메뉴 건너뛰기




Volumn 36, Issue 2, 2015, Pages 555-568

Nesfatin-1 suppresses cardiac L-type Ca channels through melanocortin type 4 receptor and the novel protein kinase C theta isoform pathway

Author keywords

Cardiomyocytes; L type Ca 2+ channels; Nesfatin 1; Protein kinase C

Indexed keywords

CALCIUM CHANNEL L TYPE; CELL SURFACE RECEPTOR; CORTICOTROPIN RELEASING FACTOR RECEPTOR 2; CYCLIC AMP; CYCLIC AMP DEPENDENT PROTEIN KINASE; CYCLIC GMP DEPENDENT PROTEIN KINASE; ETHYLENE GLYCOL 1,2 BIS(2 AMINOPHENYL) ETHER N,N,N',N' TETRAACETIC ACID; G PROTEIN COUPLED RECEPTOR; GUANOSINE 5' O (2 THIODIPHOSPHATE); MELANOCORTIN 4 RECEPTOR; NATRIURETIC PEPTIDE RECEPTOR A; NESFATIN 1; PEPTIDE DERIVATIVE; PERTUSSIS TOXIN; PROTEIN KINASE C THETA; UNCLASSIFIED DRUG; CALCIUM BINDING PROTEIN; DNA BINDING PROTEIN; INHIBITORY GUANINE NUCLEOTIDE BINDING PROTEIN; ISOENZYME; NERVE PROTEIN; NUCLEOBINDIN; PKCQ PROTEIN, RAT; PROTEIN KINASE C;

EID: 84929692786     PISSN: 10158987     EISSN: 14219778     Source Type: Journal    
DOI: 10.1159/000430120     Document Type: Article
Times cited : (22)

References (60)
  • 1
    • 84889028625 scopus 로고    scopus 로고
    • Central and peripheral expression and distribution of nucb2/nesfatin-1
    • Goebel-Stengel M, Wang L: Central and peripheral expression and distribution of nucb2/nesfatin-1. Curr Pharm Des 2013;19:6935-6940.
    • (2013) Curr Pharm des , vol.19 , pp. 6935-6940
    • Goebel-Stengel, M.1    Wang, L.2
  • 3
    • 80054933215 scopus 로고    scopus 로고
    • Minireview: Nesfatin-1-an emerging new player in the brain-gut, endocrine, and metabolic axis
    • Stengel A, Tache Y: Minireview: Nesfatin-1-an emerging new player in the brain-gut, endocrine, and metabolic axis. Endocrinology 2011;152:4033-4038.
    • (2011) Endocrinology , vol.152 , pp. 4033-4038
    • Stengel, A.1    Tache, Y.2
  • 4
    • 74149087844 scopus 로고    scopus 로고
    • Ghrelin, des-acyl ghrelin and nesfatin-1 in gastric x/a-like cells: Role as regulators of food intake and body weight
    • Stengel A, Goebel M, Wang L, Tache Y: Ghrelin, des-acyl ghrelin and nesfatin-1 in gastric x/a-like cells: Role as regulators of food intake and body weight. Peptides 2010;31:357-369.
    • (2010) Peptides , vol.31 , pp. 357-369
    • Stengel, A.1    Goebel, M.2    Wang, L.3    Tache, Y.4
  • 5
    • 68049085867 scopus 로고    scopus 로고
    • Nesfatin-1 exerts cardiovascular actions in brain: Possible interaction with the central melanocortin system
    • Yosten GL, Samson WK: Nesfatin-1 exerts cardiovascular actions in brain: Possible interaction with the central melanocortin system. Am J Physiol Regul Integr Comp Physiol 2009;297:R330-336.
    • (2009) Am J Physiol Regul Integr Comp Physiol , vol.297 , pp. R330-336
    • Yosten, G.L.1    Samson, W.K.2
  • 6
    • 84888224452 scopus 로고    scopus 로고
    • Nesfatin-1: An affair of the heart
    • Stengel A: Nesfatin-1: An affair of the heart. Endocrinology 2013;154:4443-4445.
