메뉴 건너뛰기




Volumn 16, Issue 6, 2015, Pages 584-589

HIV reservoirs as obstacles and opportunities for an HIV cure

Author keywords

[No Author keywords available]

Indexed keywords

CD3 ANTIBODY; INTERLEUKIN 2; ANTIRETROVIRUS AGENT;

EID: 84929853490     PISSN: 15292908     EISSN: 15292916     Source Type: Journal    
DOI: 10.1038/ni.3152     Document Type: Review
Times cited : (180)

References (63)
  • 1
    • 84929860641 scopus 로고    scopus 로고
    • UN Joint Programme on HIV/AIDS (UNAIDS). Global Report: UNAIDS Report on the Global AIDS Epidemic . UNAIDS, 2013
    • UN Joint Programme on HIV/AIDS (UNAIDS). Global Report: UNAIDS Report on the Global AIDS Epidemic 2013 http://www. unaids. org/sites/default/files/en/media/unaids/contentassets/documents/epidemiology/2013/gr2013/UNAIDS-Global-Report-2013-en. pdf (UNAIDS, 2013).
    • (2013)
  • 2
    • 84876921893 scopus 로고    scopus 로고
    • Life expectancies of South African adults starting antiretroviral treatment: Collaborative analysis of cohort studies
    • Johnson, L. F. et al. Life expectancies of South African adults starting antiretroviral treatment: collaborative analysis of cohort studies. PLoS Med. 10, e1001418 (2013).
    • (2013) PLoS Med. , vol.10 , pp. e1001418
    • Johnson, L.F.1
  • 3
    • 84871746299 scopus 로고    scopus 로고
    • Life expectancy living with HIV: Recent estimates and future implications
    • Nakagawa, F. , May, M. & Phillips, A. Life expectancy living with HIV: recent estimates and future implications. Curr. Opin. Infect. Dis. 26, 17-25 (2013).
    • (2013) Curr. Opin. Infect. Dis. , vol.26 , pp. 17-25
    • Nakagawa, F.1    May, M.2    Phillips, A.3
  • 4
    • 0033592967 scopus 로고    scopus 로고
    • HIV-1 and T cell dynamics after interruption of highly active antiretroviral therapy (HAART) in patients with a history of sustained viral suppression
    • Davey, R. T. Jr. et al. HIV-1 and T cell dynamics after interruption of highly active antiretroviral therapy (HAART) in patients with a history of sustained viral suppression. Proc. Natl. Acad. Sci. USA 96, 15109-15114 (1999).
    • (1999) Proc. Natl. Acad. Sci. USA , vol.96 , pp. 15109-15114
    • Davey, R.T.1
  • 5
    • 84864345953 scopus 로고    scopus 로고
    • Towards an HIV cure: A global scientific strategy
    • Deeks, S. G. et al. Towards an HIV cure: a global scientific strategy. Nat. Rev. Immunol. 12, 607-614 (2012).
    • (2012) Nat. Rev. Immunol. , vol.12 , pp. 607-614
    • Deeks, S.G.1
  • 6
    • 0030659177 scopus 로고    scopus 로고
    • Presence of an inducible HIV-1 latent reservoir during highly active antiretroviral therapy
    • Chun, T. W. et al. Presence of an inducible HIV-1 latent reservoir during highly active antiretroviral therapy. Proc. Natl. Acad. Sci. USA 94, 13193-13197 (1997).
    • (1997) Proc. Natl. Acad. Sci. USA , vol.94 , pp. 13193-13197
    • Chun, T.W.1
  • 7
    • 14444273439 scopus 로고    scopus 로고
    • Identification of a reservoir for HIV-1 in patients on highly active antiretroviral therapy
    • Finzi, D. et al. Identification of a reservoir for HIV-1 in patients on highly active antiretroviral therapy. Science 278, 1295-1300 (1997).
    • (1997) Science , vol.278 , pp. 1295-1300
    • Finzi, D.1
  • 8
    • 0030712305 scopus 로고    scopus 로고
    • Recovery of replication-competent HIV despite prolonged suppression of plasma viremia
    • Wong, J. K. et al. Recovery of replication-competent HIV despite prolonged suppression of plasma viremia. Science 278, 1291-1295 (1997).
