메뉴 건너뛰기




Volumn 411, Issue , 2015, Pages 28-37

Melanocortin 4 receptor activates ERK-cFos pathway to increase brain-derived neurotrophic factor expression in rat astrocytes and hypothalamus

Author keywords

Astrocytes; BDNF; CFos; ERK; Hypothalamus; MC4R

Indexed keywords

ALPHA INTERMEDIN; BRAIN DERIVED NEUROTROPHIC FACTOR; CYCLIC AMP; MELANOCORTIN 4 RECEPTOR; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE P38; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN C FOS; PROTEIN TYROSINE KINASE; S6 KINASE; STRESS ACTIVATED PROTEIN KINASE; MSH, 4-NLE-7-PHE-ALPHA-;

EID: 84930181415     PISSN: 03037207     EISSN: 18728057     Source Type: Journal    
DOI: 10.1016/j.mce.2015.04.008     Document Type: Article
Times cited : (33)

References (55)
  • 1
    • 66649122305 scopus 로고    scopus 로고
    • Brain-derived neurotrophic factor/tropomyosin-related kinase receptor type B signaling is a downstream effector of the brainstem melanocortin system in food intake control
    • Bariohay B., et al. Brain-derived neurotrophic factor/tropomyosin-related kinase receptor type B signaling is a downstream effector of the brainstem melanocortin system in food intake control. Endocrinology 2009, 150:2646-2653.
    • (2009) Endocrinology , vol.150 , pp. 2646-2653
    • Bariohay, B.1
  • 2
    • 84859423397 scopus 로고    scopus 로고
    • Melanocortin-3 receptors are involved in adaptation to restricted feeding
    • Begriche K., et al. Melanocortin-3 receptors are involved in adaptation to restricted feeding. Genes Brain Behav 2012, 11:291-302.
    • (2012) Genes Brain Behav , vol.11 , pp. 291-302
    • Begriche, K.1
  • 3
    • 78650273555 scopus 로고    scopus 로고
    • Alternative G protein coupling and biased agonism: new insights into melanocortin-4 receptor signalling
    • Breit A., et al. Alternative G protein coupling and biased agonism: new insights into melanocortin-4 receptor signalling. Mol. Cell. Endocrinol 2011, 331:232-240.
    • (2011) Mol. Cell. Endocrinol , vol.331 , pp. 232-240
    • Breit, A.1
  • 4
    • 3242756910 scopus 로고    scopus 로고
    • Alpha-melanocyte-stimulating hormone through melanocortin-4 receptor inhibits nitric oxide synthase and cyclooxygenase expression in the hypothalamus of male rats
    • Caruso C., et al. Alpha-melanocyte-stimulating hormone through melanocortin-4 receptor inhibits nitric oxide synthase and cyclooxygenase expression in the hypothalamus of male rats. Neuroendocrinology 2004, 79:278-286.
    • (2004) Neuroendocrinology , vol.79 , pp. 278-286
    • Caruso, C.1
  • 5
    • 34748907751 scopus 로고    scopus 로고
    • Activation of melanocortin 4 receptors reduces the inflammatory response and prevents apoptosis induced by lipopolysaccharide and interferon-gamma in astrocytes
    • Caruso C., et al. Activation of melanocortin 4 receptors reduces the inflammatory response and prevents apoptosis induced by lipopolysaccharide and interferon-gamma in astrocytes. Endocrinology 2007, 148:4918-4926.
    • (2007) Endocrinology , vol.148 , pp. 4918-4926
    • Caruso, C.1
  • 6
    • 77956647428 scopus 로고    scopus 로고
    • Alpha-melanocyte-stimulating hormone modulates lipopolysaccharide plus interferon-gamma-induced tumor necrosis factor-alpha expression but not tumor necrosis factor-alpha receptor expression in cultured hypothalamic neurons
    • Caruso C., et al. Alpha-melanocyte-stimulating hormone modulates lipopolysaccharide plus interferon-gamma-induced tumor necrosis factor-alpha expression but not tumor necrosis factor-alpha receptor expression in cultured hypothalamic neurons. J. Neuroimmunol 2010, 227:52-59.
