메뉴 건너뛰기




Volumn 184, Issue 10, 2014, Pages 2768-2778

The ErbB4 Ligand Neuregulin-4 Protects against Experimental Necrotizing Enterocolitis

Author keywords

[No Author keywords available]

Indexed keywords

AGENTS USED IN INFLAMMATORY BOWEL DISEASE; APOPTOSIS INHIBITOR; CYTOKINE; DITHIZONE; EPIDERMAL GROWTH FACTOR RECEPTOR 4; NEU DIFFERENTIATION FACTOR; NEUREGULIN 4; PROTEIN TYROSINE KINASE; PROTEIN TYROSINE KINASE INHIBITOR; UNCLASSIFIED DRUG; ERBB4 PROTEIN, HUMAN; ERBB4 PROTEIN, MOUSE; ERBB4 PROTEIN, RAT; NEUREGULIN-4;

EID: 84922454995     PISSN: 00029440     EISSN: 15252191     Source Type: Journal    
DOI: 10.1016/j.ajpath.2014.06.015     Document Type: Article
Times cited : (61)

References (58)
  • 1
    • 38349138320 scopus 로고    scopus 로고
    • Understanding the susceptibility of the premature infant to necrotizing enterocolitis (NEC)
    • Hunter CJ, Upperman JS, Ford HR, Camerini V: Understanding the susceptibility of the premature infant to necrotizing enterocolitis (NEC). Pediatr Res 2008, 63:117-123.
    • (2008) Pediatr Res , vol.63 , pp. 117-123
    • Hunter, C.J.1    Upperman, J.S.2    Ford, H.R.3    Camerini, V.4
  • 2
    • 72449122344 scopus 로고    scopus 로고
    • Role of the host defense system and intestinal microbial flora in the pathogenesis of necrotizing enterocolitis
    • Larchmt
    • Emami CN, Petrosyan M, Giuliani S, Williams M, Hunter C, Prasadarao NV, Ford HR: Role of the host defense system and intestinal microbial flora in the pathogenesis of necrotizing enterocolitis. Surg Infect (Larchmt) 2009, 10:407-417.
    • (2009) Surg Infect , vol.10 , pp. 407-417
    • Emami, C.N.1    Petrosyan, M.2    Giuliani, S.3    Williams, M.4    Hunter, C.5    Prasadarao, N.V.6    Ford, H.R.7
  • 3
    • 84866499045 scopus 로고    scopus 로고
    • Paneth cells and necrotizing enterocolitis: A novel hypothesis for disease pathogenesis
    • McElroy SJ, Underwood MA, Sherman MP: Paneth cells and necrotizing enterocolitis: A novel hypothesis for disease pathogenesis. Neonatology 2013, 103:10-20.
    • (2013) Neonatology , vol.103 , pp. 10-20
    • Mcelroy, S.J.1    Underwood, M.A.2    Sherman, M.P.3
  • 6
    • 0025333028 scopus 로고
    • Necrotizing enterocolitis: Role of platelet activating factor, endotoxin, and tumor necrosis factor
    • Caplan MS, Hsueh W: Necrotizing enterocolitis: role of platelet activating factor, endotoxin, and tumor necrosis factor. J Pediatr 1990, 117:S47-S51.
    • (1990) J Pediatr , vol.117 , pp. S47-S51
    • Caplan, M.S.1    Hsueh, W.2
  • 8
    • 24344474826 scopus 로고    scopus 로고
    • Protective effect of tumor necrosis factor alpha antibody on experimental necrotizing enterocolitis in the rat
    • Seitz G, Warmann SW, Guglielmetti A, Heitmann H, Ruck P, Kreis ME, Fuchs J: Protective effect of tumor necrosis factor alpha antibody on experimental necrotizing enterocolitis in the rat. J Pediatr Surg 2005, 40:1440-1445.
    • (2005) J Pediatr Surg , vol.40 , pp. 1440-1445
    • Seitz, G.1    Warmann, S.W.2    Guglielmetti, A.3    Heitmann, H.4    Ruck, P.5    Kreis, M.E.6    Fuchs, J.7
  • 11
    • 0027968456 scopus 로고
    • Necrotizing enterocolitis in the extremely low birth weight infant
    • discussion 90-91
    • Rowe MI, Reblock KK, Kurkchubasche AG, Healey PJ: Necrotizing enterocolitis in the extremely low birth weight infant. J Pediatr Surg 1994, 29:987-990. discussion 90-91.
