Enantiomers of higenamine inhibit LPS-induced iNOS in a macrophage cell line and improve the survival of mice with experimental endotoxemia

International Immunopharmacology

Volumn 6, Issue 2, 2006, Pages 226-233

  Park, Jee Eun ^a   Kang, Young Jin ^b   Park, Min Kyu ^a   Lee, Young Soo ^a   Kim, Hye Jung ^a   Seo, Han Geuk ^a   Lee, Jae Heun ^a   Hye Sook, Yun Choi ^c   Shin, Jae Soo ^d   Lee, Hong Woo ^d   Ahn, Soon Kil ^d   Chang, Ki Churl ^a  

^a Gyeongsang National University School of Medicine   (South Korea)

^b Yeungnam University College of Medicine   (South Korea)

^c Seoul National University   (South Korea)

^d Chong Kun Dang Research Institute   (South Korea)

Author keywords

Enantiomers (optical isomers); Higenamine; iNOS; Mice; Stereoselectivity; Survival rate

Indexed keywords

HIGENAMINE; INDUCIBLE NITRIC OXIDE SYNTHASE; LIPOPOLYSACCHARIDE; NITRIC OXIDE; NITRITE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL VIABILITY; CONTROLLED STUDY; CYTOTOXICITY; DRUG EFFECT; DRUG STRUCTURE; ENANTIOMER; ENDOTOXEMIA; ENZYME INHIBITION; IC 50; MACROPHAGE ACTIVATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; RACEMIC MIXTURE; SEPTIC SHOCK; STEREOCHEMISTRY; SURVIVAL RATE;

ALKALOIDS; ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; CELL LINE; CELL SURVIVAL; ENDOTOXEMIA; LIPOPOLYSACCHARIDES; MACROPHAGES; MICE; MICE, INBRED ICR; NITRIC OXIDE; NITRIC OXIDE SYNTHASE TYPE II; OXYGEN CONSUMPTION; STEREOISOMERISM; STIMULATION, CHEMICAL; SURVIVAL; TETRAHYDROISOQUINOLINES;

EID: 30144437268     PISSN: 15675769     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.intimp.2005.08.007     Document Type: Article

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