    • (1997) Science , vol.278 , pp. 1291-1295
    • Wong, J.K.1
  • 9
    • 0038579210 scopus 로고    scopus 로고
    • Long-term follow-up studies confirm the stability of the latent reservoir for HIV-1 in resting CD4+ T cells
    • Siliciano, J. D. et al. Long-term follow-up studies confirm the stability of the latent reservoir for HIV-1 in resting CD4+ T cells. Nat. Med. 9, 727-728 (2003).
    • (2003) Nat. Med. , vol.9 , pp. 727-728
    • Siliciano, J.D.1
  • 10
    • 68349139711 scopus 로고    scopus 로고
    • HIV reservoir size and persistence are driven by T cell survival and homeostatic proliferation
    • Chomont, N. et al. HIV reservoir size and persistence are driven by T cell survival and homeostatic proliferation. Nat. Med. 15, 893-900 (2009).
    • (2009) Nat. Med. , vol.15 , pp. 893-900
    • Chomont, N.1
  • 11
    • 27644524761 scopus 로고    scopus 로고
    • HIV-infected individuals receiving effective antiviral therapy for extended periods of time continually replenish their viral reservoir
    • Chun, T. W. et al. HIV-infected individuals receiving effective antiviral therapy for extended periods of time continually replenish their viral reservoir. J. Clin. Invest. 115, 3250-3255 (2005).
    • (2005) J. Clin. Invest. , vol.115 , pp. 3250-3255
    • Chun, T.W.1
  • 12
    • 84893830170 scopus 로고    scopus 로고
    • Persistent HIV-1 replication is associated with lower antiretroviral drug concentrations in lymphatic tissues
    • Fletcher, C. V. et al. Persistent HIV-1 replication is associated with lower antiretroviral drug concentrations in lymphatic tissues. Proc. Natl. Acad. Sci. USA 111, 2307-2312 (2014).
    • (2014) Proc. Natl. Acad. Sci. USA , vol.111 , pp. 2307-2312
    • Fletcher, C.V.1
  • 14
    • 84904115855 scopus 로고    scopus 로고
    • HIV latency. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells
    • Maldarelli, F. et al. HIV latency. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science 345, 179-183 (2014).
    • (2014) Science , vol.345 , pp. 179-183
    • Maldarelli, F.1
  • 15
    • 84905917318 scopus 로고    scopus 로고
    • HIV latency. Proliferation of cells with HIV integrated into cancer genes contributes to persistent infection
    • Wagner, T. A. et al. HIV latency. Proliferation of cells with HIV integrated into cancer genes contributes to persistent infection. Science 345, 570-573 (2014).
    • (2014) Science , vol.345 , pp. 570-573
    • Wagner, T.A.1
  • 16
    • 84922249841 scopus 로고    scopus 로고
    • HIV-1 integration landscape during latent and active infection
    • Cohn, L. B. et al. HIV-1 integration landscape during latent and active infection. Cell 160, 420-432 (2015).
    • (2015) Cell , vol.160 , pp. 420-432
    • Cohn, L.B.1
  • 17
    • 0030913366 scopus 로고    scopus 로고
    • Quantification of latent tissue reservoirs and total body viral load in HIV-1 infection
    • Chun, T. W. et al. Quantification of latent tissue reservoirs and total body viral load in HIV-1 infection. Nature 387, 183-188 (1997).
    • (1997) Nature , vol.387 , pp. 183-188
    • Chun, T.W.1
  • 18
    • 84886769508 scopus 로고    scopus 로고
    • Replication-competent noninduced proviruses in the latent reservoir increase barrier to HIV-1 cure
    • Ho, Y. C. et al. Replication-competent noninduced proviruses in the latent reservoir increase barrier to HIV-1 cure. Cell 155, 540-551 (2013).
