메뉴 건너뛰기




Volumn 32, Issue , 2015, Pages 10-17

P53 orchestrates between normal differentiation and cancer

Author keywords

Cancer stem cells; Differentiation; P53; Stem cells

Indexed keywords

PROTEIN P53;

EID: 84929951550     PISSN: 1044579X     EISSN: 10963650     Source Type: Journal    
DOI: 10.1016/j.semcancer.2013.12.006     Document Type: Review
Times cited : (44)

References (158)
  • 1
    • 79953058250 scopus 로고    scopus 로고
    • The tumorigenicity of human embryonic and induced pluripotent stem cells
    • Ben-David U., Benvenisty N. The tumorigenicity of human embryonic and induced pluripotent stem cells. Nat Rev Cancer 2011, 11:268-277.
    • (2011) Nat Rev Cancer , vol.11 , pp. 268-277
    • Ben-David, U.1    Benvenisty, N.2
  • 2
    • 42649112047 scopus 로고    scopus 로고
    • An embryonic stem cell-like gene expression signature in poorly differentiated aggressive human tumors
    • Ben-Porath I., Thomson M.W., Carey V.J., Ge R., Bell G.W., Regev A., et al. An embryonic stem cell-like gene expression signature in poorly differentiated aggressive human tumors. Nat Genet 2008, 40:499-507.
    • (2008) Nat Genet , vol.40 , pp. 499-507
    • Ben-Porath, I.1    Thomson, M.W.2    Carey, V.J.3    Ge, R.4    Bell, G.W.5    Regev, A.6
  • 3
    • 34748866686 scopus 로고    scopus 로고
    • Signaling pathways in cancer and embryonic stem cells
    • Dreesen O., Brivanlou A.H. Signaling pathways in cancer and embryonic stem cells. Stem Cell Rev 2007, 3:7-17.
    • (2007) Stem Cell Rev , vol.3 , pp. 7-17
    • Dreesen, O.1    Brivanlou, A.H.2
  • 4
    • 46449113364 scopus 로고    scopus 로고
    • The tumorigenicity of human embryonic stem cells
    • Blum B., Benvenisty N. The tumorigenicity of human embryonic stem cells. Adv Cancer Res 2008, 100:133-158.
    • (2008) Adv Cancer Res , vol.100 , pp. 133-158
    • Blum, B.1    Benvenisty, N.2
  • 5
    • 66149179125 scopus 로고    scopus 로고
    • Deconstructing stem cell tumorigenicity: a roadmap to safe regenerative medicine
    • Knoepfler P.S. Deconstructing stem cell tumorigenicity: a roadmap to safe regenerative medicine. Stem Cells 2009, 27:1050-1056.
    • (2009) Stem Cells , vol.27 , pp. 1050-1056
    • Knoepfler, P.S.1
  • 6
    • 0001007610 scopus 로고
    • Isolation of a pluripotent cell line from early mouse embryos cultured in medium conditioned by teratocarcinoma stem cells
    • Martin G.R. Isolation of a pluripotent cell line from early mouse embryos cultured in medium conditioned by teratocarcinoma stem cells. PNAS 1981, 78:7634-7638.
    • (1981) PNAS , vol.78 , pp. 7634-7638
    • Martin, G.R.1
  • 9
    • 0027109075 scopus 로고
    • Cancer. p53, guardian of the genome
    • Lane D.P. Cancer. p53, guardian of the genome. Nature 1992, 358:15-16.
    • (1992) Nature , vol.358 , pp. 15-16
    • Lane, D.P.1
  • 10
    • 70349442548 scopus 로고    scopus 로고
    • The first 30 years of p53: growing ever more complex
    • Levine A.J., Oren M. The first 30 years of p53: growing ever more complex. Nat Rev Cancer 2009, 9:749-758.
    • (2009) Nat Rev Cancer , vol.9 , pp. 749-758
    • Levine, A.J.1    Oren, M.2
  • 11
    • 70349443284 scopus 로고    scopus 로고
    • When mutants gain new powers: news from the mutant p53 field
    • Brosh R., Rotter V. When mutants gain new powers: news from the mutant p53 field. Nat Rev Cancer 2009, 9:701-713.
    • (2009) Nat Rev Cancer , vol.9 , pp. 701-713
    • Brosh, R.1    Rotter, V.2
  • 12
    • 80053039210 scopus 로고    scopus 로고
    • Mutations in the p53 tumor suppressor gene: important milestones at the various steps of tumorigenesis
    • Rivlin N., Brosh R., Oren M., Rotter V. Mutations in the p53 tumor suppressor gene: important milestones at the various steps of tumorigenesis. Genes Cancer 2011, 2:466-474.
    • (2011) Genes Cancer , vol.2 , pp. 466-474
    • Rivlin, N.1    Brosh, R.2    Oren, M.3    Rotter, V.4
  • 13
    • 77956280751 scopus 로고    scopus 로고
    • P53 is balancing development, differentiation and de-differentiation to assure cancer prevention
    • Molchadsky A., Rivlin N., Brosh R., Rotter V., Sarig R. p53 is balancing development, differentiation and de-differentiation to assure cancer prevention. Carcinogenesis 2010.
    • (2010) Carcinogenesis
    • Molchadsky, A.1    Rivlin, N.2    Brosh, R.3    Rotter, V.4    Sarig, R.5
  • 14
    • 56649118849 scopus 로고    scopus 로고
    • P53 plays a role in mesenchymal differentiation programs, in a cell fate dependent manner
    • Molchadsky A., Shats I., Goldfinger N., Pevsner-Fischer M., Olson M., Rinon A., et al. p53 plays a role in mesenchymal differentiation programs, in a cell fate dependent manner. PloS One 2008, 3:e3707.
    • (2008) PloS One , vol.3 , pp. e3707
    • Molchadsky, A.1    Shats, I.2    Goldfinger, N.3    Pevsner-Fischer, M.4    Olson, M.5    Rinon, A.6
  • 15
    • 0026076012 scopus 로고
    • Alterations in tumor development in vivo mediated by expression of wild type or mutant p53 proteins
    • Shaulsky G., Goldfinger N., Rotter V. Alterations in tumor development in vivo mediated by expression of wild type or mutant p53 proteins. Cancer Res 1991, 51:5232-5237.
    • (1991) Cancer Res , vol.51 , pp. 5232-5237
    • Shaulsky, G.1    Goldfinger, N.2    Rotter, V.3
  • 17
    • 0027452415 scopus 로고
    • Wild type p53 functions as a control protein in the differentiation pathway of the B-cell lineage
    • Aloni-Grinstein R., Zan-Bar I., Alboum I., Goldfinger N., Rotter V. Wild type p53 functions as a control protein in the differentiation pathway of the B-cell lineage. Oncogene 1993, 8:3297-3305.
    • (1993) Oncogene , vol.8 , pp. 3297-3305
    • Aloni-Grinstein, R.1    Zan-Bar, I.2    Alboum, I.3    Goldfinger, N.4    Rotter, V.5
  • 18
    • 0030905284 scopus 로고    scopus 로고
    • Mdm2 promotes the rapid degradation of p53
    • Haupt Y., Maya R., Kazaz A., Oren M. Mdm2 promotes the rapid degradation of p53. Nature 1997, 387:296-299.
    • (1997) Nature , vol.387 , pp. 296-299
    • Haupt, Y.1    Maya, R.2    Kazaz, A.3    Oren, M.4
  • 19
    • 0027459198 scopus 로고
    • Oren M. mdm2 expression is induced by wild type p53 activity
    • Barak Y., Juven T., Haffner R. Oren M. mdm2 expression is induced by wild type p53 activity. EMBO J 1993, 12:461-468.
    • (1993) EMBO J , vol.12 , pp. 461-468
    • Barak, Y.1    Juven, T.2    Haffner, R.3
  • 20
    • 0028823020 scopus 로고
    • Rescue of early embryonic lethality in mdm2-deficient mice by deletion of p53
    • Montes de Oca Luna R., Wagner D.S., Lozano G. Rescue of early embryonic lethality in mdm2-deficient mice by deletion of p53. Nature 1995, 378:203-206.
    • (1995) Nature , vol.378 , pp. 203-206
    • Montes de Oca Luna, R.1    Wagner, D.S.2    Lozano, G.3
  • 21
    • 0028834902 scopus 로고
    • Rescue of embryonic lethality in Mdm2-deficient mice by absence of p53
    • Jones S.N., Roe A.E., Donehower L.A., Bradley A. Rescue of embryonic lethality in Mdm2-deficient mice by absence of p53. Nature 1995, 378:206-208.
