Phase I safety trial of intravenous ascorbic acid in patients with severe sepsis

Journal of Translational Medicine

Volumn 12, Issue 1, 2014, Pages

  Fowler III, Alpha A ^a   Syed, Aamer A ^a   Knowlson, Shelley ^b   Sculthorpe, Robin ^a   Farthing, Don ^a   DeWilde, Christine ^a   Farthing, Christine A ^a   Larus, Terri L ^a   Martin, Erika ^a   Brophy, Donald F ^a   Gupta, Seema ^c   Fisher, Bernard J ^a   Natarajan, Ramesh ^a  

^a VIRGINIA COMMONWEALTH UNIVERSITY   (United States)

^b VIRGINIA COMMONWEALTH UNIVERSITY   (United States)

^c Health Diagnostics Laboratory   (United States)

Author keywords

Ascorbic acid; Biological markers; Clinical trials phase I as topic; Multiple organ failure; Organ dysfunction scores; Sepsis

Indexed keywords

ASCORBIC ACID; BIOLOGICAL MARKER; C REACTIVE PROTEIN; GLUCOSE; PLACEBO; PROCALCITONIN; THROMBOMODULIN; WATER;

ADULT; AGED; ANTIINFLAMMATORY ACTIVITY; ARTICLE; BLOOD VESSEL INJURY; CLINICAL ARTICLE; COHORT ANALYSIS; CONTROLLED STUDY; DISEASE SEVERITY; DOUBLE BLIND PROCEDURE; DRUG BLOOD LEVEL; DRUG INFUSION; DRUG MEGADOSE; DRUG SAFETY; DRUG TOLERABILITY; FEMALE; HEART VENTRICLE ARRHYTHMIA; HUMAN; HYPERNATREMIA; HYPOTENSION; INTENSIVE CARE UNIT; LOW DRUG DOSE; MALE; NAUSEA; PATIENT MONITORING; PHASE 1 CLINICAL TRIAL; PROTEIN BLOOD LEVEL; RANDOMIZED CONTROLLED TRIAL; SEPSIS; SEQUENTIAL ORGAN FAILURE ASSESSMENT SCORE; TACHYCARDIA; UNSPECIFIED SIDE EFFECT; VOMITING;

ADULT; AGED; AGED, 80 AND OVER; ASCORBIC ACID; BIOLOGICAL MARKERS; C-REACTIVE PROTEIN; CALCITONIN; DEMOGRAPHY; FEMALE; HUMANS; INFUSIONS, INTRAVENOUS; MALE; MIDDLE AGED; MULTIPLE ORGAN FAILURE; PLACEBOS; PROTEIN PRECURSORS; SEPSIS; THROMBOMODULIN;

EID: 84893162337     PISSN: None     EISSN: 14795876     Source Type: Journal    
DOI: 10.1186/1479-5876-12-32     Document Type: Article

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