    • (2013) Cell , vol.155 , pp. 540-551
    • Ho, Y.C.1
  • 19
    • 0033031218 scopus 로고    scopus 로고
    • Effect of interleukin-2 on the pool of latently infected, resting CD4+ T cells in HIV-1-infected patients receiving highly active anti-retroviral therapy
    • Chun, T. W. et al. Effect of interleukin-2 on the pool of latently infected, resting CD4+ T cells in HIV-1-infected patients receiving highly active anti-retroviral therapy. Nat. Med. 5, 651-655 (1999).
    • (1999) Nat. Med. , vol.5 , pp. 651-655
    • Chun, T.W.1
  • 20
    • 0033520846 scopus 로고    scopus 로고
    • Immuno-activation with anti-CD3 and recombinant human IL-2 in HIV-1-infected patients on potent antiretroviral therapy
    • Prins, J. M. et al. Immuno-activation with anti-CD3 and recombinant human IL-2 in HIV-1-infected patients on potent antiretroviral therapy. AIDS 13, 2405-2410 (1999).
    • (1999) AIDS , vol.13 , pp. 2405-2410
    • Prins, J.M.1
  • 21
    • 0030952479 scopus 로고    scopus 로고
    • Decay characteristics of HIV-1-infected compartments during combination therapy
    • Perelson, A. S. et al. Decay characteristics of HIV-1-infected compartments during combination therapy. Nature 387, 188-191 (1997).
    • (1997) Nature , vol.387 , pp. 188-191
    • Perelson, A.S.1
  • 22
    • 0033613342 scopus 로고    scopus 로고
    • Re-emergence of HIV after stopping therapy
    • Chun, T. W. , Davey, R. T. Jr. , Engel, D. , Lane, H. C. & Fauci, A. S. Re-emergence of HIV after stopping therapy. Nature 401, 874-875 (1999).
    • (1999) Nature , vol.401 , pp. 874-875
    • Chun, T.W.1    Davey, R.T.2    Engel, D.3    Lane, H.C.4    Fauci, A.S.5
  • 23
    • 23744500093 scopus 로고    scopus 로고
    • Depletion of latent HIV-1 infection in vivo: A proof-of-concept study
    • Lehrman, G. et al. Depletion of latent HIV-1 infection in vivo: a proof-of-concept study. Lancet 366, 549-555 (2005).
    • (2005) Lancet , vol.366 , pp. 549-555
    • Lehrman, G.1
  • 24
    • 79954437524 scopus 로고    scopus 로고
    • Histone deacetylase inhibitors and HIV latency
    • Margolis, D. M. Histone deacetylase inhibitors and HIV latency. Curr. Opin. HIV AIDS 6, 25-29 (2011).
    • (2011) Curr. Opin. HIV AIDS , vol.6 , pp. 25-29
    • Margolis, D.M.1
  • 25
    • 50949131800 scopus 로고    scopus 로고
    • Valproic acid without intensified antiviral therapy has limited impact on persistent HIV infection of resting CD4+ T cells
    • Archin, N. M. et al. Valproic acid without intensified antiviral therapy has limited impact on persistent HIV infection of resting CD4+ T cells. AIDS 22, 1131-1135 (2008).
    • (2008) AIDS , vol.22 , pp. 1131-1135
    • Archin, N.M.1
  • 26
    • 84859424538 scopus 로고    scopus 로고
    • Valproic acid in association with highly active antiretroviral therapy for reducing systemic HIV-1 reservoirs: Results from a multicentre randomized clinical study
    • Routy, J. P. et al. Valproic acid in association with highly active antiretroviral therapy for reducing systemic HIV-1 reservoirs: results from a multicentre randomized clinical study. HIV Med. 13, 291-296 (2012).
    • (2012) HIV Med. , vol.13 , pp. 291-296
    • Routy, J.P.1
  • 27
    • 84864203255 scopus 로고    scopus 로고
    • Administration of vorinostat disrupts HIV-1 latency in patients on antiretroviral therapy
    • Archin, N. M. et al. Administration of vorinostat disrupts HIV-1 latency in patients on antiretroviral therapy. Nature 487, 482-485 (2012).