    • (1995) Nature , vol.378 , pp. 206-208
    • Jones, S.N.1    Roe, A.E.2    Donehower, L.A.3    Bradley, A.4
  • 23
    • 0029347164 scopus 로고
    • High-frequency developmental abnormalities in p53-deficient mice
    • Armstrong J.F., Kaufman M.H., Harrison D.J., Clarke A.R. High-frequency developmental abnormalities in p53-deficient mice. Curr Biol 1995, 5:931-936.
    • (1995) Curr Biol , vol.5 , pp. 931-936
    • Armstrong, J.F.1    Kaufman, M.H.2    Harrison, D.J.3    Clarke, A.R.4
  • 24
    • 55549088527 scopus 로고    scopus 로고
    • Lin S. p53 family in development
    • Danilova N., Sakamoto K.M. Lin S. p53 family in development. Mech Dev 2008, 125:919-931.
    • (2008) Mech Dev , vol.125 , pp. 919-931
    • Danilova, N.1    Sakamoto, K.M.2
  • 25
    • 36749081541 scopus 로고    scopus 로고
    • P53 regulates maternal reproduction through LIF
    • Hu W., Feng Z., Teresky A.K., Levine A.J. p53 regulates maternal reproduction through LIF. Nature 2007, 450:721-724.
    • (2007) Nature , vol.450 , pp. 721-724
    • Hu, W.1    Feng, Z.2    Teresky, A.K.3    Levine, A.J.4
  • 26
    • 0027431374 scopus 로고
    • Mice with reduced levels of p53 protein exhibit the testicular giant-cell degenerative syndrome
    • Rotter V., Schwartz D., Almon E., Goldfinger N., Kapon A., Meshorer A., et al. Mice with reduced levels of p53 protein exhibit the testicular giant-cell degenerative syndrome. PNAS 1993, 90:9075-9079.
    • (1993) PNAS , vol.90 , pp. 9075-9079
    • Rotter, V.1    Schwartz, D.2    Almon, E.3    Goldfinger, N.4    Kapon, A.5    Meshorer, A.6
  • 28
    • 53549134949 scopus 로고    scopus 로고
    • TAp73 knockout shows genomic instability with infertility and tumor suppressor functions
    • Tomasini R., Tsuchihara K., Wilhelm M., Fujitani M., Rufini A., Cheung C.C., et al. TAp73 knockout shows genomic instability with infertility and tumor suppressor functions. Genes Dev 2008, 22:2677-2691.
    • (2008) Genes Dev , vol.22 , pp. 2677-2691
    • Tomasini, R.1    Tsuchihara, K.2    Wilhelm, M.3    Fujitani, M.4    Rufini, A.5    Cheung, C.C.6
  • 30
    • 33847230852 scopus 로고    scopus 로고
    • The p53 family in differentiation and tumorigenesis
    • Stiewe T. The p53 family in differentiation and tumorigenesis. Nat Rev Cancer 2007, 7:165-168.
    • (2007) Nat Rev Cancer , vol.7 , pp. 165-168
    • Stiewe, T.1
  • 31
    • 0019826665 scopus 로고
    • Establishment in culture of pluripotential cells from mouse embryos
    • Evans M.J., Kaufman M.H. Establishment in culture of pluripotential cells from mouse embryos. Nature 1981, 292:154-156.
    • (1981) Nature , vol.292 , pp. 154-156
    • Evans, M.J.1    Kaufman, M.H.2
  • 32
    • 0037133550 scopus 로고    scopus 로고
    • Embryonic stem cells and somatic cells differ in mutation frequency and type
    • Cervantes R.B., Stringer J.R., Shao C., Tischfield J.A., Stambrook P.J. Embryonic stem cells and somatic cells differ in mutation frequency and type. PNAS 2002, 99:3586-3590.
    • (2002) PNAS , vol.99 , pp. 3586-3590
    • Cervantes, R.B.1    Stringer, J.R.2    Shao, C.3    Tischfield, J.A.4    Stambrook, P.J.5
  • 33
    • 80052488381 scopus 로고    scopus 로고
    • Mechanisms maintaining genomic integrity in embryonic stem cells and induced pluripotent stem cells
    • Tichy E.D. Mechanisms maintaining genomic integrity in embryonic stem cells and induced pluripotent stem cells. Exp Biol Med (Maywood) 2011, 236:987-996.
    • (2011) Exp Biol Med (Maywood) , vol.236 , pp. 987-996
    • Tichy, E.D.1
  • 34
    • 77249176666 scopus 로고    scopus 로고
    • P53 and stem cells: new developments and new concerns
    • Zhao T., Xu Y. p53 and stem cells: new developments and new concerns. Trends Cell Biol 2010, 20:170-175.
    • (2010) Trends Cell Biol , vol.20 , pp. 170-175
    • Zhao, T.1    Xu, Y.2
  • 35
    • 84868227016 scopus 로고    scopus 로고
    • Induction of cancerous stem cells during embryonic stem cell differentiation
    • Fujimori H., Shikanai M., Teraoka H., Masutani M., Yoshioka K. Induction of cancerous stem cells during embryonic stem cell differentiation. J Biol Chem 2012, 287:36777-36791.
    • (2012) J Biol Chem , vol.287 , pp. 36777-36791
    • Fujimori, H.1    Shikanai, M.2    Teraoka, H.3    Masutani, M.4    Yoshioka, K.5
  • 36
    • 13944273471 scopus 로고    scopus 로고
    • P53 induces differentiation of mouse embryonic stem cells by suppressing Nanog expression
    • Lin T., Chao C., Saito S., Mazur S.J., Murphy M.E., Appella E., et al. p53 induces differentiation of mouse embryonic stem cells by suppressing Nanog expression. Nat Cell Biol 2005, 7:165-171.
    • (2005) Nat Cell Biol , vol.7 , pp. 165-171
    • Lin, T.1    Chao, C.2    Saito, S.3    Mazur, S.J.4    Murphy, M.E.5    Appella, E.6
  • 38
    • 0030663519 scopus 로고    scopus 로고
    • Regulation of ES cell differentiation by functional and conformational modulation of p53
    • Sabapathy K., Klemm M., Jaenisch R., Wagner E.F. Regulation of ES cell differentiation by functional and conformational modulation of p53. EMBO J 1997, 16:6217-6229.
    • (1997) EMBO J , vol.16 , pp. 6217-6229
    • Sabapathy, K.1    Klemm, M.2    Jaenisch, R.3    Wagner, E.F.4
  • 39
    • 77955052580 scopus 로고    scopus 로고
    • Regulation of p53 in embryonic stem cells
    • Solozobova V., Blattner C. Regulation of p53 in embryonic stem cells. Exp Cell Res 2010, 316:2434-2446.
    • (2010) Exp Cell Res , vol.316 , pp. 2434-2446
    • Solozobova, V.1    Blattner, C.2
  • 40
    • 79953669883 scopus 로고    scopus 로고
    • MDM4 downregulates p53 transcriptional activity and response to stress during differentiation
    • Menendez S., Goh A.M., Camus S., Ng K.W., Kua N., Badal V., et al. MDM4 downregulates p53 transcriptional activity and response to stress during differentiation. Cell Cycle 2011, 10:1100-1108.
    • (2011) Cell Cycle , vol.10 , pp. 1100-1108
    • Menendez, S.1    Goh, A.M.2    Camus, S.3    Ng, K.W.4    Kua, N.5    Badal, V.6
  • 43
    • 67650261871 scopus 로고    scopus 로고
    • Nuclear accumulation and activation of p53 in embryonic stem cells after DNA damage
    • Solozobova V., Rolletschek A., Blattner C. Nuclear accumulation and activation of p53 in embryonic stem cells after DNA damage. BMC Cell Biol 2009, 10:46.
    • (2009) BMC Cell Biol , vol.10 , pp. 46
    • Solozobova, V.1    Rolletschek, A.2    Blattner, C.3
  • 44
    • 39749087530 scopus 로고    scopus 로고
    • SIRT1 regulates apoptosis and Nanog expression in mouse embryonic stem cells by controlling p53 subcellular localization
    • Han M.K., Song E.K., Guo Y., Ou X., Mantel C., Broxmeyer H.E. SIRT1 regulates apoptosis and Nanog expression in mouse embryonic stem cells by controlling p53 subcellular localization. Cell Stem Cell 2008, 2:241-251.