    • (1994) J Pediatr Surg , vol.29 , pp. 987-990
    • Rowe, M.I.1    Reblock, K.K.2    Kurkchubasche, A.G.3    Healey, P.J.4
  • 12
    • 0025669875 scopus 로고
    • Breast milk and neonatal necrotising enterocolitis
    • Lucas A, Cole TJ: Breast milk and neonatal necrotising enterocolitis. Lancet 1990, 336:1519-1523.
    • (1990) Lancet , vol.336 , pp. 1519-1523
    • Lucas, A.1    Cole, T.J.2
  • 13
    • 0032999290 scopus 로고    scopus 로고
    • Feeding strategies for premature infants: Beneficial outcomes of feeding fortified human milk versus preterm formula
    • Schanler RJ, Shulman RJ, Lau C: Feeding strategies for premature infants: Beneficial outcomes of feeding fortified human milk versus preterm formula. Pediatrics 1999, 103:1150-1157.
    • (1999) Pediatrics , vol.103 , pp. 1150-1157
    • Schanler, R.J.1    Shulman, R.J.2    Lau, C.3
  • 14
    • 19044387584 scopus 로고    scopus 로고
    • NEC, EGF, milk, and spit
    • discussion 4
    • Warner BW: NEC, EGF, milk, and spit. Gastroenterology 2002, 123: 383-384. discussion 4.
    • (2002) Gastroenterology , vol.123 , pp. 383-384
    • Warner, B.W.1
  • 15
    • 0036139344 scopus 로고    scopus 로고
    • Heparinbinding EGF-like growth factor is present in human amniotic fluid and breast milk
    • Michalsky MP, Lara-Marquez M, Chun L, Besner GE: Heparinbinding EGF-like growth factor is present in human amniotic fluid and breast milk. J Pediatr Surg 2002, 37:1-6.
    • (2002) J Pediatr Surg , vol.37 , pp. 1-6
    • Michalsky, M.P.1    Lara-Marquez, M.2    Chun, L.3    Besner, G.E.4
  • 16
    • 40749150576 scopus 로고    scopus 로고
    • Role of epidermal growth factor and other growth factors in the prevention of necrotizing enterocolitis
    • Nair RR, Warner BB, Warner BW: Role of epidermal growth factor and other growth factors in the prevention of necrotizing enterocolitis. Semin Perinatol 2008, 32:107-113.
    • (2008) Semin Perinatol , vol.32 , pp. 107-113
    • Nair, R.R.1    Warner, B.B.2    Warner, B.W.3
  • 18
    • 33645280594 scopus 로고    scopus 로고
    • Heparin-binding epidermal growth factor-like growth factor reduces intestinal apoptosis in neonatal rats with necrotizing enterocolitis
    • discussion -7
    • Feng J, El-Assal ON, Besner GE: Heparin-binding epidermal growth factor-like growth factor reduces intestinal apoptosis in neonatal rats with necrotizing enterocolitis. J Pediatr Surg 2006, 41:742-747. discussion -7.
    • (2006) J Pediatr Surg , vol.41 , pp. 742-747
    • Feng, J.1    El-Assal, O.N.2    Besner, G.E.3
  • 19
    • 0037429722 scopus 로고    scopus 로고
    • ErbB-4: Mechanism of action and biology
    • Carpenter G: ErbB-4: Mechanism of action and biology. Exp Cell Res 2003, 284:66-77.
    • (2003) Exp Cell Res , vol.284 , pp. 66-77
    • Carpenter, G.1
  • 20
    • 49449092035 scopus 로고    scopus 로고
    • System-wide investigation of ErbB4 reveals 19 sites of Tyr phosphorylation that are unusually selective in their recruitment properties
    • Kaushansky A, Gordus A, Budnik BA, Lane WS, Rush J, MacBeath G: System-wide investigation of ErbB4 reveals 19 sites of Tyr phosphorylation that are unusually selective in their recruitment properties. Chem Biol 2008, 15:808-817.
    • (2008) Chem Biol , vol.15 , pp. 808-817
    • Kaushansky, A.1    Gordus, A.2    Budnik, B.A.3    Lane, W.S.4    Rush, J.5    MacBeath, G.6
  • 21
    • 0033614356 scopus 로고    scopus 로고
    • Neuregulin-4: A novel growth factor that acts through the ErbB-4 receptor tyrosine kinase
    • Harari D, Tzahar E, Romano J, Shelly M, Pierce JH, Andrews GC, Yarden Y: Neuregulin-4: A novel growth factor that acts through the ErbB-4 receptor tyrosine kinase. Oncogene 1999, 18:2681-2689.
