Cysteine/cystine redox signaling in cardiovascular disease

Free Radical Biology and Medicine

Volumn 50, Issue 4, 2011, Pages 495-509

  Go, Young Mi ^a   Jones, Dean P ^a  

^a EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Atherosclerosis; Endothelial cells; Free radicals; Inflammatory mechanism; Monocytes; Plasma redox state; Thiol disulfide

Indexed keywords

ACETYLCYSTEINE; ACTIN; ARYLDIALKYLPHOSPHATASE; CELL SURFACE PROTEIN; CERULOPLASMIN; CYSTEINE; CYSTINE; CYTOSKELETON PROTEIN; DISULFIDE; EPIDERMAL GROWTH FACTOR RECEPTOR; FIBRONECTIN; GLUTATHIONE DISULFIDE; GLUTATHIONE SYNTHASE; HOMOCYSTEINE; HYDROGEN PEROXIDE; HYDROGEN SULFIDE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1BETA; METALLOTHIONEIN; METHIONINE; MITOGEN ACTIVATED PROTEIN KINASE; MYELOPEROXIDASE; NITRIC OXIDE; PARACETAMOL; SULFUR AMINO ACID; THIOCTIC ACID; THIOL DERIVATIVE; THIOL OXIDASE; TUMOR NECROSIS FACTOR ALPHA; ZINC;

AGING; ALCOHOLISM; AMINO ACID BLOOD LEVEL; AMINO ACID METABOLISM; ANTIOXIDANT ACTIVITY; AORTA; APOPTOSIS; ARTERIAL WALL THICKNESS; ATHEROGENESIS; ATHEROSCLEROSIS; AUTOPHAGY; BLOOD VESSEL FUNCTION; BODY MASS; CARDIOVASCULAR DISEASE; CARDIOVASCULAR RISK; CAROTID ARTERY; CELL DEATH; CELL PROLIFERATION; CELL STRESS; CELL TYPE; CHOLESTEROL BLOOD LEVEL; CIGARETTE SMOKING; CIRCADIAN RHYTHM; DIABETES MELLITUS; DIETARY INTAKE; ENDOTHELIUM CELL; ENZYME BLOOD LEVEL; EXTRACELLULAR SPACE; FIBROGENESIS; GENE EXPRESSION; GENETIC ANALYSIS; HEART ATRIUM FIBRILLATION; HUMAN; INFLAMMATION; INTIMA; INTRACELLULAR SPACE; LUNG FIBROBLAST; MEDITERRANEAN DIET; MITOCHONDRION; MONOCYTE; NEUROTOXICITY; NONHUMAN; OBESITY; OXIDATION; OXIDATION REDUCTION STATE; OXIDATIVE STRESS; PHENOTYPE; PLASMA; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN CEREBROSPINAL FLUID LEVEL; PROTEIN INTERACTION; PROTEOMICS; REVIEW; SHORT BOWEL SYNDROME; SIGNAL TRANSDUCTION; SLEEP DISORDER; STEADY STATE; THROMBOCYTE ACTIVATION; VASCULAR ENDOTHELIUM; VITAMIN SUPPLEMENTATION;

ANIMALS; CARDIOVASCULAR DISEASES; CYSTEINE; CYSTINE; ENDOTHELIAL CELLS; HUMANS; INFLAMMATION; OXIDATION-REDUCTION; OXIDATIVE STRESS; SIGNAL TRANSDUCTION;

RODENTIA;

EID: 79251614656     PISSN: 08915849     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.freeradbiomed.2010.11.029     Document Type: Review

References (138)

1. O. Pechanova, and F. Simko Chronic antioxidant therapy fails to ameliorate hypertension: potential mechanisms behind J. Hypertens. 27 Suppl. 6 2009 S32 S36
2. H.D. Sesso, J.E. Buring, W.G. Christen, T. Kurth, C. Belanger, J. MacFadyen, V. Bubes, J.E. Manson, R.J. Glynn, and J.M. Gaziano Vitamins E and C in the prevention of cardiovascular disease in men: the Physicians' Health Study II randomized controlled trial JAMA 300 2008 2123 2133
3. S.R. Steinhubl Why have antioxidants failed in clinical trials? Am. J. Cardiol. 101 2008 14D 19D
4. G. Bjelakovic, D. Nikolova, L.L. Gluud, R.G. Simonetti, and C. Gluud Mortality in randomized trials of antioxidant supplements for primary and secondary prevention: systematic review and meta-analysis JAMA 297 2007 842 857
5. D.D. Duncan, and D.A. Lawrence Oxidatively stressed lymphocytes remain in G0/G1a on mitogenic stimulation J. Biochem. Toxicol. 5 1990 229 235
6. D.A. Lawrence, R. Song, and P. Weber Surface thiols of human lymphocytes and their changes after in vitro and in vivo activation J. Leukocyte Biol. 60 1996 611 618
7. Zappacosta, B.; Martorana, G. E.; Papini, S.; Gervasoni, J.; Iavarone, F.; Fasanella, S.; Giardina, B.; De Sole, P.; Persichilli, S. Morpho-functional modifications of human neutrophils induced by aqueous cigarette smoke extract: comparison with chemiluminescence activity. Luminescence, n/a. doi:10.1002/bio.1233.
