Melanocortin-3 receptors are involved in adaptation to restricted feeding

Genes, Brain and Behavior

Volumn 11, Issue 3, 2012, Pages 291-302

  Begriche, K ^a   Marston, O J ^b   Rossi, J ^a   Burke, L K ^b   Mcdonald, P ^a   Heisler, L K ^b   Butler, A A ^a  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

^b UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

Appetite; Dorsomedial hypothalamus; Hypothalamus; Melanocortin; Melanocortin 3 receptor; Nutrient sensors

Indexed keywords

MELANOCORTIN 3 RECEPTOR; MITOGEN ACTIVATED PROTEIN KINASE;

ADAPTIVE BEHAVIOR; ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTICIPATION; ARTICLE; BRAIN REGION; CONTROLLED STUDY; DIET RESTRICTION; DORSOMEDIAL HYPOTHALAMIC NUCLEUS; FEMALE; IMMUNOREACTIVITY; MALE; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN FUNCTION; WEIGHT REDUCTION; WILD TYPE;

ADAPTATION, PHYSIOLOGICAL; ANIMALS; CALORIC RESTRICTION; FEEDING BEHAVIOR; FEMALE; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; RECEPTOR, MELANOCORTIN, TYPE 3; STARVATION;

MUS;

EID: 84859423397     PISSN: 16011848     EISSN: 1601183X     Source Type: Journal    
DOI: 10.1111/j.1601-183X.2012.00766.x     Document Type: Article

References (40)

