Arctigenin, a potential anti-arrhythmic agent, inhibits aconitine-induced arrhythmia by regulating multi-ion channels

Cellular Physiology and Biochemistry

Volumn 32, Issue 5, 2013, Pages 1342-1353

  Zhao, Zhenying ^a,c   Yin, Yongqiang ^b   Wu, Hong ^b,d   Jiang, Min ^a   Lou, Jianshi ^b   Bai, Gang ^a   Luo, Guo'an ^a  

^a NANKAI UNIVERSITY   (China)

^b TIANJIN MEDICAL UNIVERSITY   (China)

^c TIANJIN UNION MEDICAL CENTER   (China)

^d MUDANJIANG MEDICAL UNIVERSITY   (China)

Author keywords

Aconitine; Arctigenin; Arrhythmia; Ion channel; Patch clamp

Indexed keywords

ACONITINE; ARCTIGENIN; ION CHANNEL; CALCIUM CHANNEL L TYPE; POTASSIUM CHANNEL;

ACTION POTENTIAL; ACTION POTENTIAL DURATION; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CALCIUM CURRENT; CELL MEMBRANE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DEATH; FEMALE; HEART ARRHYTHMIA; HEART MUSCLE CELL; HEART REPOLARIZATION; HEART VENTRICLE TACHYCARDIA; MALE; MEMBRANE STEADY POTENTIAL; MUSCLE CELL; NONHUMAN; PATCH CLAMP TECHNIQUE; POTASSIUM CURRENT; PRIORITY JOURNAL; RAT; SODIUM CURRENT; SUPRAVENTRICULAR PREMATURE BEAT; ACONITINE-INDUCED ARRHYTHMIA; ANIMAL TISSUE; ANTIARRHYTHMIC ACTIVITY; CONTINUOUS INFUSION; DRUG MECHANISM; HEART DEATH; HEART ELECTROPHYSIOLOGY; HEART MUSCLE FIBER MEMBRANE STEADY POTENTIAL; HEART VENTRICLE EXTRASYSTOLE; RAT MODEL; REPOLARIZATION; SPONTANEOUS TRANSIENT OUTWARD CURRENT; WHOLE CELL PATCH CLAMP;

RATTUS;

ACONITINE; ACTION POTENTIALS; ANIMALS; ANTI-ARRHYTHMIA AGENTS; ARRHYTHMIAS, CARDIAC; CALCIUM CHANNELS, L-TYPE; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; FURANS; ION CHANNELS; LIGNANS; MALE; MYOCYTES, CARDIAC; PATCH-CLAMP TECHNIQUES; POTASSIUM CHANNELS; RATS; RATS, WISTAR; SODIUM CHANNELS;

EID: 84890665226     PISSN: 10158987     EISSN: 14219778     Source Type: Journal    
DOI: 10.1159/000354532     Document Type: Article

References (23)

1. Sheets MF, Fozzard HA, Lipkind GM, Hanck DA: Sodium channel molecular conformations and antiarrhythmic drug affinity. Trends Cardiovas Med 2010;20:16-21.
2. Tosaki A, Szerdahelyi P, Engelman RM, Das DK: Potassium channel openers and blockers: do they possess proarrhythmic or antiarrhythmic activity in ischemic and reperfused rat hearts? J Pharmacol Exp Ther 1993;267:1355-1362.
3. Apostolakos MJ, Varon ME: Antiarrhythmic and anti-ischemic properties of calcium-channel antagonists. New Horiz 1996;4:45-57.
4. Kowey PR, Yan GX: Proarrhythmias and antiarrhythmias: two sides of the same coin. Heart Rhythm 2005;2:957-959.
5. Zhou SS, Yang J, Li YQ, Zhao LY, Xu M, Ding YF: Effect of cl-channel blockers on aconitine-induced arrhythmias in rat heart. Exp Physiol 2005;90:865-872.
6. Yang B, Shan H, Zhou Y, Gong D, Dong D, Du Z: Construction of a new model for screening antiarrhythmic drugs. Chin Pharmacol Bull 2003;19:217-221.
7. Wang L, Zhao F, Liu K: Advances in studies on pharmacological effect of arctiin and arctigenin. Chin Trad Herbal Drugs 2008;39:467-470.
8. Zhao L, Lou JS, Wu H, Yin YQ, Kang Y: Effects of taurine-magnesium coordination compound on ionic channels in rat ventricular myocytes of arrhythmia induced by ouabain. Biol Trace Elem Res 2012;147:275-284.
9. Metcalf CS, Poelzing S, Little JG, Bealer SL: Status epilepticus induces cardiac myofilament damage and increased susceptibility to arrhythmias in rats. Am J Physiol-Heart C 2009;297:H2120-H2127.
10. Zhao L, Lou J, Wu H, Yin Y, Kang Y: Effects of taurine-magnesium coordination compound on ionic channels in rat ventricular myocytes of arrhythmia induced by ouabain. Biol Trace Elem Res 2012;147:275-284.
11. Jiang W, Tang S: Review on antiarrhythmic effect of traditional chinese medicine targeting multi-ion channels. Chin J Integ Trad West Med 2011;31:858-860.
12. Peper K, Trautwein W: The effect of aconitine on the membrane current in cardiac muscle. Pflugers Archiv Gesamte Physiol Menschen Tiere 1967;296:328-336.
13. Amran S, Hashimoto K, Homma N: Effects of sodium-calcium exchange inhibitors, kb-r7943 and sea0400, on aconitine-induced arrhythmias in guinea pigs in vivo, in vitro, and in computer simulation studies. J Pharmacol Exp Ther 2004;310:83-89.
14. 2+ on aconitine-induced arrhythmias. Jpn Heart J 1996;37:709-718.
15. Zhou SS, Yang J, Li YQ, Zhao LY, Xu M, Ding YF: Effect of cl-channel blockers on aconitine-induced arrhythmias in rat heart. Exp Physiol 2005;90:865-872.
16. Hadri L, Hajjar RJ: Calcium cycling proteins and their association with heart failure. Clin Pharmacol Ther 2011;90:620-624.
17. Bers DR, Perez-Reyes E: Ca channels in cardiac myocytes: structure and function in ca influx and intracellular ca release. Cardiovasc Res 1999;42:339-360.
18. Giudicessi JR, Ackerman MJ: Potassium-channel mutations and cardiac arrhythmias-diagnosis and therapy. Nat Rev Cardiol 2012;9:319-332.
19. Shieh CC, Coghlan M, Sullivan JP, Gopalakrishnan M: Potassium channels: molecular defects, diseases, and therapeutic opportunities. Pharmacol Rev 2000;52:557-593.
20. Naebauer M, Kaeaeb S: Potassium channel down-regulation in heart failure. Cardiovasc Res 1998;37:324-334.
21. Volders P, Vos MA, Szabo B, Sipido KR, de Groot S, Gorgels A, Wellens H, Lazzara R: Progress in the understanding of cardiac early afterdepolarizations and torsades de pointes: time to revise current concepts. Cardiovasc Res 2000;46:376-392.
22. Wang L, Zhao F, Liu K: Advances in studies on pharmacological effect of arctiin and arctigenin. Chin Trad Herbal Drugs 2008;39:467-470.
23. Zhao Z, Yin Y, Wang Z, Fang R, Wu H, Jiang M, Bai G, Luo GA: Arctigenin exhibits relaxation effect on bronchus by affecting transmembrane flow of calcium. Biol Trace Elem Res DOI 10.1007/s12011-013-9839-9.