-
2
-
-
61849118840
-
Plasma cell disorders
-
(23rd Edition). Goldman L, Ausiello D (Eds). Saunders, Philadelphia, PA, USA
-
Rajkumar SV, Kyle RA: Plasma Cell Disorders. In: Cecil Textbook of Medicine (23rd Edition). Goldman L, Ausiello D (Eds). Saunders, Philadelphia, PA, USA 1426-1437 (2007).
-
(2007)
Cecil Textbook of Medicine
, pp. 1426-1437
-
-
Rajkumar, S.V.1
Kyle, R.A.2
-
3
-
-
41949130070
-
Improved survival in multiple myeloma and the impact of novel therapies
-
Kumar SK, Rajkumar SV, Dispensieri A, et al.: Improved survival in multiple myeloma and the impact of novel therapies. Blood 111, 2516-2520 (2007).
-
(2007)
Blood
, vol.111
, pp. 2516-2520
-
-
Kumar, S.K.1
Rajkumar, S.V.2
Dispensieri, A.3
-
4
-
-
11244309014
-
Proteolysis from the lysosome to ubiquitin and the proteasome
-
Ciechanover A: Proteolysis from the lysosome to ubiquitin and the proteasome. Nat. Rev. Mol. Cell Biol. 6, 79-87 (2005).
-
(2005)
Nat. Rev. Mol. Cell Biol.
, vol.6
, pp. 79-87
-
-
Ciechanover, A.1
-
5
-
-
12844281837
-
The proteasome
-
DOI 10.1053/j.seminoncol.2004.10.012, PII S0093775404004890
-
Dalton WS: The proteasome. Semin. Oncol. 31, 3-9 (2004). (Pubitemid 40164924)
-
(2004)
Seminars in Oncology
, vol.31
, Issue.SUPPL. 16
, pp. 3-9
-
-
Dalton, W.S.1
-
6
-
-
0034864799
-
Proteasome inhibitors: From research tools to drug candidates
-
DOI 10.1016/S1074-5521(01)00056-4, PII S1074552101000564
-
Kisselev AF, Goldberg AL: Proteasome inhibitors from research tools to drug candidates. Chem. Biol. 8, 739-758 (2001). (Pubitemid 32752454)
-
(2001)
Chemistry and Biology
, vol.8
, Issue.8
, pp. 739-758
-
-
Kisselev, A.F.1
Goldberg, A.L.2
-
7
-
-
2342613652
-
The proteasome: A suitable antineoplastic target
-
Adams J: The proteasome: a suitable antineoplastic target. Nat. Rev. Cancer 4, 349-360 (2004). (Pubitemid 38579481)
-
(2004)
Nature Reviews Cancer
, vol.4
, Issue.5
, pp. 349-360
-
-
Adams, J.1
-
8
-
-
66549099025
-
Targeted inhibition of the immunoproteasome is a potent strategy against models of multiple myeloma that overcomes resistance to conventional drugs and nonspecific proteasome inhibitors
-
Kuhn DJ, Hunsucker SA, Chen Q, et al.: Targeted inhibition of the immunoproteasome is a potent strategy against models of multiple myeloma that overcomes resistance to conventional drugs and nonspecific proteasome inhibitors. Blood 113, 4667-4676 (2009).
-
(2009)
Blood
, vol.113
, pp. 4667-4676
-
-
Kuhn, D.J.1
Hunsucker, S.A.2
Chen, Q.3
-
9
-
-
70350708810
-
Carfilzomib can induce tumor cell death through selective inhibition of the chymotrypsin-like activity of the proteasome
-
Parlati F, Lee SJ, Aujay M, et al.: Carfilzomib can induce tumor cell death through selective inhibition of the chymotrypsin-like activity of the proteasome. Blood 114, 3439-3447 (2009).