    • (2013) Endocrinology , vol.154 , pp. 4443-4445
    • Stengel, A.1
  • 8
    • 84872329989 scopus 로고    scopus 로고
    • Nesfatin-1 as a novel cardiac peptide: Identification, functional characterization, and protection against ischemia/ reperfusion injury
    • Angelone T, Filice E, Pasqua T, Amodio N, Galluccio M, Montesanti G, Quintieri AM, Cerra MC: Nesfatin-1 as a novel cardiac peptide: Identification, functional characterization, and protection against ischemia/ reperfusion injury. Cell Mol Life Sci 2013;70:495-509.
    • (2013) Cell Mol Life Sci , vol.70 , pp. 495-509
    • Angelone, T.1    Filice, E.2    Pasqua, T.3    Amodio, N.4    Galluccio, M.5    Montesanti, G.6    Quintieri, A.M.7    Cerra, M.C.8
  • 9
    • 0034518423 scopus 로고    scopus 로고
    • Structure and regulation of voltage-gated ca2+ channels
    • Catterall WA: Structure and regulation of voltage-gated ca2+ channels. Annu Rev Cell Dev Biol 2000;16:521-555.
    • (2000) Annu Rev Cell Dev Biol , vol.16 , pp. 521-555
    • Catterall, W.A.1
  • 10
    • 84898672639 scopus 로고    scopus 로고
    • Role of calcium channels in the protective effect of hydrogen sulfide in rat cardiomyoblasts
    • Avanzato D, Merlino A, Porrera S, Wang R, Munaron L, Mancardi D: Role of calcium channels in the protective effect of hydrogen sulfide in rat cardiomyoblasts. Cell Physiol Biochem 2014;33:1205-1214.
    • (2014) Cell Physiol Biochem , vol.33 , pp. 1205-1214
    • Avanzato, D.1    Merlino, A.2    Porrera, S.3    Wang, R.4    Munaron, L.5    Mancardi, D.6
  • 11
    • 84891509120 scopus 로고    scopus 로고
    • L-type cav1. 2 calcium channels: From in vitro findings to in vivo function
    • Hofmann F, Flockerzi V, Kahl S, Wegener JW: L-type cav1.2 calcium channels: From in vitro findings to in vivo function. Physiol Rev 2014;94:303-326.
    • (2014) Physiol Rev , vol.94 , pp. 303-326
    • Hofmann, F.1    Flockerzi, V.2    Kahl, S.3    Wegener, J.W.4
  • 12
    • 84905860598 scopus 로고    scopus 로고
    • Interleukin-1beta reduces l-type ca2+ current through protein kinase c activation in mouse heart
    • El Khoury N, Mathieu S, Fiset C: Interleukin-1beta reduces l-type ca2+ current through protein kinase c activation in mouse heart. J Biol Chem 2014;289:21896-21908.
    • (2014) J Biol Chem , vol.289 , pp. 21896-21908
    • El Khoury, N.1    Mathieu, S.2    Fiset, C.3
  • 13
    • 84890665226 scopus 로고    scopus 로고
    • Arctigenin, a potential anti-arrhythmic agent, inhibits aconitine-induced arrhythmia by regulating multi-ion channels
    • Zhao Z, Yin Y, Wu H, Jiang M, Lou J, Bai G, Luo G: Arctigenin, a potential anti-arrhythmic agent, inhibits aconitine-induced arrhythmia by regulating multi-ion channels. Cell Physiol Biochem 2013;32:1342-1353.
    • (2013) Cell Physiol Biochem , vol.32 , pp. 1342-1353
    • Zhao, Z.1    Yin, Y.2    Wu, H.3    Jiang, M.4    Lou, J.5    Bai, G.6    Luo, G.7
  • 15
    • 84880858909 scopus 로고    scopus 로고
    • Presenilins and calcium signaling-systems biology to the rescue
    • Bezprozvanny I: Presenilins and calcium signaling-systems biology to the rescue. Sci Signal 2013;6:pe24.
    • (2013) Sci Signal , vol.6 , pp. pe24
    • Bezprozvanny, I.1
  • 16
    • 84908887956 scopus 로고    scopus 로고
    • Micrornas meet calcium: Joint venture in er proteostasis
    • Finger F, Hoppe T: Micrornas meet calcium: Joint venture in er proteostasis. Sci Signal 2014;7:re11.