    • (1999) Oncogene , vol.18 , pp. 2681-2689
    • Harari, D.1    Tzahar, E.2    Romano, J.3    Shelly, M.4    Pierce, J.H.5    Andrews, G.C.6    Yarden, Y.7
  • 22
    • 84873957232 scopus 로고    scopus 로고
    • Neuregulin-4 is a survival factor for colon epithelial cells both in culture and in vivo
    • Bernard JK, McCann SP, Bhardwaj V, Washington MK, Frey MR: Neuregulin-4 is a survival factor for colon epithelial cells both in culture and in vivo. J Biol Chem 2012, 287:39850-39858.
    • (2012) J Biol Chem , vol.287 , pp. 39850-39858
    • Bernard, J.K.1    McCann, S.P.2    Bhardwaj, V.3    Washington, M.K.4    Frey, M.R.5
  • 23
    • 59849113041 scopus 로고    scopus 로고
    • The ErbB4 growth factor receptor is required for colon epithelial cell survival in the presence of TNF
    • Frey MR, Edelblum KL, Mullane MT, Liang D, Polk DB: The ErbB4 growth factor receptor is required for colon epithelial cell survival in the presence of TNF. Gastroenterology 2009, 136:217-226.
    • (2009) Gastroenterology , vol.136 , pp. 217-226
    • Frey, M.R.1    Edelblum, K.L.2    Mullane, M.T.3    Liang, D.4    Polk, D.B.5
  • 25
    • 0344683235 scopus 로고    scopus 로고
    • Committee for the Update of the Guide for the Care and Use of Laboratory Animals; National Research Council:, Eighth Edition. Washington, DC, National Academies Press
    • Committee for the Update of the Guide for the Care and Use of Laboratory Animals; National Research Council: Guide for the Care and Use of Laboratory Animals: Eighth Edition. Washington, DC, National Academies Press, 2011.
    • (2011) Guide for the Care and Use of Laboratory Animals
  • 27
    • 84863470791 scopus 로고    scopus 로고
    • Paneth cell ablation in the presence of Klebsiella pneumoniae induces necrotizing enterocolitis (NEC)-like injury in the small intestine of immature mice
    • Zhang C, ShermanMP, Prince LS, Bader D, Weitkamp JH, Slaughter JC, McElroy SJ: Paneth cell ablation in the presence of Klebsiella pneumoniae induces necrotizing enterocolitis (NEC)-like injury in the small intestine of immature mice. Dis Model Mech 2012, 5:522-532.
    • (2012) Dis Model Mech , vol.5 , pp. 522-532
    • Zhang, C.1    Sherman, M.P.2    Prince, L.S.3    Bader, D.4    Weitkamp, J.H.5    Slaughter, J.C.6    McElroy, S.J.7
  • 28
    • 0025821387 scopus 로고
    • Selective killing of Paneth cells by intravenous administration of dithizone in rats
    • Sawada M, Takahashi K, Sawada S, Midorikawa O: Selective killing of Paneth cells by intravenous administration of dithizone in rats. Int J Exp Pathol 1991, 72:407-421.
    • (1991) Int J Exp Pathol , vol.72 , pp. 407-421
    • Sawada, M.1    Takahashi, K.2    Sawada, S.3    Midorikawa, O.4
  • 29
    • 0242550638 scopus 로고    scopus 로고
    • Impaired differentiation and lactational failure of Erbb4-deficient mammary glands identify ERBB4 as an obligate mediator of STAT5
    • Long W, Wagner KU, Lloyd KC, Binart N, Shillingford JM, Hennighausen L, Jones FE: Impaired differentiation and lactational failure of Erbb4-deficient mammary glands identify ERBB4 as an obligate mediator of STAT5. Development 2003, 130:5257-5268.
    • (2003) Development , vol.130 , pp. 5257-5268
    • Long, W.1    Wagner, K.U.2    Lloyd, K.C.3    Binart, N.4    Shillingford, J.M.5    Hennighausen, L.6    Jones, F.E.7
  • 31
    • 48549099464 scopus 로고    scopus 로고
    • Cronobacter gen. Nov., a new genus to accommodate the biogroups of Enterobacter sakazakii, and proposal of Cronobacter sakazakii gen. Nov.