-
(2009)
Blood
, vol.114
, pp. 3439-3447
-
-
Parlati, F.1
Lee, S.J.2
Aujay, M.3
-
10
-
-
27644518292
-
Monitoring activity and inhibition of 26S proteasomes with fluorogenic peptide substrates
-
DOI 10.1016/S0076-6879(05)98030-0, PII S0076687905980300, Ubiquitin and Protein Degradation (Part A)
-
Kisselev AF, Goldberg AL: Monitoring activity and inhibition of 26S proteasomes with fluorogenic peptide substrates. Methods Enzymol. 398, 364-378 (2005). (Pubitemid 41578898)
-
(2005)
Methods in Enzymology
, vol.398
, pp. 364-378
-
-
Kisselev, A.F.1
Goldberg, A.L.2
-
11
-
-
0027980319
-
Inhibitors of the proteasome block the degradation of most cell proteins and the generation of peptides presented on MHC class I molecules
-
DOI 10.1016/S0092-8674(94)90462-6
-
Rock KL, Gramm C, Rothstein L, et al.: Inhibitors of the proteasome block the degradation of most cell proteins and the generations of peptides presented on most MHC class I molecules. Cell 78, 761-771 (1994). (Pubitemid 24294452)
-
(1994)
Cell
, vol.78
, Issue.5
, pp. 761-771
-
-
Rock, K.L.1
Gramm, C.2
Rothstein, L.3
Clark, K.4
Stein, R.5
Dick, L.6
Hwang, D.7
Goldberg, A.L.8
-
12
-
-
34447116376
-
Antitumor activity of PR-171, a novel irreversible inhibitor of the proteasome
-
DOI 10.1158/0008-5472.CAN-06-4086
-
Demo SD, Kirk CJ, Aujay MA, et al.: Antitumor activity of PR-171, a novel irreversible inhibitor of the proteasome. Cancer Res. 67(13), 6383-6391 (2007). (Pubitemid 47037522)
-
(2007)
Cancer Research
, vol.67
, Issue.13
, pp. 6383-6391
-
-
Demo, S.D.1
Kirk, C.J.2
Aujay, M.A.3
Buchholz, T.J.4
Dajee, M.5
Ho, M.N.6
Jiang, J.7
Laidig, G.J.8
Lewis, E.R.9
Parlati, F.10
Shenk, K.D.11
Smyth, M.S.12
Sun, C.M.13
Vallone, M.K.14
Woo, T.M.15
Molineaux, C.J.16
Bennett, M.K.17
-
13
-
-
2342667387
-
The development of proteasome inhibitors as anticancer drugs
-
DOI 10.1016/S1535-6108(04)00120-5, PII S1535610804001205
-
Adams J: The development of proteasome inhibitors as anticancer drugs. Cancer Cells 5, 417-421 (2004). (Pubitemid 38610244)
-
(2004)
Cancer Cell
, vol.5
, Issue.5
, pp. 417-421
-
-
Adams, J.1
-
14
-
-
0032539702
-
Potent and selective inhibitors of the proteasome: Dipeptidyl boronic acids
-
DOI 10.1016/S0960-894X(98)00029-8, PII S0960894X98000298
-
Adams J, Behnke M, Chen S, et al.: Potent and selective inhibitors of the proteasome; dipeptidyl boronic acids. Bioorg. Med. Chem. Lett. 8, 333-338 (1998). (Pubitemid 28072702)
-
(1998)
Bioorganic and Medicinal Chemistry Letters
, vol.8
, Issue.4
, pp. 333-338
-
-
Adams, J.1
Behnke, M.2
Chen, S.3
Cruickshank, A.A.4
Dick, L.R.5
Grenier, L.6
Klunder, J.M.7
Ma, Y.-T.8
Plamondon, L.9
Stein, R.L.10
-
15
-
-
20444433230
-
Bortezomib or high-dose dexamethasone for relapsed multiple myeloma
-
DOI 10.1056/NEJMoa043445
-
Richardson PG, Sonneveld P, Schuster MW, et al.: Bortezomib or high-dose dexamethasone for relapsed multiple myeloma. N. Engl. J. Med. 352, 2487-2498 (2005). (Pubitemid 41007864)
-
(2005)
New England Journal of Medicine
, vol.352
, Issue.24
, pp. 2487-2498
-
-
Richardson, P.G.1
Sonneveld, P.2
Schuster, M.W.3
Irwin, D.4
Stadtmauer, E.A.5
Facon, T.6
Harousseau, J.-L.7
Ben-Yehuda, D.8
Lonial, S.9
Goldschmidt, H.10
Reece, D.11
San-Miguel, J.F.12
Blade, J.13
Boccadoro, M.14
Cavenagh, J.15
Dalton, W.S.16
Boral, A.L.17
Esseltine, D.L.18
Porter, J.B.19
Schenkein, D.20
Anderson, K.C.21
more..
