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Volumn 45, Issue 7, 2013, Pages 552-555

Smad7 antisense oligonucleotide-based therapy for inflammatory bowel diseases

Author keywords

Inflammatory bowel disease; Smad7

Indexed keywords

ANTISENSE OLIGONUCLEOTIDE; GAMMA INTERFERON; GED 0301; INTERLEUKIN 12; INTERLEUKIN 17; INTERLEUKIN 4; OXAZOLONE; SMAD3 PROTEIN; SMAD7 PROTEIN; TRANSFORMING GROWTH FACTOR BETA RECEPTOR; TRANSFORMING GROWTH FACTOR BETA1; UNCLASSIFIED DRUG;

EID: 84881260209     PISSN: 15908658     EISSN: 18783562     Source Type: Journal    
DOI: 10.1016/j.dld.2012.11.011     Document Type: Article
Times cited : (14)

References (32)
  • 2
    • 34547176642 scopus 로고    scopus 로고
    • Unravelling the pathogenesis of inflammatory bowel disease
    • Xavier R.J., Podolsky D.K. Unravelling the pathogenesis of inflammatory bowel disease. Nature 2007, 448:427-434.
    • (2007) Nature , vol.448 , pp. 427-434
    • Xavier, R.J.1    Podolsky, D.K.2
  • 3
    • 79959216005 scopus 로고    scopus 로고
    • Genetics and pathogenesis of inflammatory bowel disease
    • Khor B., Gardet A., Xavier R.J. Genetics and pathogenesis of inflammatory bowel disease. Nature 2011, 474:307-317.
    • (2011) Nature , vol.474 , pp. 307-317
    • Khor, B.1    Gardet, A.2    Xavier, R.J.3
  • 4
    • 0142053206 scopus 로고    scopus 로고
    • The immunological and genetic basis of inflammatory bowel disease
    • Bouma G., Strober W. The immunological and genetic basis of inflammatory bowel disease. Nature Reviews Immunology 2003, 3:521-533.
    • (2003) Nature Reviews Immunology , vol.3 , pp. 521-533
    • Bouma, G.1    Strober, W.2
  • 6
    • 0027724228 scopus 로고
    • Transforming growth factor-beta 1 knockout mice. A mutation in one cytokine gene causes a dramatic inflammatory disease
    • Kulkarni A.B., Karlsson S. Transforming growth factor-beta 1 knockout mice. A mutation in one cytokine gene causes a dramatic inflammatory disease. American Journal of Pathology 1993, 143:3-9.
    • (1993) American Journal of Pathology , vol.143 , pp. 3-9
    • Kulkarni, A.B.1    Karlsson, S.2
  • 7
    • 0036372440 scopus 로고    scopus 로고
    • Transforming growth factor β in T cell biology
    • Gorelik L., Flavel R.A. Transforming growth factor β in T cell biology. Nature Reviews Immunology 2002, 2:46-53.
    • (2002) Nature Reviews Immunology , vol.2 , pp. 46-53
    • Gorelik, L.1    Flavel, R.A.2
  • 8
    • 0029995799 scopus 로고    scopus 로고
    • Experimental granulomatous colitis in mice is abrogated by induction of TGF-β-mediated oral tolerance
    • Neurath M.F., Fuss I., Kelsall B.L., et al. Experimental granulomatous colitis in mice is abrogated by induction of TGF-β-mediated oral tolerance. Journal of Experimental Medicine 1996, 183:2605-2616.
    • (1996) Journal of Experimental Medicine , vol.183 , pp. 2605-2616
    • Neurath, M.F.1    Fuss, I.2    Kelsall, B.L.3
  • 9
    • 0032538915 scopus 로고    scopus 로고
    • Oxazolone colitis: a murine model of T helper cell type 2 colitis treatable with antibodies to interleukin 4
    • Boirivant M., Fuss I.J., Chu A., et al. Oxazolone colitis: a murine model of T helper cell type 2 colitis treatable with antibodies to interleukin 4. Journal of Experimental Medicine 1998, 188:1929-1939.
