Choline supplementation promotes hepatic insulin resistance in phosphatidylethanolamine N-methyltransferase-deficient mice via increased glucagon action

Journal of Biological Chemistry

Volumn 288, Issue 2, 2013, Pages 837-847

  Wu, Gengshu ^a   Zhang, Liyan ^a   Li, Tete ^a   Zuniga, Azeret ^a   Lopaschuk, Gary D ^a   Li, Liang ^a   Jacobs, René L ^a   Vance, Dennis E ^a  

^a UNIVERSITY OF ALBERTA   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

AMP-ACTIVATED PROTEIN KINASE; GLUCONEOGENESIS; GLUCOSE OXIDATION; HEPATIC EXPRESSION; HEPATIC INSULIN RESISTANCE; HIGH-FAT DIET; INSULIN RECEPTOR SUBSTRATE 1; INSULIN SENSITIVITY; INSULIN SIGNALING; KNOCK OUTS; LIPID HOMEOSTASIS; PHOSPHATIDYLETHANOLAMINE; PHOSPHATIDYLETHANOLAMINE N-METHYLTRANSFERASE; RECEPTOR ANTAGONISTS; TRIACYLGLYCEROLS; TYPE-2 DIABETES; UP-REGULATION; WILD TYPES;

AMINO ACIDS; BIOCHEMISTRY; BIOSYNTHESIS; ENZYME ACTIVITY; GLUCOSE; GLYCEROL; INSULIN; MAMMALS; PHOSPHORYLATION;

NUTRITION;

2 AMINOBENZIMIDAZOLE; CHOLINE; GLUCAGON; GLUCAGON RECEPTOR; GLUCOSE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; INSULIN; INSULIN RECEPTOR SUBSTRATE 1; LIPID; PHOSPHATIDYLETHANOLAMINE METHYLTRANSFERASE; RECEPTOR BLOCKING AGENT; SERINE; TRIACYLGLYCEROL; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BIOSYNTHESIS; CONTROLLED STUDY; ENZYME DEFICIENCY; ENZYME INDUCTION; ENZYME PHOSPHORYLATION; FAT INTAKE; FOOD INTAKE; GLUCAGON BLOOD LEVEL; GLUCONEOGENESIS; GLUCOSE INTOLERANCE; GLUCOSE OXIDATION; HEPATIC INSULIN RESISTANCE; HOMEOSTASIS; HYPERGLYCEMIA; INSULIN RESISTANCE; INSULIN RESPONSE; INSULIN SENSITIVITY; KNOCKOUT MOUSE; LIPOGENESIS; MALE; MITOCHONDRIAL RESPIRATION; MOUSE; MOUSE STRAIN; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN EXPRESSION; WILD TYPE;

ANIMALS; BASE SEQUENCE; CHOLINE; DNA PRIMERS; GLUCAGON; GLUCONEOGENESIS; GLUCOSE TOLERANCE TEST; INSULIN RESISTANCE; LIVER; MICE; MICE, INBRED C57BL; PHOSPHATIDYLETHANOLAMINE N-METHYLTRANSFERASE;

MUS;

EID: 84872350879     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M112.415117     Document Type: Article

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