Body composition in gene knockouts of sulfur amino acid-metabolizing enzymes

Mammalian Genome

Volumn 25, Issue 9-10, 2014, Pages 455-463

  Elshorbagy, Amany K ^a,b  

^a UNIVERSITY OF OXFORD   (United Kingdom)

^b ALEXANDRIA UNIVERSITY   (Egypt)

Author keywords

[No Author keywords available]

Indexed keywords

BETAINE HOMOCYSTEINE METHYLTRANSFERASE; CHOLINE; CYSTATHIONINE BETA SYNTHASE; CYSTATHIONINE GAMMA LYASE; CYSTEINE; CYSTEINE DIOXYGENASE; ENZYME; GAMMA GLUTAMYLTRANSFERASE; GLUTAMATE CYSTEINE LIGASE; METHIONINE; PHOSPHATIDYLETHANOLAMINE METHYLTRANSFERASE; SULFUR AMINO ACID; SULFUR AMINO ACID METABOLIZING ENZYME; UNCLASSIFIED DRUG;

AMINO ACID BLOOD LEVEL; BODY COMPOSITION; BODY WEIGHT; DIET SUPPLEMENTATION; ENERGY EXPENDITURE; FAT MASS; GENE INACTIVATION; HUMAN; INSULIN SENSITIVITY; KNOCKOUT MOUSE; NONHUMAN; OBESITY; REVIEW; ANIMAL; GENE EXPRESSION REGULATION; METABOLISM;

AMINO ACIDS, SULFUR; ANIMALS; BODY COMPOSITION; GENE EXPRESSION REGULATION, ENZYMOLOGIC; GENE KNOCKOUT TECHNIQUES; HUMANS; METABOLIC NETWORKS AND PATHWAYS;

EID: 84929508299     PISSN: 09388990     EISSN: 14321777     Source Type: Journal    
DOI: 10.1007/s00335-014-9527-x     Document Type: Review

References (63)