1. Arble, D.M., Ramsey, K.M., Bass, J. & Turek, F.W. (2010) Circadian disruption and metabolic disease: findings from animal models. Best Pract Res Clin Endocrinol Metab 24, 785-800.
2. Begriche, K., Sutton, G.M., Fang, J. & Butler, A.A. (2009) The role of melanocortin neuronal pathways in circadian biology: a new homeostatic output involving melanocortin-3 receptors? Obes Rev 10(Suppl. 2), 14-24.
3. Begriche, K., Levasseur, P.R., Zhang, J., Rossi, J., Skorupa, D., Solt, L.A., Young, B., Burris, T.P., Marks, D.L., Mynatt, R.L. & Butler, A.A. (2011a) Genetic dissection of the functions of the melanocortin-3 receptor, a seven-transmembrane g-protein coupled receptor, suggests roles for central and peripheral receptors in energy homeostasis. J Biol Chem 286, 40771-40781.
4. Begriche, K., Sutton, G.M. & Butler, A.A. (2011b) Homeostatic and non-homeostatic functions of melanocortin-3 receptors in the control of energy balance and metabolism. Physiol Behav 104, 546-554.
5. Butler, A.A. (2006) The melanocortin system and energy balance. Peptides 27, 281-290.
6. Butler, A.A., Kesterson, R.A., Khong, K., Cullen, M.J., Pelleymounter, M.A., Dekoning, J., Baetscher, M. & Cone, R.D. (2000) A unique metabolic syndrome causes obesity in the melanocortin-3 receptor-deficient mouse. Endocrinology 141, 3518-3521.
7. Chai, B., Li, J.Y., Zhang, W., Ammori, J.B. & Mulholland, M.W. (2007) Melanocortin-3 receptor activates MAP kinase via PI3 kinase. Regul Pept 139, 115-121.
8. Chen, A.S., Marsh, D.J., Trumbauer, M.E. et al. (2000) Inactivation of the mouse melanocortin-3 receptor results in increased fat mass and reduced lean body mass. Nat Genet 26, 97-102.
9. Choi, S., Wong, L.S., Yamat, C. & Dallman, M.F. (1998) Hypothalamic ventromedial nuclei amplify circadian rhythms: do they contain a food-entrained endogenous oscillator? J Neurosci 18, 3843-3852.
10. Chou, T.C., Scammell, T.E., Gooley, J.J., Gaus, S.E., Saper, C.B. & Lu, J. (2003) Critical role of dorsomedial hypothalamic nucleus in a wide range of behavioral circadian rhythms. J Neurosci 23, 10691-10702.
11. Daniels, D., Patten, C.S., Roth, J.D., Yee, D.K. & Fluharty, S.J. (2003) Melanocortin receptor signaling through mitogen-activated protein kinase in vitro and in rat hypothalamus. Brain Res 986, 1-11.
12. Feng, N., Young, S.F., Aguilera, G., Puricelli, E., Adler-Wailes, D.C., Sebring, N.G. & Yanovski, J.A. (2005) Co-occurrence of two partially inactivating polymorphisms of MC3R is associated with pediatric-onset obesity. Diabetes 54, 2663-2667.
13. Fu, L.Y. & van den Pol, A.N. (2008) Agouti-related peptide and MC3/4 receptor agonists both inhibit excitatory hypothalamic ventromedial nucleus neurons. J Neurosci 28, 5433-5449.
14. Gooley, J.J., Schomer, A. & Saper, C.B. (2006) The dorsomedial hypothalamic nucleus is critical for the expression of food-entrainable circadian rhythms. Nat Neurosci 9, 398-407.
15. Grieco, P., Balse, P.M., Weinberg, D., MacNeil, T. & Hruby, V.J. (2000) D-Amino acid scan of gamma-melanocyte-stimulating hormone: importance of Trp(8) on human MC3 receptor selectivity. J Med Chem 43, 4998-5002.
16. Hahn, T.M., Breininger, J.F., Baskin, D.G. & Schwartz, M.W. (1998) Coexpression of Agrp and NPY in fasting-activated hypothalamic neurons. Nat Neurosci 1, 271-272.
17. Hsu, J.L., Yu, L., Sullivan, E., Bowman, M., Mistlberger, R.E. & Tecott, L.H. (2010) Enhanced food anticipatory activity associated with enhanced activation of extrahypothalamic neural pathways in serotonin2C receptor null mutant mice. PLoS One 5, e11802.
18. Johnstone, L.E., Fong, T.M. & Leng, G. (2006) Neuronal activation in the hypothalamus and brainstem during feeding in rats. Cell Metab 4, 313-321.
19. Krieger, D.T. (1980) Ventromedial hypothalamic lesions abolish food-shifted circadian adrenal and temperature rhythmicity. Endocrinology 106, 649-654.
20. Krieger, D.T., Hauser, H. & Krey, L.C. (1977) Suprachiasmatic nuclear lesions do not abolish food-shifted circadian adrenal and temperature rhythmicity. Science 197, 398-399.
21. Kumar, K.G., Sutton, G.M., Dong, J.Z., Roubert, P., Plas, P., Halem, H.A., Culler, M.D., Yang, H., Dixit, V.D. & Butler, A.A. (2009) Analysis of the therapeutic functions of novel melanocortin receptor agonists in MC3R- and MC4R-deficient C57BL/6J mice. Peptides 30, 1892-1900.
