Involvement of enniatins-induced cytotoxicity in human HepG2 cells

Toxicology Letters

Volumn 218, Issue 2, 2013, Pages 166-173

  Juan García, Ana ^a   Manyes, Lara ^a   Ruiz, María José ^a   Font, Guillermina ^a  

^a UNIVERSITY OF VALENCIA   (Spain)

Author keywords

Apoptosis; Cell cycle; Enniatins; Flow cytometry; HepG2 cells; Mitochondria

Indexed keywords

ENNIATIN; IONOPHORE;

APOPTOSIS; ARTICLE; CELL CYCLE PROGRESSION; CELL DEATH; CELL MEMBRANE; CELL PROLIFERATION; CONTROLLED STUDY; CYTOTOXICITY; FLOW CYTOMETRY; HOMEOSTASIS; HUMAN; HUMAN CELL; METABOLISM; MITOCHONDRIAL TOXICITY; MITOCHONDRION; PRIORITY JOURNAL;

APOPTOSIS; CELL CYCLE; CELL DIVISION; CELL PROLIFERATION; CELL SURVIVAL; DEPSIPEPTIDES; FUSARIUM; HEP G2 CELLS; HUMANS; MEMBRANE POTENTIAL, MITOCHONDRIAL; MITOCHONDRIA; MYCOTOXINS; PROPIDIUM;

EID: 84874684601     PISSN: 03784274     EISSN: 18793169     Source Type: Journal    
DOI: 10.1016/j.toxlet.2013.01.014     Document Type: Article

References (33)