    • (2008) Cell Stem Cell , vol.2 , pp. 241-251
    • Han, M.K.1    Song, E.K.2    Guo, Y.3    Ou, X.4    Mantel, C.5    Broxmeyer, H.E.6
  • 45
    • 44249101836 scopus 로고    scopus 로고
    • Wolvetang EJ. p53 is required for etoposide-induced apoptosis of human embryonic stem cells
    • Grandela C., Pera M.F., Grimmond S.M., Kolle G. Wolvetang EJ. p53 is required for etoposide-induced apoptosis of human embryonic stem cells. Stem Cell Res 2007, 1:116-128.
    • (2007) Stem Cell Res , vol.1 , pp. 116-128
    • Grandela, C.1    Pera, M.F.2    Grimmond, S.M.3    Kolle, G.4
  • 48
    • 78049423721 scopus 로고    scopus 로고
    • Delta40p53 controls the switch from pluripotency to differentiation by regulating IGF signaling in ESCs
    • Ungewitter E., Scrable H. Delta40p53 controls the switch from pluripotency to differentiation by regulating IGF signaling in ESCs. Genes Dev 2010, 24:2408-2419.
    • (2010) Genes Dev , vol.24 , pp. 2408-2419
    • Ungewitter, E.1    Scrable, H.2
  • 49
    • 0032576768 scopus 로고    scopus 로고
    • ES cells do not activate p53-dependent stress responses and undergo p53-independent apoptosis in response to DNA damage
    • Aladjem M.I., Spike B.T., Rodewald L.W., Hope T.J., Klemm M., Jaenisch R., et al. ES cells do not activate p53-dependent stress responses and undergo p53-independent apoptosis in response to DNA damage. Curr Biol 1998, 8:145-155.
    • (1998) Curr Biol , vol.8 , pp. 145-155
    • Aladjem, M.I.1    Spike, B.T.2    Rodewald, L.W.3    Hope, T.J.4    Klemm, M.5    Jaenisch, R.6
  • 50
    • 0034710870 scopus 로고    scopus 로고
    • Phosphorylation of murine p53 at ser-18 regulates the p53 responses to DNA damage
    • Chao C., Saito S., Anderson C.W., Appella E., Xu Y. Phosphorylation of murine p53 at ser-18 regulates the p53 responses to DNA damage. PNAS 2000, 97:11936-11941.
    • (2000) PNAS , vol.97 , pp. 11936-11941
    • Chao, C.1    Saito, S.2    Anderson, C.W.3    Appella, E.4    Xu, Y.5
  • 51
    • 0032507970 scopus 로고    scopus 로고
    • Absence of p53-dependent cell cycle regulation in pluripotent mouse cell lines
    • Schmidt-Kastner P.K., Jardine K., Cormier M., McBurney M.W. Absence of p53-dependent cell cycle regulation in pluripotent mouse cell lines. Oncogene 1998, 16:3003-3011.
    • (1998) Oncogene , vol.16 , pp. 3003-3011
    • Schmidt-Kastner, P.K.1    Jardine, K.2    Cormier, M.3    McBurney, M.W.4
  • 52
    • 51849165629 scopus 로고    scopus 로고
    • Activation of DNA damage response signaling in mouse embryonic stem cells
    • Chuykin I.A., Lianguzova M.S., Pospelova T.V., Pospelov V.A. Activation of DNA damage response signaling in mouse embryonic stem cells. Cell Cycle 2008, 7:2922-2928.
    • (2008) Cell Cycle , vol.7 , pp. 2922-2928
    • Chuykin, I.A.1    Lianguzova, M.S.2    Pospelova, T.V.3    Pospelov, V.A.4
  • 53
    • 84862777719 scopus 로고    scopus 로고
    • Distinct regulatory mechanisms and functions for p53-activated and p53-repressed DNA damage response genes in embryonic stem cells
    • Li M., He Y., Dubois W., Wu X., Shi J., Huang J. Distinct regulatory mechanisms and functions for p53-activated and p53-repressed DNA damage response genes in embryonic stem cells. Mol Cell 2012, 46:30-42.
    • (2012) Mol Cell , vol.46 , pp. 30-42
    • Li, M.1    He, Y.2    Dubois, W.3    Wu, X.4    Shi, J.5    Huang, J.6
  • 54
    • 84864370845 scopus 로고    scopus 로고
    • Sirt1, p53, and p38(MAPK) are crucial regulators of detrimental phenotypes of embryonic stem cells with Max expression ablation
    • Hishida T., Nozaki Y., Nakachi Y., Mizuno Y., Iseki H., Katano M., et al. Sirt1, p53, and p38(MAPK) are crucial regulators of detrimental phenotypes of embryonic stem cells with Max expression ablation. Stem Cells 2012, 30:1634-1644.
    • (2012) Stem Cells , vol.30 , pp. 1634-1644
    • Hishida, T.1    Nozaki, Y.2    Nakachi, Y.3    Mizuno, Y.4    Iseki, H.5    Katano, M.6
  • 55
    • 34247172579 scopus 로고    scopus 로고
    • Regulation of apoptosis and differentiation by p53 in human embryonic stem cells
    • Qin H., Yu T., Qing T., Liu Y., Zhao Y., Cai J., et al. Regulation of apoptosis and differentiation by p53 in human embryonic stem cells. J Biol Chem 2007, 282:5842-5852.
    • (2007) J Biol Chem , vol.282 , pp. 5842-5852
    • Qin, H.1    Yu, T.2    Qing, T.3    Liu, Y.4    Zhao, Y.5    Cai, J.6
  • 56
    • 10744221485 scopus 로고    scopus 로고
    • In vivo activation of the p53 pathway by small-molecule antagonists of MDM2
    • Vassilev L.T., Vu B.T., Graves B., Carvajal D., Podlaski F., Filipovic Z., et al. In vivo activation of the p53 pathway by small-molecule antagonists of MDM2. Science 2004, 303:844-848.
    • (2004) Science , vol.303 , pp. 844-848
    • Vassilev, L.T.1    Vu, B.T.2    Graves, B.3    Carvajal, D.4    Podlaski, F.5    Filipovic, Z.6
  • 57
    • 51649129472 scopus 로고    scopus 로고
    • Activation of p53 by nutlin leads to rapid differentiation of human embryonic stem cells
    • Maimets T., Neganova I., Armstrong L., Lako M. Activation of p53 by nutlin leads to rapid differentiation of human embryonic stem cells. Oncogene 2008, 27:5277-5287.
    • (2008) Oncogene , vol.27 , pp. 5277-5287
    • Maimets, T.1    Neganova, I.2    Armstrong, L.3    Lako, M.4
  • 58
    • 76249102530 scopus 로고    scopus 로고
    • A genomewide study identifies the Wnt signaling pathway as a major target of p53 in murine embryonic stem cells
    • Lee K.H., Li M., Michalowski A.M., Zhang X., Liao H., Chen L., et al. A genomewide study identifies the Wnt signaling pathway as a major target of p53 in murine embryonic stem cells. PNAS 2010, 107:69-74.
    • (2010) PNAS , vol.107 , pp. 69-74
    • Lee, K.H.1    Li, M.2    Michalowski, A.M.3    Zhang, X.4    Liao, H.5    Chen, L.6
  • 60
    • 33747195353 scopus 로고    scopus 로고
    • Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors
    • Takahashi K., Yamanaka S. Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. Cell 2006, 126:663-676.
    • (2006) Cell , vol.126 , pp. 663-676
    • Takahashi, K.1    Yamanaka, S.2
  • 61
    • 48749109906 scopus 로고    scopus 로고
    • Improved efficiency and pace of generating induced pluripotent stem cells from human adult and fetal fibroblasts
    • Mali P., Ye Z., Hommond H.H., Yu X., Lin J., Chen G., et al. Improved efficiency and pace of generating induced pluripotent stem cells from human adult and fetal fibroblasts. Stem Cells 2008, 26:1998-2005.
    • (2008) Stem Cells , vol.26 , pp. 1998-2005
    • Mali, P.1    Ye, Z.2    Hommond, H.H.3    Yu, X.4    Lin, J.5    Chen, G.6
  • 62
    • 69349100179 scopus 로고    scopus 로고
    • Suppression of induced pluripotent stem cell generation by the p53-p21 pathway
    • Hong H., Takahashi K., Ichisaka T., Aoi T., Kanagawa O., Nakagawa M., et al. Suppression of induced pluripotent stem cell generation by the p53-p21 pathway. Nature 2009, 460:1132-1135.
