IFN-α inhibits telomerase in human CD8+ T cells by both hTERT downregulation and induction of p38 MAPK signaling

Journal of Immunology

Volumn 191, Issue 7, 2013, Pages 3744-3752

  Lanna, Alessio ^a,b   Coutavas, Elias ^c   Levati, Lauretta ^d   Seidel, Judith ^b   Rustin, Malcolm H A ^e   Henson, Sian M ^b   Akbar, Arne N ^a,b   Franzese, Ornella ^a,b  

^a UNIVERSITY OF ROME TOR VERGATA   (Italy)

^b UNIVERSITY COLLEGE LONDON   (United Kingdom)

^c ROCKEFELLER UNIVERSITY   (United States)

^d LABORATORIO DI PATOLOGIA VASCOLARE   (Italy)

^e ROYAL FREE HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA INTERFERON; CYTOKINE; DORAMAPIMOD; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE P38; PROTEIN KINASE B; TELOMERASE; TELOMERASE REVERSE TRANSCRIPTASE; TRANSCRIPTION FACTOR E2F;

ADULT; AGING; ARTICLE; CD8+ T LYMPHOCYTE; CELL DIFFERENTIATION; CELL NUCLEUS; CELL PROLIFERATION; CONTROLLED STUDY; CYTOKINE RELEASE; CYTOPLASM; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME INDUCTION; ENZYME INHIBITION; ENZYME LOCALIZATION; ENZYME REGULATION; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; INTRACELLULAR SIGNALING; MOLECULAR MECHANICS; PRIORITY JOURNAL; PROTEIN PROCESSING; T LYMPHOCYTE ACTIVATION; TRANSCRIPTION INITIATION; VIRUS INFECTION;

ANTIGENS, CD27; ANTIGENS, CD28; CD8-POSITIVE T-LYMPHOCYTES; CELLS, CULTURED; DOWN-REGULATION; E2F TRANSCRIPTION FACTORS; ENZYME ACTIVATION; HUMANS; INTERFERON-ALPHA; LYMPHOCYTE ACTIVATION; NF-KAPPA B; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PROTO-ONCOGENE PROTEINS C-AKT; SIGNAL TRANSDUCTION; TELOMERASE; TRANSCRIPTION, GENETIC;

EID: 84885139461     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.1301409     Document Type: Article

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