    • comb. Nov., Cronobacter malonaticus sp. Nov., Cronobacter turicensis sp. Nov., Cronobacter muytjensii sp. Nov., Cronobacter dublinensis sp. Nov., Cronobacter genomospecies 1, and of three subspecies, Cronobacter dublinensis subsp. Dublinensis subsp. Nov., Cronobacter dublinensis subsp. Lausannensis subsp. Nov. And Cronobacter dublinensis subsp. Lactaridi subsp. Nov
    • Iversen C, Mullane N, McCardell B, Tall BD, Lehner A, Fanning S, Stephan R, Joosten H: Cronobacter gen. nov., a new genus to accommodate the biogroups of Enterobacter sakazakii, and proposal of Cronobacter sakazakii gen. nov., comb. nov., Cronobacter malonaticus sp. nov., Cronobacter turicensis sp. nov., Cronobacter muytjensii sp. nov., Cronobacter dublinensis sp. nov., Cronobacter genomospecies 1, and of three subspecies, Cronobacter dublinensis subsp. dublinensis subsp. nov., Cronobacter dublinensis subsp. lausannensis subsp. nov. and Cronobacter dublinensis subsp. lactaridi subsp. nov. Int J Syst Evol Microbiol 2008, 58:1442-1447.
    • (2008) Int J Syst Evol Microbiol , vol.58 , pp. 1442-1447
    • Iversen, C.1    Mullane, N.2    McCardell, B.3    Tall, B.D.4    Lehner, A.5    Fanning, S.6    Stephan, R.7    Joosten, H.8
  • 33
    • 79957907960 scopus 로고    scopus 로고
    • Colon-specific delivery of a probiotic-derived soluble protein ameliorates intestinal inflammation in mice through an EGFR-dependent mechanism
    • Yan F, Cao H, Cover TL, Washington MK, Shi Y, Liu L, Chaturvedi R, Peek RM Jr, Wilson KT, Polk DB: Colon-specific delivery of a probiotic-derived soluble protein ameliorates intestinal inflammation in mice through an EGFR-dependent mechanism. J Clin Invest 2011, 121:2242-2253.
    • (2011) J Clin Invest , vol.121 , pp. 2242-2253
    • Yan, F.1    Cao, H.2    Cover, T.L.3    Washington, M.K.4    Shi, Y.5    Liu, L.6    Chaturvedi, R.7    Peek, R.M.8    Wilson, K.T.9    Polk, D.B.10
  • 34
    • 84863248698 scopus 로고    scopus 로고
    • ErbB2 and ErbB3 regulate recovery from dextran sulfate sodium-induced colitis by promoting mouse colon epithelial cell survival
    • Zhang Y, Dube PE, Washington MK, Yan F, Polk DB: ErbB2 and ErbB3 regulate recovery from dextran sulfate sodium-induced colitis by promoting mouse colon epithelial cell survival. Lab Invest 2012, 92:437-450.
    • (2012) Lab Invest , vol.92 , pp. 437-450
    • Zhang, Y.1    Dube, P.E.2    Washington, M.K.3    Yan, F.4    Polk, D.B.5
  • 35
    • 50149105621 scopus 로고    scopus 로고
    • Transactivation of EGF receptor and ErbB2 protects intestinal epithelial cells from TNF-induced apoptosis
    • Yamaoka T, Yan F, Cao H, Hobbs SS, Dise RS, Tong W, Polk DB: Transactivation of EGF receptor and ErbB2 protects intestinal epithelial cells from TNF-induced apoptosis. Proc Natl Acad Sci U S A 2008, 105:11772-11777.
    • (2008) Proc Natl Acad Sci U S A , vol.105 , pp. 11772-11777
    • Yamaoka, T.1    Yan, F.2    Cao, H.3    Hobbs, S.S.4    Dise, R.S.5    Tong, W.6    Polk, D.B.7
  • 36
    • 77957282682 scopus 로고    scopus 로고
    • ErbB4 promotes cyclooxygenase-2 expression and cell survival in colon epithelial cells
    • Frey MR, Hilliard VC, Mullane MT, Polk DB: ErbB4 promotes cyclooxygenase-2 expression and cell survival in colon epithelial cells. Lab Invest 2010, 90:1415-1424.
    • (2010) Lab Invest , vol.90 , pp. 1415-1424
    • Frey, M.R.1    Hilliard, V.C.2    Mullane, M.T.3    Polk, D.B.4
  • 37
    • 0038309528 scopus 로고    scopus 로고
    • Increased epidermal growth factor levels in human milk of mothers with extremely premature infants
    • Dvorak B, Fituch CC, Williams CS, Hurst NM, Schanler RJ: Increased epidermal growth factor levels in human milk of mothers with extremely premature infants. Pediatr Res 2003, 54:15-19.
