Mechanisms of tolvaptan-induced toxicity in HepG2 cells

Biochemical Pharmacology

Volumn 95, Issue 4, 2015, Pages 324-336

  Wu, Yuanfeng ^a   Beland, Frederick A ^a   Chen, Si ^a   Liu, Fang ^a   Guo, Lei ^a   Fang, Jia Long ^a  

^a NATIONAL CENTER FOR TOXICOLOGICAL RESEARCH   (United States)

Author keywords

Apoptosis; Autophagy; DNA damage; Liver injury; Proteasome; Tolvaptan

Indexed keywords

8 HYDROXYGUANINE; CYCLIN DEPENDENT KINASE; CYCLINE; CYTOCHROME C; HISTONE H2AX; PROTEIN BCL 2; SYNAPTOPHYSIN; TOLVAPTAN; BENZAZEPINE DERIVATIVE; CYCLIN D3; CYCLIN DEPENDENT KINASE 4; CYTOCHROME P450 3A; MITOGEN ACTIVATED PROTEIN KINASE; PROTEASOME; PROTEASOME INHIBITOR; VASOPRESSIN RECEPTOR ANTAGONIST;

ARTICLE; AUTOPHAGY; CELL CYCLE PROGRESSION; CELL DEATH; CELL GROWTH; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOTOXICITY; DNA DAMAGE; DOWN REGULATION; HEPG2 CELL LINE; HUMAN; HUMAN CELL; LIVER TOXICITY; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; APOPTOSIS; CELL CYCLE; CELL PROLIFERATION; DRUG EFFECTS; ENZYME ACTIVATION; GENETICS; METABOLISM;

ANTIDIURETIC HORMONE RECEPTOR ANTAGONISTS; APOPTOSIS; AUTOPHAGY; BENZAZEPINES; CELL CYCLE; CELL DEATH; CELL PROLIFERATION; CYCLIN D3; CYCLIN-DEPENDENT KINASE 4; CYTOCHROME P-450 CYP3A; DNA DAMAGE; ENZYME ACTIVATION; HEP G2 CELLS; HUMANS; MITOGEN-ACTIVATED PROTEIN KINASES; PROTEASOME ENDOPEPTIDASE COMPLEX; PROTEASOME INHIBITORS;

EID: 84929705874     PISSN: 00062952     EISSN: 18732968     Source Type: Journal    
DOI: 10.1016/j.bcp.2015.03.015     Document Type: Article

References (65)