    • (2010) J. Neuroimmunol , vol.227 , pp. 52-59
    • Caruso, C.1
  • 7
    • 80755187744 scopus 로고    scopus 로고
    • Melanocortin 4 receptor activation induces brain-derived neurotrophic factor expression in rat astrocytes through cyclic AMP-protein kinase A pathway
    • Caruso C., et al. Melanocortin 4 receptor activation induces brain-derived neurotrophic factor expression in rat astrocytes through cyclic AMP-protein kinase A pathway. Mol. Cell. Endocrinol 2012, 348:47-54.
    • (2012) Mol. Cell. Endocrinol , vol.348 , pp. 47-54
    • Caruso, C.1
  • 8
    • 84908283261 scopus 로고    scopus 로고
    • Melanocortins: anti-inflammatory and neuroprotective peptides
    • Intech, Croatia, L.M.M.A.S. Loh (Ed.)
    • Caruso C., et al. Melanocortins: anti-inflammatory and neuroprotective peptides. Neurodegeneration 2012, 93-120. Intech, Croatia. L.M.M.A.S. Loh (Ed.).
    • (2012) Neurodegeneration , pp. 93-120
    • Caruso, C.1
  • 9
    • 84884618116 scopus 로고    scopus 로고
    • Astrocytes: new targets of melanocortin 4 receptor actions
    • Caruso C., et al. Astrocytes: new targets of melanocortin 4 receptor actions. J. Mol. Endocrinol 2013, 51:R33-R50.
    • (2013) J. Mol. Endocrinol , vol.51 , pp. R33-R50
    • Caruso, C.1
  • 10
    • 84892748471 scopus 로고    scopus 로고
    • Synaptic changes induced by melanocortin signalling
    • Caruso V., et al. Synaptic changes induced by melanocortin signalling. Nat. Rev. Neurosci 2014, 15:98-110.
    • (2014) Nat. Rev. Neurosci , vol.15 , pp. 98-110
    • Caruso, V.1
  • 11
    • 45849102029 scopus 로고    scopus 로고
    • Neuroprotective actions of melanocortins: a therapeutic opportunity
    • Catania A. Neuroprotective actions of melanocortins: a therapeutic opportunity. Trends Neurosci 2008, 31:353-360.
    • (2008) Trends Neurosci , vol.31 , pp. 353-360
    • Catania, A.1
  • 12
    • 33750042605 scopus 로고    scopus 로고
    • Melanocortin-4 receptor-mediated inhibition of apoptosis in immortalized hypothalamic neurons via mitogen-activated protein kinase
    • Chai B., et al. Melanocortin-4 receptor-mediated inhibition of apoptosis in immortalized hypothalamic neurons via mitogen-activated protein kinase. Peptides 2006, 27:2846-2857.
    • (2006) Peptides , vol.27 , pp. 2846-2857
    • Chai, B.1
  • 13
    • 67349277177 scopus 로고    scopus 로고
    • Melanocortin-4 receptor activation inhibits c-Jun N-terminal kinase activity and promotes insulin signaling
    • Chai B., et al. Melanocortin-4 receptor activation inhibits c-Jun N-terminal kinase activity and promotes insulin signaling. Peptides 2009, 30:1098-1104.
    • (2009) Peptides , vol.30 , pp. 1098-1104
    • Chai, B.1
  • 14
    • 0033818103 scopus 로고    scopus 로고
    • Inactivation of the mouse melanocortin-3 receptor results in increased fat mass and reduced lean body mass
    • Chen A.S., et al. Inactivation of the mouse melanocortin-3 receptor results in increased fat mass and reduced lean body mass. Nat. Genet 2000, 26:97-102.