8. H.C. Oliveira, R.G. Cosso, L.C. Alberici, E.N. Maciel, A.G. Salerno, G.G. Dorighello, J.A. Velho, E.C. de Faria, and A.E. Vercesi Oxidative stress in atherosclerosis-prone mouse is due to low antioxidant capacity of mitochondria FASEB J. 19 2005 278 280
9. R. Stocker, and J.F. Keaney Jr. Role of oxidative modifications in atherosclerosis Physiol. Rev. 84 2004 1381 1478
10. K.D. Held, E.R. Epp, S. Awad, and J.E. Biaglow Postirradiation sensitization of mammalian cells by the thiol-depleting agent dimethyl fumarate Radiat. Res. 127 1991 75 80
11. N. Jacob, E. Bruckert, P. Giral, M.J. Foglietti, and G. Turpin Cysteine is a cardiovascular risk factor in hyperlipidemic patients Atherosclerosis 146 1999 53 59
12. K.S. McCully Homocysteine and vascular disease Nat. Med. 2 1996 386 389
13. W. Droge The plasma redox state and ageing Ageing Res. Rev. 1 2002 257 278
14. V. Hack, R. Breitkreutz, R. Kinscherf, H. Rohrer, P. Bartsch, F. Taut, A. Benner, and W. Droge The redox state as a correlate of senescence and wasting and as a target for therapeutic intervention Blood 92 1998 59 67
15. M.A. Mansoor, C. Bergmark, A.M. Svardal, P.E. Lonning, and P.M. Ueland Redox status and protein binding of plasma homocysteine and other aminothiols in patients with early-onset peripheral vascular disease: homocysteine and peripheral vascular disease Arterioscler. Thromb. Vasc. Biol. 15 1995 232 240
16. I. Saito, A.R. Folsom, F.L. Brancati, B.B. Duncan, L.E. Chambless, and P.G. McGovern Nontraditional risk factors for coronary heart disease incidence among persons with diabetes: the Atherosclerosis Risk in Communities (ARIC) Study Ann. Int. Med. 133 2000 81 91
17. J.K. Virtanen, S. Voutilainen, T.H. Rissanen, P. Happonen, J. Mursu, J.A. Laukkanen, H. Poulsen, T.A. Lakka, and J.T. Salonen High dietary methionine intake increases the risk of acute coronary events in middle-aged men Nutr. Metab. Cardiovasc. Dis. 16 2006 113 120
18. A. Zulli, D.L. Hare, B.F. Buxton, and M.J. Black High dietary methionine plus cholesterol exacerbates atherosclerosis formation in the left main coronary artery of rabbits Atherosclerosis 176 2004 83 89
19. L. El-Khairy, P.M. Ueland, O. Nygard, H. Refsum, and S.E. Vollset Lifestyle and cardiovascular disease risk factors as determinants of total cysteine in plasma: the Hordaland Homocysteine Study Am. J. Clin. Nutr. 70 1999 1016 1024
20. L. El-Khairy, P.M. Ueland, H. Refsum, I.M. Graham, and S.E. Vollset Plasma total cysteine as a risk factor for vascular disease: the European Concerted Action Project Circulation 103 2001 2544 2549
21. B.J. Mills, M.M. Weiss, C.A. Lang, M.C. Liu, and C. Ziegler Blood glutathione and cysteine changes in cardiovascular disease J. Lab. Clin. Med. 135 2000 396 401
22. Y. Ozkan, E. Ozkan, and B. Simsek Plasma total homocysteine and cysteine levels as cardiovascular risk factors in coronary heart disease Int. J. Cardiol. 82 2002 269 277
23. D.P. Jones, V.C. Mody Jr., J.L. Carlson, M.J. Lynn, and P. Sternberg Jr. Redox analysis of human plasma allows separation of pro-oxidant events of aging from decline in antioxidant defenses Free Radic. Biol. Med. 33 2002 1290 1300
24. Y.M. Go, S.E. Craige, M. Orr, K.M. Gernert, and D.P. Jones Gene and protein responses of human monocytes to extracellular cysteine redox potential Toxicol. Sci. 112 2009 354 362
25. Y.M. Go, and D.P. Jones Intracellular proatherogenic events and cell adhesion modulated by extracellular thiol/disulfide redox state Circulation 111 2005 2973 2980
26. Y.M. Go, H. Park, M. Koval, M. Orr, M. Reed, Y. Liang, D. Smith, J. Pohl, and D.P. Jones A key role for mitochondria in endothelial signaling by plasma cysteine/cystine redox potential Free Radic. Biol. Med. 48 2010 275 283