    • (2009) Nature , vol.460 , pp. 1132-1135
    • Hong, H.1    Takahashi, K.2    Ichisaka, T.3    Aoi, T.4    Kanagawa, O.5    Nakagawa, M.6
  • 63
    • 69349100455 scopus 로고    scopus 로고
    • Linking the p53 tumour suppressor pathway to somatic cell reprogramming
    • Kawamura T., Suzuki J., Wang Y.V., Menendez S., Morera L.B., Raya A., et al. Linking the p53 tumour suppressor pathway to somatic cell reprogramming. Nature 2009, 460:1140-1144.
    • (2009) Nature , vol.460 , pp. 1140-1144
    • Kawamura, T.1    Suzuki, J.2    Wang, Y.V.3    Menendez, S.4    Morera, L.B.5    Raya, A.6
  • 64
  • 65
    • 69349094006 scopus 로고    scopus 로고
    • A p53-mediated DNA damage response limits reprogramming to ensure iPS cell genomic integrity
    • Marion R.M., Strati K., Li H., Murga M., Blanco R., Ortega S., et al. A p53-mediated DNA damage response limits reprogramming to ensure iPS cell genomic integrity. Nature 2009, 460:1149-1153.
    • (2009) Nature , vol.460 , pp. 1149-1153
    • Marion, R.M.1    Strati, K.2    Li, H.3    Murga, M.4    Blanco, R.5    Ortega, S.6
  • 66
    • 77957748239 scopus 로고    scopus 로고
    • Mutant p53 facilitates somatic cell reprogramming and augments the malignant potential of reprogrammed cells
    • Sarig R., Rivlin N., Brosh R., Bornstein C., Kamer I., Ezra O., et al. Mutant p53 facilitates somatic cell reprogramming and augments the malignant potential of reprogrammed cells. J Exp Med 2010.
    • (2010) J Exp Med
    • Sarig, R.1    Rivlin, N.2    Brosh, R.3    Bornstein, C.4    Kamer, I.5    Ezra, O.6
  • 67
  • 68
    • 54949136146 scopus 로고    scopus 로고
    • Two supporting factors greatly improve the efficiency of human iPSC generation
    • Zhao Y., Yin X., Qin H., Zhu F., Liu H., Yang W., et al. Two supporting factors greatly improve the efficiency of human iPSC generation. Cell Stem Cell 2008, 3:475-479.
    • (2008) Cell Stem Cell , vol.3 , pp. 475-479
    • Zhao, Y.1    Yin, X.2    Qin, H.3    Zhu, F.4    Liu, H.5    Yang, W.6
  • 69
    • 77957733786 scopus 로고    scopus 로고
    • P53 connects tumorigenesis and reprogramming to pluripotency
    • Tapia N., Scholer H.R. p53 connects tumorigenesis and reprogramming to pluripotency. J Exp Med 2010, 207:2045-2048.
    • (2010) J Exp Med , vol.207 , pp. 2045-2048
    • Tapia, N.1    Scholer, H.R.2
  • 70
    • 77956320116 scopus 로고    scopus 로고
    • Functional genomics reveals a BMP-driven mesenchymal-to-epithelial transition in the initiation of somatic cell reprogramming
    • Samavarchi-Tehrani P., Golipour A., David L., Sung H.K., Beyer T.A., Datti A., et al. Functional genomics reveals a BMP-driven mesenchymal-to-epithelial transition in the initiation of somatic cell reprogramming. Cell Stem Cell 2010, 7:64-77.
    • (2010) Cell Stem Cell , vol.7 , pp. 64-77
    • Samavarchi-Tehrani, P.1    Golipour, A.2    David, L.3    Sung, H.K.4    Beyer, T.A.5    Datti, A.6
  • 72
    • 84868224979 scopus 로고    scopus 로고
    • Multiple roles of p53 related pathways in somatic cell reprogramming and stem cell differentiation
    • Yi L., Lu C., Hu W., Sun Y., Levine A.J. Multiple roles of p53 related pathways in somatic cell reprogramming and stem cell differentiation. Cancer Res 2012.
    • (2012) Cancer Res
    • Yi, L.1    Lu, C.2    Hu, W.3    Sun, Y.4    Levine, A.J.5
  • 73
    • 80455149978 scopus 로고    scopus 로고
    • MiR-34 miRNAs provide a barrier for somatic cell reprogramming
    • Choi Y.J., Lin C.P., Ho J.J., He X., Okada N., Bu P., et al. miR-34 miRNAs provide a barrier for somatic cell reprogramming. Nat Cell Biol 2011, 13:1353-1360.
    • (2011) Nat Cell Biol , vol.13 , pp. 1353-1360
    • Choi, Y.J.1    Lin, C.P.2    Ho, J.J.3    He, X.4    Okada, N.5    Bu, P.6
  • 75
    • 84861885141 scopus 로고    scopus 로고
    • The emerging functions of the p53-miRNA network in stem cell biology
    • Lin C.P., Choi Y.J., Hicks G.G., He L. The emerging functions of the p53-miRNA network in stem cell biology. Cell Cycle 2012, 11:2063-2072.
    • (2012) Cell Cycle , vol.11 , pp. 2063-2072
    • Lin, C.P.1    Choi, Y.J.2    Hicks, G.G.3    He, L.4
  • 76
    • 67349149082 scopus 로고    scopus 로고
    • MicroRNA-145 regulates OCT4, SOX2, and KLF4 and represses pluripotency in human embryonic stem cells
    • Xu N., Papagiannakopoulos T., Pan G., Thomson J.A., Kosik K.S. MicroRNA-145 regulates OCT4, SOX2, and KLF4 and represses pluripotency in human embryonic stem cells. Cell 2009, 137:647-658.
    • (2009) Cell , vol.137 , pp. 647-658
    • Xu, N.1    Papagiannakopoulos, T.2    Pan, G.3    Thomson, J.A.4    Kosik, K.S.5
  • 77
    • 84862843347 scopus 로고    scopus 로고
    • P53-facilitated miR-199a-3p regulates somatic cell reprogramming
    • Wang J., He Q., Han C., Gu H., Jin L., Li Q., et al. p53-facilitated miR-199a-3p regulates somatic cell reprogramming. Stem Cells 2012, 30:1405-1413.
    • (2012) Stem Cells , vol.30 , pp. 1405-1413
    • Wang, J.1    He, Q.2    Han, C.3    Gu, H.4    Jin, L.5    Li, Q.6
  • 78
    • 84857483281 scopus 로고    scopus 로고
    • P53 regulates cell cycle and microRNAs to promote differentiation of human embryonic stem cells
    • Jain A.K., Allton K., Iacovino M., Mahen E., Milczarek R.J., Zwaka T.P., et al. p53 regulates cell cycle and microRNAs to promote differentiation of human embryonic stem cells. PLoS Biol 2012, 10:e1001268.
    • (2012) PLoS Biol , vol.10 , pp. e1001268
    • Jain, A.K.1    Allton, K.2    Iacovino, M.3    Mahen, E.4    Milczarek, R.J.5    Zwaka, T.P.6
  • 79
    • 79957855262 scopus 로고    scopus 로고
    • Reprogramming of mouse and human cells to pluripotency using mature microRNAs
    • Miyoshi N., Ishii H., Nagano H., Haraguchi N., Dewi D.L., Kano Y., et al. Reprogramming of mouse and human cells to pluripotency using mature microRNAs. Cell Stem Cell 2011, 8:633-638.
    • (2011) Cell Stem Cell , vol.8 , pp. 633-638
    • Miyoshi, N.1    Ishii, H.2    Nagano, H.3    Haraguchi, N.4    Dewi, D.L.5    Kano, Y.6
  • 80
    • 78649644924 scopus 로고    scopus 로고
    • MicroRNA profiling reveals two distinct p53-related human pluripotent stem cell states
    • Neveu P., Kye M.J., Qi S., Buchholz D.E., Clegg D.O., Sahin M., et al. MicroRNA profiling reveals two distinct p53-related human pluripotent stem cell states. Cell Stem Cell 2010, 7:671-681.
    • (2010) Cell Stem Cell , vol.7 , pp. 671-681
    • Neveu, P.1    Kye, M.J.2    Qi, S.3    Buchholz, D.E.4    Clegg, D.O.5    Sahin, M.6
  • 82
    • 84872315356 scopus 로고    scopus 로고
    • Martin-Zanca D. p53 restoration kills primitive leukemia cells in vivo and increases survival of leukemic mice
    • Velasco-Hernandez T., Vicente-Duenas C., Sanchez-Garcia I. Martin-Zanca D. p53 restoration kills primitive leukemia cells in vivo and increases survival of leukemic mice. Cell Cycle 2013, 12:122-132.