1. Banjerdpongchai R., Kongtawelert P., Khantamat O., Srisomsap C., Chokchaichamnankit D., Subhasitanont P., Svasti J. Mitochondrial and endoplasmic reticulum stress pathways cooperate in zearalenone-induced apoptosis of human leukemic cells. Journal of Hematology and Oncology 2010, 3:50-66.
2. Behm C., Degen G.H., Follmann W. The fusarium toxin enniatin B exerts no genotoxic activity, but pronounced cytotoxicity in vitro. Molecular Nutrition and Food Research 2009, 53:423-430.
3. Bouaziz C., Marte C., Sharaf Al Dein O., Abid-Essefi S., Brenner C., Lemaire C., Bacha H. Fusarial toxin-induced toxicity in cultured cells and in isolated mitochondria involves PTPC-dependent activation of the mitochondrial pathway of apoptosis. Toxicological Sciences 2011, 110:363-375.
4. Chang C., Zhu Y.-Q., Mei J.-J., Liu S.-Q., Luo J. Involvement of mitochondrial pathway in NCTD-induced cytotoxicity in human hepG2 cells. Journal of Experimental and Clinical Cancer Research 2010, 29:145.
5. Comas-Riu J., Rius N. Flow cytometry applications in the food industry. Journal of Industrial Microbiology and Biotechnology 2009, 36:999-1011.
6. Dornetshuber R., Heffeter P., Lemmens-Gruber R., Elbling L., Marko D., Micksche M., Berger W. Oxidative stress and DNA interactions are not involved in Enniatin- and Beauvericin-mediated apoptosis induction. Molecular Nutrition and Food Research 2009, 53:1112-1122.
7. Dornetshuber R., Heffeter P., Kamyar M., Peterbauer T., Berger W., Lemmens-Gruber R. Enniatin exerts p53-dependent cytostatic and p53-independent cytotoxic activities against human cancer cells RID A-8001-2008. Chemical Research in Toxicology 2007, 20:465-473.
8. EU Commission Setting maximum levels for certain contaminants in foodstuffs. Official Journal of European Community 2006, L364:5. (Commission Regulation (EC) No. 1881/2006 of 19 December 2006).
9. Feudjio F.T., Dornetshuber R., Lemmens M., Hoffman O., Lemmens-Gruber R., Berger W. Beauvericin and enniatin: emerging toxins and/or remedies?. World Mycotoxin Journal 2010, 3:415-430.
10. Follman W., Behm C., Degen G.H. The emerging Fusarium toxin enniatin B: in-vitro studies on its genotoxic potential and cytotoxicity in V79 cells in relation to other mycotoxins. Mycotoxin Research 2009, 25:11-19.
11. Hiraga K., Yamamoto S., Fukuda H., Hamanaka N., Oda K. Ennitain has a new function as an inhibitor of Pdr5p, one of the ABC transporters in Saccharomyces cerevisiae. Biochemical and Biophysical Research Communications 2005, 328:1119-1125.
12. Ivanova L., Skjerve E., Eriksen G.S., Uhling S. Cytotoxicity of enniatins A, A1, B, B1, B2 and B3 from Fusarium avenaceum. Toxicon 2006, 47:868-876.
13. Ivanova L., Uhlig S. A bioassay for the simultaneous measurements of metabolic activity, membrane integrity, and lysosomal activity in cell cultures. Analytical Biochemistry 2008, 379:16-19.
14. Jestoi M. Emerging Fusarium-mycotoxins fusaproliferin, beauvericin, enniatins, and moniliformin: a review. Critical Reviews in Food Sciences and Nutrition 2008, 48:21-49.
15. Kamyar M., Rawnduzi P., Sudenik C.R., Kouri K., Lemmens-Gruber R. Investigation of the electrophysiological properties of enniatins. Archives of Biochemistry and Biophysics 2004, 429:215-223.
16. Le Drean G., Auffret M., Batina P., Arnold F., Sibiril Y., Arzur D., Parent-Massin D. Myelotoxicity of trichothecenes and apoptosis: an in vitro study on human cord blood CD34(+) hematopoietic progenitor. Toxicology In Vitro 2005, 19:1015-1024.
17. Lee D.H., Park T., Kim H.W. Induction of apoptosis by disturbing mitochondrial-membrane potential and cleaving PARP in Jurkat T cells through treatment with acetoxyscirpenol mycotoxins. Biological and Pharmaceutical Bulletin 2006, 29:648-654.
18. Lehmann L., Wagner J., Metzler M. Estrogenic and clastogenic potential of the mycotoxin alternariol in cultured mammalian cells. Food Chemistry and Toxicology 2006, 44:398-408.
19. Marin D.E., Gouze M., Taranu I., Oswald I.P. Fumonisin B1 alters cell cycle progression and interleukin-2 synthesis in swine peripheral blood mononuclear cells. Molecular Nutrition and Food Research 2007, 51:1406-1412.
20. Meca G., Mañes J., Font G., Ruiz M.J. Study of the potential toxicity of enniatins A, A(1), B, B(1) by evaluation of duodenal and colonic bioavailability applying an in vitro method by Caco-2 cells. Toxicon 2011, 59:1-11.
21. Meca G., Font G., Ruiz M.J. Comparative cytotoxicity study of enniatins A, A1, A2, B, B1, B4 and J3 on Caco-2 cells, HepG2 and HT-29. Food Chemistry and Toxicology 2011, 49:2464-2469.
22. Minervini F., Fornelli F., Flynn K.M. Toxicity and apoptosis induced by the mycotoxins nivalenol, deoxynivalenol and fumonisin B-1 in a human erythroleukemia cell line. Toxicology In Vitro 2004, 18:21-28.
23. Mronga T., Stahnke T., Goldbaum O., Richter-Landsberg C. Mitochondrial pathway is involved in hydrogen-peroxide induced apoptotic cell death of oligodendrocytes. Glia 2004, 46:446-455.
24. Negedu A., Atawodi S.E., Amed J.B., Umoh V.J., Tanko H.Y. Economic and health perspectives of mycotoxins: a review. Journal of Biomedical Sciences 2011, 5:5-26.
25. Nicholson P., Simpson D.R., Wilson A.H., Chandler E., Thomsett M. Detection and differentiation of trichotecene and enniatin-producing Fusarium species on small-grain cereals. European Journal of Plants and Pathology 2004, 110:503-514.
26. Prosperini A., Font g., Ruiz M.J. Cytotoxicity and oxidative stress induction by fusarium mycotoxins Beauvericin, Enniatin and Fusaproliferin in Caco-2 cells. Toxicon 2012, in press.
27. Tan D.V., Flematti G.R., Ghisalberti E.L., Sivasithamparam K., Barbetti M.J. Toxigenicity of enniatins from western Australian Fusarium species to brine shrimp (Artemia Franciscana). Toxicon 2011, 57:817-825.
28. Tonshin A.A., Teplova V.V., Andersson M.A., Salkinoja-Salonen M.S. The Fusarium mycotoxins enniatins and beauvericin cause mitochondrial dysfunction by affecting the mitochondrial volume regulation, oxidative phosphorylation and ion homeostasis. Toxicology 2010, 276:49-57.
29. Tsiper M.V., Sturgis J., Avramova L.V., Parakh S., Fatig R., Juan-García A., Li N., Rajwa B., Narayanan P., Qualls C.W., Robinson J.P., Davisson V.J. Differential mitochondrial toxicity screening and multi-parametric data analysis. PLoS ONE 2012, 7(10):e45226. 10.1371/journal.pone.0045226.
30. Uhlig S., Ivanova L. Determiantion of beauvericin and four other enniatins in grain by liquid chromatography-mass spectrometry. Journal of Chromatography A 2004, 1050:173-178.
31. van Engeland M., Nieland L.J.W., Ramaekers F.C.S., Shutte B., Reutelingsperger C.P.M. Annexin V-affinity assay: a review on an apoptosis detection system based on phosphatidylserine exposure. Cytometry 2010, 31:1-9.
32. Watjen W., Debbab A., Hohlfeld A., Chovolou Y., Kampkotter A., Edrada R.A., Ebel R., Hakiki A., Mosaddak M., Totzke F., Kubbutat M.H.G., Proksch P. Enniatins A1, B and B1 from an endophytic strain of Fusarium tritictum induce apoptotic cell death in H4IIE hepatoma cells accompanied by inhibition of ERK phosphorylation. Molecular Nutrition and Food Research 2009, 53:431-440.
33. Yang G.-H., Jarvis B.B., Chung Y.-J., Pestka J.J. Apoptosis induction by the stratoxins and other trichotecenes mycotoxins: relationship to ERK, p38 MAPK and SAPK/JNK action. Toxicology and Applied Pharmacology 2000, 164:149-160.