27. C.R. Jonas, T.R. Ziegler, L.H. Gu, and D.P. Jones Extracellular thiol/disulfide redox state affects proliferation rate in a human colon carcinoma (Caco2) cell line Free Radic. Biol. Med. 33 2002 1499 1506
28. S. Jiang, S.E. Moriarty-Craige, M. Orr, J. Cai, P. Sternberg Jr., and D.P. Jones Oxidant-induced apoptosis in human retinal pigment epithelial cells: dependence on extracellular redox state Invest. Ophthalmol. Vis. Sci. 46 2005 1054 1061
29. W. Hildebrandt, R. Kinscherf, K. Hauer, E. Holm, and W. Droge Plasma cystine concentration and redox state in aging and physical exercise Mech. Ageing Dev. 123 2002 1269 1281
30. S.E. Moriarty, J.H. Shah, M. Lynn, S. Jiang, K. Openo, D.P. Jones, and P. Sternberg Oxidation of glutathione and cysteine in human plasma associated with smoking Free Radic. Biol. Med. 35 2003 1582 1588
31. S.E. Moriarty-Craige, J. Adkison, M. Lynn, G. Gensler, S. Bressler, D.P. Jones, and P. Sternberg Jr. Antioxidant supplements prevent oxidation of cysteine/cystine redox in patients with age-related macular degeneration Am. J. Ophthalmol. 140 2005 1020 1026
32. S.E. Moriarty-Craige, K.N. Ha, P. Sternberg Jr., M. Lynn, S. Bressler, G. Gensler, and D.P. Jones Effects of long-term zinc supplementation on plasma thiol metabolites and redox status in patients with age-related macular degeneration Am. J. Ophthalmol. 143 2007 206 211
33. J. Mestas, and K. Ley Monocyte-endothelial cell interactions in the development of atherosclerosis Trends Cardiovasc. Med. 18 2008 228 232
34. R. Ross The pathogenesis of atherosclerosis: a perspective for the 1990s Nature 362 1993 801 809
35. Y.M. Go, and D.P. Jones Redox clamp model for study of extracellular thiols and disulfides in redox signaling Meth. Enzymol. 474 2010 165 179
36. L. Busconi, and T. Michel Endothelial nitric oxide synthase membrane targeting: evidence against involvement of a specific myristate receptor J. Biol. Chem. 269 1994 25016 25020
37. 2 acts on cellular membranes to generate ceramide signaling and initiate apoptosis in tracheobronchial epithelial cells J. Cell Sci. 111 Pt 21 1998 3209 3220
38. M.J. Somers, J.S. Burchfield, and D.G. Harrison Evidence for a NADH/NADPH oxidase in human umbilical vein endothelial cells using electron spin resonance Antioxid. Redox Signaling 2 2000 779 787
39. A. Holmgren Thioredoxin and glutaredoxin systems J. Biol. Chem. 264 1989 13963 13966
40. H.F. Gilbert Catalysis of thiol/disulfide exchange: single-turnover reduction of protein disulfide-isomerase by glutathione and catalysis of peptide disulfide reduction Biochemistry 28 1989 7298 7305
41. W. Jeong, Y. Jung, H. Kim, S.J. Park, and S.G. Rhee Thioredoxin-related protein 14, a new member of the thioredoxin family with disulfide reductase activity: implication in the redox regulation of TNF-α signaling Free Radic. Biol. Med. 47 2009 1294 1303
42. Y.S. Nkabyo, Y.M. Go, T.R. Ziegler, and D.P. Jones Extracellular cysteine/cystine redox regulates the p44/p42 MAPK pathway by metalloproteinase-dependent epidermal growth factor receptor signaling Am. J. Physiol. 289 2005 G70 G78
43. Y.M. Go, J. Pohl, and D.P. Jones Quantification of redox conditions in the nucleus R. Hancock, The Nucleus 2009 Humana Press Totowa, NJ 303 317
44. N. Gurusamy, and D.K. Das Autophagy, redox signaling, and ventricular remodeling Antioxid. Redox Signaling 11 2009 1975 1988
45. P. Bruno, A. Calastretti, M. Priulla, L. Asnaghi, F. Scarlatti, A. Nicolin, and G. Canti Cell survival under nutrient stress is dependent on metabolic conditions regulated by Akt and not by autophagic vacuoles Cell Signal. 19 2007 2118 2126