1. Akahoshi N, Kobayashi C, Ishizaki Y, Izumi T, Himi T, Suematsu M, Ishii I (2008) Genetic background conversion ameliorates semi-lethality and permits behavioral analyses in cystathionine β-synthase-deficient mice, an animal model for hyperhomocysteinemia. Hum Mol Genet 17(13):1994–2005
2. Auwerx J, Cock TA, Knouff C (2003) PPAR-gamma: a thrifty transcription factor. Nucl Recept Signal 1:e006
3. Bauer M, Hamm AC, Bonaus M, Jacob A, Jaekel J, Schorle H, Pankratz MJ, Katzenberger JD (2004) Starvation response in mouse liver shows strong correlation with life-span-prolonging processes. Physiol Genomics 17(2):44–230
4. Brosnan JT, Brosnan ME (2006) The sulfur-containing amino acids: an overview. J Nutr 136(6 Suppl):40S–1636S
5. Crunk AE, Monks J, Murakami A, Jackman M, Maclean PS, Ladinsky M, Bales ES, Cain S, Orlicky DJ, McManaman JL (2013) Dynamic regulation of hepatic lipid droplet properties by diet. PLoS One 8(7):e67631
6. Di Renzo L, Galvano F, Orlandi C, Bianchi A, Di Giacomo C, La Fauci L, Acquaviva R, De Lorenzo A (2010) Oxidative stress in normal-weight obese syndrome. Obesity (Silver Spring) 18(11):30–2125
7. Elshorbagy AK, Nurk E, Gjesdal CG, Tell GS, Ueland PM, Nygard O, Tverdal A, Vollset SE, Refsum H (2008) Homocysteine, cysteine, and body composition in the Hordaland Homocysteine Study: does cysteine link amino acid and lipid metabolism? Am J Clin Nutr 88(3):46–738
8. Elshorbagy AK, Refsum H, Smith AD, Graham IM (2009) The association of plasma cysteine and gamma-glutamyltransferase with BMI and obesity. Obesity (Silver Spring) 17(7):40–1435
9. Elshorbagy AK, Valdivia-Garcia M, Refsum H, Smith AD, Mattocks DA, Perrone CE (2010) Sulfur amino acids in methionine-restricted rats: hyperhomocysteinemia. Nutrition 26(11–12):4–1201
10. Elshorbagy AK, Valdivia-Garcia M, Mattocks DA, Plummer JD, Smith AD, Drevon CA, Refsum H, Perrone CE (2011) Cysteine supplementation reverses methionine restriction effects on rat adiposity: significance of stearoyl-coenzyme A desaturase. J Lipid Res 52(1):12–104
11. Elshorbagy AK, Kozich V, Smith AD, Refsum H (2012a) Cysteine and obesity: consistency of the evidence across epidemiologic, animal and cellular studies. Curr Opin Clin Nutr Metab Care 15(1):49–57
12. Elshorbagy AK, Valdivia-Garcia M, Refsum H, Butte N (2012b) The association of cysteine with obesity, inflammatory cytokines and insulin resistance in Hispanic children and adolescents. PLoS One 7(9):e44166
13. Elshorbagy AK, Valdivia-Garcia M, Graham IM, Palma Reis R, Sales Luis A, Smith AD, Refsum H (2012c) The association of fasting plasma sulfur-containing compounds with BMI, serum lipids and apolipoproteins. Nutr Metab Cardiovasc Dis 22(12):8–1031
14. Elshorbagy AK, Church C, Valdivia-Garcia M, Smith AD, Refsum H, Cox R (2012d) Dietary cystine level affects metabolic rate and glycaemic control in adult mice. J Nutr Biochem 23(4):40–332
15. Elshorbagy AK, Nijpels G, Valdivia-Garcia M, Stehouwer CD, Ocke M, Refsum H, Dekker JM (2013a) S-adenosylmethionine is associated with fat mass and truncal adiposity in older adults. J Nutr 143(12):8–1982
16. Elshorbagy AK, Valdivia-Garcia M, Mattocks DA, Plummer JD, Orentreich DS, Orentreich N, Refsum H, Perrone CE (2013b) Effect of taurine and N-acetylcysteine on methionine restriction-mediated adiposity resistance. Metabolism 62(4):17–509
17. Floegel A, Stefan N, Yu Z, Muhlenbruch K, Drogan D, Joost HG, Fritsche A, Haring HU, Hrabe de Angelis M, Peters A et al (2013) Identification of serum metabolites associated with risk of type 2 diabetes using a targeted metabolomic approach. Diabetes 62(2):639–648
18. Flowers MT, Ade L, Strable MS, Ntambi JM (2012) Combined deletion of SCD1 from adipose tissue and liver does not protect mice from obesity. J Lipid Res 53(8):53–1646
19. Go YM, Jones DP (2011) Cysteine/cystine redox signaling in cardiovascular disease. Free Radic Biol Med 50(4):495–509
20. Gupta S, Kruger WD (2011) Cystathionine beta-synthase deficiency causes fat loss in mice. PLoS One 6(11):e27598
21. Gupta S, Melnyk SB, Kruger WD (2014) Cystathionine beta-synthase-deficient mice thrive on a low-methionine diet. FASEB J 28(2):90–781
22. Haj-Yasein NN, Dalen KT, Berg O, Bastani N, Refsum H, Nebb HI (2013) Low cysteine interferes with PPARγ activity and reduces adipocyte differentiation. J Inherit Metab Dis 36(Suppl. 1):973