    • (2012) Nature , vol.487 , pp. 482-485
    • Archin, N.M.1
  • 28
    • 84912122037 scopus 로고    scopus 로고
    • Activation of HIV transcription with short-course vorinostat in HIV-infected patients on suppressive antiretroviral therapy
    • Elliott, J. H. et al. Activation of HIV transcription with short-course vorinostat in HIV-infected patients on suppressive antiretroviral therapy. PLoS Pathog. 10, e1004473 (2014).
    • (2014) PLoS Pathog. , vol.10 , pp. e1004473
    • Elliott, J.H.1
  • 29
    • 84911460971 scopus 로고    scopus 로고
    • Panobinostat, a histone deacetylase inhibitor, for latent-virus reactivation in HIV-infected patients on suppressive antiretroviral therapy: A phase 1/2, single group, clinical trial
    • Rasmussen, T. A. et al. Panobinostat, a histone deacetylase inhibitor, for latent-virus reactivation in HIV-infected patients on suppressive antiretroviral therapy: a phase 1/2, single group, clinical trial. Lancet HIV 1, e13-e21 (2014).
    • (2014) Lancet HIV , vol.1 , pp. e13-e21
    • Rasmussen, T.A.1
  • 30
    • 84864934043 scopus 로고    scopus 로고
    • Effect of histone deacetylase inhibitors on HIV production in latently infected, resting CD4+ T cells from infected individuals receiving effective antiretroviral therapy
    • Blazkova, J. et al. Effect of histone deacetylase inhibitors on HIV production in latently infected, resting CD4+ T cells from infected individuals receiving effective antiretroviral therapy. J. Infect. Dis. 206, 765-769 (2012).
    • (2012) J. Infect. Dis. , vol.206 , pp. 765-769
    • Blazkova, J.1
  • 31
    • 84898423894 scopus 로고    scopus 로고
    • New ex vivo approaches distinguish effective and ineffective single agents for reversing HIV-1 latency in vivo
    • Bullen, C. K. , Laird, G. M. , Durand, C. M. , Siliciano, J. D. & Siliciano, R. F. New ex vivo approaches distinguish effective and ineffective single agents for reversing HIV-1 latency in vivo. Nat. Med. 20, 425-429 (2014).
    • (2014) Nat. Med. , vol.20 , pp. 425-429
    • Bullen, C.K.1    Laird, G.M.2    Durand, C.M.3    Siliciano, J.D.4    Siliciano, R.F.5
  • 32
    • 84863337769 scopus 로고    scopus 로고
    • Stimulation of HIV-1-specific cytolytic T lymphocytes facilitates elimination of latent viral reservoir after virus reactivation
    • Shan, L. et al. Stimulation of HIV-1-specific cytolytic T lymphocytes facilitates elimination of latent viral reservoir after virus reactivation. Immunity 36, 491-501 (2012).
    • (2012) Immunity , vol.36 , pp. 491-501
    • Shan, L.1
  • 33
    • 84922764937 scopus 로고    scopus 로고
    • Broad CTL response is required to clear latent HIV-1 due to dominance of escape mutations
    • Deng, K. et al. Broad CTL response is required to clear latent HIV-1 due to dominance of escape mutations. Nature 517, 381-385 (2015).
    • (2015) Nature , vol.517 , pp. 381-385
    • Deng, K.1
  • 34
    • 60549090253 scopus 로고    scopus 로고
    • Long-term control of HIV by CCR5 delta32/delta32 stem-cell transplantation
    • Hütter, G. et al. Long-term control of HIV by CCR5 delta32/delta32 stem-cell transplantation. N. Engl. J. Med. 360, 692-698 (2009).
    • (2009) N. Engl. J. Med. , vol.360 , pp. 692-698
    • Hütter, G.1
  • 35
    • 84878503062 scopus 로고    scopus 로고
    • Challenges in detecting HIV persistence during potentially curative interventions: A study of the Berlin patient
    • Yukl, S. A. et al. Challenges in detecting HIV persistence during potentially curative interventions: a study of the Berlin patient. PLoS Pathog. 9, e1003347 (2013).