46. R. Scherz-Shouval, E. Shvets, E. Fass, H. Shorer, L. Gil, and Z. Elazar Reactive oxygen species are essential for autophagy and specifically regulate the activity of Atg4 EMBO J. 26 2007 1749 1760
47. S.S. Iyer, C.J. Accardi, T.R. Ziegler, R.A. Blanco, J.D. Ritzenthaler, M. Rojas, J. Roman, and D.P. Jones Cysteine redox potential determines pro-inflammatory IL-1beta levels PLoS ONE 4 2009 e5017
48. S.S. Iyer, A.M. Ramirez, J.D. Ritzenthaler, E. Torres-Gonzalez, S. Roser-Page, A.L. Mora, K.L. Brigham, D.P. Jones, J. Roman, and M. Rojas Oxidation of extracellular cysteine/cystine redox state in bleomycin-induced lung fibrosis Am. J. Physiol. Lung Cell. Mol. Physiol. 296 2009 L37 L45
49. T.S. Ingrassia III, J.H. Ryu, V.F. Trastek, and E.C. Rosenow III Oxygen-exacerbated bleomycin pulmonary toxicity Mayo Clin. Proc. 66 1991 173 178
50. W.G. Martin, K.M. Ristow, T.M. Habermann, J.P. Colgan, T.E. Witzig, and S.M. Ansell Bleomycin pulmonary toxicity has a negative impact on the outcome of patients with Hodgkin's lymphoma J. Clin. Oncol. 23 2005 7614 7620
51. D.M. Lloyd-Jones, E.P. Leip, M.G. Larson, R.B. D'Agostino, A. Beiser, P.W. Wilson, P.A. Wolf, and D. Levy Prediction of lifetime risk for cardiovascular disease by risk factor burden at 50 years of age Circulation 113 2006 791 798
52. W. Droge Oxidative stress and ageing: is ageing a cysteine deficiency syndrome? Philos. Trans. R. Soc. Lond. 360 2005 2355 2372
53. R. Kinscherf, K. Cafaltzis, F. Roder, W. Hildebrandt, L. Edler, H.P. Deigner, R. Breitkreutz, G. Feussner, J. Kreuzer, E. Werle, G. Michel, J. Metz, and W. Droge Cholesterol levels linked to abnormal plasma thiol concentrations and thiol/disulfide redox status in hyperlipidemic subjects Free Radic. Biol. Med. 35 2003 1286 1292
54. Y. Takajo, H. Ikeda, N. Haramaki, T. Murohara, and T. Imaizumi Augmented oxidative stress of platelets in chronic smokers: mechanisms of impaired platelet-derived nitric oxide bioactivity and augmented platelet aggregability J. Am. Coll. Cardiol. 38 2001 1320 1327
55. Yeh, M. Y.-P. Determining and monitoring systemic and pulmonary redox states in chronic alcohol abusers. Atlanta: Emory University; 2007:203. [Ph.D. dissertation].
56. N.P. Wang, P.S. Lim, T.T. Chen, L.M. Thien, T.H. Wang, and W.M. Hsu Smoking is associated with alterations of blood thiol-group related antioxidants in patients on hemodialysis Nephron 92 2002 772 779
57. D.W. Essex, and M. Li Redox control of platelet aggregation Biochemistry 42 2003 129 136
58. S. Ashfaq, J.L. Abramson, D.P. Jones, S.D. Rhodes, W.S. Weintraub, W.C. Hooper, V. Vaccarino, D.G. Harrison, and A.A. Quyyumi The relationship between plasma levels of oxidized and reduced thiols and early atherosclerosis in healthy adults J. Am. Coll. Cardiol. 47 2006 1005 1011
59. A. Galinier, A. Carriere, Y. Fernandez, C. Carpene, M. Andre, S. Caspar-Bauguil, J.P. Thouvenot, B. Periquet, L. Penicaud, and L. Casteilla Adipose tissue proadipogenic redox changes in obesity J. Biol. Chem. 281 2006 12682 12687
60. S. Kaur, K. Zilmer, C. Kairane, M. Kals, and M. Zilmer Clear differences in adiponectin level and glutathione redox status revealed in obese and normal-weight patients with psoriasis Br. J. Dermatol. 159 2008 1364 1367
61. A.K. Elshorbagy, H. Refsum, A.D. Smith, and I.M. Graham The association of plasma cysteine and gamma-glutamyltransferase with BMI and obesity Obes. Silver Spring 17 2009 1435 1440
62. J. Dai, D.P. Jones, J. Goldberg, T.R. Ziegler, R.M. Bostick, P.W. Wilson, A.K. Manatunga, L. Shallenberger, L. Jones, and V. Vaccarino Association between adherence to the Mediterranean diet and oxidative stress Am. J. Clin. Nutr. 88 2008 1364 1370