    • (1998) Journal of Experimental Medicine , vol.188 , pp. 1929-1939
    • Boirivant, M.1    Fuss, I.J.2    Chu, A.3
  • 10
    • 0029956024 scopus 로고    scopus 로고
    • A critical role for transforming growth factor-β but not interleukin 4 in the suppression of T helper type 1-mediated colitis by CD45RBlow CD4+ T cells
    • Powrie F., Carlino J., Leach M.W., et al. A critical role for transforming growth factor-β but not interleukin 4 in the suppression of T helper type 1-mediated colitis by CD45RBlow CD4+ T cells. Journal of Experimental Medicine 1996, 183:2669-2674.
    • (1996) Journal of Experimental Medicine , vol.183 , pp. 2669-2674
    • Powrie, F.1    Carlino, J.2    Leach, M.W.3
  • 11
    • 0038682002 scopus 로고    scopus 로고
    • Mechanisms of TGF-beta signaling from cell membrane to the nucleus
    • Shi Y., Massague J. Mechanisms of TGF-beta signaling from cell membrane to the nucleus. Cell 2003, 113:685-700.
    • (2003) Cell , vol.113 , pp. 685-700
    • Shi, Y.1    Massague, J.2
  • 12
    • 0031438047 scopus 로고    scopus 로고
    • TGF-beta signalling from cell membrane to nucleus through SMAD proteins
    • Heldin C.H., Kohei M., Ten Dijke P. TGF-beta signalling from cell membrane to nucleus through SMAD proteins. Nature 1997, 390:465-471.
    • (1997) Nature , vol.390 , pp. 465-471
    • Heldin, C.H.1    Kohei, M.2    Ten Dijke, P.3
  • 13
    • 0033104503 scopus 로고    scopus 로고
    • Targeted disruption of SMAD3 results in impaired mucosal immunity and diminished T cell responsiveness to TGF-beta
    • Yang X., Letterio J.J., Lechleider R.J., et al. Targeted disruption of SMAD3 results in impaired mucosal immunity and diminished T cell responsiveness to TGF-beta. EMBO Journal 1999, 18:1280-1291.
    • (1999) EMBO Journal , vol.18 , pp. 1280-1291
    • Yang, X.1    Letterio, J.J.2    Lechleider, R.J.3
  • 14
    • 42549143615 scopus 로고    scopus 로고
    • Blockade of transforming growth factor beta upregulates T-box transcription factor T-bet, and increases T helper cell type 1 cytokine and matrix metalloproteinase-3 production in the human gut mucosa
    • Di Sabatino A., Pickard K.M., Rampton D., et al. Blockade of transforming growth factor beta upregulates T-box transcription factor T-bet, and increases T helper cell type 1 cytokine and matrix metalloproteinase-3 production in the human gut mucosa. Gut 2008, 57:605-612.
    • (2008) Gut , vol.57 , pp. 605-612
    • Di Sabatino, A.1    Pickard, K.M.2    Rampton, D.3
  • 15
    • 0034894059 scopus 로고    scopus 로고
    • Blocking Smad7 restores TGF-beta1 signaling in chronic inflammatory bowel disease
    • Monteleone G., Kumberova A., Croft N.M., et al. Blocking Smad7 restores TGF-beta1 signaling in chronic inflammatory bowel disease. Journal of Clinical Investigation 2001, 108:601-609.
    • (2001) Journal of Clinical Investigation , vol.108 , pp. 601-609
    • Monteleone, G.1    Kumberova, A.2    Croft, N.M.3
  • 16
    • 0029913624 scopus 로고    scopus 로고
    • Expression of transforming growth factors alpha and beta in colonic mucosa in inflammatory bowel disease
