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Volumn 7, Issue 5, 2011, Pages 607-612

Carfilzomib: A novel second-generation proteasome inhibitor

Author keywords

bortezomib; carfilzomib; chymotrypsin like; multiple myeloma; PR 171; proteasome inhibitor

Indexed keywords

BORTEZOMIB; CARFILZOMIB; DEXAMETHASONE;

EID: 79956071998     PISSN: 14796694     EISSN: 17448301     Source Type: Journal    
DOI: 10.2217/fon.11.42     Document Type: Article
Times cited : (72)

References (36)
  • 2
    • 61849118840 scopus 로고    scopus 로고
    • Plasma cell disorders
    • (23rd Edition). Goldman L, Ausiello D (Eds). Saunders, Philadelphia, PA, USA
    • Rajkumar SV, Kyle RA: Plasma Cell Disorders. In: Cecil Textbook of Medicine (23rd Edition). Goldman L, Ausiello D (Eds). Saunders, Philadelphia, PA, USA 1426-1437 (2007).
    • (2007) Cecil Textbook of Medicine , pp. 1426-1437
    • Rajkumar, S.V.1    Kyle, R.A.2
  • 3
    • 41949130070 scopus 로고    scopus 로고
    • Improved survival in multiple myeloma and the impact of novel therapies
    • Kumar SK, Rajkumar SV, Dispensieri A, et al.: Improved survival in multiple myeloma and the impact of novel therapies. Blood 111, 2516-2520 (2007).
    • (2007) Blood , vol.111 , pp. 2516-2520
    • Kumar, S.K.1    Rajkumar, S.V.2    Dispensieri, A.3
  • 4
    • 11244309014 scopus 로고    scopus 로고
    • Proteolysis from the lysosome to ubiquitin and the proteasome
    • Ciechanover A: Proteolysis from the lysosome to ubiquitin and the proteasome. Nat. Rev. Mol. Cell Biol. 6, 79-87 (2005).
    • (2005) Nat. Rev. Mol. Cell Biol. , vol.6 , pp. 79-87
    • Ciechanover, A.1
  • 5
    • 12844281837 scopus 로고    scopus 로고
    • The proteasome
    • DOI 10.1053/j.seminoncol.2004.10.012, PII S0093775404004890
    • Dalton WS: The proteasome. Semin. Oncol. 31, 3-9 (2004). (Pubitemid 40164924)
    • (2004) Seminars in Oncology , vol.31 , Issue.SUPPL. 16 , pp. 3-9
    • Dalton, W.S.1
  • 6
    • 0034864799 scopus 로고    scopus 로고
    • Proteasome inhibitors: From research tools to drug candidates
    • DOI 10.1016/S1074-5521(01)00056-4, PII S1074552101000564
    • Kisselev AF, Goldberg AL: Proteasome inhibitors from research tools to drug candidates. Chem. Biol. 8, 739-758 (2001). (Pubitemid 32752454)
    • (2001) Chemistry and Biology , vol.8 , Issue.8 , pp. 739-758
    • Kisselev, A.F.1    Goldberg, A.L.2
  • 7
    • 2342613652 scopus 로고    scopus 로고
    • The proteasome: A suitable antineoplastic target
    • Adams J: The proteasome: a suitable antineoplastic target. Nat. Rev. Cancer 4, 349-360 (2004). (Pubitemid 38579481)
    • (2004) Nature Reviews Cancer , vol.4 , Issue.5 , pp. 349-360
    • Adams, J.1
  • 8
    • 66549099025 scopus 로고    scopus 로고
    • Targeted inhibition of the immunoproteasome is a potent strategy against models of multiple myeloma that overcomes resistance to conventional drugs and nonspecific proteasome inhibitors
    • Kuhn DJ, Hunsucker SA, Chen Q, et al.: Targeted inhibition of the immunoproteasome is a potent strategy against models of multiple myeloma that overcomes resistance to conventional drugs and nonspecific proteasome inhibitors. Blood 113, 4667-4676 (2009).
    • (2009) Blood , vol.113 , pp. 4667-4676
    • Kuhn, D.J.1    Hunsucker, S.A.2    Chen, Q.3
  • 9
    • 70350708810 scopus 로고    scopus 로고
    • Carfilzomib can induce tumor cell death through selective inhibition of the chymotrypsin-like activity of the proteasome
