3T3-L1 adipocytes and rat adipose tissue have a high capacity for taurine synthesis by the cysteine dioxygenase/cysteinesulfinate decarboxylase and cysteamine dioxygenase pathways

Journal of Nutrition

Volumn 139, Issue 2, 2009, Pages 207-214

  Ueki, Iori ^a   Stipanuk, Martha H ^a  

^a Department of Obstetrics Gynecology   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIN; CARBOXYLYASE; CYSTEAMINE DIOXYGENASE; CYSTEINE DIOXYGENASE; CYSTEINE SULFINATE DECARBOXYLASE; CYSTEINE SULFINIC ACID; CYSTINE; DIOXYGENASE; FATTY ACID BINDING PROTEIN 4; HYPOTAURINE; MERCAPTAMINE; MESSENGER RNA; TAURINE; UNCLASSIFIED DRUG; CYSTEINE; CYSTEINE PROTEINASE INHIBITOR; SULFOALANINE DECARBOXYLASE;

ADIPOCYTE; ADIPOSE TISSUE; AMINO ACID SYNTHESIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL DIFFERENTIATION; CELL STRAIN 3T3; CONTROLLED STUDY; DECARBOXYLATION; FEMALE; MALE; NONHUMAN; OXIDATION; PHENOTYPE; PROTEIN EXPRESSION; PROTEIN INTAKE; RAT; REGULATORY MECHANISM; ANIMAL; BIOSYNTHESIS; CYTOLOGY; ENZYMOLOGY; GENETICS; METABOLISM; MOUSE; POLYMERASE CHAIN REACTION; SPRAGUE DAWLEY RAT; WESTERN BLOTTING;

MAMMALIA; RATTUS;

3T3-L1 CELLS; ADIPOCYTES; ANIMALS; BLOTTING, WESTERN; CARBOXY-LYASES; CELL DIFFERENTIATION; CYSTEAMINE; CYSTEINE; CYSTEINE DIOXYGENASE; CYSTEINE PROTEINASE INHIBITORS; DIOXYGENASES; FEMALE; MALE; MICE; POLYMERASE CHAIN REACTION; RATS; RATS, SPRAGUE-DAWLEY; RNA, MESSENGER; TAURINE;

EID: 60249086784     PISSN: 00223166     EISSN: 15416100     Source Type: Journal    
DOI: 10.3945/jn.108.099085     Document Type: Article

References (47)