    • (2013) Cell Cycle , vol.12 , pp. 122-132
    • Velasco-Hernandez, T.1    Vicente-Duenas, C.2    Sanchez-Garcia, I.3
  • 83
    • 0034712047 scopus 로고    scopus 로고
    • Mammalian neural stem cells
    • Gage F.H. Mammalian neural stem cells. Science 2000, 287:1433-1438.
    • (2000) Science , vol.287 , pp. 1433-1438
    • Gage, F.H.1
  • 84
    • 0037948854 scopus 로고    scopus 로고
    • In vitro propagation and transcriptional profiling of human mammary stem/progenitor cells
    • Dontu G., Abdallah W.M., Foley J.M., Jackson K.W., Clarke M.F., Kawamura M.J., et al. In vitro propagation and transcriptional profiling of human mammary stem/progenitor cells. Genes Dev 2003, 17:1253-1270.
    • (2003) Genes Dev , vol.17 , pp. 1253-1270
    • Dontu, G.1    Abdallah, W.M.2    Foley, J.M.3    Jackson, K.W.4    Clarke, M.F.5    Kawamura, M.J.6
  • 90
    • 67349216689 scopus 로고    scopus 로고
    • The non-apoptotic role of p53 in neuronal biology: enlightening the dark side of the moon
    • Tedeschi A., Di Giovanni S. The non-apoptotic role of p53 in neuronal biology: enlightening the dark side of the moon. EMBO Rep 2009, 10:576-583.
    • (2009) EMBO Rep , vol.10 , pp. 576-583
    • Tedeschi, A.1    Di Giovanni, S.2
  • 91
    • 0029767029 scopus 로고    scopus 로고
    • P53 plays a regulatory role in differentiation and apoptosis of central nervous system-associated cells
    • Eizenberg O., Faber-Elman A., Gottlieb E., Oren M., Rotter V., Schwartz M. p53 plays a regulatory role in differentiation and apoptosis of central nervous system-associated cells. Mol Cell Biol 1996, 16:5178-5185.
    • (1996) Mol Cell Biol , vol.16 , pp. 5178-5185
    • Eizenberg, O.1    Faber-Elman, A.2    Gottlieb, E.3    Oren, M.4    Rotter, V.5    Schwartz, M.6
  • 93
    • 54549095950 scopus 로고    scopus 로고
    • P53 and Pten control neural and glioma stem/progenitor cell renewal and differentiation
    • Zheng H., Ying H., Yan H., Kimmelman A.C., Hiller D.J., Chen A.J., et al. p53 and Pten control neural and glioma stem/progenitor cell renewal and differentiation. Nature 2008, 455:1129-1133.
    • (2008) Nature , vol.455 , pp. 1129-1133
    • Zheng, H.1    Ying, H.2    Yan, H.3    Kimmelman, A.C.4    Hiller, D.J.5    Chen, A.J.6
  • 94
    • 70349123829 scopus 로고    scopus 로고
    • The tumor suppressor p53 regulates polarity of self-renewing divisions in mammary stem cells
    • Cicalese A., Bonizzi G., Pasi C.E., Faretta M., Ronzoni S., Giulini B., et al. The tumor suppressor p53 regulates polarity of self-renewing divisions in mammary stem cells. Cell 2009, 138:1083-1095.
    • (2009) Cell , vol.138 , pp. 1083-1095
    • Cicalese, A.1    Bonizzi, G.2    Pasi, C.E.3    Faretta, M.4    Ronzoni, S.5    Giulini, B.6
  • 95
    • 34250822389 scopus 로고    scopus 로고
    • Prostate cancer associated with p53 and Rb deficiency arises from the stem/progenitor cell-enriched proximal region of prostatic ducts
    • Zhou Z., Flesken-Nikitin A., Nikitin A.Y. Prostate cancer associated with p53 and Rb deficiency arises from the stem/progenitor cell-enriched proximal region of prostatic ducts. Cancer Res 2007, 67:5683-5690.
    • (2007) Cancer Res , vol.67 , pp. 5683-5690
    • Zhou, Z.1    Flesken-Nikitin, A.2    Nikitin, A.Y.3
  • 96
    • 84856013431 scopus 로고    scopus 로고
    • Clonal evolution in cancer
    • Greaves M., Maley C.C. Clonal evolution in cancer. Nature 2012, 481:306-313.
    • (2012) Nature , vol.481 , pp. 306-313
    • Greaves, M.1    Maley, C.C.2
  • 98
    • 58149380742 scopus 로고    scopus 로고
    • Stem cell concepts renew cancer research
    • Dick J.E. Stem cell concepts renew cancer research. Blood 2008, 112:4793-4807.
    • (2008) Blood , vol.112 , pp. 4793-4807
    • Dick, J.E.1
  • 100
    • 78751676408 scopus 로고    scopus 로고
    • Cells of origin in cancer
    • Visvader J.E. Cells of origin in cancer. Nature 2011, 469:314-322.
    • (2011) Nature , vol.469 , pp. 314-322
    • Visvader, J.E.1
  • 101
    • 69449096005 scopus 로고    scopus 로고
    • Heterogeneity in cancer: cancer stem cells versus clonal evolution
    • Shackleton M., Quintana E., Fearon E.R., Morrison S.J. Heterogeneity in cancer: cancer stem cells versus clonal evolution. Cell 2009, 138:822-829.
    • (2009) Cell , vol.138 , pp. 822-829
    • Shackleton, M.1    Quintana, E.2    Fearon, E.R.3    Morrison, S.J.4
  • 102
    • 16844368698 scopus 로고    scopus 로고
    • Tumour stem cells and drug resistance
    • Dean M., Fojo T., Bates S. Tumour stem cells and drug resistance. Nat Rev Cancer 2005, 5:275-284.
    • (2005) Nat Rev Cancer , vol.5 , pp. 275-284
    • Dean, M.1    Fojo, T.2    Bates, S.3
  • 103
    • 85047690508 scopus 로고    scopus 로고
    • Opinion: the origin of the cancer stem cell: current controversies and new insights
    • Bjerkvig R., Tysnes B.B., Aboody K.S., Najbauer J., Terzis A.J. Opinion: the origin of the cancer stem cell: current controversies and new insights. Nat Rev Cancer 2005, 5:899-904.
    • (2005) Nat Rev Cancer , vol.5 , pp. 899-904
    • Bjerkvig, R.1    Tysnes, B.B.2    Aboody, K.S.3    Najbauer, J.4    Terzis, A.J.5
  • 104
    • 82255175072 scopus 로고    scopus 로고
    • Lessons from common markers of tumor-initiating cells in solid cancers
    • Gires O. Lessons from common markers of tumor-initiating cells in solid cancers. Cell Mol Life Sci 2011, 68:4009-4022.
    • (2011) Cell Mol Life Sci , vol.68 , pp. 4009-4022
    • Gires, O.1
  • 105
    • 79953042645 scopus 로고    scopus 로고
    • CD44: can a cancer-initiating cell profit from an abundantly expressed molecule
    • Zoller M. CD44: can a cancer-initiating cell profit from an abundantly expressed molecule. Nat Rev Cancer 2011, 11:254-267.
    • (2011) Nat Rev Cancer , vol.11 , pp. 254-267
    • Zoller, M.1
  • 106
    • 84880059674 scopus 로고    scopus 로고
    • Cancer stem-like cell marker CD44 promotes bone metastases by enhancing tumorigenicity, cell motility, and hyaluronan production
    • Hiraga T., Ito S., Nakamura H. Cancer stem-like cell marker CD44 promotes bone metastases by enhancing tumorigenicity, cell motility, and hyaluronan production. Cancer Res 2013, 73:4112-4122.
    • (2013) Cancer Res , vol.73 , pp. 4112-4122
    • Hiraga, T.1    Ito, S.2    Nakamura, H.3
  • 108
    • 79751473114 scopus 로고    scopus 로고
    • The microRNA miR-34a inhibits prostate cancer stem cells and metastasis by directly repressing CD44
    • Liu C., Kelnar K., Liu B., Chen X., Calhoun-Davis T., Li H., et al. The microRNA miR-34a inhibits prostate cancer stem cells and metastasis by directly repressing CD44. Nat Med 2011, 17:211-215.