    • (2013) PLoS Pathog. , vol.9 , pp. e1003347
    • Yukl, S.A.1
  • 36
    • 84907367370 scopus 로고    scopus 로고
    • Shift of HIV tropism in stem-cell transplantation with CCR5 delta32 mutation
    • Kordelas, L. et al. Shift of HIV tropism in stem-cell transplantation with CCR5 delta32 mutation. N. Engl. J. Med. 371, 880-882 (2014).
    • (2014) N. Engl. J. Med. , vol.371 , pp. 880-882
    • Kordelas, L.1
  • 37
    • 84922394525 scopus 로고    scopus 로고
    • More on shift of HIV tropism in stem-cell transplantation with CCR5 delta32/delta32 mutation
    • Hütter, G. More on shift of HIV tropism in stem-cell transplantation with CCR5 delta32/delta32 mutation. N. Engl. J. Med. 371, 2437-2438 (2014).
    • (2014) N. Engl. J. Med. , vol.371 , pp. 2437-2438
    • Hütter, G.1
  • 38
    • 84906970468 scopus 로고    scopus 로고
    • Antiretroviral-free HIV-1 remission and viral rebound after allogeneic stem cell transplantation: Report of 2 cases
    • Henrich, T. J. et al. Antiretroviral-free HIV-1 remission and viral rebound after allogeneic stem cell transplantation: report of 2 cases. Ann. Intern. Med. 161, 319-327 (2014).
    • (2014) Ann. Intern. Med. , vol.161 , pp. 319-327
    • Henrich, T.J.1
  • 39
    • 84895487305 scopus 로고    scopus 로고
    • Gene editing of CCR5 in autologous CD4 T cells of persons infected with HIV
    • Tebas, P. et al. Gene editing of CCR5 in autologous CD4 T cells of persons infected with HIV. N. Engl. J. Med. 370, 901-910 (2014).
    • (2014) N. Engl. J. Med. , vol.370 , pp. 901-910
    • Tebas, P.1
  • 41
    • 84879614980 scopus 로고    scopus 로고
    • Unravelling the mechanisms of durable control of HIV-1
    • Walker, B. D. & Yu, X. G. Unravelling the mechanisms of durable control of HIV-1. Nat. Rev. Immunol. 13, 487-498 (2013).
    • (2013) Nat. Rev. Immunol. , vol.13 , pp. 487-498
    • Walker, B.D.1    Yu, X.G.2
  • 42
    • 84885407337 scopus 로고    scopus 로고
    • Effect of antiretroviral therapy on HIV reservoirs in elite controllers
    • Chun, T. W. et al. Effect of antiretroviral therapy on HIV reservoirs in elite controllers. J. Infect. Dis. 208, 1443-1447 (2013).
    • (2013) J. Infect. Dis. , vol.208 , pp. 1443-1447
    • Chun, T.W.1
  • 43
    • 58149382617 scopus 로고    scopus 로고
    • Evidence for persistent low-level viremia in individuals who control human immunodeficiency virus in the absence of antiretroviral therapy
    • Hatano, H. et al. Evidence for persistent low-level viremia in individuals who control human immunodeficiency virus in the absence of antiretroviral therapy. J. Virol. 83, 329-335 (2009).
    • (2009) J. Virol. , vol.83 , pp. 329-335
    • Hatano, H.1
  • 44
    • 78649431227 scopus 로고    scopus 로고
    • HIV-1 continues to replicate and evolve in patients with natural control of HIV infection
    • Mens, H. et al. HIV-1 continues to replicate and evolve in patients with natural control of HIV infection J. Virol. 84, 12971-12981 (2010).
    • (2010) J. Virol. , vol.84 , pp. 12971-12981
    • Mens, H.1
  • 45
    • 77954617321 scopus 로고    scopus 로고
    • Long-term nonprogressive disease among untreated HIV-infected individuals: Clinical implications of understanding immune control of HIV
    • Migueles, S. A. & Connors, M. Long-term nonprogressive disease among untreated HIV-infected individuals: clinical implications of understanding immune control of HIV. J. Am. Med. Assoc. 304, 194-201 (2010).
