Inhibition of β-Catenin signaling suppresses pancreatic tumor growth by disrupting nuclear β-Catenin/TCF-1 complex: Critical role of STAT-3

Oncotarget

Volumn 6, Issue 13, 2015, Pages 11561-11574

  Pramanik, Kartick C ^a   Fofaria, Neel M ^a   Gupta, Parul ^a   Ranjan, Alok ^a   Kim, Sung Hoon ^b   Srivastava, Sanjay K ^a,b  

^a TEXAS TECH UNIVERSITY HEALTH SCIENCES CENTER   (United States)

^b Kyung Hee University   (South Korea)

Author keywords

b catenin; GSK 3b; Orthotopic tumor; Pancreatic cancer; STAT3

Indexed keywords

2 (3 CHLORO 4 HYDROXYANILINO) 3 (2 NITROPHENYL)MALEIMIDE; APC PROTEIN; AXIN; BENZYLOXYCARBONYLLEUCYLLEUCYLLEUCINAL; BETA CATENIN; CAPSAICIN; CASPASE 3; CYCLIN D1; FRIZZLED PROTEIN; GLYCOGEN SYNTHASE KINASE 3BETA; INTERLEUKIN 6; LITHIUM CHLORIDE; MYC PROTEIN; STAT3 PROTEIN; TRANSCRIPTION FACTOR 7; ANTINEOPLASTIC AGENT; CTNNB1 PROTEIN, HUMAN; DISHEVELLED PROTEIN; PHOSPHOPROTEIN; PROTEASOME; SIGNAL TRANSDUCING ADAPTOR PROTEIN; STAT3 PROTEIN, HUMAN; TCF7 PROTEIN, HUMAN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CANCER INHIBITION; CELL NUCLEUS; CONCENTRATION RESPONSE; CONTROLLED STUDY; DOWN REGULATION; DRUG EFFECT; ENZYME INDUCTION; FEMALE; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; MOUSE; NONHUMAN; PANCREAS TUMOR; PROTEIN CLEAVAGE; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; PROTEIN TRANSPORT; SIGNAL TRANSDUCTION; ANIMAL; ANTAGONISTS AND INHIBITORS; CELL PROLIFERATION; DOSE RESPONSE; DRUG EFFECTS; DRUG SCREENING; GENETIC TRANSFECTION; GENETICS; METABOLISM; NUDE MOUSE; PANCREATIC NEOPLASMS; PATHOLOGY; PHOSPHORYLATION; TIME FACTOR; TUMOR CELL LINE; TUMOR VOLUME; WNT SIGNALING PATHWAY;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ANIMALS; ANTINEOPLASTIC AGENTS; APOPTOSIS; BETA CATENIN; CAPSAICIN; CELL LINE, TUMOR; CELL NUCLEUS; CELL PROLIFERATION; DISHEVELLED PROTEINS; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; HUMANS; MICE, NUDE; PANCREATIC NEOPLASMS; PHOSPHOPROTEINS; PHOSPHORYLATION; PROTEASOME ENDOPEPTIDASE COMPLEX; PROTEOLYSIS; STAT3 TRANSCRIPTION FACTOR; T CELL TRANSCRIPTION FACTOR 1; TIME FACTORS; TRANSFECTION; TUMOR BURDEN; WNT SIGNALING PATHWAY; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 84929643173     PISSN: None     EISSN: 19492553     Source Type: Journal    
DOI: 10.18632/oncotarget.3427     Document Type: Article

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