The Heme Oxygenase-1 Inducer THI-56 Negatively Regulates iNOS Expression and HMGB1 Release in LPS-Activated RAW 264.7 Cells and CLP-Induced Septic Mice

PLoS ONE

Volumn 8, Issue 10, 2013, Pages

  Park, Eun Jung ^a   Jang, Hwa Jin ^a   Tsoyi, Konstantin ^a   Kim, Young Min ^a   Park, Sang Won ^a   Kim, Hye Jung ^a   Lee, Jae Heun ^a   Chang, Ki Churl ^a  

^a Gyeongsang National University   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

6,7 DIHYDROXY 1 (4 HYDROXYNAPHTHYLMETHYL) 1,2,3,4 TETRAHYDROISOQUINOLINE ALKALOID; ALANINE AMINOTRANSFERASE; ASPARTATE AMINOTRANSFERASE; CREATININE; HEME OXYGENASE 1; HEME OXYGENASE INHIBITOR; HIGH MOBILITY GROUP B1 PROTEIN; INDUCIBLE NITRIC OXIDE SYNTHASE; SMALL INTERFERING RNA; TETRAHYDROISOQUINOLINE DERIVATIVE; THI 56; TRANSCRIPTION FACTOR NRF2; UNCLASSIFIED DRUG; UREA; ZINC PROTOPORPHYRIN IX;

ALANINE AMINOTRANSFERASE BLOOD LEVEL; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; CELL VIABILITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; CREATININE BLOOD LEVEL; ENDOTOXEMIA; ENZYME ACTIVITY; GENE SILENCING; HO 1 GENE; LUNG INJURY; MACROPHAGE; MALE; MEDIATOR; MORTALITY; MOUSE; NONHUMAN; PROTEIN BLOOD LEVEL; PROTEIN EXPRESSION; PROTEIN SECRETION; SEPSIS; UREA BLOOD LEVEL;

ANIMALS; ANTI-INFLAMMATORY AGENTS; CELL LINE; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; GENE EXPRESSION REGULATION; HEME OXYGENASE-1; HMGB1 PROTEIN; LIPOPOLYSACCHARIDES; MACROPHAGES; MALE; MICE; NF-E2-RELATED FACTOR 2; NITRIC OXIDE SYNTHASE TYPE II; RNA INTERFERENCE; SEPSIS; TETRAHYDROISOQUINOLINES;

EID: 84884840434     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0076293     Document Type: Article

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