23. Haque JA, McMahan RS, Campbell JS, Shimizu-Albergine M, Wilson AM, Botta D, Bammler TK, Beyer RP, Montine TJ, Yeh MM et al (2010) Attenuated progression of diet-induced steatohepatitis in glutathione-deficient mice. Lab Invest 90(12):17–1704
24. Hargreaves IP, Lee PJ, Briddon A (2002) Homocysteine and cysteine–albumin binding in homocystinuria: assessment of cysteine status and implications for glutathione synthesis? Amino Acids 22(2):18–109
25. Hasek BE, Stewart LK, Henagan TM, Boudreau A, Lenard NR, Black C, Shin J, Huypens P, Malloy VL, Plaisance EP et al (2010) Dietary methionine restriction enhances metabolic flexibility and increases uncoupled respiration in both fed and fasted states. Am J Physiol Regul Integr Comp Physiol 299(3):R728–R739
26. Hasek BE, Boudreau A, Shin J, Feng D, Hulver M, Van NT, Laque A, Stewart LK, Stone KP, Wanders D et al (2013) Remodeling the integration of lipid metabolism between liver and adipose tissue by dietary methionine restriction in rats. Diabetes 62(10):72–3362
27. Hodson L, Fielding BA (2012) Stearoyl-CoA desaturase: rogue or innocent bystander? Prog Lipid Res 52(1):15–42
28. Horl G, Wagner A, Cole LK, Malli R, Reicher H, Kotzbeck P, Kofeler H, Hofler G, Frank S, Bogner-Strauss JG et al (2011) Sequential synthesis and methylation of phosphatidylethanolamine promote lipid droplet biosynthesis and stability in tissue culture and in vivo. J Biol Chem 286(19):50–17338
29. Iida M, Yasuhara T, Mochizuki H, Takakura H, Yanagisawa T, Kubo H (2005) Two Japanese brothers with hereditary gamma-glutamyl transpeptidase deficiency. J Inherit Metab Dis 28(1):49–55
30. Jacobs RL, Zhao Y, Koonen DP, Sletten T, Su B, Lingrell S, Cao G, Peake DA, Kuo MS, Proctor SD et al (2010) Impaired de novo choline synthesis explains why phosphatidylethanolamine N-methyltransferase-deficient mice are protected from diet-induced obesity. J Biol Chem 285(29):13–22403
31. Kaur S, Zilmer K, Kairane C, Kals M, Zilmer M (2008) Clear differences in adiponectin level and glutathione redox status revealed in obese and normal-weight patients with psoriasis. Br J Dermatol 159(6):7–1364
32. Kendig EL, Chen Y, Krishan M, Johansson E, Schneider SN, Genter MB, Nebert DW, Shertzer HG (2011) Lipid metabolism and body composition in Gclm(−/−) mice. Toxicol Appl Pharmacol 257(3):48–338
33. Kinross J, Li JV, Muirhead LJ, Nicholson J (2014) Nutritional modulation of the metabonome: applications of metabolic phenotyping in translational nutritional research. Curr Opin Gastroenterol 30(2):196–207
34. Konstantinova SV, Tell GS, Vollset SE, Nygard O, Bleie O, Ueland PM (2008) Divergent associations of plasma choline and betaine with components of metabolic syndrome in middle age and elderly men and women. J Nutr 138(5):20–914
35. Levasseur R, Barrios R, Elefteriou F, Glass DA 2nd, Lieberman MW, Karsenty G (2003) Reversible skeletal abnormalities in gamma-glutamyl transpeptidase-deficient mice. Endocrinology 144(7):4–2761
36. Lieberman MW, Wiseman AL, Shi ZZ, Carter BZ, Barrios R, Ou CN, Chevez-Barrios P, Wang Y, Habib GM, Goodman JC et al (1996) Growth retardation and cysteine deficiency in gamma-glutamyl transpeptidase-deficient mice. Proc Natl Acad Sci USA 93(15):6–7923
37. Lu SC (2013) Glutathione synthesis. Biochim Biophys Acta 1830(5):53–3143
38. Mani S, Yang G, Wang R (2011) A critical life-supporting role for cystathionine gamma-lyase in the absence of dietary cysteine supply. Free Radic Biol Med 50(10):7–1280
39. Miyazaki M, Sampath H, Liu X, Flowers MT, Chu K, Dobrzyn A, Ntambi JM (2009) Stearoyl-CoA desaturase-1 deficiency attenuates obesity and insulin resistance in leptin-resistant obese mice. Biochem Biophys Res Commun 380(4):22–818
40. Morris C, O’Grada C, Ryan M, Roche HM, Gibney MJ, Gibney ER, Brennan L (2012) The relationship between BMI and metabolomic profiles: a focus on amino acids. Proc Nutr Soc 71(4):8–634
41. Mudd SH, Skovby F, Levy HL, Pettigrew KD, Wilcken B, Pyeritz RE, Andria G, Boers GH, Bromberg IL, Cerone R et al (1985) The natural history of homocystinuria due to cystathionine beta-synthase deficiency. Am J Hum Genet 37(1):1–31
42. Noga AA, Stead LM, Zhao Y, Brosnan ME, Brosnan JT, Vance DE (2003) Plasma homocysteine is regulated by phospholipid methylation. J Biol Chem 278(8):5–5952
43. Ntambi JM, Miyazaki M, Stoehr JP, Lan H, Kendziorski CM, Yandell BS, Song Y, Cohen P, Friedman JM, Attie AD (2002) Loss of stearoyl-CoA desaturase-1 function protects mice against adiposity. Proc Natl Acad Sci USA 99(17):6–11482