    • Babyatsky M.W., Rossiter G., Podolsky D.K. Expression of transforming growth factors alpha and beta in colonic mucosa in inflammatory bowel disease. Gastroenterology 1996, 110:975-984.
    • (1996) Gastroenterology , vol.110 , pp. 975-984
    • Babyatsky, M.W.1    Rossiter, G.2    Podolsky, D.K.3
  • 17
    • 1042266673 scopus 로고    scopus 로고
    • A failure of transforming growth factor-β1 negative regulation maintains sustained NF-κB activation in gut inflammation
    • Monteleone G., Mann J., Monteleone I., et al. A failure of transforming growth factor-β1 negative regulation maintains sustained NF-κB activation in gut inflammation. Journal of Biological Chemistry 2004, 279:3925-3932.
    • (2004) Journal of Biological Chemistry , vol.279 , pp. 3925-3932
    • Monteleone, G.1    Mann, J.2    Monteleone, I.3
  • 18
    • 0030611757 scopus 로고    scopus 로고
    • Identification of Smad7, a TGFbeta-inducible antagonist of TGF betasignalling
    • Nakao A., Afrakhte M., Morén A., et al. Identification of Smad7, a TGFbeta-inducible antagonist of TGF betasignalling. Nature 1997, 389:631-635.
    • (1997) Nature , vol.389 , pp. 631-635
    • Nakao, A.1    Afrakhte, M.2    Morén, A.3
  • 19
    • 1642539976 scopus 로고    scopus 로고
    • GADD34-PP1c recruited by Smad7 dephosphorylates TGFbeta type I receptor
    • Shi W., Sun C., He B., et al. GADD34-PP1c recruited by Smad7 dephosphorylates TGFbeta type I receptor. Journal of Cell Biology 2004, 164:291-300.
    • (2004) Journal of Cell Biology , vol.164 , pp. 291-300
    • Shi, W.1    Sun, C.2    He, B.3
  • 20
    • 10744231157 scopus 로고    scopus 로고
    • Induction and regulation of Smad7 in the gastric mucosa of patients with Helicobacter pylori infection
    • Monteleone G., Del Vecchio Blanco G., Palmieri G., et al. Induction and regulation of Smad7 in the gastric mucosa of patients with Helicobacter pylori infection. Gastroenterology 2004, 126:674-682.
    • (2004) Gastroenterology , vol.126 , pp. 674-682
    • Monteleone, G.1    Del Vecchio Blanco, G.2    Palmieri, G.3
  • 21
    • 33947322862 scopus 로고    scopus 로고
    • Inhibition of TGF-β signaling by IL-15: a new role for IL-15 in the loss of immune homeostasis in celiac disease
    • Benahmed M., Meresse B., Arnulf B., et al. Inhibition of TGF-β signaling by IL-15: a new role for IL-15 in the loss of immune homeostasis in celiac disease. Gastroenterology 2007, 132:994-1008.
    • (2007) Gastroenterology , vol.132 , pp. 994-1008
    • Benahmed, M.1    Meresse, B.2    Arnulf, B.3
  • 22
    • 0028861975 scopus 로고
    • Antibodies to IL-12 abrogate established experimental colitis in mice
    • Neurath M.F., Fuss I., Kelsal B.L., et al. Antibodies to IL-12 abrogate established experimental colitis in mice. Journal of Experimental Medicine 1995, 182:1281-1289.
    • (1995) Journal of Experimental Medicine , vol.182 , pp. 1281-1289
    • Neurath, M.F.1    Fuss, I.2    Kelsal, B.L.3
  • 23
    • 33845647693 scopus 로고    scopus 로고
    • Di Giacinto CAT-AL Inhibition of Smad7 with a specific antisense oligonucleotide facilitates TGF-beta1-mediated suppression of colitis
    • Boirivant M., Pallone F., Di Giacinto C Inhibition of Smad7 with a specific antisense oligonucleotide facilitates TGF-beta1-mediated suppression of colitis. Gastroenterology 2006, 131:1786-1798.