    • (2000) Nat. Genet , vol.26 , pp. 97-102
    • Chen, A.S.1
  • 15
    • 84862938884 scopus 로고    scopus 로고
    • Melanocortin 4 receptor induces hyperalgesia and allodynia after chronic constriction injury by activation of p38 MAPK in DRG
    • Chu H., et al. Melanocortin 4 receptor induces hyperalgesia and allodynia after chronic constriction injury by activation of p38 MAPK in DRG. Int. J. Neurosci 2012, 122:74-81.
    • (2012) Int. J. Neurosci , vol.122 , pp. 74-81
    • Chu, H.1
  • 16
    • 38349105880 scopus 로고    scopus 로고
    • Disruption of the RIIbeta subunit of PKA reverses the obesity syndrome of Agouti lethal yellow mice
    • Czyzyk T.A., et al. Disruption of the RIIbeta subunit of PKA reverses the obesity syndrome of Agouti lethal yellow mice. Proc. Natl. Acad. Sci. U.S.A. 2008, 105:276-281.
    • (2008) Proc. Natl. Acad. Sci. U.S.A. , vol.105 , pp. 276-281
    • Czyzyk, T.A.1
  • 17
    • 84859151395 scopus 로고    scopus 로고
    • Melanocortin-induced PKA activation inhibits AMPK activity via ERK-1/2 and LKB-1 in hypothalamic GT1-7 cells
    • Damm E., et al. Melanocortin-induced PKA activation inhibits AMPK activity via ERK-1/2 and LKB-1 in hypothalamic GT1-7 cells. Mol. Endocrinol 2012, 26:643-654.
    • (2012) Mol. Endocrinol , vol.26 , pp. 643-654
    • Damm, E.1
  • 18
    • 0142026885 scopus 로고    scopus 로고
    • Melanocortin receptor signaling through mitogen-activated protein kinase in vitro and in rat hypothalamus
    • Daniels D., et al. Melanocortin receptor signaling through mitogen-activated protein kinase in vitro and in rat hypothalamus. Brain Res 2003, 986:1-11.
    • (2003) Brain Res , vol.986 , pp. 1-11
    • Daniels, D.1
  • 19
    • 79960340621 scopus 로고    scopus 로고
    • Reduced cAMP, Akt activation and p65-c-Rel dimerization: mechanisms involved in the protective effects of mGluR3 agonists in cultured astrocytes
    • Durand D., et al. Reduced cAMP, Akt activation and p65-c-Rel dimerization: mechanisms involved in the protective effects of mGluR3 agonists in cultured astrocytes. PLoS ONE 2011, 6:e22235.
    • (2011) PLoS ONE , vol.6 , pp. e22235
    • Durand, D.1
  • 20
    • 77957009475 scopus 로고    scopus 로고
    • Small-molecule inducers of insulin expression in pancreatic alpha-cells
    • Fomina-Yadlin D., et al. Small-molecule inducers of insulin expression in pancreatic alpha-cells. Proc. Natl. Acad. Sci. U.S.A. 2010, 107:15099-15104.
    • (2010) Proc. Natl. Acad. Sci. U.S.A. , vol.107 , pp. 15099-15104
    • Fomina-Yadlin, D.1
  • 21
    • 32544461870 scopus 로고    scopus 로고
    • Both early and delayed treatment with melanocortin 4 receptor-stimulating melanocortins produces neuroprotection in cerebral ischemia
    • Giuliani D., et al. Both early and delayed treatment with melanocortin 4 receptor-stimulating melanocortins produces neuroprotection in cerebral ischemia. Endocrinology 2006, 147:1126-1135.
    • (2006) Endocrinology , vol.147 , pp. 1126-1135
    • Giuliani, D.1
  • 22
    • 84889586854 scopus 로고    scopus 로고
    • Melanocortins protect against progression of Alzheimer's disease in triple-transgenic mice by targeting multiple pathophysiological pathways
    • Giuliani D., et al. Melanocortins protect against progression of Alzheimer's disease in triple-transgenic mice by targeting multiple pathophysiological pathways. Neurobiol. Aging 2014, 35:537-547.