-
16
-
-
33746010219
-
Frequency, characteristics, and reversibility of peripheral neuropathy during treatment of advanced multiple myeloma with bortezomib
-
DOI 10.1200/JCO.2005.04.7779
-
Richardson PG, Briemberg H, Jaggannath S, et al.: Frequency, characteristics, and reversibility of peripheral neuropathy during treatment of advanced multiple myeloma with bortezomib. J. Clin. Oncol. 24, 3113-3120 (2006). (Pubitemid 46638949)
-
(2006)
Journal of Clinical Oncology
, vol.24
, Issue.19
, pp. 3113-3120
-
-
Richardson, P.G.1
Briemberg, H.2
Jagannath, S.3
Wen, P.Y.4
Barlogie, B.5
Berenson, J.6
Singhal, S.7
Siegel, D.S.8
Irwin, D.9
Schuster, M.10
Srkalovic, G.11
Alexanian, R.12
Rajkumar, S.V.13
Limentani, S.14
Alsina, M.15
Orlowski, R.Z.16
Najarian, K.17
Esseltine, D.18
Anderson, K.C.19
Amato, A.A.20
more..
-
17
-
-
28444436266
-
Risk factors and kinetics of thrombocytopenia associated with bortezomib for relapsed, refractory multiple myeloma
-
DOI 10.1182/blood-2005-03-1173
-
Lonial S, Walker EK, Richardson PG, et al.: Risk factors and kinetics of thrombocytopenia associated with bortezomib for relapsed, refractory multiple myeloma. Blood 106, 3777-3784 (2005). (Pubitemid 41739012)
-
(2005)
Blood
, vol.106
, Issue.12
, pp. 3777-3784
-
-
Lonial, S.1
Waller, E.K.2
Richardson, P.G.3
Jagannath, S.4
Orlowski, R.Z.5
Giver, C.R.6
Jaye, D.L.7
Francis, D.8
Giusti, S.9
Torre, C.10
Barlogie, B.11
Berenson, J.R.12
Singhal, S.13
Schenkein, D.P.14
Esseltine, D.-L.W.15
Anderson, J.16
Xiao, H.17
Heffner, L.T.18
Anderson, K.C.19
-
18
-
-
0037111832
-
Phase I trial of the proteasome inhibitor PS-341 in patients with refractory hematologic malignancies
-
DOI 10.1200/JCO.2002.01.133
-
Orlowski RZ, Stinchcombe TE, Mitchell BS, et al.: Phase I trial of the proteasome inhibitor PS-341 in patients with refractory hematologic malignancies. J. Clin. Oncol. 20, 4420-4427 (2002). (Pubitemid 35334752)
-
(2002)
Journal of Clinical Oncology
, vol.20
, Issue.22
, pp. 4420-4427
-
-
Orlowski, R.Z.1
Stinchcombe, T.E.2
Mitchell, B.S.3
Shea, T.C.4
Baldwin, A.S.5
Stahl, S.6
Adams, J.7
Esseltine, D.-L.8
Elliott, P.J.9
Pien, C.S.10
Guerciolini, R.11
Anderson, J.K.12
Depcik-Smith, N.D.13
Bhagat, R.14
Lehman, M.J.15
Novick, S.C.16
O'Connor, O.A.17
Soignet, S.L.18
-
19
-
-
2942692143
-
Phase I trial of the proteasome inhibitor bortezomib in patients with advanced solid tumors with observations in androgen-independent prostate cancer
-
DOI 10.1200/JCO.2004.02.106
-
Papandreou CN, Daliani DD, Nix D, et al.: Phase I trial of the proteasome inhibitor bortezomib in patients with advanced solid tumors with observations in androgen-independent prostate cancer. J. Clin. Oncol. 22, 2108-2121 (2004). (Pubitemid 41095144)