    • (2014) Sci Signal , vol.7 , pp. re11
    • Finger, F.1    Hoppe, T.2
  • 17
    • 84891473103 scopus 로고    scopus 로고
    • Insulin-like growth factor-1 receptor-mediated inhibition of a-type k(+) current induces sensory neuronal hyperexcitability through the phosphatidylinositol 3-kinase and extracellular signal-regulated kinase 1/2 pathways, independently of akt
    • Wang H, Qin J, Gong S, Feng B, Zhang Y, Tao J: Insulin-like growth factor-1 receptor-mediated inhibition of a-type k(+) current induces sensory neuronal hyperexcitability through the phosphatidylinositol 3-kinase and extracellular signal-regulated kinase 1/2 pathways, independently of akt. Endocrinology 2014;155:168-179.
    • (2014) Endocrinology , vol.155 , pp. 168-179
    • Wang, H.1    Qin, J.2    Gong, S.3    Feng, B.4    Zhang, Y.5    Tao, J.6
  • 18
    • 84903779617 scopus 로고    scopus 로고
    • Hedgehog induces formation of pka-smoothened complexes to promote smoothened phosphorylation and pathway activation
    • Li S, Ma G, Wang B, Jiang J: Hedgehog induces formation of pka-smoothened complexes to promote smoothened phosphorylation and pathway activation. Sci Signal 2014;7:ra62.
    • (2014) Sci Signal , vol.7 , pp. ra62
    • Li, S.1    Ma, G.2    Wang, B.3    Jiang, J.4
  • 19
    • 84905848408 scopus 로고    scopus 로고
    • The cav1. 2 n terminus contains a cam kinase site that modulates channel trafficking and function
    • Simms BA, Souza IA, Rehak R, Zamponi GW: The cav1.2 n terminus contains a cam kinase site that modulates channel trafficking and function. Pflugers Arch 2014
    • (2014) Pflugers Arch
    • Simms, B.A.1    Souza, I.A.2    Rehak, R.3    Zamponi, G.W.4
  • 20
    • 84873037009 scopus 로고    scopus 로고
    • Genistein ameliorates adverse cardiac effects induced by arsenic trioxide through preventing cardiomyocytes apoptosis
    • Fan Y, Wang C, Zhang Y, Hang P, Liu Y, Pan Z, Wang N, Du Z: Genistein ameliorates adverse cardiac effects induced by arsenic trioxide through preventing cardiomyocytes apoptosis. Cell Physiol Biochem 2013;31:80-91.
    • (2013) Cell Physiol Biochem , vol.31 , pp. 80-91
    • Fan, Y.1    Wang, C.2    Zhang, Y.3    Hang, P.4    Liu, Y.5    Pan, Z.6    Wang, N.7    Du, Z.8
  • 21
    • 84876324198 scopus 로고    scopus 로고
    • Cav1. 2 signaling complexes in the heart
    • Harvey RD, Hell JW: Cav1.2 signaling complexes in the heart. J Mol Cell Cardiol 2013;58:143-152.
    • (2013) J Mol Cell Cardiol , vol.58 , pp. 143-152
    • Harvey, R.D.1    Hell, J.W.2
  • 22
    • 42549123321 scopus 로고    scopus 로고
    • Signaling complexes of voltage-gated calcium channels and g protein-coupled receptors
    • Altier C, Zamponi GW: Signaling complexes of voltage-gated calcium channels and g protein-coupled receptors. J Recept Signal Transduct Res 2008;28:71-81.
    • (2008) J Recept Signal Transduct Res , vol.28 , pp. 71-81
    • Altier, C.1    Zamponi, G.W.2
  • 23
    • 5344271183 scopus 로고    scopus 로고
    • Effect of urocortin on l-type calcium currents in adult rat ventricular myocytes
    • Tao J, Xu H, Yang C, Liu CN, Li S: Effect of urocortin on l-type calcium currents in adult rat ventricular myocytes. Pharmacol Res 2004;50:471-476.
    • (2004) Pharmacol Res , vol.50 , pp. 471-476
    • Tao, J.1    Xu, H.2    Yang, C.3    Liu, C.N.4    Li, S.5
  • 24
    • 84861554993 scopus 로고    scopus 로고
    • Neuromedin u type 1 receptor stimulation of a-type k+ current requires the betagamma subunits of go protein, protein kinase a, and extracellular signal-regulated kinase 1/2 (erk1/2) in sensory neurons
    • Zhang Y, Jiang D, Jiang X, Wang F, Tao J: Neuromedin u type 1 receptor stimulation of a-type k+ current requires the betagamma subunits of go protein, protein kinase a, and extracellular signal-regulated kinase 1/2 (erk1/2) in sensory neurons. J Biol Chem 2012;287:18562-18572.
