Peripheral pain is enhanced by insulin-like growth factor 1 through a G protein-mediated stimulation of T-type calcium channels

Science Signaling

Volumn 7, Issue 346, 2014, Pages ra94-

  Zhang, Yuan ^a,b   Qin, Wenjuan ^a   Qian, Zhiyuan ^b   Liu, Xingjun ^c   Wang, Hua ^a   Gong, Shan ^a   Sun, Yan Gang ^c   Snutch, Terrance P ^d   Jiang, Xinghong ^a   Tao, Jin ^a  

^a MEDICAL COLLEGE OF SOOCHOW UNIVERSITY   (China)

^b THE SECOND AFFILIATED HOSPITAL OF SOOCHOW UNIVERSITY   (China)

^c Chinese Academy of Sciences   (China)

^d UNIVERSITY OF BRITISH COLUMBIA   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM CHANNEL BLOCKING AGENT; CALCIUM CHANNEL T TYPE; GUANOSINE DIPHOSPHATE; HETEROTRIMERIC GUANINE NUCLEOTIDE BINDING PROTEIN; PERTUSSIS TOXIN; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE C ALPHA INHIBITOR; PROTEIN KINASE C BETA; SOMATOMEDIN C; SOMATOMEDIN C RECEPTOR; GUANINE NUCLEOTIDE BINDING PROTEIN; INSULIN-LIKE GROWTH FACTOR-1, MOUSE; PROTEIN KINASE C ALPHA; SMALL INTERFERING RNA;

ADULT; ANIMAL CELL; ARTICLE; CONTROLLED STUDY; DORSAL ROOT; ENZYME INHIBITION; HYPERALGESIA; IN VITRO STUDY; INTRACELLULAR SIGNALING; INTRAPLANTAR DRUG ADMINISTRATION; MOUSE; NERVE EXCITABILITY; NERVE POTENTIAL; NONHUMAN; SPINAL CORD NERVE CELL; ACTION POTENTIAL; ANALYSIS OF VARIANCE; ANIMAL; CELL FRACTIONATION; CYTOLOGY; DRUG EFFECTS; FLUORESCENCE MICROSCOPY; GENETICS; IMMUNOHISTOCHEMISTRY; IMMUNOPRECIPITATION; METABOLISM; PAIN; PATCH CLAMP TECHNIQUE; PERIPHERAL NERVOUS SYSTEM; PHYSIOLOGY; SENSORY NERVE CELL; SIGNAL TRANSDUCTION; SPINAL GANGLION; TEMPERATURE SENSE; WESTERN BLOTTING;

MUS;

ACTION POTENTIALS; ANALYSIS OF VARIANCE; ANIMALS; BLOTTING, WESTERN; CALCIUM CHANNELS, T-TYPE; CELL FRACTIONATION; GANGLIA, SPINAL; GTP-BINDING PROTEINS; IMMUNOHISTOCHEMISTRY; IMMUNOPRECIPITATION; INSULIN-LIKE GROWTH FACTOR I; MICE; MICROSCOPY, FLUORESCENCE; NEURONS, AFFERENT; PAIN; PATCH-CLAMP TECHNIQUES; PERIPHERAL NERVOUS SYSTEM; PROTEIN KINASE C-ALPHA; RECEPTOR, IGF TYPE 1; RNA, SMALL INTERFERING; SIGNAL TRANSDUCTION; THERMOSENSING;

EID: 84908463499     PISSN: 19450877     EISSN: 19379145     Source Type: Journal    
DOI: 10.1126/scisignal.2005283     Document Type: Article

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