    • Parlati F, Lee SJ, Aujay M, et al.: Carfilzomib can induce tumor cell death through selective inhibition of the chymotrypsin-like activity of the proteasome. Blood 114, 3439-3447 (2009).
    • (2009) Blood , vol.114 , pp. 3439-3447
    • Parlati, F.1    Lee, S.J.2    Aujay, M.3
  • 10
    • 27644518292 scopus 로고    scopus 로고
    • Monitoring activity and inhibition of 26S proteasomes with fluorogenic peptide substrates
    • DOI 10.1016/S0076-6879(05)98030-0, PII S0076687905980300, Ubiquitin and Protein Degradation (Part A)
    • Kisselev AF, Goldberg AL: Monitoring activity and inhibition of 26S proteasomes with fluorogenic peptide substrates. Methods Enzymol. 398, 364-378 (2005). (Pubitemid 41578898)
    • (2005) Methods in Enzymology , vol.398 , pp. 364-378
    • Kisselev, A.F.1    Goldberg, A.L.2
  • 11
    • 0027980319 scopus 로고
    • Inhibitors of the proteasome block the degradation of most cell proteins and the generation of peptides presented on MHC class I molecules
    • DOI 10.1016/S0092-8674(94)90462-6
    • Rock KL, Gramm C, Rothstein L, et al.: Inhibitors of the proteasome block the degradation of most cell proteins and the generations of peptides presented on most MHC class I molecules. Cell 78, 761-771 (1994). (Pubitemid 24294452)
    • (1994) Cell , vol.78 , Issue.5 , pp. 761-771
    • Rock, K.L.1    Gramm, C.2    Rothstein, L.3    Clark, K.4    Stein, R.5    Dick, L.6    Hwang, D.7    Goldberg, A.L.8
  • 13
    • 2342667387 scopus 로고    scopus 로고
    • The development of proteasome inhibitors as anticancer drugs
    • DOI 10.1016/S1535-6108(04)00120-5, PII S1535610804001205
    • Adams J: The development of proteasome inhibitors as anticancer drugs. Cancer Cells 5, 417-421 (2004). (Pubitemid 38610244)
    • (2004) Cancer Cell , vol.5 , Issue.5 , pp. 417-421
    • Adams, J.1
  • 21
    • 0343262654 scopus 로고    scopus 로고
    • Crystal structure of epoxomicin:20S proteasome reveals a molecular basis for selectivity of α',β'-epoxyketone proteasome inhibitors [12]
    • DOI 10.1021/ja993588m
    • Groll M, Kim KB, Kaires N, Huber R, Crews CM: Crystal structure of epoxymicin:20S proteasome reveals a molecular basis of a b-epoxyketone proteasome inhibitors. J. Am. Chem. Soc. 122, 1237-1238 (2000). (Pubitemid 30117471)
    • (2000) Journal of the American Chemical Society , vol.122 , Issue.6 , pp. 1237-1238
    • Groll, M.1    Kim, K.B.2    Kairies, N.3    Huber, R.4    Crews, C.M.5
  • 22
    • 72549116835 scopus 로고    scopus 로고
    • A Phase 1 dose escalation study of the safety and pharmacokinetics of the novel proteasome inhibitor carfilzomib (PR-171) in patients with hematologic malignancies
    • OConnor OA, Stewart AK, Vallone M, et al.: A Phase 1 dose escalation study of the safety and pharmacokinetics of the novel proteasome inhibitor carfilzomib (PR-171) in patients with hematologic malignancies. Clin. Cancer Res. 15(22), 7085-7091 (2009).
    • (2009) Clin. Cancer Res. , vol.15 , Issue.22 , pp. 7085-7091
    • Oconnor, O.A.1    Stewart, A.K.2    Vallone, M.3
  • 23
    • 79956064483 scopus 로고    scopus 로고
    • Histone deacetylase inhibitors potentiate the lethality of the irreversible proteasome inhibitor carfilzomib in mantle cell lymphoma cells in vitro and in vivo
    • Abstract 3938
    • Dasmahapatra G, Lembersky D, Freidberg JW, et al.: Histone deacetylase inhibitors potentiate the lethality of the irreversible proteasome inhibitor carfilzomib in mantle cell lymphoma cells in vitro and in vivo. Blood 116 (2010) (Abstract 3938).
    • (2010) Blood , vol.116
    • Dasmahapatra, G.1    Lembersky, D.2    Freidberg, J.W.3