    • (2012) J Biol Chem , vol.287 , pp. 18562-18572
    • Zhang, Y.1    Jiang, D.2    Jiang, X.3    Wang, F.4    Tao, J.5
  • 25
    • 84908463499 scopus 로고    scopus 로고
    • Peripheral pain is enhanced by insulin-like growth factor 1 through a g protein-mediated stimulation of t-type calcium channels
    • Zhang Y, Qin W, Qian Z, Liu X, Wang H, Gong S, Sun YG, Snutch TP, Jiang X, Tao J: Peripheral pain is enhanced by insulin-like growth factor 1 through a g protein-mediated stimulation of t-type calcium channels. Sci Signal 2014;7:ra94.
    • (2014) Sci Signal , vol.7 , pp. ra94
    • Zhang, Y.1    Qin, W.2    Qian, Z.3    Liu, X.4    Wang, H.5    Gong, S.6    Sun, Y.G.7    Snutch, T.P.8    Jiang, X.9    Tao, J.10
  • 29
    • 84893059304 scopus 로고    scopus 로고
    • Scaffold state switching amplifies, accelerates, and insulates protein kinase c signaling
    • Greenwald EC, Redden JM, Dodge-Kafka KL, Saucerman JJ: Scaffold state switching amplifies, accelerates, and insulates protein kinase c signaling. J Biol Chem 2014;289:2353-2360.
    • (2014) J Biol Chem , vol.289 , pp. 2353-2360
    • Greenwald, E.C.1    Redden, J.M.2    Dodge-Kafka, K.L.3    Saucerman, J.J.4
  • 30
    • 84900525281 scopus 로고    scopus 로고
    • Neural circuitry underlying the central hypertensive action of nesfatin-1: Melanocortins, corticotropin-releasing hormone, and oxytocin
    • Yosten GL, Samson WK: Neural circuitry underlying the central hypertensive action of nesfatin-1: Melanocortins, corticotropin-releasing hormone, and oxytocin. Am J Physiol Regul Integr Comp Physiol 2014;306:R722-727.
    • (2014) Am J Physiol Regul Integr Comp Physiol , vol.306 , pp. R722-727
    • Yosten, G.L.1    Samson, W.K.2
  • 33
    • 34748902793 scopus 로고    scopus 로고
    • Nesfatin-1: Distribution and interaction with a g protein-coupled receptor in the rat brain
    • Brailoiu GC, Dun SL, Brailoiu E, Inan S, Yang J, Chang JK, Dun NJ: Nesfatin-1: Distribution and interaction with a g protein-coupled receptor in the rat brain. Endocrinology 2007;148:5088-5094.
    • (2007) Endocrinology , vol.148 , pp. 5088-5094
    • Brailoiu, G.C.1    Dun, S.L.2    Brailoiu, E.3    Inan, S.4    Yang, J.5    Chang, J.K.6    Dun, N.J.7
  • 34
    • 84855937399 scopus 로고    scopus 로고
    • Alpha-cobratoxin inhibits t-type calcium currents through muscarinic m4 receptor and gomicron-protein betagamma subunits-dependent protein kinase a pathway in dorsal root ganglion neurons
    • Zhang L, Zhang Y, Jiang D, Reid PF, Jiang X, Qin Z, Tao J: Alpha-cobratoxin inhibits t-type calcium currents through muscarinic m4 receptor and gomicron-protein betagamma subunits-dependent protein kinase a pathway in dorsal root ganglion neurons. Neuropharmacology 2012;62:1062-1072.
    • (2012) Neuropharmacology , vol.62 , pp. 1062-1072
    • Zhang, L.1    Zhang, Y.2    Jiang, D.3    Reid, P.F.4    Jiang, X.5    Qin, Z.6    Tao, J.7
  • 35
    • 0036479130 scopus 로고    scopus 로고
    • A novel long n-terminal isoform of human l-type ca2+ channel is up-regulated by protein kinase c
    • Blumenstein Y, Kanevsky N, Sahar G, Barzilai R, Ivanina T, Dascal N: A novel long n-terminal isoform of human l-type ca2+ channel is up-regulated by protein kinase c. J Biol Chem 2002;277:3419-3423.