1. Sturman JA. Taurine in development. Physiol Rev. 1993;73:119-47.
2. Huxtable RJ. Physiological actions of taurine. Physiol Rev. 1992;72:101-63.
3. Arany E, Strutt B, Romanus P, Remacle C, Reusens B, Hill DJ. Taurine supplement in early life altered islet morphology, decreased insulitis and delayed the onset of diabetes in non-obese diabetic mice. Diabetologia. 2004;47:1831-7.
4. Boujendar S, Reusens B, Merezak S, Ahn MT, Arany E, Hill D, Remacle C. Taurine supplementation to a low protein diet during foetal and early postnatal life restores a normal proliferation and apoptosis of rat pancreatic islets. Diabetologia. 2002;45:856-66.
5. Cherif H, Reusens B, Ahn MT, Hoet JJ, Remade C. Effects of taurine on the insulin secretion of rat fetal islets from dams fed a low-protein diet. J Endocrinol. 1998;159:341-8.
6. Sjoholm K, Palming J, Lystig TC, Jennische E, Woodruff TK, Carlsson B, Carlsson LM. The expression of inhibin beta B is high in human adipocytes, reduced by weight loss, and correlates to factors implicated in metabolic disease. Biochem Biophys Res Commun. 2006;344:1308-14.
7. Tsuboyama-Kasaoka N, Shozawa C, Sano K, Kamei Y, Kasaoka S, Hosokawa Y, Ezaki O. Taurine (2-aminoethanesulfonic acid) deficiency creates a vicious circle promoting obesity. Endocrinology. 2006;147: 3276-84.
8. Ueki I, Stipanuk MH. Enzymes of the taurine biosynthetic pathway are expressed in rat mammary gland. J Nutr. 2007;137:1887-94.
9. Ide T, Kushiro M, Takahashi Y, Shinohara K, Cha S. mRNA expression of enzymes involved in taurine biosynthesis in rat adipose tissues. Metabolism. 2002;51:1191-7.
10. Chen SS, Chen JF, Johnson PF, Muppala V, Lee YH. C/EBPbeta, when expressed from the C/ebpalpha gene locus, can functionally replace C/EBPalpha in liver but not in adipose tissue. Mol Cell Biol. 2000; 20:7292-9.
11. Dominy JE Jr, Simmons CR, Hirschberger LL, Hwang J, Coloso RM, Stipanuk MH. Discovery and characterization of a second mammalianthiol dioxygenase, cysteamine dioxygenase. J Biol Chem. 2007;282:25189-98.
12. Coloso RM, Hirschberger LL, Dominy JE Jr, Lee JI, Stipanuk MH. Cysteamine dioxygenase: evidence for the physiological conversion of cysteamine to hypotaurine in rat and mouse tissues. In: Oja SS, Saransaari P, editors. Taurine 6. New York: Springer; 2006. p. 25-36.
13. Stipanuk MH, Dominy JE Jr, Lee JI, Coloso RM. Mammalian cysteine metabolism: new insights into regulation of cysteine metabolism. J Nutr. 2006;136:S1652-9.
14. Tsuboyama-Kasaoka N, Hosokawa Y, Kodama H, Matsumoto A, Oka J, Totani M. Human cysteine dioxygenase gene: structural organization, tissue-specific expression and downregulation by phorbol 12-myristate 13-acetate. Biosci Biotechnol Biochem. 1999;63:1017-24.
15. Tsuboyama N, Hosokawa Y, Totani M, Oka J, Matsumoto A, Koide T, Kodama H. Structural organization and tissue-specific expression of the gene encoding rat cysteine dioxygenase. Gene. 1996;181:161-5.
16. Hirschberger LL, Daval S, Stover PJ, Stipanuk MH. Murine cysteine dioxygenase gene: structural organization, tissue-specific expression and promoter identification. Gene. 2001;277:153-61.
17. Stipanuk MH, Hirschberger LL, Londono MP, Cresenzi CL, Yu AF. The ubiquitin-proteasome system is responsible for cysteine-responsive regulation of cysteine dioxygenase concentration in liver. Am J Physiol Endocrinol Metab. 2004;286:E439-48.
18. Dominy JE Jr, Hirschberger LL, Coloso RM, Stipanuk MH. Regulation of cysteine dioxygenase degradation is mediated by intracellular cysteine levels and the ubiquitin-26 S proteasome system in the living rat. Biochem J. 2006;394:267-73.
19. Lee JI, Londono M, Hirschberger LL, Stipanuk MH. Regulation of cysteine dioxygenase and gamma-glutamylcysteine synthetase is as-sociated with hepatic cysteine level. J Nutr Biochem. 2004;15:112-22.
20. Bella DL, Hirschberger LL, Hosokawa Y, Stipanuk MH. Mechanisms involved in the regulation of key enzymes of cysteine metabolism in rat liver in vivo. Am J Physiol. 1999;276:E326-35.
21. Bella DL, Hahn C, Stipanuk MH. Effects of nonsulfur and sulfur aminoacids on the regulation of hepatic enzymes of cysteine metabolism. Am J Physiol. 1999;277:E144-53.
22. Finkelstein JD. Methionine metabolism in mammals. J Nutr Biochem. 1990;1:228-37.
23. Ishii I, Akahoshi N, Yu XN, Kobayashi Y, Namekata K, Komaki G, Kimura H. Murine cystathionine gamma-lyase: complete cDNA and genomic sequences, promoter activity, tissue distribution and developmental expression. Biochem J. 2004;381:113-23.