  • 24
    • 79956121097 scopus 로고    scopus 로고
    • Carfilzomib (CFZ): A novel proteasome inhibitor that induces cell cycle arrest and cell death in rituximab-chemotherapy resistant lymphoma and potentiates the anti-tumor activity of chemotherapeutic agents
    • Abstract 4908
    • Gu J, Hernandez-Ilizaliturri FJ, Kaufman GP, et al.: Carfilzomib (CFZ): a novel proteasome inhibitor that induces cell cycle arrest and cell death in rituximab-chemotherapy resistant lymphoma and potentiates the anti-tumor activity of chemotherapeutic agents. Blood 116 (2010) (Abstract 4908).
    • (2010) Blood , vol.116
    • Gu, J.1    Hernandez-Ilizaliturri, F.J.2    Kaufman, G.P.3
  • 25
    • 79956127594 scopus 로고    scopus 로고
    • Carfilzomib exerts anti-neoplastic activity in Waldenstrom macroglobulinemia
    • Abstract 4916
    • Sacco A, Roccaro AM, Aujay M, et al.: Carfilzomib exerts anti-neoplastic activity in Waldenstrom macroglobulinemia. Blood 114 (2009) (Abstract 4916).
    • (2009) Blood , vol.114
    • Sacco, A.1    Roccaro, A.M.2    Aujay, M.3
  • 26
    • 50249150555 scopus 로고    scopus 로고
    • Phase i single agent antitumor activity of twice weekly consecutive day dosing of the proteasome inhibitor carfilzomib (PR-171) in hematologic malignancies
    • Abstract 411
    • Alsina M, Trudel S, Vallone M, et al.: Phase I single agent antitumor activity of twice weekly consecutive day dosing of the proteasome inhibitor carfilzomib (PR-171) in hematologic malignancies. Blood 110 (2007) (Abstract 411).
    • (2007) Blood , vol.110
    • Alsina, M.1    Trudel, S.2    Vallone, M.3
  • 27
    • 60849121199 scopus 로고    scopus 로고
    • Initial results of PX-171-003, an open-label, single-arm, Phase II study of carfilzomib (CFZ) in patients with relapsed and refractory multiple myeloma (MM)
    • Abstract 864
    • Jagannath S, Vij R, Stewart AK, et al.: Initial results of PX-171-003, an open-label, single-arm, Phase II study of carfilzomib (CFZ) in patients with relapsed and refractory multiple myeloma (MM). Blood 112 (2008) (Abstract 864).
    • (2008) Blood , vol.112
    • Jagannath, S.1    Vij, R.2    Stewart, A.K.3
  • 28
    • 60849121199 scopus 로고    scopus 로고
    • Initial results of PX-171-004, an open-label, single-arm, Phase II study of carfilzomib (CFZ) in patients with relapsed myeloma (MM)
    • Abstract 865
    • Vij R, Wang M, Orlowski R, et al.: Initial results of PX-171-004, an open-label, single-arm, Phase II study of carfilzomib (CFZ) in patients with relapsed myeloma (MM). Blood 112 (2008) (Abstract 865).
    • (2008) Blood , vol.112
    • Vij, R.1    Wang, M.2    Orlowski, R.3
  • 29
    • 79956160861 scopus 로고    scopus 로고
    • PX-171-004, an ongoing open-label, Phase II study of single-agent carfilzomib (CFZ) in patients with relapsed or refractory myeloma (MM); Updated results from the bortezomib-treated cohort
    • Abstract 303
    • Seigel D, Wang L, Orlowski RZ, et al.: PX-171-004, an ongoing open-label, Phase II study of single-agent carfilzomib (CFZ) in patients with relapsed or refractory myeloma (MM); updated results from the bortezomib-treated cohort. Blood 114 (2009) (Abstract 303).
    • (2009) Blood , vol.114
    • Seigel, D.1    Wang, L.2    Orlowski, R.Z.3
  • 30
    • 77249146098 scopus 로고    scopus 로고
    • Updated results of bortezomib-nave patients in PX-171-004, an ongoing open-label, Phase II study of single-agent carfilzomib (CFZ) in patients with relapsed or refractory myeloma (MM)
    • Abstract 302