    • (2002) J Biol Chem , vol.277 , pp. 3419-3423
    • Blumenstein, Y.1    Kanevsky, N.2    Sahar, G.3    Barzilai, R.4    Ivanina, T.5    Dascal, N.6
  • 38
    • 84887862575 scopus 로고    scopus 로고
    • Budded baculoviruses as a tool for a homogeneous fluorescence anisotropy-based assay of ligand binding to g protein-coupled receptors: The case of melanocortin 4 receptors
    • Veiksina S, Kopanchuk S, Rinken A: Budded baculoviruses as a tool for a homogeneous fluorescence anisotropy-based assay of ligand binding to g protein-coupled receptors: The case of melanocortin 4 receptors. Biochim Biophys Acta 2014;1838:372-381.
    • (2014) Biochim Biophys Acta , vol.1838 , pp. 372-381
    • Veiksina, S.1    Kopanchuk, S.2    Rinken, A.3
  • 39
    • 70649106886 scopus 로고    scopus 로고
    • L-type channel inhibition by cb1 cannabinoid receptors is mediated by ptx-sensitive g proteins and camp/pka in gt1-7 hypothalamic neurons
    • Hoddah H, Marcantoni A, Comunanza V, Carabelli V, Carbone E: L-type channel inhibition by cb1 cannabinoid receptors is mediated by ptx-sensitive g proteins and camp/pka in gt1-7 hypothalamic neurons. Cell Calcium 2009;46:303-312.
    • (2009) Cell Calcium , vol.46 , pp. 303-312
    • Hoddah, H.1    Marcantoni, A.2    Comunanza, V.3    Carabelli, V.4    Carbone, E.5
  • 41
    • 30744455306 scopus 로고    scopus 로고
    • Urocortin ii enhances contractility in rabbit ventricular myocytes via crf(2) receptor-mediated stimulation of protein kinase a
    • Yang LZ, Kockskamper J, Heinzel FR, Hauber M, Walther S, Spiess J, Pieske B: Urocortin ii enhances contractility in rabbit ventricular myocytes via crf(2) receptor-mediated stimulation of protein kinase a. Cardiovasc Res 2006;69:402-411.
    • (2006) Cardiovasc Res , vol.69 , pp. 402-411
    • Yang, L.Z.1    Kockskamper, J.2    Heinzel, F.R.3    Hauber, M.4    Walther, S.5    Spiess, J.6    Pieske, B.7
  • 42
    • 0034623827 scopus 로고    scopus 로고
    • Regulation of cardiac l-type calcium channels by protein kinase a and protein kinase c
    • Kamp TJ, Hell JW: Regulation of cardiac l-type calcium channels by protein kinase a and protein kinase c. Circ Res 2000;87:1095-1102.
    • (2000) Circ Res , vol.87 , pp. 1095-1102
    • Kamp, T.J.1    Hell, J.W.2
  • 43
    • 77955656076 scopus 로고    scopus 로고
    • Activation of neuromedin u type 1 receptor inhibits l-type ca2+ channel currents via phosphatidylinositol 3-kinase-dependent protein kinase c epsilon pathway in mouse hippocampal neurons
    • Zhang Y, Jiang D, Zhang J, Wang F, Jiang X, Tao J: Activation of neuromedin u type 1 receptor inhibits l-type ca2+ channel currents via phosphatidylinositol 3-kinase-dependent protein kinase c epsilon pathway in mouse hippocampal neurons. Cell Signal 2010;22:1660-1668.
    • (2010) Cell Signal , vol.22 , pp. 1660-1668
    • Zhang, Y.1    Jiang, D.2    Zhang, J.3    Wang, F.4    Jiang, X.5    Tao, J.6
  • 45
    • 84878174436 scopus 로고    scopus 로고
    • Stimulation of arterial smooth muscle l-type calcium channels by hydrogen peroxide requires protein kinase c
    • Chaplin NL, Amberg GC: Stimulation of arterial smooth muscle l-type calcium channels by hydrogen peroxide requires protein kinase c. Channels (Austin) 2012;6:385-389.
    • (2012) Channels (Austin) , vol.6 , pp. 385-389
    • Chaplin, N.L.1    Amberg, G.C.2
  • 46
    • 79952620128 scopus 로고    scopus 로고
    • Involvement of protein kinase c and protein kinase a in the enhancement of l-type calcium current by gabab receptor activation in neonatal hippocampus
    • Bray JG, Mynlieff M: Involvement of protein kinase c and protein kinase a in the enhancement of l-type calcium current by gabab receptor activation in neonatal hippocampus. Neuroscience 2011;179:62-72.