    • (2010) J. Am. Med. Assoc. , vol.304 , pp. 194-201
    • Migueles, S.A.1    Connors, M.2
  • 46
    • 0032555117 scopus 로고    scopus 로고
    • Early establishment of a pool of latently infected, resting CD4+ T cells during primary HIV-1 infection
    • Chun, T. W. et al. Early establishment of a pool of latently infected, resting CD4+ T cells during primary HIV-1 infection. Proc. Natl. Acad. Sci. USA 95, 8869-8873 (1998).
    • (1998) Proc. Natl. Acad. Sci. USA , vol.95 , pp. 8869-8873
    • Chun, T.W.1
  • 47
    • 84905565097 scopus 로고    scopus 로고
    • Rapid seeding of the viral reservoir prior to SIV viraemia in rhesus monkeys
    • Whitney, J. B. et al. Rapid seeding of the viral reservoir prior to SIV viraemia in rhesus monkeys. Nature 512, 74-77 (2014).
    • (2014) Nature , vol.512 , pp. 74-77
    • Whitney, J.B.1
  • 48
    • 0033609373 scopus 로고    scopus 로고
    • Quantifying residual HIV-1 replication in patients receiving combination antiretroviral therapy
    • Zhang, L. et al. Quantifying residual HIV-1 replication in patients receiving combination antiretroviral therapy. N. Engl. J. Med. 340, 1605-1613 (1999).
    • (1999) N. Engl. J. Med. , vol.340 , pp. 1605-1613
    • Zhang, L.1
  • 49
    • 34249883292 scopus 로고    scopus 로고
    • Decay of the HIV reservoir in patients receiving antiretroviral therapy for extended periods: Implications for eradication of virus
    • Chun, T. W. et al. Decay of the HIV reservoir in patients receiving antiretroviral therapy for extended periods: implications for eradication of virus. J. Infect. Dis. 195, 1762-1764 (2007).
    • (2007) J. Infect. Dis. , vol.195 , pp. 1762-1764
    • Chun, T.W.1
  • 50
    • 33748428894 scopus 로고    scopus 로고
    • A multicenter observational study of the potential benefits of initiating combination antiretroviral therapy during acute HIV infection
    • Hecht, F. M. et al. A multicenter observational study of the potential benefits of initiating combination antiretroviral therapy during acute HIV infection. J. Infect. Dis. 194, 725-733 (2006).
    • (2006) J. Infect. Dis. , vol.194 , pp. 725-733
    • Hecht, F.M.1
  • 51
    • 84887028999 scopus 로고    scopus 로고
    • Absence of detectable HIV-1 viremia after treatment cessation in an infant
    • Persaud, D. et al. Absence of detectable HIV-1 viremia after treatment cessation in an infant. N. Engl. J. Med. 369, 1828-1835 (2013).
    • (2013) N. Engl. J. Med. , vol.369 , pp. 1828-1835
    • Persaud, D.1
  • 52
    • 84875985311 scopus 로고    scopus 로고
    • Post-treatment HIV-1 controllers with a long-term virological remission after the interruption of early initiated antiretroviral therapy ANRS VISCONTI Study
    • Sáez-Cirión, A. et al. Post-treatment HIV-1 controllers with a long-term virological remission after the interruption of early initiated antiretroviral therapy ANRS VISCONTI Study. PLoS Pathog. 9, e1003211 (2013).
    • (2013) PLoS Pathog. , vol.9 , pp. e1003211
    • Sáez-Cirión, A.1
  • 53
    • 84923064466 scopus 로고    scopus 로고
    • Viremic relapse after HIV-1 remission in a perinatally infected child
    • Luzuriaga, K. et al. Viremic relapse after HIV-1 remission in a perinatally infected child. N. Engl. J. Med. 372, 786-788 (2015).
    • (2015) N. Engl. J. Med. , vol.372 , pp. 786-788
    • Luzuriaga, K.1
  • 54
    • 79955016281 scopus 로고    scopus 로고
    • HIV-1 vaccines and adaptive trial designs
    • Corey, L. et al. HIV-1 vaccines and adaptive trial designs. Sci. Transl. Med. 3, 79ps13 (2011).