63. J. Dai, A.H. Miller, J.D. Bremner, J. Goldberg, L. Jones, L. Shallenberger, R. Buckham, N.V. Murrah, E. Veledar, P.W. Wilson, and V. Vaccarino Adherence to the Mediterranean diet is inversely associated with circulating interleukin-6 among middle-aged men: a twin study Circulation 117 2008 169 175
64. H. Schroder, J. Marrugat, J. Vila, M.I. Covas, and R. Elosua Adherence to the traditional Mediterranean diet is inversely associated with body mass index and obesity in a Spanish population J. Nutr. 134 2004 3355 3361
65. U. Cakatay, R. Kayali, and H. Uzun Relation of plasma protein oxidation parameters and paraoxonase activity in the ageing population Clin. Exp. Med. 8 2008 51 57
66. L.T. Rael, R. Bar-Or, R.M. Aumann, D.S. Slone, C.W. Mains, and D. Bar-Or Oxidation-reduction potential and paraoxonase-arylesterase activity in trauma patients Biochem. Biophys. Res. Commun. 361 2007 561 565
67. S. Ashfaq, J.L. Abramson, D.P. Jones, S.D. Rhodes, W.S. Weintraub, W.C. Hooper, V. Vaccarino, R.W. Alexander, D.G. Harrison, and A.A. Quyyumi Endothelial function and aminothiol biomarkers of oxidative stress in healthy adults Hypertension 52 2008 80 85
68. R.S. Patel, E. Veledar, R.B. Patel, S. Sher, S. Arshad, S. Clements, J. Douglas, D. Morris, S.T. Rab, H. Samady, R.W. Alexander, V. Vaccarino, A.M. Zafari, D.P. Jones, and A.A. Quyyumi The oxidized disulphide cystine predicts adverse long term cardiovascular outcomes Circulation 120 2009 S454
69. Maetzler, W.; Schmid, S. P.; Wurster, I.; Liepelt, I.; Gaenslen, A.; Gasser, T.; Berg, D. Reduced but not oxidized cerebrospinal fluid glutathione levels are lowered in Lewy body diseases. Mov. Disord. n/a. doi:10.1002/mds. 23358.
70. R.F. Regan, and Y. Guo Extracellular reduced glutathione increases neuronal vulnerability to combined chemical hypoxia and glucose deprivation Brain Res. 817 1999 145 150
71. M. Puka-Sundvall, P. Eriksson, M. Nilsson, M. Sandberg, and A. Lehmann Neurotoxicity of cysteine: interaction with glutamate Brain Res. 705 1995 65 70
72. A. Castagna, C. Le Grazie, A. Accordini, P. Giulidori, G. Cavalli, T. Bottiglieri, and A. Lazzarin Cerebrospinal fluid S-adenosylmethionine (SAMe) and glutathione concentrations in HIV infection: effect of parenteral treatment with SAMe Neurology 45 1995 1678 1683
73. H. Sato, M. Tamba, S. Okuno, K. Sato, K. Keino-Masu, M. Masu, and S. Bannai Distribution of cystine/glutamate exchange transporter, system x(c)-, in the mouse brain J. Neurosci. 22 2002 8028 8033
74. R.A. Blanco, T.R. Ziegler, B.A. Carlson, P.Y. Cheng, Y. Park, G.A. Cotsonis, C.J. Accardi, and D.P. Jones Diurnal variation in glutathione and cysteine redox states in human plasma Am. J. Clin. Nutr. 86 2007 1016 1023
75. A.K. Elshorbagy, E. Nurk, C.G. Gjesdal, G.S. Tell, P.M. Ueland, O. Nygard, A. Tverdal, S.E. Vollset, and H. Refsum Homocysteine, cysteine, and body composition in the Hordaland Homocysteine Study: does cysteine link amino acid and lipid metabolism? Am. J. Clin. Nutr. 88 2008 738 746
76. N.K. Fukagawa, A.M. Ajami, and V.R. Young Plasma methionine and cysteine kinetics in response to an intravenous glutathione infusion in adult humans Am. J. Physiol. 270 1996 E209 E214
77. C.A. Raguso, A.M. Ajami, R. Gleason, and V.R. Young Effect of cystine intake on methionine kinetics and oxidation determined with oral tracers of methionine and cysteine in healthy adults Am. J. Clin. Nutr. 66 1997 283 292
78. C.A. Raguso, M.M. Regan, and V.R. Young Cysteine kinetics and oxidation at different intakes of methionine and cystine in young adults Am. J. Clin. Nutr. 71 2000 491 499
79. Jones, D. P.; Park, Y.; Gletsu-Miller, N.; Liang, Y.; Yu, T.; Accardi, C. J.; Ziegler, T. R. Dietary sulfur amino acid effects on fasting plasma cysteine/cystine redox potential in humans. Nutrition. doi:10.1016/j.physletb. 2003.10.071.