    • (2011) Neuroscience , vol.179 , pp. 62-72
    • Bray, J.G.1    Mynlieff, M.2
  • 47
    • 0035661773 scopus 로고    scopus 로고
    • Regulation of cardiac and smooth muscle ca(2+) channels (ca(v)1.2a,b) by protein kinases
    • Keef KD, Hume JR, Zhong J: Regulation of cardiac and smooth muscle ca(2+) channels (ca(v)1.2a,b) by protein kinases. Am J Physiol Cell Physiol 2001;281:C1743-1756.
    • (2001) Am J Physiol Cell Physiol , vol.281 , pp. C1743-1756
    • Keef, K.D.1    Hume, J.R.2    Zhong, J.3
  • 49
    • 84891855477 scopus 로고    scopus 로고
    • Plcepsilon, pkd1, and ssh1l transduce rhoa signaling to protect mitochondria from oxidative stress in the heart
    • Xiang SY, Ouyang K, Yung BS, Miyamoto S, Smrcka AV, Chen J, Heller Brown J: Plcepsilon, pkd1, and ssh1l transduce rhoa signaling to protect mitochondria from oxidative stress in the heart. Sci Signal 2013;6:ra108.
    • (2013) Sci Signal , vol.6 , pp. ra108
    • Xiang, S.Y.1    Ouyang, K.2    Yung, B.S.3    Miyamoto, S.4    Smrcka, A.V.5    Chen, J.6    Heller Brown, J.7
  • 50
    • 0028289497 scopus 로고
    • Localization of protein kinase c isozymes in cardiac myocytes
    • Disatnik MH, Buraggi G, Mochly-Rosen D: Localization of protein kinase c isozymes in cardiac myocytes. Exp Cell Res 1994;210:287-297.
    • (1994) Exp Cell Res , vol.210 , pp. 287-297
    • Disatnik, M.H.1    Buraggi, G.2    Mochly-Rosen, D.3
  • 54
    • 9644264030 scopus 로고    scopus 로고
    • Smooth muscle-selective alternatively spliced exon generates functional variation in cav1. 2 calcium channels
    • Liao P, Yu D, Lu S, Tang Z, Liang MC, Zeng S, Lin W, Soong TW: Smooth muscle-selective alternatively spliced exon generates functional variation in cav1.2 calcium channels. J Biol Chem 2004;279:50329-50335.
    • (2004) J Biol Chem , vol.279 , pp. 50329-50335
    • Liao, P.1    Yu, D.2    Lu, S.3    Tang, Z.4    Liang, M.C.5    Zeng, S.6    Lin, W.7    Soong, T.W.8
  • 55
    • 47049092004 scopus 로고    scopus 로고
    • New determinant for the cavbeta2 subunit modulation of the cav1. 2 calcium channel
    • Lao QZ, Kobrinsky E, Harry JB, Ravindran A, Soldatov NM: New determinant for the cavbeta2 subunit modulation of the cav1.2 calcium channel. J Biol Chem 2008;283:15577-15588.
    • (2008) J Biol Chem , vol.283 , pp. 15577-15588
    • Lao, Q.Z.1    Kobrinsky, E.2    Harry, J.B.3    Ravindran, A.4    Soldatov, N.M.5
  • 56
    • 80053208017 scopus 로고    scopus 로고
    • Understanding molecular recognition by g protein betagamma subunits on the path to pharmacological targeting
    • Lin Y, Smrcka AV: Understanding molecular recognition by g protein betagamma subunits on the path to pharmacological targeting. Mol Pharmacol 2011;80:551-557.
    • (2011) Mol Pharmacol , vol.80 , pp. 551-557
    • Lin, Y.1    Smrcka, A.V.2
  • 60
    • 1642359140 scopus 로고    scopus 로고
    • Muscarinic m2 receptor stimulation of cav1. 2b requires phosphatidylinositol 3-kinase, protein kinase c, and c-src
    • Callaghan B, Koh SD, Keef KD: Muscarinic m2 receptor stimulation of cav1.2b requires phosphatidylinositol 3-kinase, protein kinase c, and c-src. Circ Res 2004;94:626-633.
    • (2004) Circ Res , vol.94 , pp. 626-633
    • Callaghan, B.1    Koh, S.D.2    Keef, K.D.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.