-
(2004)
Journal of Clinical Oncology
, vol.22
, Issue.11
, pp. 2108-2121
-
-
Papandreou, C.N.1
Daliani, D.D.2
Nix, D.3
Yang, H.4
Madden, T.5
Wang, X.6
Pien, C.S.7
Millikan, R.E.8
Tu, S.-M.9
Pagliaro, L.10
Kim, J.11
Adams, J.12
Elliott, P.13
Esseltine, D.14
Petrusich, A.15
Dieringer, P.16
Perez, C.17
Logothetis, C.J.18
-
20
-
-
36148944490
-
Potent activity of carfilzomib, a novel, irreversible inhibitor of the ubiquitin-proteasome pathway, against preclinical models of multiple myeloma
-
DOI 10.1182/blood-2007-01-065888
-
Kuhn DJ, Chen Q, Voorhees PM, et al.: Potent activity of carfilzomib, a novel, irreversible inhibitor of the ubiquitin-proteasome pathway, agains preclinical models of multiple myeloma. Blood 110(9), 3281-3290 (2007). (Pubitemid 350106321)
-
(2007)
Blood
, vol.110
, Issue.9
, pp. 3281-3290
-
-
Kuhn, D.J.1
Chen, Q.2
Voorhees, P.M.3
Strader, J.S.4
Shenk, K.D.5
Sun, C.M.6
Demo, S.D.7
Bennett, M.K.8
Van Leeuwen, F.W.B.9
Chanan-Khan, A.A.10
Orlowski, R.Z.11
-
21
-
-
0343262654
-
Crystal structure of epoxomicin:20S proteasome reveals a molecular basis for selectivity of α',β'-epoxyketone proteasome inhibitors [12]
-
DOI 10.1021/ja993588m
-
Groll M, Kim KB, Kaires N, Huber R, Crews CM: Crystal structure of epoxymicin:20S proteasome reveals a molecular basis of a b-epoxyketone proteasome inhibitors. J. Am. Chem. Soc. 122, 1237-1238 (2000). (Pubitemid 30117471)
-
(2000)
Journal of the American Chemical Society
, vol.122
, Issue.6
, pp. 1237-1238
-
-
Groll, M.1
Kim, K.B.2
Kairies, N.3
Huber, R.4
Crews, C.M.5
-
22
-
-
72549116835
-
A Phase 1 dose escalation study of the safety and pharmacokinetics of the novel proteasome inhibitor carfilzomib (PR-171) in patients with hematologic malignancies
-
OConnor OA, Stewart AK, Vallone M, et al.: A Phase 1 dose escalation study of the safety and pharmacokinetics of the novel proteasome inhibitor carfilzomib (PR-171) in patients with hematologic malignancies. Clin. Cancer Res. 15(22), 7085-7091 (2009).
-
(2009)
Clin. Cancer Res.
, vol.15
, Issue.22
, pp. 7085-7091
-
-
Oconnor, O.A.1
Stewart, A.K.2
Vallone, M.3
-
23
-
-
79956064483
-
Histone deacetylase inhibitors potentiate the lethality of the irreversible proteasome inhibitor carfilzomib in mantle cell lymphoma cells in vitro and in vivo
-
Abstract 3938
-
Dasmahapatra G, Lembersky D, Freidberg JW, et al.: Histone deacetylase inhibitors potentiate the lethality of the irreversible proteasome inhibitor carfilzomib in mantle cell lymphoma cells in vitro and in vivo. Blood 116 (2010) (Abstract 3938).