1. 2-receptor antagonist tolvaptan J. Crit. Care 28 219 2013 e1 e12
2. 2-receptor antagonist, for hyponatremia N. Engl. J. Med. 355 2006 2099 2112
3. V.E. Torres, A.B. Chapman, O. Devuyst, R.T. Gansevoort, J.J. Grantham, and E. Higashihara Tolvaptan in patients with autosomal dominant polycystic kidney disease N. Engl. J. Med. 367 2012 2407 2418
4. S.E. Shoaf, S. Mallikaarjun, and P. Bricmont Effect of grapefruit juice on the pharmacokinetics of tolvaptan, a non-peptide arginine vasopressin antagonist, in healthy subjects Eur. J. Clin. Pharmacol. 68 2012 207 211
5. S.E. Shoaf, P. Bricmont, and S. Mallikaarjun Effects of CYP3A4 inhibition and induction on the pharmacokinetics and pharmacodynamics of tolvaptan, a non-peptide AVP antagonist in healthy subjects Br. J. Clin. Pharmacol. 73 2012 579 587
6. C. Frémin, and S. Meloche From basic research to clinical development of MEK1/2 inhibitors for cancer therapy J. Hematol. Oncol. 3 2010 8
7. R. Roskoski Jr. MEK1/2 dual-specificity protein kinases: structure and regulation Biochem. Biophys. Res. Commun. 417 2012 5 10
8. P.R. Young, M.M. McLaughlin, S. Kumar, S. Kassis, M.L. Doyle, and D. McNulty Pyridinyl imidazole inhibitors of p38 mitogen-activated protein kinase bind in the ATP site J. Biol. Chem. 272 1997 12116 12121
9. S. Tsubuki, Y. Saito, M. Tomioka, H. Ito, and S. Kawashima Differential inhibition of calpain and proteasome activities by peptidyl aldehydes of di-leucine and tri-leucine J. Biochem. 119 1996 572 576
10. S. Chen, J. Xuan, L. Couch, A. Iyer, Y. Wu, and Q.-Z. Li Sertraline induces endoplasmic reticulum stress in hepatic cells Toxicology 322 2014 78 88
11. L. Guo, S. Dial, L. Shi, W. Branham, J. Liu, and J.-L. Fang Similarities and differences in the expression of drug-metabolizing enzymes between human hepatic cell lines and primary human hepatocytes Drug Metab. Dispos. 39 2011 528 538
12. S. Chen, V.N. Dobrovolsky, F. Liu, Y. Wu, Z. Zhang, and N. Mei The role of autophagy in usnic acidinduced toxicity in hepatic cells Toxicol. Sci. 142 2014 33 44
13. Y. Wu, F.A. Beland, S. Chen, and J.-L. Fang Extracellular signal-regulated kinases 1/2 and Akt contribute to triclosan-stimulated proliferation of JB6 Cl 41-5a cells Arch. Toxicol. 2014 10.1007/s00204-014-1308-5
14. J.-L. Fang, and F.A. Beland Long-term exposure to zidovudine delays cell cycle progression, induces apoptosis, and decreases telomerase activity in human hepatocytes Toxicol. Sci. 111 2009 120 130
15. C. Crosio, G.M. Fimia, R. Loury, M. Kimura, Y. Okano, and H. Zhou Mitotic phosphorylation of histone H3: spatiooral regulation by mammalian Aurora kinases Mol. Cell Biol. 22 2002 874 885
16. Y. Wu, X. Qi, L. Gong, G. Xing, M. Chen, and L. Miao Identification of BC005512 as a DNA damage responsive murine endogenous retrovirus of GLN family involved in cell growth regulation PLoS ONE 7 2012 e35010
17. Y. Wu, Q. Wu, F.A. Beland, P. Ge, M.G. Manjanatha, and J.-L. Fang Differential effects of triclosan on the activation of mouse and human peroxisome proliferator-activated receptor alpha Toxicol. Lett. 231 2014 17 28
18. K. Vermeulen, D.R. Van Bockstaele, and Z.N. Berneman The cell cycle: a review of regulation, deregulation and therapeutic targets in cancer Cell Prolif. 36 2003 131 149
19. 1 cyclin-dependent kinases in the mammalian cell cycle Curr. Opin. Cell Biol. 12 2000 676 684
20. A.R. Collins, A.A. Oscoz, G. Brunborg, I. Gaivão, L. Giovannelli, and M. Kruszewski The comet assay: topical issues Mutagenesis 23 2008 143 151