80. L.J. Dahm, and D.P. Jones Clearance of glutathione disulfide from rat mesenteric vasculature Toxicol. Appl. Pharmacol. 129 1994 272 282
81. V. Ganapathy, M.E. Ganapathy, and F.H. Leibach Intestinal Transport of Peptides and Amino Acids 2001 Academic Press San Diego
82. Y. Park, T.R. Ziegler, N. Gletsu-Miller, Y. Liang, T. Yu, C.J. Accardi, and D.P. Jones Postprandial cysteine/cystine redox potential in human plasma varies with meal content of sulfur amino acids J. Nutr. 140 2010 760 765
83. D.P. Jones, J.L. Carlson, V.C. Mody, J. Cai, M.J. Lynn, and P. Sternberg Redox state of glutathione in human plasma Free Radic. Biol. Med. 28 2000 625 635
84. M.H. Stipanuk Sulfur amino acid metabolism: pathways for production and removal of homocysteine and cysteine Annu. Rev. Nutr. 24 2004 539 577
85. D.J. Reed, and P.W. Beatty The Role of Cystithionine Pathway in Glutathione Regulation by Isolated Hepatocytes 1978 Springer Berlin
86. P.M. Ueland Homocysteine species as components of plasma redox thiol status Clin. Chem. 41 1995 340 342
87. C.G. Zou, and R. Banerjee Homocysteine and redox signaling Antioxid. Redox Signaling 7 2005 547 559
88. C.L. Anderson, S.S. Iyer, T.R. Ziegler, and D.P. Jones Control of extracellular cysteine/cystine redox state by HT-29 cells is independent of cellular glutathione Am. J. Physiol. Regul. Integr. Comp. Physiol. 293 2007 R1069 R1075
89. R. Sitia, and S.N. Molteni Stress, protein (mis)folding, and signaling: the redox connection Sci. STKE 2004 2004 pe27
90. C. Berndt, C.H. Lillig, and A. Holmgren Thiol-based mechanisms of the thioredoxin and glutaredoxin systems: implications for diseases in the cardiovascular system Am. J. Physiol. Heart Circ. Physiol. 292 2007 H1227 H1236
91. F.Q. Schafer, and G.R. Buettner Redox environment of the cell as viewed through the redox state of the glutathione disulfide/glutathione couple Free Radic. Biol. Med. 30 2001 1191 1212
92. Y.M. Go, and D.P. Jones Redox compartmentalization in eukaryotic cells Biochim. Biophys. Acta 1780 2008 1273 1290
93. N. Kondo, Y. Ishii, A. Son, J. Sakakura-Nishiyama, Y.W. Kwon, M. Tanito, Y. Nishinaka, Y. Matsuo, T. Nakayama, M. Taniguchi, and J. Yodoi Cysteine-dependent immune regulation by TRX and MIF/GIF family proteins Immunol. Lett. 92 2004 143 147
94. M. Kemp, Y.M. Go, and D.P. Jones Nonequilibrium thermodynamics of thiol/disulfide redox systems: a perspective on redox systems biology Free Radic. Biol. Med. 44 2008 921 937
95. J. Lyons, A. Rauh-Pfeiffer, Y.M. Yu, X.M. Lu, D. Zurakowski, R.G. Tompkins, A.M. Ajami, V.R. Young, and L. Castillo Blood glutathione synthesis rates in healthy adults receiving a sulfur amino acid-free diet Proc. Natl Acad. Sci. USA 97 2000 5071 5076
96. M. Ookhtens, A.V. Mittur, and N.A. Erhart Changes in plasma glutathione concentrations, turnover, and disposal in developing rats Am. J. Physiol. 266 1994 R979 R988
97. M.H. Stipanuk, J.E. Dominy Jr., J.I. Lee, and R.M. Coloso Mammalian cysteine metabolism: new insights into regulation of cysteine metabolism J. Nutr. 136 2006 1652S 1659S
98. C.R. Jonas, L.H. Gu, Y.S. Nkabyo, Y.O. Mannery, N.E. Avissar, H.C. Sax, D.P. Jones, and T.R. Ziegler Glutamine and KGF each regulate extracellular thiol/disulfide redox and enhance proliferation in Caco-2 cells Am. J. Physiol. Regul. Integr. Comp. Physiol. 285 2003 R1421 R1429
99. D.P. Jones Radical-free biology of oxidative stress Am. J. Physiol. Cell Physiol. 295 2008 C849 C868
100. S.E. Moriarty-Craige, and D.P. Jones Extracellular thiols and thiol/disulfide redox in metabolism Annu. Rev. Nutr. 24 2004 481 509
101. R. Kinscherf, V. Hack, T. Fischbach, B. Friedmann, C. Weiss, L. Edler, P. Bartsch, and W. Droge Low plasma glutamine in combination with high glutamate levels indicate risk for loss of body cell mass in healthy individuals: the effect of N-acetyl-cysteine J. Mol. Med. (Berlin) 74 1996 393 400