    • (2006) Gastroenterology , vol.131 , pp. 1786-1798
    • Boirivant, M.1    Pallone, F.2
  • 24
    • 54349127897 scopus 로고    scopus 로고
    • TGF-beta1 and Smad7 in the regulation of IBD
    • Monteleone G., Boirivant M., Pallone F., et al. TGF-beta1 and Smad7 in the regulation of IBD. Mucosal Immunology 2008, 1(Suppl. 1):S50-S53.
    • (2008) Mucosal Immunology , vol.1 , Issue.SUPPL. 1
    • Monteleone, G.1    Boirivant, M.2    Pallone, F.3
  • 25
    • 84859439270 scopus 로고    scopus 로고
    • Phase I clinical trial of Smad7 knockdown using antisense oligonucleotide in patients with active Crohn's disease
    • Monteleone G., Fantini M.C., Onali S., et al. Phase I clinical trial of Smad7 knockdown using antisense oligonucleotide in patients with active Crohn's disease. Molecular Therapy 2012, 20:870-876.
    • (2012) Molecular Therapy , vol.20 , pp. 870-876
    • Monteleone, G.1    Fantini, M.C.2    Onali, S.3
  • 26
    • 33847390444 scopus 로고    scopus 로고
    • Phenotype and effector function of CC chemokine receptor 9-expressing lymphocytes in small intestinal Crohn's disease
    • Saruta M., Yu Q.T., Avanesyan A., et al. Phenotype and effector function of CC chemokine receptor 9-expressing lymphocytes in small intestinal Crohn's disease. Journal of Immunology 2007, 178:3293-3300.
    • (2007) Journal of Immunology , vol.178 , pp. 3293-3300
    • Saruta, M.1    Yu, Q.T.2    Avanesyan, A.3
  • 27
    • 84878568056 scopus 로고    scopus 로고
    • A phase 1 open-label trial shows that Smad7 antisense oligonucleotide (GED0301) does not increase the risk of small bowel strictures in Crohn's disease
    • [Epub ahead of print]
    • Zorzi F., Calabrese E., Monteleone I., et al. A phase 1 open-label trial shows that Smad7 antisense oligonucleotide (GED0301) does not increase the risk of small bowel strictures in Crohn's disease. Alimentary Pharmacology and Therapeutics 2012, [Epub ahead of print].
    • (2012) Alimentary Pharmacology and Therapeutics
    • Zorzi, F.1    Calabrese, E.2    Monteleone, I.3
  • 29
    • 19344374130 scopus 로고    scopus 로고
    • Smad7 in TGF-β-mediated negative regulation of gut inflammation
    • Monteleone G., Pallone F., MacDonald T.T. Smad7 in TGF-β-mediated negative regulation of gut inflammation. Trends in Immunology 2004, 25:513-517.
    • (2004) Trends in Immunology , vol.25 , pp. 513-517
    • Monteleone, G.1    Pallone, F.2    MacDonald, T.T.3
  • 30
    • 2142646426 scopus 로고    scopus 로고
    • TGF-beta signaling and the fibrotic response
    • Leask A., Abraham D.J. TGF-beta signaling and the fibrotic response. FASEB Journal 2004, 18:816-827.
    • (2004) FASEB Journal , vol.18 , pp. 816-827
    • Leask, A.1    Abraham, D.J.2
  • 32
    • 84255192090 scopus 로고    scopus 로고
    • Smad7 expression in T cells prevents colitis-associated cancer
    • Rizzo A., Waldner M.J., Stolfi C., et al. Smad7 expression in T cells prevents colitis-associated cancer. Cancer Research 2011, 71:7423-7432.
    • (2011) Cancer Research , vol.71 , pp. 7423-7432
    • Rizzo, A.1    Waldner, M.J.2    Stolfi, C.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.