    • (2014) Neurobiol. Aging , vol.35 , pp. 537-547
    • Giuliani, D.1
  • 23
    • 33845312299 scopus 로고    scopus 로고
    • ERK1/2 regulates ANG II-dependent cell proliferation via cytoplasmic activation of RSK2 and nuclear activation of elk1
    • Godeny M.D., Sayeski P.P. ERK1/2 regulates ANG II-dependent cell proliferation via cytoplasmic activation of RSK2 and nuclear activation of elk1. Am. J. Physiol. Cell Physiol 2006, 291:C1308-C1317.
    • (2006) Am. J. Physiol. Cell Physiol , vol.291 , pp. C1308-C1317
    • Godeny, M.D.1    Sayeski, P.P.2
  • 24
    • 84885024415 scopus 로고    scopus 로고
    • Molecular mechanisms involved in interleukin 1-beta (IL-1beta)-induced memory impairment. Modulation by alpha-melanocyte-stimulating hormone (alpha-MSH)
    • Gonzalez P., et al. Molecular mechanisms involved in interleukin 1-beta (IL-1beta)-induced memory impairment. Modulation by alpha-melanocyte-stimulating hormone (alpha-MSH). Brain Behav. Immun 2013, 34:141-150.
    • (2013) Brain Behav. Immun , vol.34 , pp. 141-150
    • Gonzalez, P.1
  • 25
    • 67650077092 scopus 로고    scopus 로고
    • Memory impairment induced by IL-1beta is reversed by alpha-MSH through central melanocortin-4 receptors
    • Gonzalez P.V., et al. Memory impairment induced by IL-1beta is reversed by alpha-MSH through central melanocortin-4 receptors. Brain Behav. Immun 2009, 23:817-822.
    • (2009) Brain Behav. Immun , vol.23 , pp. 817-822
    • Gonzalez, P.V.1
  • 26
    • 78650881154 scopus 로고    scopus 로고
    • Signaling from the human melanocortin 1 receptor to ERK1 and ERK2 mitogen-activated protein kinases involves transactivation of cKIT
    • Herraiz C., et al. Signaling from the human melanocortin 1 receptor to ERK1 and ERK2 mitogen-activated protein kinases involves transactivation of cKIT. Mol. Endocrinol 2011, 25:138-156.
    • (2011) Mol. Endocrinol , vol.25 , pp. 138-156
    • Herraiz, C.1
  • 27
    • 0030889192 scopus 로고    scopus 로고
    • Targeted disruption of the melanocortin-4 receptor results in obesity in mice
    • Huszar D., et al. Targeted disruption of the melanocortin-4 receptor results in obesity in mice. Cell 1997, 88:131-141.
    • (1997) Cell , vol.88 , pp. 131-141
    • Huszar, D.1
  • 28
    • 0029892470 scopus 로고    scopus 로고
    • Physiology of the neurotrophins
    • Lewin G.R., Barde Y.A. Physiology of the neurotrophins. Annu. Rev. Neurosci 1996, 19:289-317.
    • (1996) Annu. Rev. Neurosci , vol.19 , pp. 289-317
    • Lewin, G.R.1    Barde, Y.A.2
  • 29
    • 0034807142 scopus 로고    scopus 로고
    • Regulation of MAP kinase activity by peptide receptor signalling pathway: paradigms of multiplicity
    • Liebmann C. Regulation of MAP kinase activity by peptide receptor signalling pathway: paradigms of multiplicity. Cell. Signal 2001, 13:777-785.
    • (2001) Cell. Signal , vol.13 , pp. 777-785
    • Liebmann, C.1
  • 30
    • 0033613938 scopus 로고    scopus 로고
    • Beta-arrestin-dependent formation of beta2 adrenergic receptor-Src protein kinase complexes
    • Luttrell L.M., et al. Beta-arrestin-dependent formation of beta2 adrenergic receptor-Src protein kinase complexes. Science 1999, 283:655-661.
    • (1999) Science , vol.283 , pp. 655-661
    • Luttrell, L.M.1
  • 31
    • 0034268796 scopus 로고    scopus 로고
    • Src tyrosine kinase is a novel direct effector of G proteins
    • Ma Y.C., et al. Src tyrosine kinase is a novel direct effector of G proteins. Cell 2000, 102:635-646.