    • (2011) Nat Med , vol.17 , pp. 211-215
    • Liu, C.1    Kelnar, K.2    Liu, B.3    Chen, X.4    Calhoun-Davis, T.5    Li, H.6
  • 109
    • 46149089421 scopus 로고    scopus 로고
    • Growth-inhibitory and tumor-suppressive functions of p53 depend on its repression of CD44 expression
    • Godar S., Ince T.A., Bell G.W., Feldser D., Donaher J.L., Bergh J., et al. Growth-inhibitory and tumor-suppressive functions of p53 depend on its repression of CD44 expression. Cell 2008, 134:62-73.
    • (2008) Cell , vol.134 , pp. 62-73
    • Godar, S.1    Ince, T.A.2    Bell, G.W.3    Feldser, D.4    Donaher, J.L.5    Bergh, J.6
  • 110
    • 84866423871 scopus 로고    scopus 로고
    • MicroRNAs in the p53 network: micromanagement of tumour suppression
    • Hermeking H. MicroRNAs in the p53 network: micromanagement of tumour suppression. Nat Rev Cancer 2012, 12:613-626.
    • (2012) Nat Rev Cancer , vol.12 , pp. 613-626
    • Hermeking, H.1
  • 111
    • 69949087531 scopus 로고    scopus 로고
    • MicroRNA miR-34 inhibits human pancreatic cancer tumor-initiating cells
    • Ji Q., Hao X., Zhang M., Tang W., Yang M., Li L., et al. MicroRNA miR-34 inhibits human pancreatic cancer tumor-initiating cells. PloS One 2009, 4:e6816.
    • (2009) PloS One , vol.4 , pp. e6816
    • Ji, Q.1    Hao, X.2    Zhang, M.3    Tang, W.4    Yang, M.5    Li, L.6
  • 112
    • 49249091523 scopus 로고    scopus 로고
    • Identification and characterization of ovarian cancer-initiating cells from primary human tumors
    • Zhang S., Balch C., Chan M.W., Lai H.C., Matei D., Schilder J.M., et al. Identification and characterization of ovarian cancer-initiating cells from primary human tumors. Cancer Res 2008, 68:4311-4320.
    • (2008) Cancer Res , vol.68 , pp. 4311-4320
    • Zhang, S.1    Balch, C.2    Chan, M.W.3    Lai, H.C.4    Matei, D.5    Schilder, J.M.6
  • 113
    • 77953170540 scopus 로고    scopus 로고
    • CD117 and Stro-1 identify osteosarcoma tumor-initiating cells associated with metastasis and drug resistance
    • Adhikari A.S., Agarwal N., Wood B.M., Porretta C., Ruiz B., Pochampally R.R., et al. CD117 and Stro-1 identify osteosarcoma tumor-initiating cells associated with metastasis and drug resistance. Cancer Res 2010, 70:4602-4612.
    • (2010) Cancer Res , vol.70 , pp. 4602-4612
    • Adhikari, A.S.1    Agarwal, N.2    Wood, B.M.3    Porretta, C.4    Ruiz, B.5    Pochampally, R.R.6
  • 114
    • 41949117754 scopus 로고    scopus 로고
    • Potential identity of multi-potential cancer stem-like subpopulation after radiation of cultured brain glioma
    • Kang M.K., Hur B.I., Ko M.H., Kim C.H., Cha S.H., Kang S.K. Potential identity of multi-potential cancer stem-like subpopulation after radiation of cultured brain glioma. BMC Neurosci 2008, 9:15.
    • (2008) BMC Neurosci , vol.9 , pp. 15
    • Kang, M.K.1    Hur, B.I.2    Ko, M.H.3    Kim, C.H.4    Cha, S.H.5    Kang, S.K.6
  • 115
    • 84884679127 scopus 로고    scopus 로고
    • Repression of c-Kit by p53 is mediated by miR-34 and is associated with reduced chemoresistance, migration and stemness
    • Siemens H., Jackstadt R., Kaller M., Hermeking H. Repression of c-Kit by p53 is mediated by miR-34 and is associated with reduced chemoresistance, migration and stemness. Oncotarget 2013, 4:1399-1415.
    • (2013) Oncotarget , vol.4 , pp. 1399-1415
    • Siemens, H.1    Jackstadt, R.2    Kaller, M.3    Hermeking, H.4
  • 116
    • 70450198396 scopus 로고    scopus 로고
    • Epithelial-mesenchymal transitions in development and disease
    • Thiery J.P., Acloque H., Huang R.Y., Nieto M.A. Epithelial-mesenchymal transitions in development and disease. Cell 2009, 139:871-890.
    • (2009) Cell , vol.139 , pp. 871-890
    • Thiery, J.P.1    Acloque, H.2    Huang, R.Y.3    Nieto, M.A.4
  • 117
    • 84055184850 scopus 로고    scopus 로고
    • MiR-34 and SNAIL form a double-negative feedback loop to regulate epithelial-mesenchymal transitions
    • Siemens H., Jackstadt R., Hunten S., Kaller M., Menssen A., Gotz U., et al. miR-34 and SNAIL form a double-negative feedback loop to regulate epithelial-mesenchymal transitions. Cell Cycle 2011, 10:4256-4271.
    • (2011) Cell Cycle , vol.10 , pp. 4256-4271
    • Siemens, H.1    Jackstadt, R.2    Hunten, S.3    Kaller, M.4    Menssen, A.5    Gotz, U.6
  • 118
    • 0036595629 scopus 로고    scopus 로고
    • Epithelial-mesenchymal transitions in tumour progression
    • Thiery J.P. Epithelial-mesenchymal transitions in tumour progression. Nat Rev Cancer 2002, 2:442-454.
    • (2002) Nat Rev Cancer , vol.2 , pp. 442-454
    • Thiery, J.P.1
  • 119
    • 79952284127 scopus 로고    scopus 로고
    • Hallmarks of cancer: the next generation
    • Hanahan D., Weinberg R.A. Hallmarks of cancer: the next generation. Cell 2011, 144:646-674.
    • (2011) Cell , vol.144 , pp. 646-674
    • Hanahan, D.1    Weinberg, R.A.2
  • 120
    • 43049165453 scopus 로고    scopus 로고
    • The epithelial-mesenchymal transition generates cells with properties of stem cells
    • Mani S.A., Guo W., Liao M.J., Eaton E.N., Ayyanan A., Zhou A.Y., et al. The epithelial-mesenchymal transition generates cells with properties of stem cells. Cell 2008, 133:704-715.
    • (2008) Cell , vol.133 , pp. 704-715
    • Mani, S.A.1    Guo, W.2    Liao, M.J.3    Eaton, E.N.4    Ayyanan, A.5    Zhou, A.Y.6
  • 121
    • 79955628616 scopus 로고    scopus 로고
    • P53 Spreads out further: suppression of EMT and stemness by activating miR-200c expression
    • Schubert J., Brabletz T. p53 Spreads out further: suppression of EMT and stemness by activating miR-200c expression. Cell Res 2011, 21:705-707.
    • (2011) Cell Res , vol.21 , pp. 705-707
    • Schubert, J.1    Brabletz, T.2
  • 122
    • 47249091921 scopus 로고    scopus 로고
    • The miR-200 family inhibits epithelial-mesenchymal transition and cancer cell migration by direct targeting of E-cadherin transcriptional repressors ZEB1 and ZEB2
    • Korpal M., Lee E.S., Hu G., Kang Y. The miR-200 family inhibits epithelial-mesenchymal transition and cancer cell migration by direct targeting of E-cadherin transcriptional repressors ZEB1 and ZEB2. J Biol Chem 2008, 283:14910-14914.
    • (2008) J Biol Chem , vol.283 , pp. 14910-14914
    • Korpal, M.1    Lee, E.S.2    Hu, G.3    Kang, Y.4
  • 123
    • 79952283482 scopus 로고    scopus 로고
    • P53 regulates epithelial-mesenchymal transition and stem cell properties through modulating miRNAs
    • Chang C.J., Chao C.H., Xia W., Yang J.Y., Xiong Y., Li C.W., et al. p53 regulates epithelial-mesenchymal transition and stem cell properties through modulating miRNAs. Nat Cell Biol 2011, 13:317-323.
    • (2011) Nat Cell Biol , vol.13 , pp. 317-323
    • Chang, C.J.1    Chao, C.H.2    Xia, W.3    Yang, J.Y.4    Xiong, Y.5    Li, C.W.6
  • 124
    • 78651289008 scopus 로고    scopus 로고
    • Mutant p53(R175H) upregulates Twist1 expression and promotes epithelial-mesenchymal transition in immortalized prostate cells
    • Kogan-Sakin I., Tabach Y., Buganim Y., Molchadsky A., Solomon H., Madar S., et al. Mutant p53(R175H) upregulates Twist1 expression and promotes epithelial-mesenchymal transition in immortalized prostate cells. Cell Death Differ 2011, 18:271-281.
