Alpha-cobratoxin inhibits T-type calcium currents through muscarinic M4 receptor and G o-protein βγ subunits-dependent protein kinase A pathway in dorsal root ganglion neurons

Neuropharmacology

Volumn 62, Issue 2, 2012, Pages 1062-1072

  Zhang, Ling ^a   Zhang, Yiming ^a   Jiang, Dongsheng ^b   Reid, Paul F ^c   Jiang, Xinghong ^a   Qin, Zhenghong ^a   Tao, Jin ^a  

^a MEDICAL COLLEGE OF SOOCHOW UNIVERSITY   (China)

^b UNIVERSITY OF ULM   (Germany)

^c ReceptoPharm   (United States)

Author keywords

Alpha cobratoxin ( CTx); Dorsal root ganglia (DRG); Muscarinic M4 receptor; T type calcium channels

Indexed keywords

4 DIPHENYLACETOXY 1 METHYLPIPERIDINE; CALCIUM CHANNEL T TYPE; COBROTOXIN; CYCLIC AMP DEPENDENT PROTEIN KINASE; GUANINE NUCLEOTIDE BINDING PROTEIN ALPHA SUBUNIT; GUANINE NUCLEOTIDE BINDING PROTEIN BETA SUBUNIT; GUANINE NUCLEOTIDE BINDING PROTEIN GAMMA SUBUNIT; METHOCTRAMINE; METHYLLYCACONITINE; MUSCARINIC M4 RECEPTOR; MUSCARINIC RECEPTOR; PHOSPHATIDYLINOSITOL 3 KINASE; PIRENZEPINE; SMALL INTERFERING RNA; TROPICAMIDE;

ANIMAL CELL; ARTICLE; BRAIN ELECTROPHYSIOLOGY; CALCIUM CURRENT; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG INHIBITION; DRUG MECHANISM; ENZYME ACTIVITY; HYPERPOLARIZATION; IMMUNOFLUORESCENCE TEST; MOUSE; NOCICEPTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN SYNTHESIS INHIBITION; RECEPTOR DOWN REGULATION; RNA TRANSPORT; SPINAL GANGLION; STEADY STATE; WESTERN BLOTTING;

ANIMALS; CALCIUM; CALCIUM CHANNELS, T-TYPE; CELLS, CULTURED; COBRA NEUROTOXIN PROTEINS; CYCLIC AMP-DEPENDENT PROTEIN KINASES; DOSE-RESPONSE RELATIONSHIP, DRUG; GANGLIA, SPINAL; GTP-BINDING PROTEINS; MEMBRANE POTENTIALS; MICE; NEURONS; RECEPTOR, MUSCARINIC M4; SIGNAL TRANSDUCTION;

EID: 84855937399     PISSN: 00283908     EISSN: 18737064     Source Type: Journal    
DOI: 10.1016/j.neuropharm.2011.10.017     Document Type: Article

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