Regulatable transgenic mouse models of Alzheimer disease: Onset, reversibility and spreading of Tau pathology

FEBS Journal

Volumn 280, Issue 18, 2013, Pages 4371-4381

  Hochgräfe, Katja ^a,b   Sydow, Astrid ^a,b   Mandelkow, Eva Maria ^a,b,c  

^a GERMAN CENTER FOR NEURODEGENERATIVE DISEASES DZNE   (Germany)

^b DESY   (Germany)

^c CENTER OF ADVANCED EUROPEAN STUDIES AND RESEARCH CAESAR   (Germany)

Author keywords

aggregation; Alzheimer disease; behavioral and electrophysiological impairments; loss of synapses; neurotoxicity; reversibility; spreading of Tau pathology; Tau; tauopathy; transgenic mouse model

Indexed keywords

PROTEIN VARIANT; TAU PROTEIN;

ALZHEIMER DISEASE; AMYLOID NEUROPATHY; BEHAVIOR DISORDER; COGNITIVE DEFECT; DENDRITE; DISEASE ASSOCIATION; DISEASE MODEL; FRONTOTEMPORAL DEMENTIA; HIPPOCAMPUS; HISTOPATHOLOGY; NERVE CELL NECROSIS; NERVE CELL PLASTICITY; NERVE DEGENERATION; NEUROFIBRILLARY TANGLE; NEUROTOXICITY; NONHUMAN; PATHOPHYSIOLOGY; PRIORITY JOURNAL; PROTEIN AGGREGATION; PROTEIN CONFORMATION; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PROTEIN MODIFICATION; PROTEIN PHOSPHORYLATION; PROTEIN STRUCTURE; REVIEW; SOMATODENDRITIC COMPARTMENT; SYNAPTIC TRANSMISSION; TAUOPATHY; TRANSGENIC MOUSE;

AGGREGATION; ALZHEIMER DISEASE; BEHAVIORAL AND ELECTROPHYSIOLOGICAL IMPAIRMENTS; LOSS OF SYNAPSES; NEUROTOXICITY; REVERSIBILITY; SPREADING OF TAU PATHOLOGY; TAU; TAUOPATHY; TRANSGENIC MOUSE MODEL;

ALZHEIMER DISEASE; ANIMALS; DISEASE MODELS, ANIMAL; GENE EXPRESSION REGULATION; HIPPOCAMPUS; HUMANS; MEMORY; MICE; MUTATION; NEUROFIBRILLARY TANGLES; PROTEIN STRUCTURE, TERTIARY; SYNAPSES; SYNAPTIC TRANSMISSION; TAU PROTEINS;

MUS MUSCULUS;

EID: 84883466237     PISSN: 1742464X     EISSN: 17424658     Source Type: Journal    
DOI: 10.1111/febs.12250     Document Type: Review

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