    • Wang L, Seigel D, Kaufman JL, et al.: Updated results of bortezomib-nave patients in PX-171-004, an ongoing open-label, Phase II study of single-agent carfilzomib (CFZ) in patients with relapsed or refractory myeloma (MM). Blood 114 (2009) (Abstract 302).
    • (2009) Blood , vol.114
    • Wang, L.1    Seigel, D.2    Kaufman, J.L.3
  • 31
    • 79955731920 scopus 로고    scopus 로고
    • Carfilzomib: High single agent response rate with minimal neuropathy even in high risk patients
    • Abstract 1938
    • Vij R, Kaufman JL, Jakubowiak AJ, et al.: Carfilzomib: high single agent response rate with minimal neuropathy even in high risk patients. Blood 116 (2010) (Abstract 1938).
    • (2010) Blood , vol.116
    • Vij, R.1    Kaufman, J.L.2    Jakubowiak, A.J.3
  • 32
    • 70349643684 scopus 로고    scopus 로고
    • Final results of PX-171-003-A0 part 1 of an open-label single-arm Phase II study on carfilzomib (CFZ) in patients (pts) with relapsed and refractory multiple myeloma (MM)
    • Abstract 8504
    • Jagannath S, Vij R, Somlo SG, et al.: Final results of PX-171-003-A0, part 1 of an open-label, single-arm, Phase II study on carfilzomib (CFZ) in patients (pts) with relapsed and refractory multiple myeloma (MM). J. Clin. Oncol. 27(Suppl. 15) (2009) (Abstract 8504).
    • (2009) J. Clin. Oncol. , vol.27 , Issue.SUPPL. 15
    • Jagannath, S.1    Vij, R.2    Somlo, S.G.3
  • 33
    • 77955450608 scopus 로고    scopus 로고
    • Phase Ib multicenter dose escalation study of carfilzomib plus lenalidomide and low dose dexamethasone (CRd) in relapsed and refractory multiple myeloma (MM)
    • Abstract 304
    • Niesvizky R, Wang L, Orlowski RZ, et al.: Phase Ib multicenter dose escalation study of carfilzomib plus lenalidomide and low dose dexamethasone (CRd) in relapsed and refractory multiple myeloma (MM). Blood 114 (2009) (Abstract 304).
    • (2009) Blood , vol.114
    • Niesvizky, R.1    Wang, L.2    Orlowski, R.Z.3
  • 34
    • 79955722886 scopus 로고    scopus 로고
    • Carfilzomib, lenalidomide, and dexamethasone in newly diagnosed multiple myeloma: Initial results of Phase I/II MMRC trial
    • Abstract 862
    • Jakubowiak AJ, Dytfeld D, Jagannath S, et al.: Carfilzomib, lenalidomide, and dexamethasone in newly diagnosed multiple myeloma: initial results of Phase I/II MMRC trial. Blood 116 (2010) (Abstract 862).
    • (2010) Blood , vol.116
    • Jakubowiak, A.J.1    Dytfeld, D.2    Jagannath, S.3
  • 35
    • 77649236055 scopus 로고    scopus 로고
    • The selective proteasome inhibitor carfilzomib is well tolerated in experimental animals with dose intensive administration
    • Abstract 2765
    • Kirk CJ, Jiang J, Muchamuel T, et al.: The selective proteasome inhibitor carfilzomib is well tolerated in experimental animals with dose intensive administration. Blood 112 (2008) (Abstract 2765).
    • (2008) Blood , vol.112
    • Kirk, C.J.1    Jiang, J.2    Muchamuel, T.3
  • 36
    • 79956152822 scopus 로고    scopus 로고
    • Phase 1b evaluation of the safety and efficacy of a 30-minute IV infusion of carfilzomib in patients with relapsed and/or refractory multiple myeloma
    • Abstract 3024
    • Papadopoulous K, Samuel diCapua Siegel D, Singhal SB, et al.: Phase 1b evaluation of the safety and efficacy of a 30-minute IV infusion of carfilzomib in patients with relapsed and/or refractory multiple myeloma. Blood 116 (2010) (Abstract 3024).
    • (2010) Blood , vol.116
    • Papadopoulous, K.1    Samuel DiCapua Siegel, D.2    Singhal, S.B.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.