102. V. Hack, D. Schmid, R. Breitkreutz, C. Stahl-Henning, P. Drings, R. Kinscherf, F. Taut, E. Holm, and W. Droge Cystine levels, cystine flux, and protein catabolism in cancer cachexia, HIV/SIV infection, and senescence FASEB J. 11 1997 84 92
103. W. Droge, and R. Kinscherf Aberrant insulin receptor signaling and amino acid homeostasis as a major cause of oxidative stress in aging Antioxid. Redox Signaling 10 2008 661 678
104. J. Isaacs, and F. Binkley Glutathione dependent control of protein disulfide-sulfhydryl content by subcellular fractions of hepatic tissue Biochim. Biophys. Acta 497 1977 192 204
105. H. Jaeschke, and A. Wendel Diurnal fluctuation and pharmacological alteration of mouse organ glutathione content Biochem. Pharmacol. 34 1985 1029 1033
106. L. Li, A. Smith, T.M. Hagen, and B. Frei Vascular oxidative stress and inflammation increase with age: ameliorating effects of alpha-lipoic acid supplementation Ann. NY Acad. Sci. 1203 2010 151 159
107. D. Han, G. Handelman, L. Marcocci, C.K. Sen, S. Roy, H. Kobuchi, H.J. Tritschler, L. Flohe, and L. Packer Lipoic acid increases de novo synthesis of cellular glutathione by improving cystine utilization Biofactors 6 1997 321 338
108. V. Massey The identity of diaphorase and lipoyl dehydrogenase Biochim. Biophys. Acta 37 1960 314 322
109. J.H. Suh, S.V. Shenvi, B.M. Dixon, H. Liu, A.K. Jaiswal, R.M. Liu, and T.M. Hagen Decline in transcriptional activity of Nrf2 causes age-related loss of glutathione synthesis, which is reversible with lipoic acid Proc. Natl Acad. Sci. USA 101 2004 3381 3386
110. P. Coyle, J.C. Philcox, L.C. Carey, and A.M. Rofe Metallothionein: the multipurpose protein Cell. Mol. Life Sci. 59 2002 627 647
111. T.B. Aydemir, R.K. Blanchard, and R.J. Cousins Zinc supplementation of young men alters metallothionein, zinc transporter, and cytokine gene expression in leukocyte populations Proc. Natl Acad. Sci. USA 103 2006 1699 1704
112. J. Cao, J.A. Bobo, J.P. Liuzzi, and R.J. Cousins Effects of intracellular zinc depletion on metallothionein and ZIP2 transporter expression and apoptosis J. Leukoc. Biol. 70 2001 559 566
113. A. Grider, L.B. Bailey, and R.J. Cousins Erythrocyte metallothionein as an index of zinc status in humans Proc. Natl Acad. Sci. USA 87 1990 1259 1262
114. W. Maret The function of zinc metallothionein: a link between cellular zinc and redox state J. Nutr. 130 2000 1455S 1458S
115. L.J. Jiang, W. Maret, and B.L. Vallee The glutathione redox couple modulates zinc transfer from metallothionein to zinc-depleted sorbitol dehydrogenase Proc. Natl Acad. Sci. USA 95 1998 3483 3488
116. L.H. Lash, and D.P. Jones Purification and properties of the membranal thiol oxidase from porcine kidney Arch. Biochem. Biophys. 247 1986 120 130
117. K.L. Taylor, D.J. Uhlinger, and J.M. Kinkade Jr. Expression of recombinant myeloperoxidase using a baculovirus expression system Biochem. Biophys. Res. Commun. 187 1992 1572 1578
118. A. Ramirez, B. Ramadan, J.D. Ritzenthaler, H.N. Rivera, D.P. Jones, and J. Roman Extracellular cysteine/cystine redox potential controls lung fibroblast proliferation and matrix expression through upregulation of transforming growth factor-beta Am. J. Physiol. Lung Cell. Mol. Physiol. 293 2007 L972 L981
119. Y.O. Mannery, T.R. Ziegler, Y. Park, and D. Jones Oxidation of plasma cysteine/cystine and GSH/GSSG redox potentials by acetaminophen and sulfur amino acid insufficiency in humans J. Pharmacol. Exp. Ther. 333 2010 939 947
120. K.R. Atkuri, J.J. Mantovani, L.A. Herzenberg, and L.A. Herzenberg N-acetylcysteine-a safe antidote for cysteine/glutathione deficiency Curr. Opin. Pharmacol. 7 2007 355 359
121. W. Droge, A. Gross, V. Hack, R. Kinscherf, M. Schykowski, M. Bockstette, S. Mihm, and D. Galter Role of cysteine and glutathione in HIV infection and cancer cachexia: therapeutic intervention with N-acetylcysteine Adv. Pharmacol. (San Diego) 38 1997 581 600
