Presenilins and calcium signaling - Systems biology to the rescue

Science Signaling

Volumn 6, Issue 283, 2013, Pages

  Bezprozvanny, Ilya ^a,b  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^b PETER THE GREAT ST PETERSBURG POLYTECHNIC UNIVERSITY   (Russian Federation)

Author keywords

[No Author keywords available]

Indexed keywords

AMYLOID BETA PROTEIN; CALCIUM; GAMMA SECRETASE; PRESENILIN 1; SMALL INTERFERING RNA;

ALZHEIMER DISEASE; CALCIUM HOMEOSTASIS; CALCIUM SIGNALING; ENDOPLASMIC RETICULUM; ENZYME ACTIVITY; FAMILIAL ALZHEIMER DISEASE; FIBROBLAST; GENE MUTATION; MISSENSE MUTATION; PHENOTYPE; POINT MUTATION; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN FUNCTION; REVIEW; SEQUENCE HOMOLOGY; SPASTIC PARAPLEGIA; SYSTEMS BIOLOGY;

ALZHEIMER DISEASE; AMYLOID PRECURSOR PROTEIN SECRETASES; ANIMALS; BACTERIAL PROTEINS; CALCIUM SIGNALING; CRYSTALLOGRAPHY, X-RAY; ENDOPLASMIC RETICULUM; HUMANS; MUTATION; PRESENILINS; STRUCTURAL HOMOLOGY, PROTEIN; SYSTEMS BIOLOGY;

EID: 84880858909     PISSN: 19450877     EISSN: 19379145     Source Type: Journal    
DOI: 10.1126/scisignal.2004296     Document Type: Review

References (10)

1. 2+ mobilization is altered in fi-broblasts from patients with Alzheimer disease. Proc. Natl. Acad. Sci. U.S.A. 91, 534-538 (1994).
2. 2+ leak channels, a function disrupted by familial Alzheimer's disease-linked mutations. Cell 126, 981-983 (2006).
3. O. Nelson, C. Supnet, H. Liu, I. Bezprozvanny, Familial Alzheimer's disease mutations in prese-nilins: Effects on endoplasmic reticulum calcium homeostasis and correlation with clinical pheno-types. JAD 21, 781-793 (2010).
4. 2+ disruption in Alzheimer's disease by presenilin regulation of InsP3 receptor channel gating. Neuron 58, 871-883 (2008). (Pubitemid 351842747)
5. K. N. Green, A. Demuro, Y. Akbari, B. D. Hitt, I. F. Smith, I. Parker, F. M. LaFerla, SERCA pump activity is physiologically regulated by presenilin and regulates amyloid beta production. J. Cell Biol. 181, 1107-1116 (2008). (Pubitemid 351915486)
6. 2+ leak channels. J. Biol. Chem. 287, 10933-10944 (2012).
7. X. Li, S. Dang, C. Yan, X. Gong, J. Wang, Y. Shi, Structure of a presenilin family intramembrane aspartate protease. Nature 493, 56-61 (2013).
8. O. Nelson, C. Supnet, A. Tolia, K. Horré, B. De Strooper, I. Bezprozvanny, Mutagenesis mapping of the presenilin 1 calcium leak conductance pore. J. Biol. Chem. 286, 22339-22347 (2011).
9. S. Bandara, S. Malmersjö, T. Meyer, Regulators of calcium homeostasis identified by inference of kinetic model parameters from live single cells perturbed by siRNA. Sci. Signal. 6, ra56 (2013).
10. A. J. Larner, M. Doran, Clinical phenotypic heterogeneity of Alzheimer's disease associated with mutations of the presenilin-1 gene. J. Neurol. 253, 139-158 (2006). (Pubitemid 43255883)