44. Perrone CE, Mattocks DA, Hristopoulos G, Plummer JD, Krajcik RA, Orentreich N (2008) Methionine restriction effects on 11β-HSD1 activity and lipogenic/lipolytic balance in F344 rat adipose tissue. J Lipid Res 49(1):12–23
45. Ratnam S, Maclean KN, Jacobs RL, Brosnan ME, Kraus JP, Brosnan JT (2002) Hormonal regulation of cystathionine beta-synthase expression in liver. J Biol Chem 277(45):8–42912
46. Richie JP Jr, Komninou D, Leutzinger Y, Kleinman W, Orentreich N, Malloy V, Zimmerman JA (2004) Tissue glutathione and cysteine levels in methionine-restricted rats. Nutrition 20(9):5–800
47. 2S/HS(−) production and evidence of pancreatic and lung toxicity. Antioxid Redox Signal 19(12):36–1321
48. Sedda V, De Chiara B, Parolini M, Caruso R, Campolo J, Cighetti G, De Maria R, Sachero A, Donato L, Parodi O (2008) Plasma glutathione levels are independently associated with gamma-glutamyltransferase activity in subjects with cardiovascular risk factors. Free Radic Res 42(2):41–135
49. Sharma NK, Langberg KA, Mondal AK, Das SK (2013) Phospholipid biosynthesis genes and susceptibility to obesity: analysis of expression and polymorphisms. PLoS One 8(5):e65303
50. Stead LM, Brosnan JT, Brosnan ME, Vance DE, Jacobs RL (2006) Is it time to reevaluate methyl balance in humans? Am J Clin Nutr 83(1):5–10
51. Stipanuk MH, Dominy JE Jr, Lee JI, Coloso RM (2006) Mammalian cysteine metabolism: new insights into regulation of cysteine metabolism. J Nutr 136(6 Suppl):9S–1652S
52. Stipanuk MH, Ueki I, Dominy JE Jr, Simmons CR, Hirschberger LL (2009) Cysteine dioxygenase: a robust system for regulation of cellular cysteine levels. Amino Acids 37(1):55–63
53. Teng YW, Mehedint MG, Garrow TA, Zeisel SH (2011) Deletion of betaine-homocysteine S-methyltransferase in mice perturbs choline and 1-carbon metabolism, resulting in fatty liver and hepatocellular carcinomas. J Biol Chem 286(42):67–36258
54. Teng YW, Ellis JM, Coleman RA, Zeisel SH (2012) Mouse betaine-homocysteine S-methyltransferase deficiency reduces body fat via increasing energy expenditure and impairing lipid synthesis and enhancing glucose oxidation in white adipose tissue. J Biol Chem 287(20):98–16187
55. Ueki I, Stipanuk MH (2009) 3T3-L1 adipocytes and rat adipose tissue have a high capacity for taurine synthesis by the cysteine dioxygenase/cysteinesulfinate decarboxylase and cysteamine dioxygenase pathways. J Nutr 139(2):14–207
56. Ueki I, Roman HB, Valli A, Fieselmann K, Lam J, Peters R, Hirschberger LL, Stipanuk MH (2011) Knockout of the murine cysteine dioxygenase gene results in severe impairment in ability to synthesize taurine and an increased catabolism of cysteine to hydrogen sulfide. Am J Physiol Endocrinol Metab 301(4):E668–E684
57. Ueki I, Roman HB, Hirschberger LL, Junior C, Stipanuk MH (2012) Extrahepatic tissues compensate for loss of hepatic taurine synthesis in mice with liver-specific knockout of cysteine dioxygenase. Am J Physiol Endocrinol Metab 302(10):E1292–E1299
58. Vigilanza P, Aquilano K, Baldelli S, Rotilio G, Ciriolo MR (2011) Modulation of intracellular glutathione affects adipogenesis in 3T3-L1 cells. J Cell Physiol 226(8):24–2016
59. Whiteman M, Gooding KM, Whatmore JL, Ball CI, Mawson D, Skinner K, Tooke JE, Shore AC (2010) Adiposity is a major determinant of plasma levels of the novel vasodilator hydrogen sulphide. Diabetologia 53(8):6–1722
60. Will Y, Fischer KA, Horton RA, Kaetzel RS, Brown MK, Hedstrom O, Lieberman MW, Reed DJ (2000) Gamma-glutamyltranspeptidase-deficient knockout mice as a model to study the relationship between glutathione status, mitochondrial function, and cellular function. Hepatology 32(4 Pt 1):9–740
61. Wu G, Zhang L, Li T, Zuniga A, Lopaschuk GD, Li L, Jacobs RL, Vance DE (2013) Choline supplementation promotes hepatic insulin resistance in phosphatidylethanolamine N-methyltransferase-deficient mice via increased glucagon action. J Biol Chem 288(2):47–837
62. Yang G, Wu L, Jiang B, Yang W, Qi J, Cao K, Meng Q, Mustafa AK, Mu W, Zhang S et al (2008) H2S as a physiologic vasorelaxant: hypertension in mice with deletion of cystathionine gamma-lyase. Science 322(5901):90–587
63. Zhu X, Song J, Mar MH, Edwards LJ, Zeisel SH (2003) Phosphatidylethanolamine N-methyltransferase (PEMT) knockout mice have hepatic steatosis and abnormal hepatic choline metabolite concentrations despite ingesting a recommended dietary intake of choline. Biochem J 370(Pt 3):93–987