    • (2000) Cell , vol.102 , pp. 635-646
    • Ma, Y.C.1
  • 32
    • 77957828987 scopus 로고    scopus 로고
    • Alpha-melanocyte-stimulating hormone (alpha-MSH) reverses impairment of memory reconsolidation induced by interleukin-1 beta (IL-1 beta) hippocampal infusions
    • Machado I., et al. Alpha-melanocyte-stimulating hormone (alpha-MSH) reverses impairment of memory reconsolidation induced by interleukin-1 beta (IL-1 beta) hippocampal infusions. Peptides 2010, 31:2141-2144.
    • (2010) Peptides , vol.31 , pp. 2141-2144
    • Machado, I.1
  • 33
    • 0032900284 scopus 로고    scopus 로고
    • Response of melanocortin-4 receptor-deficient mice to anorectic and orexigenic peptides
    • Marsh D.J., et al. Response of melanocortin-4 receptor-deficient mice to anorectic and orexigenic peptides. Nat. Genet 1999, 21:119-122.
    • (1999) Nat. Genet , vol.21 , pp. 119-122
    • Marsh, D.J.1
  • 34
    • 0033867056 scopus 로고    scopus 로고
    • Effect of intracerebroventricular alpha-MSH on food intake, adiposity, c-Fos induction, and neuropeptide expression
    • McMinn J.E., et al. Effect of intracerebroventricular alpha-MSH on food intake, adiposity, c-Fos induction, and neuropeptide expression. Am. J. Physiol. Regul. Integr. Comp. Physiol 2000, 279:R695-R703.
    • (2000) Am. J. Physiol. Regul. Integr. Comp. Physiol , vol.279 , pp. R695-R703
    • McMinn, J.E.1
  • 35
    • 33747345898 scopus 로고    scopus 로고
    • P2Y receptors activate MAPK/ERK through a pathway involving PI3K/PDK1/PKC-zeta in human vein endothelial cells
    • Montiel M., de la Blanca E.P., Jimenez E. P2Y receptors activate MAPK/ERK through a pathway involving PI3K/PDK1/PKC-zeta in human vein endothelial cells. Cell. Physiol. Biochem 2006, 18:123-134.
    • (2006) Cell. Physiol. Biochem , vol.18 , pp. 123-134
    • Montiel, M.1    de la Blanca, E.P.2    Jimenez, E.3
  • 36
    • 78651284004 scopus 로고    scopus 로고
    • Characterization of GSK2334470, a novel and highly specific inhibitor of PDK1
    • Najafov A., et al. Characterization of GSK2334470, a novel and highly specific inhibitor of PDK1. Biochem. J. 2011, 433:357-369.
    • (2011) Biochem. J. , vol.433 , pp. 357-369
    • Najafov, A.1
  • 38
    • 79955023405 scopus 로고    scopus 로고
    • Activation and function of immediate-early genes in the nervous system
    • Perez-Cadahia B., Drobic B., Davie J.R. Activation and function of immediate-early genes in the nervous system. Biochem. Cell Biol 2011, 89:61-73.
    • (2011) Biochem. Cell Biol , vol.89 , pp. 61-73
    • Perez-Cadahia, B.1    Drobic, B.2    Davie, J.R.3
  • 39
    • 62949102680 scopus 로고    scopus 로고
    • Melanocortin 5 receptor activates ERK1/2 through a PI3K-regulated signaling mechanism
    • Rodrigues A.R., et al. Melanocortin 5 receptor activates ERK1/2 through a PI3K-regulated signaling mechanism. Mol. Cell. Endocrinol 2009, 303:74-81.
    • (2009) Mol. Cell. Endocrinol , vol.303 , pp. 74-81
    • Rodrigues, A.R.1
  • 40
    • 84864359242 scopus 로고    scopus 로고
    • Melanocortin 5 receptor signaling and internalization: role of MAPK/ERK pathway and beta-arrestins 1/2
    • Rodrigues A.R., Almeida H., Gouveia A.M. Melanocortin 5 receptor signaling and internalization: role of MAPK/ERK pathway and beta-arrestins 1/2. Mol. Cell. Endocrinol 2012, 361:69-79.