122. Y. Shyntum, S.S. Iyer, J. Tian, L. Hao, Y.O. Mannery, D.P. Jones, and T.R. Ziegler Dietary sulfur amino acid supplementation reduces small bowel thiol/disulfide redox state and stimulates ileal mucosal growth after massive small bowel resection in rats J. Nutr. 139 2009 2272 2278
123. M. Palacin, E. Fernandez, J. Chillaron, and A. Zorzano The amino acid transport system b(o,+) and cystinuria Mol. Membr. Biol. 18 2001 21 26
124. Y.O. Mannery, T.R. Ziegler, L.H. Hao, Y. Shyntum, and D.P. Jones Characterization of apical and basal thiol-disulfide redox regulation in human colonic epithelial cells Am. J. Physiol. Gastrointest. Liver Physiol. 299 2010 G523 G530
125. H. Sato, M. Tamba, T. Ishii, and S. Bannai Cloning and expression of a plasma membrane cystine/glutamate exchange transporter composed of two distinct proteins J. Biol. Chem. 274 1999 11455 11458
126. S.S. Iyer, D.P. Jones, K.L. Brigham, and M. Rojas Oxidation of plasma cysteine/cystine redox state in endotoxin-induced lung injury Am. J. Respir. Cell Mol. Biol. 40 2009 90 98
127. B. Stanic, M. Katsuyama, and F.J. Miller Jr. An oxidized extracellular oxidation-reduction state increases nox1 expression and proliferation in vascular smooth muscle cells via epidermal growth factor receptor activation Arterioscler. Thromb. Vasc. Biol. 30 2010 2234 2241
128. M. Aoki, T. Nata, R. Morishita, H. Matsushita, H. Nakagami, K. Yamamoto, K. Yamazaki, M. Nakabayashi, T. Ogihara, and Y. Kaneda Endothelial apoptosis induced by oxidative stress through activation of NF-kappaB: antiapoptotic effect of antioxidant agents on endothelial cells Hypertension 38 2001 48 55
129. J. Chen, and J.L. Mehta Angiotensin II-mediated oxidative stress and procollagen-1 expression in cardiac fibroblasts: blockade by pravastatin and pioglitazone Am. J. Physiol. Heart Circ. Physiol. 291 2006 H1738 H1745
130. I.A. van den Oever, H.G. Raterman, M.T. Nurmohamed, and S. Simsek Endothelial dysfunction, inflammation, and apoptosis in diabetes mellitus Mediat. Inflamm. 2010 2010 792393
131. S. Mizuno, H.J. Bogaard, N.F. Voelkel, Y. Umeda, M. Kadowaki, S. Ameshima, I. Miyamori, and T. Ishizaki Hypoxia regulates human lung fibroblast proliferation via p53-dependent and -independent pathways Respir. Res. 10 2009 17
132. E. Sivridis, A. Giatromanolaki, and M.I. Koukourakis Proliferating fibroblasts at the invading tumour edge of colorectal adenocarcinomas are associated with endogenous markers of hypoxia, acidity, and oxidative stress J. Clin. Pathol. 58 2005 1033 1038
133. A.C. Newby, and A.B. Zaltsman Fibrous cap formation or destruction-the critical importance of vascular smooth muscle cell proliferation, migration and matrix formation Cardiovasc. Res. 41 1999 345 360
134. A. Zulli, and D.L. Hare High dietary methionine plus cholesterol stimulates early atherosclerosis and late fibrous cap development which is associated with a decrease in GRP78 positive plaque cells Int. J. Exp. Pathol. 90 2009 311 320
135. B.R. Imhoff, and J.M. Hansen Extracellular redox status regulates Nrf2 activation through mitochondrial reactive oxygen species Biochem. J. 424 2009 491 500
136. B.S. Duman, M. Ozturk, S. Yilmazeri, and H. Hatemi Thiols, malonaldehyde and total antioxidant status in the Turkish patients with type 2 diabetes mellitus Tohoku J. Exp. Med. 201 2003 147 155
137. P.S. Samiec, C. Drews-Botsch, E.W. Flagg, J.C. Kurtz, P. Sternberg Jr., R.L. Reed, and D.P. Jones Glutathione in human plasma: decline in association with aging, age-related macular degeneration, and diabetes Free Radic. Biol. Med. 24 1998 699 704
138. R.B. Neuman, H.L. Bloom, I. Shukrullah, L.A. Darrow, D. Kleinbaum, D.P. Jones, and S.C. Dudley Jr. Oxidative stress markers are associated with persistent atrial fibrillation Clin. Chem. 53 2007 1652 1657