24. Hackl H, Burkard TR, Sturn A, Rubio R, Schleiffer A, Tian S, Quackenbush J, Eisenhaber F, Trajanoski Z. Molecular processes during fat cell development revealed by gene expression profiling and functional annotation. Genome Biol. 2005;6:R108.
25. Hanlon PR, Cimafranca MA, Liu X, Cho YC, Jefcoate CR. Microarray analysis of early adipogenesis in C3H10T1/2 cells: cooperative inhibitory effects of growth factors and 2,3,7,8-tetrachlorodibenzo-p-dioxin. Toxicol Appl Pharmacol. 2005;207:39-58.
26. Kalajzic I, Staal A, Yang WP, Wu Y, Johnson SE, Feyen JH, Krueger W, Maye P, Yu F, et al. Expression profile of osteoblast lineage at defined stages of differentiation. J Biol Chem. 2005;280:24618-26.
27. Reeves PG, Nielsen FH, Fahey GC Jr. AIN-93 purified diets for laboratory rodents: final report of the American Institute of Nutrition ad hoc writing committee on the reformulation of the AIN-76A rodent diet. J Nutr. 1993;123:1939-51.
28. Rubin CS, Hirsch A, Fung C, Rosen OM. Development of hormone receptors and hormonal responsiveness in vitro. Insulin receptors and insulin sensitivity in the preadipocyte and adipocyte forms of 3T3-L1 cells. J Biol Chem. 1978;253:7570-8.
29. Stipanuk MH, Londono M, Hirschberger LL, Hickey C, Thiel DJ, Wang L. Evidence for expression of a single distinct form of mammalian cysteine dioxygenase. Amino Acids. 2004;26:99-106.
30. Reymond I, Sergeant A, Tappaz M. Molecular cloning and sequence analysis of the cDNA encoding rat liver cysteine sulfinate decarboxylase (CSD). Biochim Biophys Acta. 1996;1307:152-6.
31. Stipanuk MH, Dominy JE Jr, Ueki I, Hirschberger LL. Measurement of cysteine dioxygenase activity and protein abundance. Curr Prot Toxicol. 2008:6.15.1-6.25.
32. Gaitonde MK. A spectrophotometric method for the direct determination of cysteine in the presence of other naturally occurring amino acids. Biochem J. 1967;104:627-33.
33. Dominy JE Jr, Hwang J, Stipanuk MH. Overexpression of cysteine dioxygenase reduces intracellular cysteine and glutathione pools in HepG2/C3A cells. Am J Physiol Endocrinol Metab. 2007;293:E62-9.
34. Stipanuk MH, Londono M, Lee JI, Hu M, Yu AF. Enzymes and metabolites of cysteine metabolism in nonhepatic tissues of rats show little response to changes in dietary protein or sulfur amino acid levels. J Nutr. 2002;132:3369-78.
35. Rosen ED, Spiegelman BM. Adipocytes as regulators of energy balance and glucose homeostasis. Nature. 2006;444:847-53.
36. Tran TT, Yamamoto Y, Gesta S, Kahn CR. Beneficial effects of subcutaneous fat transplantation on metabolism. Cell Metab. 2008;7:410-20.
37. Konrad D, Rudich A, Schoenle EJ. Improved glucose tolerance in mice receiving intraperitoneal transplantation of normal fat tissue. Diabeto-logia. 2007;50:833-9.
38. Barzilai N, She L, Liu BQ, Vuguin P, Cohen P, Wang J, Rossetti L. Surgical removal of visceral fat reverses hepatic insulin resistance. Diabetes. 1999;48:94-8.
39. Barzilai N, Banerjee S, Hawkins M, Chen W, Rossetti L. Caloric restriction reverses hepatic insulin resistance in aging rats by decreasing visceral fat. J Clin Invest. 1998;101:1353-61.
40. Wojtecka-Lukasik E, Czuprynska K, Maslinska D, Gajewski M, Gujski M, Maslinski S. Taurine-chloramine is a potent antiinflammatory substance. Inflamm Res. 2006;55 Suppl l:S17-8.
41. Wojtecka-Lukasik E, Gujski M, Roguska K, Maslinska D, Maslinski S. Taurine chloramine modifies adjuvant arthritis in rats. Inflamm Res. 2005;54 Suppl l:S21-2.
42. Weiss SJ, Klein R, Slivka A, Wei M. Chlorination of taurine by human neutrophils. Evidence for hypochlorous acid generation. J Clin Invest. 1982;70:598-607.
43. Marcinkiewicz J, Grabowska A, Bereta J, Stelmaszynska T. Taurine chloramine, a product of activated neutrophils, inhibits in vitro the generation of nitric oxide and other macrophage inflammatory mediators. J Leukoc Biol. 1995;58:667-74.
44. Hotamisligil GS. Inflammation and metabolic disorders. Nature. 2006;444:860-7.
45. Hotamisligil GS, Arner P, Caro JF, Atkinson RL, Spiegelman BM. Increased adipose tissue expression of tumor necrosis factor-alpha in human obesity and insulin resistance. J Clin Invest. 1995;95:2409-15.
46. Qusti S, Parsons RB, Abouglila KD, Waring RH, Williams AC, Ramsden DB. Development of an in vitro model for cysteine dioxygenase expression in the brain. Cell Biol Toxicol. 2000;16:243-55.
47. Oda H. Functions of sulfur-containing amino acids in lipid metabolism. J Nutr. 2006;136:S1666-9.