    • (2011) Cell Death Differ , vol.18 , pp. 271-281
    • Kogan-Sakin, I.1    Tabach, Y.2    Buganim, Y.3    Molchadsky, A.4    Solomon, H.5    Madar, S.6
  • 125
    • 84880298880 scopus 로고    scopus 로고
    • Mutant p53 gain-of-function induces epithelial-mesenchymal transition through modulation of the miR-130b-ZEB1 axis
    • Dong P., Karaayvaz M., Jia N., Kaneuchi M., Hamada J., Watari H., et al. Mutant p53 gain-of-function induces epithelial-mesenchymal transition through modulation of the miR-130b-ZEB1 axis. Oncogene 2013, 32:3286-3295.
    • (2013) Oncogene , vol.32 , pp. 3286-3295
    • Dong, P.1    Karaayvaz, M.2    Jia, N.3    Kaneuchi, M.4    Hamada, J.5    Watari, H.6
  • 126
    • 85027923138 scopus 로고    scopus 로고
    • NANOG promotes cancer stem cell characteristics and prostate cancer resistance to androgen deprivation
    • Jeter C.R., Liu B., Liu X., Chen X., Liu C., Calhoun-Davis T., et al. NANOG promotes cancer stem cell characteristics and prostate cancer resistance to androgen deprivation. Oncogene 2011, 30:3833-3845.
    • (2011) Oncogene , vol.30 , pp. 3833-3845
    • Jeter, C.R.1    Liu, B.2    Liu, X.3    Chen, X.4    Liu, C.5    Calhoun-Davis, T.6
  • 127
    • 84884163527 scopus 로고    scopus 로고
    • Targeting cancer stem cells: emerging role of Nanog transcription factor
    • Wang M.L., Chiou S.H., Wu C.W. Targeting cancer stem cells: emerging role of Nanog transcription factor. OncoTargets Ther 2013, 6:1207-1220.
    • (2013) OncoTargets Ther , vol.6 , pp. 1207-1220
    • Wang, M.L.1    Chiou, S.H.2    Wu, C.W.3
  • 128
    • 77955428416 scopus 로고    scopus 로고
    • Ruiz i Altaba A. NANOG regulates glioma stem cells and is essential in vivo acting in a cross-functional network with GLI1 and p53
    • Zbinden M., Duquet A., Lorente-Trigos A., Ngwabyt S.N., Borges I. Ruiz i Altaba A. NANOG regulates glioma stem cells and is essential in vivo acting in a cross-functional network with GLI1 and p53. EMBO J 2010, 29:2659-2674.
    • (2010) EMBO J , vol.29 , pp. 2659-2674
    • Zbinden, M.1    Duquet, A.2    Lorente-Trigos, A.3    Ngwabyt, S.N.4    Borges, I.5
  • 130
    • 66149167315 scopus 로고    scopus 로고
    • Functional evidence that the self-renewal gene NANOG regulates human tumor development
    • Jeter C.R., Badeaux M., Choy G., Chandra D., Patrawala L., Liu C., et al. Functional evidence that the self-renewal gene NANOG regulates human tumor development. Stem Cells 2009, 27:993-1005.
    • (2009) Stem Cells , vol.27 , pp. 993-1005
    • Jeter, C.R.1    Badeaux, M.2    Choy, G.3    Chandra, D.4    Patrawala, L.5    Liu, C.6
  • 131
    • 84877354623 scopus 로고    scopus 로고
    • Resveratrol promotes proteasome-dependent degradation of Nanog via p53 activation and induces differentiation of glioma stem cells
    • Sato A., Okada M., Shibuya K., Watanabe E., Seino S., Suzuki K., et al. Resveratrol promotes proteasome-dependent degradation of Nanog via p53 activation and induces differentiation of glioma stem cells. Stem Cell Res 2013, 11:601-610.
    • (2013) Stem Cell Res , vol.11 , pp. 601-610
    • Sato, A.1    Okada, M.2    Shibuya, K.3    Watanabe, E.4    Seino, S.5    Suzuki, K.6
  • 132
    • 84877989716 scopus 로고    scopus 로고
    • Resveratrol impedes the stemness, epithelial-mesenchymal transition, and metabolic reprogramming of cancer stem cells in nasopharyngeal carcinoma through p53 activation
    • Shen Y.A., Lin C.H., Chi W.H., Wang C.Y., Hsieh Y.T., Wei Y.H., et al. Resveratrol impedes the stemness, epithelial-mesenchymal transition, and metabolic reprogramming of cancer stem cells in nasopharyngeal carcinoma through p53 activation. Evidence-Based Complementary Altern Med 2013, 2013:590393.
    • (2013) Evidence-Based Complementary Altern Med , vol.2013 , pp. 590393
    • Shen, Y.A.1    Lin, C.H.2    Chi, W.H.3    Wang, C.Y.4    Hsieh, Y.T.5    Wei, Y.H.6
  • 133
    • 84876736201 scopus 로고    scopus 로고
    • FAK and Nanog cross talk with p53 in cancer stem cells
    • Golubovskaya V.M. FAK and Nanog cross talk with p53 in cancer stem cells. Anti-Cancer Agents Med Chem 2013, 13:576-580.
    • (2013) Anti-Cancer Agents Med Chem , vol.13 , pp. 576-580
    • Golubovskaya, V.M.1
  • 134
    • 38149070791 scopus 로고    scopus 로고
    • Nuclear FAK promotes cell proliferation and survival through FERM-enhanced p53 degradation
    • Lim S.T., Chen X.L., Lim Y., Hanson D.A., Vo T.T., Howerton K., et al. Nuclear FAK promotes cell proliferation and survival through FERM-enhanced p53 degradation. Mol Cell 2008, 29:9-22.
    • (2008) Mol Cell , vol.29 , pp. 9-22
    • Lim, S.T.1    Chen, X.L.2    Lim, Y.3    Hanson, D.A.4    Vo, T.T.5    Howerton, K.6
  • 135
    • 84861535841 scopus 로고    scopus 로고
    • Nanog increases focal adhesion kinase (FAK) promoter activity and expression and directly binds to FAK protein to be phosphorylated
    • Ho B., Olson G., Figel S., Gelman I., Cance W.G., Golubovskaya V.M. Nanog increases focal adhesion kinase (FAK) promoter activity and expression and directly binds to FAK protein to be phosphorylated. J Biol Chem 2012, 287:18656-18673.
    • (2012) J Biol Chem , vol.287 , pp. 18656-18673
    • Ho, B.1    Olson, G.2    Figel, S.3    Gelman, I.4    Cance, W.G.5    Golubovskaya, V.M.6
  • 136
    • 33845317573 scopus 로고    scopus 로고
    • Glioma stem cells promote radioresistance by preferential activation of the DNA damage response
    • Bao S., Wu Q., McLendon R.E., Hao Y., Shi Q., Hjelmeland A.B., et al. Glioma stem cells promote radioresistance by preferential activation of the DNA damage response. Nature 2006, 444:756-760.
    • (2006) Nature , vol.444 , pp. 756-760
    • Bao, S.1    Wu, Q.2    McLendon, R.E.3    Hao, Y.4    Shi, Q.5    Hjelmeland, A.B.6
  • 137
    • 52549087785 scopus 로고    scopus 로고
    • Cancer stem cells in solid tumours: accumulating evidence and unresolved questions
    • Visvader J.E., Lindeman G.J. Cancer stem cells in solid tumours: accumulating evidence and unresolved questions. Nat Rev Cancer 2008, 8:755-768.
    • (2008) Nat Rev Cancer , vol.8 , pp. 755-768
    • Visvader, J.E.1    Lindeman, G.J.2
  • 138
    • 0026555717 scopus 로고
    • Modulation of activity of the promoter of the human MDR1 gene by Ras and p53
    • Chin K.V., Ueda K., Pastan I., Gottesman M.M. Modulation of activity of the promoter of the human MDR1 gene by Ras and p53. Science 1992, 255:459-462.
    • (1992) Science , vol.255 , pp. 459-462
    • Chin, K.V.1    Ueda, K.2    Pastan, I.3    Gottesman, M.M.4
  • 139
    • 84863011183 scopus 로고    scopus 로고
    • Activation of p53 by SIRT1 inhibition enhances elimination of CML leukemia stem cells in combination with imatinib
    • Li L., Wang L., Li L., Wang Z., Ho Y., McDonald T., et al. Activation of p53 by SIRT1 inhibition enhances elimination of CML leukemia stem cells in combination with imatinib. Cancer Cell 2012, 21:266-281.