21. E.P. Rogakou, D.R. Pilch, A.H. Orr, V.S. Ivanova, and W.M. Bonner DNA double-stranded breaks induce histone H2AX phosphorylation on serine 139 J. Biol. Chem. 273 1998 5858 5868
22. R.T. Abraham Cell cycle checkpoint signaling through the ATM and ATR kinases Genes Dev. 15 2001 2177 2196
23. E.A. Slee, C. Adrain, and S.J. Martin Executioner caspase-3, -6, and -7 perform distinct, non-redundant roles during the demolition phase of apoptosis J. Biol. Chem. 276 2001 7320 7326
24. N.N. Danial, and S.J. Korsmeyer Cell death: critical control points Cell 116 2004 205 219
25. S.W.G. Tait, and D.R. Green Mitochondria and cell death: outer membrane permeabilization and beyond Nat. Rev. Mol. Cell Biol. 11 2010 621 632
26. R.C. Taylor, S.P. Cullen, and S.J. Martin Apoptosis: controlled demolition at the cellular level Nat. Rev. Mol. Cell Biol. 9 2008 231 241
27. D.T. Chao, and S.J. Korsmeyer BCL-2 family: regulators of cell death Annu. Rev. Immunol. 16 1998 395 419
28. A. Gross, J.M. McDonnell, and S.J. Korsmeyer BCL-2 family members and the mitochondria in apoptosis Genes Dev. 13 1999 1899 1911
29. J.-C. Martinou, and R.J. Youle Mitochondria in apoptosis: Bcl-2 family members and mitochondrial dynamics Dev. Cell. 21 2011 92 101
30. Y. Keshet, and R. Seger The MAP kinase signaling cascades: a system of hundreds of components regulates a diverse array of physiological functions Methods Mol. Biol. 661 2010 3 38 (MAP Kinase Signaling Protocols, Methods in Molecular Biology)
31. D.K. Morrison MAP kinase pathways Cold Spring Harbor Perspect. Biol. 4 2012 a011254
32. L. Chang, and M. Karin Mammalian MAP kinase signalling cascades Nature 410 2001 37 40
33. K.I. Nakayama, and K. Nakayama Ubiquitin ligases: cell-cycle control and cancer Nat. Rev. Cancer 6 2006 369 381
34. L.K. Teixeira, and S.I. Reed Ubiquitin ligases and cell cycle control Annu. Rev. Biochem. 82 2013 387 414
35. R.Z. Orlowski The role of the ubiquitin-proteasome pathway in apoptosis Cell Death Differ. 6 1999 303 313
36. C. Wójcik Regulation of apoptosis by the ubiquitin and proteasome pathway J. Cell. Mol. Med. 6 2002 25 48
37. H. Kim, H.-C. Tu, D. Ren, O. Takeuchi, J.R. Jeffers, and G.P. Zambetti Stepwise activation of BAX and BAK by tBID, BIM, and PUMA initiates mitochondrial apoptosis Mol. Cell 36 2009 487 499
38. H. Li, H. Zhu, C.-J. Xu, and J. Yuan Cleavage of BID by caspase 8 mediates the mitochondrial damage in the Fas pathway of apoptosis Cell 94 1998 491 501
39. D.E. Wood, and E.W. Newcomb Cleavage of Bax enhances its cell death function Exp. Cell Res. 256 2000 375 382
40. B. Levine, and G. Kroemer Autophagy in the pathogenesis of disease Cell 132 2008 27 42
41. N. Mizushima, T. Yoshimori, and B. Levine Methods in mammalian autophagy research Cell 140 2010 313 326
42. E.H. Baehrecke Autophagy: dual roles in life and death Nat. Rev. Mol. Cell Biol. 6 2005 505 510
43. N. Apostolova, L.J. Gomez-Sucerquia, A. Gortat, A. Blas-Garcia, and J.V. Esplugues Autophagy as a rescue mechanism in Efavirenz-induced mitochondrial dysfunction: a lesson from hepatic cells Autophagy 7 2011 1402 1404
44. S. Chen, W.B. Melchior Jr., Y. Wu, and L. Guo Autophagy in drug-induced liver toxicity J. Food Drug Anal. 22 2014 161 168
45. H.-M. Ni, A. Bockus, N. Boggess, H. Jaeschke, and W.-X. Ding Activation of autophagy protects against acetaminophen-induced hepatotoxicity Hepatology 55 2012 222 231
46. Y. Kabeya, N. Mizushima, T. Ueno, A. Yamamoto, T. Kirisako, and T. Noda LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing EMBO J. 19 2000 5720 5728