    • (2012) Mol. Cell. Endocrinol , vol.361 , pp. 69-79
    • Rodrigues, A.R.1    Almeida, H.2    Gouveia, A.M.3
  • 41
    • 84555189440 scopus 로고    scopus 로고
    • Regulation and function of the RSK family of protein kinases
    • Romeo Y., Zhang X., Roux P.P. Regulation and function of the RSK family of protein kinases. Biochem. J. 2012, 441:553-569.
    • (2012) Biochem. J. , vol.441 , pp. 553-569
    • Romeo, Y.1    Zhang, X.2    Roux, P.P.3
  • 42
    • 0037178647 scopus 로고    scopus 로고
    • Intracerebroventricular administration of alpha-melanocyte stimulating hormone increases phosphorylation of CREB in TRH- and CRH-producing neurons of the hypothalamic paraventricular nucleus
    • Sarkar S., Legradi G., Lechan R.M. Intracerebroventricular administration of alpha-melanocyte stimulating hormone increases phosphorylation of CREB in TRH- and CRH-producing neurons of the hypothalamic paraventricular nucleus. Brain Res 2002, 945:50-59.
    • (2002) Brain Res , vol.945 , pp. 50-59
    • Sarkar, S.1    Legradi, G.2    Lechan, R.M.3
  • 43
    • 33846311331 scopus 로고    scopus 로고
    • Identification of differential melanocortin 4 receptor agonist profiles at natively expressed receptors in rat cortical astrocytes and recombinantly expressed receptors in human embryonic kidney cells
    • Selkirk J.V., et al. Identification of differential melanocortin 4 receptor agonist profiles at natively expressed receptors in rat cortical astrocytes and recombinantly expressed receptors in human embryonic kidney cells. Neuropharmacology 2007, 52:459-466.
    • (2007) Neuropharmacology , vol.52 , pp. 459-466
    • Selkirk, J.V.1
  • 44
    • 84864387283 scopus 로고    scopus 로고
    • Refeeding-activated glutamatergic neurons in the hypothalamic paraventricular nucleus (PVN) mediate effects of melanocortin signaling in the nucleus tractus solitarius (NTS)
    • Singru P.S., et al. Refeeding-activated glutamatergic neurons in the hypothalamic paraventricular nucleus (PVN) mediate effects of melanocortin signaling in the nucleus tractus solitarius (NTS). Endocrinology 2012, 153:3804-3814.
    • (2012) Endocrinology , vol.153 , pp. 3804-3814
    • Singru, P.S.1
  • 45
    • 1242269968 scopus 로고    scopus 로고
    • Roles of the melanocortin-4 receptor in antipyretic and hyperthermic actions of centrally administered alpha-MSH
    • Sinha P.S., Schioth H.B., Tatro J.B. Roles of the melanocortin-4 receptor in antipyretic and hyperthermic actions of centrally administered alpha-MSH. Brain Res 2004, 1001:150-158.
    • (2004) Brain Res , vol.1001 , pp. 150-158
    • Sinha, P.S.1    Schioth, H.B.2    Tatro, J.B.3
  • 46
    • 23844542825 scopus 로고    scopus 로고
    • Melanocortinergic modulation of cholecystokinin-induced suppression of feeding through extracellular signal-regulated kinase signaling in rat solitary nucleus
    • Sutton G.M., et al. Melanocortinergic modulation of cholecystokinin-induced suppression of feeding through extracellular signal-regulated kinase signaling in rat solitary nucleus. Endocrinology 2005, 146:3739-3747.
    • (2005) Endocrinology , vol.146 , pp. 3739-3747
    • Sutton, G.M.1
  • 47
    • 77955409173 scopus 로고    scopus 로고
    • The melanocortin-4 receptor: physiology, pharmacology, and pathophysiology
    • Tao Y.X. The melanocortin-4 receptor: physiology, pharmacology, and pathophysiology. Endocr. Rev 2010, 31:506-543.