-
(2010)
Blood
, vol.116
-
-
Dasmahapatra, G.1
Lembersky, D.2
Freidberg, J.W.3
-
24
-
-
79956121097
-
Carfilzomib (CFZ): A novel proteasome inhibitor that induces cell cycle arrest and cell death in rituximab-chemotherapy resistant lymphoma and potentiates the anti-tumor activity of chemotherapeutic agents
-
Abstract 4908
-
Gu J, Hernandez-Ilizaliturri FJ, Kaufman GP, et al.: Carfilzomib (CFZ): a novel proteasome inhibitor that induces cell cycle arrest and cell death in rituximab-chemotherapy resistant lymphoma and potentiates the anti-tumor activity of chemotherapeutic agents. Blood 116 (2010) (Abstract 4908).
-
(2010)
Blood
, vol.116
-
-
Gu, J.1
Hernandez-Ilizaliturri, F.J.2
Kaufman, G.P.3
-
25
-
-
79956127594
-
Carfilzomib exerts anti-neoplastic activity in Waldenstrom macroglobulinemia
-
Abstract 4916
-
Sacco A, Roccaro AM, Aujay M, et al.: Carfilzomib exerts anti-neoplastic activity in Waldenstrom macroglobulinemia. Blood 114 (2009) (Abstract 4916).
-
(2009)
Blood
, vol.114
-
-
Sacco, A.1
Roccaro, A.M.2
Aujay, M.3
-
26
-
-
50249150555
-
Phase i single agent antitumor activity of twice weekly consecutive day dosing of the proteasome inhibitor carfilzomib (PR-171) in hematologic malignancies
-
Abstract 411
-
Alsina M, Trudel S, Vallone M, et al.: Phase I single agent antitumor activity of twice weekly consecutive day dosing of the proteasome inhibitor carfilzomib (PR-171) in hematologic malignancies. Blood 110 (2007) (Abstract 411).
-
(2007)
Blood
, vol.110
-
-
Alsina, M.1
Trudel, S.2
Vallone, M.3
-
27
-
-
60849121199
-
Initial results of PX-171-003, an open-label, single-arm, Phase II study of carfilzomib (CFZ) in patients with relapsed and refractory multiple myeloma (MM)
-
Abstract 864
-
Jagannath S, Vij R, Stewart AK, et al.: Initial results of PX-171-003, an open-label, single-arm, Phase II study of carfilzomib (CFZ) in patients with relapsed and refractory multiple myeloma (MM). Blood 112 (2008) (Abstract 864).
-
(2008)
Blood
, vol.112
-
-
Jagannath, S.1
Vij, R.2
Stewart, A.K.3
-
28
-
-
60849121199
-
Initial results of PX-171-004, an open-label, single-arm, Phase II study of carfilzomib (CFZ) in patients with relapsed myeloma (MM)
-
Abstract 865
-
Vij R, Wang M, Orlowski R, et al.: Initial results of PX-171-004, an open-label, single-arm, Phase II study of carfilzomib (CFZ) in patients with relapsed myeloma (MM). Blood 112 (2008) (Abstract 865).
-
(2008)
Blood
, vol.112
-
-
Vij, R.1
Wang, M.2
Orlowski, R.3
-
29
-
-
79956160861
-
PX-171-004, an ongoing open-label, Phase II study of single-agent carfilzomib (CFZ) in patients with relapsed or refractory myeloma (MM); Updated results from the bortezomib-treated cohort
-
Abstract 303
-
Seigel D, Wang L, Orlowski RZ, et al.: PX-171-004, an ongoing open-label, Phase II study of single-agent carfilzomib (CFZ) in patients with relapsed or refractory myeloma (MM); updated results from the bortezomib-treated cohort. Blood 114 (2009) (Abstract 303).
-
(2009)
Blood
, vol.114
-
-
Seigel, D.1
Wang, L.2
Orlowski, R.Z.3
-
30
-
-
77249146098
-
Updated results of bortezomib-nave patients in PX-171-004, an ongoing open-label, Phase II study of single-agent carfilzomib (CFZ) in patients with relapsed or refractory myeloma (MM)
-
Abstract 302
-
Wang L, Seigel D, Kaufman JL, et al.: Updated results of bortezomib-nave patients in PX-171-004, an ongoing open-label, Phase II study of single-agent carfilzomib (CFZ) in patients with relapsed or refractory myeloma (MM). Blood 114 (2009) (Abstract 302).