    • (2012) Cancer Cell , vol.21 , pp. 266-281
    • Li, L.1    Wang, L.2    Li, L.3    Wang, Z.4    Ho, Y.5    McDonald, T.6
  • 140
    • 84879411487 scopus 로고    scopus 로고
    • Feline mammary carcinoma stem cells are tumorigenic, radioresistant, chemoresistant and defective in activation of the ATM/p53 DNA damage pathway
    • Pang L.Y., Blacking T.M., Else R.W., Sherman A., Sang H.M., Whitelaw B.A., et al. Feline mammary carcinoma stem cells are tumorigenic, radioresistant, chemoresistant and defective in activation of the ATM/p53 DNA damage pathway. Vet J (London, England: 1997) 2013, 196:414-423.
    • (2013) Vet J (London, England: 1997) , vol.196 , pp. 414-423
    • Pang, L.Y.1    Blacking, T.M.2    Else, R.W.3    Sherman, A.4    Sang, H.M.5    Whitelaw, B.A.6
  • 142
    • 62449117918 scopus 로고    scopus 로고
    • MiR-34, SIRT1 and p53: the feedback loop
    • Yamakuchi M., Lowenstein C.J. MiR-34, SIRT1 and p53: the feedback loop. Cell Cycle 2009, 8:712-715.
    • (2009) Cell Cycle , vol.8 , pp. 712-715
    • Yamakuchi, M.1    Lowenstein, C.J.2
  • 143
    • 70349859809 scopus 로고    scopus 로고
    • Snail and slug mediate radioresistance and chemoresistance by antagonizing p53-mediated apoptosis and acquiring a stem-like phenotype in ovarian cancer cells
    • Kurrey N.K., Jalgaonkar S.P., Joglekar A.V., Ghanate A.D., Chaskar P.D., Doiphode R.Y., et al. Snail and slug mediate radioresistance and chemoresistance by antagonizing p53-mediated apoptosis and acquiring a stem-like phenotype in ovarian cancer cells. Stem Cells 2009, 27:2059-2068.
    • (2009) Stem Cells , vol.27 , pp. 2059-2068
    • Kurrey, N.K.1    Jalgaonkar, S.P.2    Joglekar, A.V.3    Ghanate, A.D.4    Chaskar, P.D.5    Doiphode, R.Y.6
  • 144
    • 0037673984 scopus 로고    scopus 로고
    • Bmi-1 determines the proliferative capacity of normal and leukaemic stem cells
    • Lessard J., Sauvageau G. Bmi-1 determines the proliferative capacity of normal and leukaemic stem cells. Nature 2003, 423:255-260.
    • (2003) Nature , vol.423 , pp. 255-260
    • Lessard, J.1    Sauvageau, G.2
  • 145
    • 20544453888 scopus 로고    scopus 로고
    • Ink4a and Arf differentially affect cell proliferation and neural stem cell self-renewal in Bmi1-deficient mice
    • Bruggeman S.W., Valk-Lingbeek M.E., van der Stoop P.P., Jacobs J.J., Kieboom K., Tanger E., et al. Ink4a and Arf differentially affect cell proliferation and neural stem cell self-renewal in Bmi1-deficient mice. Genes Dev 2005, 19:1438-1443.
    • (2005) Genes Dev , vol.19 , pp. 1438-1443
    • Bruggeman, S.W.1    Valk-Lingbeek, M.E.2    van der Stoop, P.P.3    Jacobs, J.J.4    Kieboom, K.5    Tanger, E.6
  • 146
    • 84881232015 scopus 로고    scopus 로고
    • Direct effects of Bmi1 on p53 protein stability inactivates oncoprotein stress responses in embryonal cancer precursor cells at tumor initiation
    • Calao M., Sekyere E.O., Cui H.J., Cheung B.B., Thomas W.D., Keating J., et al. Direct effects of Bmi1 on p53 protein stability inactivates oncoprotein stress responses in embryonal cancer precursor cells at tumor initiation. Oncogene 2013, 32:3616-3626.
    • (2013) Oncogene , vol.32 , pp. 3616-3626
    • Calao, M.1    Sekyere, E.O.2    Cui, H.J.3    Cheung, B.B.4    Thomas, W.D.5    Keating, J.6
  • 150
    • 84864387277 scopus 로고    scopus 로고
    • Birnbaum D. p53 and cancer stem cells: the mevalonate connexion
    • Ginestier C., Charafe-Jauffret E. Birnbaum D. p53 and cancer stem cells: the mevalonate connexion. Cell Cycle 2012, 11:2583-2584.
    • (2012) Cell Cycle , vol.11 , pp. 2583-2584
    • Ginestier, C.1    Charafe-Jauffret, E.2
  • 151
    • 84862902027 scopus 로고    scopus 로고
    • Mevalonate metabolism regulates Basal breast cancer stem cells and is a potential therapeutic target
    • Ginestier C., Monville F., Wicinski J., Cabaud O., Cervera N., Josselin E., et al. Mevalonate metabolism regulates Basal breast cancer stem cells and is a potential therapeutic target. Stem Cells 2012, 30:1327-1337.
    • (2012) Stem Cells , vol.30 , pp. 1327-1337
    • Ginestier, C.1    Monville, F.2    Wicinski, J.3    Cabaud, O.4    Cervera, N.5    Josselin, E.6
  • 153
    • 84881084722 scopus 로고    scopus 로고
    • LGR5 is a proneural factor and is regulated by OLIG2 in glioma stem-like cells
    • Mao X.G., Song S.J., Xue X.Y., Yan M., Wang L., Lin W., et al. LGR5 is a proneural factor and is regulated by OLIG2 in glioma stem-like cells. Cell Mol Neurobiol 2013, 33:851-865.
    • (2013) Cell Mol Neurobiol , vol.33 , pp. 851-865
    • Mao, X.G.1    Song, S.J.2    Xue, X.Y.3    Yan, M.4    Wang, L.5    Lin, W.6
  • 154
    • 33846815345 scopus 로고    scopus 로고
    • Olig2-regulated lineage-restricted pathway controls replication competence in neural stem cells and malignant glioma
    • Ligon K.L., Huillard E., Mehta S., Kesari S., Liu H., Alberta J.A., et al. Olig2-regulated lineage-restricted pathway controls replication competence in neural stem cells and malignant glioma. Neuron 2007, 53:503-517.
    • (2007) Neuron , vol.53 , pp. 503-517
    • Ligon, K.L.1    Huillard, E.2    Mehta, S.3    Kesari, S.4    Liu, H.5    Alberta, J.A.6
  • 155
    • 79952217981 scopus 로고    scopus 로고
    • The central nervous system-restricted transcription factor Olig2 opposes p53 responses to genotoxic damage in neural progenitors and malignant glioma
    • Mehta S., Huillard E., Kesari S., Maire C.L., Golebiowski D., Harrington E.P., et al. The central nervous system-restricted transcription factor Olig2 opposes p53 responses to genotoxic damage in neural progenitors and malignant glioma. Cancer Cell 2011, 19:359-371.
    • (2011) Cancer Cell , vol.19 , pp. 359-371
    • Mehta, S.1    Huillard, E.2    Kesari, S.3    Maire, C.L.4    Golebiowski, D.5    Harrington, E.P.6
  • 156
    • 65649142176 scopus 로고    scopus 로고
    • Expression of mutant p53 proteins implicates a lineage relationship between neural stem cells and malignant astrocytic glioma in a murine model
    • Wang Y., Yang J., Zheng H., Tomasek G.J., Zhang P., McKeever P.E., et al. Expression of mutant p53 proteins implicates a lineage relationship between neural stem cells and malignant astrocytic glioma in a murine model. Cancer Cell 2009, 15:514-526.
    • (2009) Cancer Cell , vol.15 , pp. 514-526
    • Wang, Y.1    Yang, J.2    Zheng, H.3    Tomasek, G.J.4    Zhang, P.5    McKeever, P.E.6
  • 158
    • 84855477391 scopus 로고    scopus 로고
    • Modeling sarcomagenesis using multipotent mesenchymal stem cells
    • Rodriguez R., Rubio R., Menendez P. Modeling sarcomagenesis using multipotent mesenchymal stem cells. Cell Res 2012, 22:62-77.
    • (2012) Cell Res , vol.22 , pp. 62-77
    • Rodriguez, R.1    Rubio, R.2    Menendez, P.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.