    • (2003) Pediatr Res , vol.54 , pp. 15-19
    • Dvorak, B.1    Fituch, C.C.2    Williams, C.S.3    Hurst, N.M.4    Schanler, R.J.5
  • 38
    • 0031827634 scopus 로고    scopus 로고
    • Expression of the c-erbB-4/HER4 protein and mRNA in normal human fetal and adult tissues and in a survey of nine solid tumour types
    • Srinivasan R, Poulsom R, Hurst HC, Gullick WJ: Expression of the c-erbB-4/HER4 protein and mRNA in normal human fetal and adult tissues and in a survey of nine solid tumour types. J Pathol 1998, 185: 236-245.
    • (1998) J Pathol , vol.185 , pp. 236-245
    • Srinivasan, R.1    Poulsom, R.2    Hurst, H.C.3    Gullick, W.J.4
  • 39
    • 84855304103 scopus 로고    scopus 로고
    • Epidermal growth factor/TNF-alpha transactivation modulates epithelial cell proliferation and apoptosis in a mouse model of parenteral nutrition
    • Feng Y, Teitelbaum DH: Epidermal growth factor/TNF-alpha transactivation modulates epithelial cell proliferation and apoptosis in a mouse model of parenteral nutrition. Am J Physiol Gastrointest Liver Physiol 2012, 302:G236-G249.
    • (2012) Am J Physiol Gastrointest Liver Physiol , vol.302 , pp. G236-G249
    • Feng, Y.1    Teitelbaum, D.H.2
  • 40
    • 0022362070 scopus 로고
    • Growth factor concentrations and growth-promoting activity in human milk following premature birth
    • Read LC, Francis GL, Wallace JC, Ballard FJ: Growth factor concentrations and growth-promoting activity in human milk following premature birth. J Dev Physiol 1985, 7:135-145.
    • (1985) J Dev Physiol , vol.7 , pp. 135-145
    • Read, L.C.1    Francis, G.L.2    Wallace, J.C.3    Ballard, F.J.4
  • 41
    • 79961011027 scopus 로고    scopus 로고
    • Specific epidermal growth factor receptor autophosphorylation sites promote mouse colon epithelial cell chemotaxis and restitution
    • Yamaoka T, Frey MR, Dise RS, Bernard JK, Polk DB: Specific epidermal growth factor receptor autophosphorylation sites promote mouse colon epithelial cell chemotaxis and restitution. Am J Physiol Gastrointest Liver Physiol 2011, 301:G368-G376.
    • (2011) Am J Physiol Gastrointest Liver Physiol , vol.301 , pp. G368-G376
    • Yamaoka, T.1    Frey, M.R.2    Dise, R.S.3    Bernard, J.K.4    Polk, D.B.5
  • 42
  • 44
    • 77957766222 scopus 로고    scopus 로고
    • Heparin-binding epidermal growth factor-like growth factor overexpression in transgenic mice increases resistance to necrotizing enterocolitis
    • Radulescu A, Zhang HY, Yu X, Olson JK, Darbyshire AK, Chen Y, Besner GE: Heparin-binding epidermal growth factor-like growth factor overexpression in transgenic mice increases resistance to necrotizing enterocolitis. J Pediatr Surg 2010, 45:1933-1939.
    • (2010) J Pediatr Surg , vol.45 , pp. 1933-1939
    • Radulescu, A.1    Zhang, H.Y.2    Yu, X.3    Olson, J.K.4    Darbyshire, A.K.5    Chen, Y.6    Besner, G.E.7
  • 45
    • 33845927363 scopus 로고    scopus 로고
    • Heparin-binding epidermal growth factor-like growth factor promotes enterocyte migration and proliferation in neonatal rats with necrotizing enterocolitis
    • Feng J, Besner GE: Heparin-binding epidermal growth factor-like growth factor promotes enterocyte migration and proliferation in neonatal rats with necrotizing enterocolitis. J Pediatr Surg 2007, 42: 214-220.