22. Landry, G.J., Simon, M.M., Webb, I.C. & Mistlberger, R.E. (2006) Persistence of a behavioral food-anticipatory circadian rhythm following dorsomedial hypothalamic ablation in rats. Am J Physiol Regul Integr Comp Physiol 290, R1527-R1534.
23. Landry, G.J., Yamakawa, G.R., Webb, I.C., Mear, R.J. & Mistlberger, R.E. (2007) The dorsomedial hypothalamic nucleus is not necessary for the expression of circadian food-anticipatory activity in rats. J Biol Rhythms 22, 467-478.
24. Mencarelli, M., Dubern, B., Alili, R., Maestrini, S., Benajiba, L., Tagliaferri, M., Galan, P., Rinaldi, M., Simon, C., Tounian, P., Hercberg, S., Liuzzi, A., Di Blasio, A.M. & Clement, K. (2011) Rare melanocortin-3 receptor mutations with in vitro functional consequences are associated with human obesity. Hum Mol Genet 20, 392-399.
25. Mieda, M., Williams, S.C., Sinton, C.M., Richardson, J.A., Sakurai, T. & Yanagisawa, M. (2004) Orexin neurons function in an efferent pathway of a food-entrainable circadian oscillator in eliciting food-anticipatory activity and wakefulness. J Neurosci 24, 10493-10501.
26. Mieda, M., Williams, S.C., Richardson, J.A., Tanaka, K. & Yanagisawa, M. (2006) The dorsomedial hypothalamic nucleus as a putative food-entrainable circadian pacemaker. Proc Natl Acad Sci U S A 103, 12150-12155.
27. Mistlberger, R.E. & Rechtschaffen, A. (1984) Recovery of anticipatory activity to restricted feeding in rats with ventromedial hypothalamic lesions. Physiol Behav 33, 227-235.
28. Mizuno, T.M. & Mobbs, C.V. (1999) Hypothalamic agouti-related protein messenger ribonucleic acid is inhibited by leptin and stimulated by fasting. Endocrinology 140, 814-817.
29. Mountjoy, K.G. (2011) Distribution and function of melanocortin receptors within the brain. Adv Exp Med Biol 681, 29-48.
30. Renquist, B.J., Lippert, R.N., Sebag, J.A., Ellacott, K.L. & Cone, R.D. (2011) Physiological roles of the melanocortin MC receptor. Eur J Pharmacol 660, 13-20.
31. Roselli-Rehfuss, L., Mountjoy, K.G., Robbins, L.S., Mortrud, M.T., Low, M.J., Tatro, J.B., Entwistle, M.L., Simerly, R.B. & Cone, R.D. (1993) Identification of a receptor for gamma melanotropin and other proopiomelanocortin peptides in the hypothalamus and limbic system. Proc Natl Acad Sci U S A 90, 8856-8860.
32. Savastano, D.M., Tanofsky-Kraff, M., Han, J.C., Ning, C., Sorg, R.A., Roza, C.A., Wolkoff, L.E., Anandalingam, K., Jefferson-George, K.S., Figueroa, R.E., Sanford, E.L., Brady, S., Kozlosky, M., Schoeller, D.A. & Yanovski, J.A. (2009) Energy intake and energy expenditure among children with polymorphisms of the melanocortin-3 receptor. Am J Clin Nutr 90, 912-920.
33. Singru, P.S., Sanchez, E., Fekete, C. & Lechan, R.M. (2007) Importance of melanocortin signaling in refeeding-induced neuronal activation and satiety. Endocrinology 148, 638-646.
34. Stephan, F.K. (2002) The "other" circadian system: food as a Zeitgeber. J Biol Rhythms 17, 284-292.
35. Stephan, F.K., Swann, J.M. & Sisk, C.L. (1979) Entrainment of circadian rhythms by feeding schedules in rats with suprachiasmatic lesions. Behav Neural Biol 25, 545-554.
36. Sutton, G.M., Trevaskis, J.L., Hulver, M.W., McMillan, R.P., Markward, N.J., Babin, M.J., Meyer, E.A. & Butler, A.A. (2006) Diet-genotype interactions in the development of the obese, insulin-resistant phenotype of C57BL/6J mice lacking melanocortin-3 or -4 receptors. Endocrinology 147, 2183-2196.
37. Sutton, G.M., Perez-Tilve, D., Nogueiras, R., Fang, J., Kim, J.K., Cone, R.D., Gimble, J.M., Tschop, M.H. & Butler, A.A. (2008) The melanocortin-3 receptor is required for entrainment to meal intake. J Neurosci 28, 12946-12955.
38. Sutton, G.M., Begriche, K., Kumar, K.G., Gimble, J.M., Perez-Tilve, D., Nogueiras, R., McMillan, R.P., Hulver, M.W., Tschop, M.H. & Butler, A.A. (2010) Central nervous system melanocortin-3 receptors are required for synchronizing metabolism during entrainment to restricted feeding during the light cycle. FASEB J 24, 862-872.
39. Wilson, B.D., Bagnol, D., Kaelin, C.B., Ollmann, M.M., Gantz, I., Watson, S.J. & Barsh, G.S. (1999) Physiological and anatomical circuitry between Agouti-related protein and leptin signaling. Endocrinology 140, 2387-2397.
40. Zegers, D., Beckers, S., de Freitas, F., Peeters, A.V., Mertens, I.L., Verhulst, S.L., Rooman, R.P., Timmermans, J.P., Desager, K.N., Massa, G., Van Gaal, L.F. & Van Hul, W. (2011) Identification of three novel genetic variants in the melanocortin-3 receptor of obese children. Obesity (Silver Spring) 19, 152-159.