47. E. Shvets, E. Fass, and Z. Elazar Utilizing flow cytometry to monitor autophagy in living mammalian cells Autophagy 4 2008 621 628
48. M. Komatsu, S. Waguri, T. Ueno, J. Iwata, S. Murata, and I. Tanida Impairment of starvation-induced and constitutive autophagy in Atg7-deficient mice J. Cell Biol. 169 2005 425 434
49. J.A. Dykens, J.D. Jamieson, L.D. Marroquin, S. Nadanaciva, J.J. Xu, and M.C. Dunn In vitro assessment of mitochondrial dysfunction and cytotoxicity of nefazodone, trazodone, and buspirone Toxicol. Sci. 103 2008 335 345
50. A. Felser, K. Blum, P.W. Lindinger, J. Bouitbir, and S. Krähenbühl Mechanisms of hepatocellular toxicity associated with dronedarone - a comparison to amiodarone Toxicol. Sci. 131 2013 480 490
51. M.L. Greer, J. Barber, J. Eakins, and J.G. Kenna Cell based approaches for evaluation of drug-induced liver injury Toxicology 268 2010 125 131
52. A. Juan-García, L. Manyes, M.-J. Ruiz, and G. Font Involvement of enniatins-induced cytotoxicity in human HepG2 cells Toxicol. Lett. 218 2013 166 173
53. K.C. Nguyen, W.G. Willmore, and A.F. Tayabali Cadmium telluride quantum dots cause oxidative stress leading to extrinsic and intrinsic apoptosis in hepatocellular carcinoma HepG2 cells Toxicology 306 2013 114 123
54. J.W. Brown, L.M. Prieto, C. Perez-Stable, M. Montoya, S. Cappell, and L.M. Fishman Estrogen and progesterone lower cyclin B1 and D1 expression, block cell cycle in G2/M, and trigger apoptosis in human adrenal carcinoma cell cultures Horm. Metab. Res. 40 2008 306 310
55. W.-W. Huang, S.-W. Ko, H.-Y. Tsai, J.-G. Chung, J.-H. Chiang, and K.-T. Chen Cantharidin induces G2/M phase arrest and apoptosis in human colorectal cancer colo 205 cells through inhibition of CDK1 activity and caspase-dependent signaling pathways Int. J. Oncol. 38 2011 1067 1073
56. 2 checkpoint through cyclin B1 Proc. Natl. Acad. Sci. U.S.A. 96 1999 2147 2152
57. 2/M arrest by inhibiting CDK1 activity and causing apoptosis via ROS-mitochondrial apoptotic pathway in human hepatocarcinoma cells in vitro and in vivo Carcinogenesis 34 2013 1636 1643
58. D. Chen, M. Frezza, S. Schmitt, J. Kanwar, and Q.P. Dou Bortezomib as the first proteasome inhibitor anticancer drug: current status and future perspectives Curr. Cancer Drug Targets 11 2011 239 253
59. M.L. Khan, and A.K. Stewart Carfilzomib: a novel second-generation proteasome inhibitor Future Oncol. 7 2011 607 612
60. 2-receptor antagonist: results of single- and multiple-dose studies in healthy Japanese male volunteers Cardiovasc. Drugs Ther. 25 Suppl. 1 2011 S5 S17
61. S.E. Shoaf, S.R. Kim, P. Bricmont, and S. Mallikaarjun Pharmacokinetics and pharmacodynamics of single-dose oral tolvaptan in fasted and non-fasted states in healthy Caucasian and Japanese male subjects Eur. J. Clin. Pharmacol. 68 2012 1595 1603
62. J.L.C.M. Dorne, K. Walton, and A.G. Renwick Human variability in xenobiotic metabolism and pathway-related uncertainty factors for chemical risk assessment: a review Food Chem. Toxicol. 43 2005 203 216
63. W.M. Lee Drug-induced hepatotoxicity N. Engl. J. Med. 349 2003 474 485
64. P.A. Routledge, M.S. O'Mahony, and K.W. Woodhouse Adverse drug reactions in elderly patients Br. J. Clin. Pharmacol. 57 2004 121 126
65. J.J. Xu, P.V. Henstock, M.C. Dunn, A.R. Smith, J.R. Chabot, and D. de Graaf Cellular imaging predictions of clinical drug-induced liver injury Toxicol. Sci. 105 2008 97 105