, Unger C, eds. Onkologie Integrativ. Munchen: Elsevier, Urban and Fischer, 2006;226.
11. Johanning GL, Wang-Johanning F. Efficacy of a medical nutriment in the treatment of cancer. Altern Ther Health Med 2007;13:56.
12. Memorial Sloan-Kettering Cancer Center. Wheat germ extract, 2008. Online document at: www.mskcc.org/mskcc/html/69418.cfm Accessed August 12, 2008.
13. Hidvegi M, Raso E, Tomoskozi-Farkas R, et al. MSC, a new benzoquinone-containing natural product with antimetastatic effect. Cancer Biother Radiopharm 1999;14:277.
14. Jakab F, Shoenfeld Y, Balogh A, et al. A medical nutriment has supportive value in the treatment of colorectal cancer. Br J Cancer 2003;89:465.
15. Berd D, Mastrangelo MJ, Sato T. Calculation of survival of patients with stage III melanoma. J Clin Oncol 2005;23:9427.
16. Gorbunova VA, Orel NF, Semina OV, et al. Aranoza - a new Russian antineoplastic drug. [In Russian]. Vopr Onkol 2001;47:672.
17. Boros LG, Lapis K, Szende B, et al. Wheat germ extract decreases glucose uptake and RNA ribose formation but increases fatty acid synthesis in MIA pancreatic adenocarcinoma cells. Pancreas 2001;23:141.
18. Lee SN, Park H, Lee KE. Cytotoxic activities of fermented wheat germ extract on human gastric carcinoma cells by induction of apoptosis. J Clin Oncol 2005;23:4254.
19. Telekes A, Raso E. Changes in the kinase expression panel of K562 human leukemia after Avemar treatment. J Clin Oncol 2007;25:14143.
20. Tejeda M, Gaál D, Szucs I, et al. Avemar inhibits the growth of mouse and human xenograft mammary carcinomas comparable to endocrine treatments. J Clin Oncol 2007;25:21132.
21. Saiko P, Ozsvar-Kozma M, Madlener S, et al. Avemar, a nontoxic fermented wheat germ extract, induces apoptosis and inhibits ribonucleotide reductase in human HL-60 promyelocytic leukemia cells. Cancer Lett 2007;250:323.
22. Comin-Anduix B, Boros LG, Marin S, et al. Fermented wheat germ extract inhibits glycolysis/pentose cycle enzymes and induces apoptosis through poly(ADP-ribose) polymerase activation in Jurkat T-cell leukemia tumor cells. J Biol Chem 2002;277:46408.
23. Lonn U, Lonn S. Inhibition of poly(ADP-ribose) synthetase potentiates cell dacarbazine cytotoxicity. Biochem Biophys Res Commun 1987;142:1089.