-
(2009)
Blood
, vol.114
-
-
Wang, L.1
Seigel, D.2
Kaufman, J.L.3
-
31
-
-
79955731920
-
Carfilzomib: High single agent response rate with minimal neuropathy even in high risk patients
-
Abstract 1938
-
Vij R, Kaufman JL, Jakubowiak AJ, et al.: Carfilzomib: high single agent response rate with minimal neuropathy even in high risk patients. Blood 116 (2010) (Abstract 1938).
-
(2010)
Blood
, vol.116
-
-
Vij, R.1
Kaufman, J.L.2
Jakubowiak, A.J.3
-
32
-
-
70349643684
-
Final results of PX-171-003-A0 part 1 of an open-label single-arm Phase II study on carfilzomib (CFZ) in patients (pts) with relapsed and refractory multiple myeloma (MM)
-
Abstract 8504
-
Jagannath S, Vij R, Somlo SG, et al.: Final results of PX-171-003-A0, part 1 of an open-label, single-arm, Phase II study on carfilzomib (CFZ) in patients (pts) with relapsed and refractory multiple myeloma (MM). J. Clin. Oncol. 27(Suppl. 15) (2009) (Abstract 8504).
-
(2009)
J. Clin. Oncol.
, vol.27
, Issue.SUPPL. 15
-
-
Jagannath, S.1
Vij, R.2
Somlo, S.G.3
-
33
-
-
77955450608
-
Phase Ib multicenter dose escalation study of carfilzomib plus lenalidomide and low dose dexamethasone (CRd) in relapsed and refractory multiple myeloma (MM)
-
Abstract 304
-
Niesvizky R, Wang L, Orlowski RZ, et al.: Phase Ib multicenter dose escalation study of carfilzomib plus lenalidomide and low dose dexamethasone (CRd) in relapsed and refractory multiple myeloma (MM). Blood 114 (2009) (Abstract 304).
-
(2009)
Blood
, vol.114
-
-
Niesvizky, R.1
Wang, L.2
Orlowski, R.Z.3
-
34
-
-
79955722886
-
Carfilzomib, lenalidomide, and dexamethasone in newly diagnosed multiple myeloma: Initial results of Phase I/II MMRC trial
-
Abstract 862
-
Jakubowiak AJ, Dytfeld D, Jagannath S, et al.: Carfilzomib, lenalidomide, and dexamethasone in newly diagnosed multiple myeloma: initial results of Phase I/II MMRC trial. Blood 116 (2010) (Abstract 862).
-
(2010)
Blood
, vol.116
-
-
Jakubowiak, A.J.1
Dytfeld, D.2
Jagannath, S.3
-
35
-
-
77649236055
-
The selective proteasome inhibitor carfilzomib is well tolerated in experimental animals with dose intensive administration
-
Abstract 2765
-
Kirk CJ, Jiang J, Muchamuel T, et al.: The selective proteasome inhibitor carfilzomib is well tolerated in experimental animals with dose intensive administration. Blood 112 (2008) (Abstract 2765).
-
(2008)
Blood
, vol.112
-
-
Kirk, C.J.1
Jiang, J.2
Muchamuel, T.3
-
36
-
-
79956152822
-
Phase 1b evaluation of the safety and efficacy of a 30-minute IV infusion of carfilzomib in patients with relapsed and/or refractory multiple myeloma
-
Abstract 3024
-
Papadopoulous K, Samuel diCapua Siegel D, Singhal SB, et al.: Phase 1b evaluation of the safety and efficacy of a 30-minute IV infusion of carfilzomib in patients with relapsed and/or refractory multiple myeloma. Blood 116 (2010) (Abstract 3024).
-
(2010)
Blood
, vol.116
-
-
Papadopoulous, K.1
Samuel DiCapua Siegel, D.2
Singhal, S.B.3
|