    • (2007) J Pediatr Surg , vol.42 , pp. 214-220
    • Feng, J.1    Besner, G.E.2
  • 46
    • 0037044783 scopus 로고    scopus 로고
    • Transactivation of the epidermal growth factor receptor in colonic epithelial cells by carbachol requires extracellular release of transforming growth factoralpha
    • McCole DF, Keely SJ, Coffey RJ, Barrett KE: Transactivation of the epidermal growth factor receptor in colonic epithelial cells by carbachol requires extracellular release of transforming growth factoralpha. J Biol Chem 2002, 277:42603-42612.
    • (2002) J Biol Chem , vol.277 , pp. 42603-42612
    • Mccole, D.F.1    Keely, S.J.2    Coffey, R.J.3    Barrett, K.E.4
  • 50
    • 78751625682 scopus 로고    scopus 로고
    • Necrotizing enterocolitis
    • Neu J, Walker WA: Necrotizing enterocolitis. N Engl J Med 2011, 364:255-264.
    • (2011) N Engl J Med , vol.364 , pp. 255-264
    • Neu, J.1    Walker, W.A.2
  • 51
    • 84863021827 scopus 로고    scopus 로고
    • Canadian Neonatal Network: Incidence and timing of presentation of necrotizing enterocolitis in preterm infants
    • Yee WH, Soraisham AS, Shah VS, Aziz K, Yoon W, Lee SK; Canadian Neonatal Network: Incidence and timing of presentation of necrotizing enterocolitis in preterm infants. Pediatrics 2012, 129: 298-304.
    • (2012) Pediatrics , vol.129 , pp. 298-304
    • Yee, W.H.1    Soraisham, A.S.2    Shah, V.S.3    Aziz, K.4    Yoon, W.5    Lee, S.K.6
  • 52
    • 84863229817 scopus 로고    scopus 로고
    • Heparin-binding EGF-like growth factor protects intestinal stem cells from injury in a rat model of necrotizing enterocolitis
    • Chen CL, Yu X, James IO, Zhang HY, Yang J, Radulescu A, Zhou Y, Besner GE: Heparin-binding EGF-like growth factor protects intestinal stem cells from injury in a rat model of necrotizing enterocolitis. Lab Invest 2012, 92:331-344.
    • (2012) Lab Invest , vol.92 , pp. 331-344
    • Chen, C.L.1    Yu, X.2    James, I.O.3    Zhang, H.Y.4    Yang, J.5    Radulescu, A.6    Zhou, Y.7    Besner, G.E.8
  • 55
    • 84869864069 scopus 로고    scopus 로고
    • Redundant sources of Wnt regulate intestinal stem cells and promote formation of Paneth cells
    • Farin HF, Van Es JH, Clevers H: Redundant sources of Wnt regulate intestinal stem cells and promote formation of Paneth cells. Gastroenterology 2012, 143:1518-1529.
    • (2012) Gastroenterology , vol.143 , pp. 1518-1529
    • Farin, H.F.1    Van Es, J.H.2    Clevers, H.3
  • 56
    • 0042858208 scopus 로고    scopus 로고
    • WW domain-containing protein YAP associates with ErbB-4 and acts as a co-transcriptional activator for the carboxyl-terminal fragment of ErbB-4 that translocates to the nucleus
    • Komuro A, Nagai M, Navin NE, Sudol M: WW domain-containing protein YAP associates with ErbB-4 and acts as a co-transcriptional activator for the carboxyl-terminal fragment of ErbB-4 that translocates to the nucleus. J Biol Chem 2003, 278:33334-33341.
    • (2003) J Biol Chem , vol.278 , pp. 33334-33341
    • Komuro, A.1    Nagai, M.2    Navin, N.E.3    Sudol, M.4
  • 58
    • 62449218076 scopus 로고    scopus 로고
    • Lactobacillus bulgaricus prevents intestinal epithelial cell injury caused by Enterobacter sakazakii-induced nitric oxide both in vitro and in the newborn rat model of necrotizing enterocolitis
    • Hunter CJ, Williams M, Petrosyan M, Guner Y, Mittal R, Mock D, Upperman JS, Ford HR, Prasadarao NV: Lactobacillus bulgaricus prevents intestinal epithelial cell injury caused by Enterobacter sakazakii-induced nitric oxide both in vitro and in the newborn rat model of necrotizing enterocolitis. Infect Immun 2009, 77: 1031-1043.
    • (2009) Infect Immun , vol.77 , pp. 1031-1043
    • Hunter, C.J.1    Williams, M.2    Petrosyan, M.3    Guner, Y.4    Mittal, R.5    Mock, D.6    Upperman, J.S.7    Ford, H.R.8    Prasadarao, N.V.9


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.