    • (2010) Endocr. Rev , vol.31 , pp. 506-543
    • Tao, Y.X.1
  • 48
    • 0038444775 scopus 로고    scopus 로고
    • SP600125, an inhibitor of c-jun N-terminal kinase, activates CREB by a p38 MAPK-mediated pathway
    • Vaishnav D., et al. SP600125, an inhibitor of c-jun N-terminal kinase, activates CREB by a p38 MAPK-mediated pathway. Biochem. Biophys. Res. Commun 2003, 307:855-860.
    • (2003) Biochem. Biophys. Res. Commun , vol.307 , pp. 855-860
    • Vaishnav, D.1
  • 49
    • 2642517794 scopus 로고    scopus 로고
    • Activation of MAP kinase by MC4-R through PI3 kinase
    • Vongs A., Lynn N.M., Rosenblum C.I. Activation of MAP kinase by MC4-R through PI3 kinase. Regul. Pept 2004, 120:113-118.
    • (2004) Regul. Pept , vol.120 , pp. 113-118
    • Vongs, A.1    Lynn, N.M.2    Rosenblum, C.I.3
  • 50
    • 0034624822 scopus 로고    scopus 로고
    • Activation of the c-fos enhancer by the erk MAP kinase pathway through two sequence elements: the c-fos AP-1 and p62TCF sites
    • Wang Y., Prywes R. Activation of the c-fos enhancer by the erk MAP kinase pathway through two sequence elements: the c-fos AP-1 and p62TCF sites. Oncogene 2000, 19:1379-1385.
    • (2000) Oncogene , vol.19 , pp. 1379-1385
    • Wang, Y.1    Prywes, R.2
  • 51
    • 0038392755 scopus 로고    scopus 로고
    • Brain-derived neurotrophic factor regulates energy balance downstream of melanocortin-4 receptor
    • Xu B., et al. Brain-derived neurotrophic factor regulates energy balance downstream of melanocortin-4 receptor. Nat. Neurosci 2003, 6:736-742.
    • (2003) Nat. Neurosci , vol.6 , pp. 736-742
    • Xu, B.1
  • 52
    • 2942618768 scopus 로고    scopus 로고
    • A renaissance for SRC
    • Yeatman T.J. A renaissance for SRC. Nat. Rev. Cancer 2004, 4:470-480.
    • (2004) Nat. Rev. Cancer , vol.4 , pp. 470-480
    • Yeatman, T.J.1
  • 53
    • 0036544756 scopus 로고    scopus 로고
    • C-fos regulates neuronal excitability and survival
    • Zhang J., et al. c-fos regulates neuronal excitability and survival. Nat. Genet 2002, 30:416-420.
    • (2002) Nat. Genet , vol.30 , pp. 416-420
    • Zhang, J.1
  • 54
    • 0037166291 scopus 로고    scopus 로고
    • RANTES-mediated chemokine transcription in astrocytes involves activation and translocation of p90 ribosomal S6 protein kinase (RSK)
    • Zhang Y., et al. RANTES-mediated chemokine transcription in astrocytes involves activation and translocation of p90 ribosomal S6 protein kinase (RSK). J. Biol. Chem 2002, 277:19042-19048.
    • (2002) J. Biol. Chem , vol.277 , pp. 19042-19048
    • Zhang, Y.1
  • 55
    • 3042562279 scopus 로고    scopus 로고
    • From the cyclooxygenase-2 inhibitor celecoxib to a novel class of 3-phosphoinositide-dependent protein kinase-1 inhibitors
    • Zhu J., et al. From the cyclooxygenase-2 inhibitor celecoxib to a novel class of 3-phosphoinositide-dependent protein kinase-1 inhibitors. Cancer Res 2004, 64:4309-4318.
    • (2004) Cancer Res , vol.64 , pp. 4309-4318
    • Zhu, J.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.