    • (2011) Sci. Transl. Med. , vol.3 , pp. 79ps13
    • Corey, L.1
  • 55
    • 84867630116 scopus 로고    scopus 로고
    • A blueprint for HIV vaccine discovery
    • Burton, D. R. et al. A blueprint for HIV vaccine discovery. Cell Host Microbe 12, 396-407 (2012).
    • (2012) Cell Host Microbe , vol.12 , pp. 396-407
    • Burton, D.R.1
  • 56
    • 84879300903 scopus 로고    scopus 로고
    • Immune interventions in HIV infection
    • Carcelain, G. & Autran, B. Immune interventions in HIV infection. Immunol. Rev. 254, 355-371 (2013).
    • (2013) Immunol. Rev. , vol.254 , pp. 355-371
    • Carcelain, G.1    Autran, B.2
  • 57
    • 82955201800 scopus 로고    scopus 로고
    • Prospects for an HIV vaccine: Leading B cells down the right path
    • Moir, S. , Malaspina, A. & Fauci, A. S. Prospects for an HIV vaccine: leading B cells down the right path. Nat. Struct. Mol. Biol. 18, 1317-1321 (2011).
    • (2011) Nat. Struct. Mol. Biol. , vol.18 , pp. 1317-1321
    • Moir, S.1    Malaspina, A.2    Fauci, A.S.3
  • 58
    • 84906968862 scopus 로고    scopus 로고
    • Broadly neutralizing antibodies suppress HIV in the persistent viral reservoir
    • Chun, T. W. et al. Broadly neutralizing antibodies suppress HIV in the persistent viral reservoir. Proc. Natl. Acad. Sci. USA 111, 13151-13156 (2014).
    • (2014) Proc. Natl. Acad. Sci. USA , vol.111 , pp. 13151-13156
    • Chun, T.W.1
  • 59
    • 84887626950 scopus 로고    scopus 로고
    • Therapeutic efficacy of potent neutralizing HIV-1-specific monoclonal antibodies in SHIV-infected rhesus monkeys
    • Barouch, D. H. et al. Therapeutic efficacy of potent neutralizing HIV-1-specific monoclonal antibodies in SHIV-infected rhesus monkeys. Nature 503, 224-228 (2013).
    • (2013) Nature , vol.503 , pp. 224-228
    • Barouch, D.H.1
  • 60
    • 84887627657 scopus 로고    scopus 로고
    • Antibody-mediated immunotherapy of macaques chronically infected with SHIV suppresses viraemia
    • Shingai, M. et al. Antibody-mediated immunotherapy of macaques chronically infected with SHIV suppresses viraemia. Nature 503, 277-280 (2013).
    • (2013) Nature , vol.503 , pp. 277-280
    • Shingai, M.1
  • 61
    • 84907379431 scopus 로고    scopus 로고
    • Broadly neutralizing antibodies and viral inducers decrease rebound from HIV-1 latent reservoirs in humanized mice
    • Halper-Stromberg, A. et al. Broadly neutralizing antibodies and viral inducers decrease rebound from HIV-1 latent reservoirs in humanized mice. Cell 158, 989-999 (2014).
    • (2014) Cell , vol.158 , pp. 989-999
    • Halper-Stromberg, A.1
  • 62
    • 84904128252 scopus 로고    scopus 로고
    • Immunologic strategies for HIV-1 remission and eradication
    • Barouch, D. H. & Deeks, S. G. Immunologic strategies for HIV-1 remission and eradication. Science 345, 169-174 (2014).
    • (2014) Science , vol.345 , pp. 169-174
    • Barouch, D.H.1    Deeks, S.G.2
  • 63
    • 84873472629 scopus 로고    scopus 로고
    • Comparative analysis of measures of viral reservoirs in HIV-1 eradication studies
    • Eriksson, S. et al. Comparative analysis of measures of viral reservoirs in HIV-1 eradication studies. PLoS Pathog. 9, e1003174 (2013).
    • (2013) PLoS Pathog. , vol.9 , pp. e1003174
    • Eriksson, S.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.