S-adenosylmethionine is associated with fat mass and truncal adiposity in older adults

Journal of Nutrition

Volumn 143, Issue 12, 2013, Pages 1982-1988

  Elshorbagy, Amany K ^a,b   Nijpels, Giel ^c   Valdivia Garcia, Maria ^a   Stehouwer, Coen D A ^d   Ocke, Marga ^e   Refsum, Helga ^a,f   Dekker, Jacqueline M ^c  

^a UNIVERSITY OF OXFORD   (United Kingdom)

^b ALEXANDRIA UNIVERSITY   (Egypt)

^c VU UNIVERSITY MEDICAL CENTER   (Netherlands)

^d MAASTRICHT UNIVERSITY   (Netherlands)

^e NATIONAL INSTITUTE FOR PUBLIC HEALTH AND THE ENVIRONMENT   (Netherlands)

^f UNIVERSITY OF OSLO   (Norway)

Author keywords

[No Author keywords available]

Indexed keywords

CREATININE; CYSTEINE; FAT; LIPID; METHIONINE; PROTEIN; S ADENOSYLHOMOCYSTEINE; S ADENOSYLMETHIONINE;

ABDOMINAL OBESITY; AGED; ARTICLE; BODY MASS; BODY WEIGHT; CALORIC INTAKE; CONTROLLED STUDY; CREATININE BLOOD LEVEL; CROSS-SECTIONAL STUDY; ERYTHROCYTE; FAT MASS; FEMALE; HEALTH BEHAVIOR; HUMAN; LEAN BODY WEIGHT; LIFESTYLE; LIPID BLOOD LEVEL; MAJOR CLINICAL STUDY; MALE; NUTRITIONAL ASSESSMENT; PROTEIN INTAKE; TRUNK; ABDOMINAL FAT; COHORT ANALYSIS; METABOLISM; MIDDLE AGED; OBESITY; ORGAN SIZE;

ABDOMINAL FAT; ADIPOSITY; AGED; COHORT STUDIES; CROSS-SECTIONAL STUDIES; FEMALE; HUMANS; MALE; MIDDLE AGED; ORGAN SIZE; S-ADENOSYLMETHIONINE;

EID: 84886949032     PISSN: 00223166     EISSN: 15416100     Source Type: Journal    
DOI: 10.3945/jn.113.179192     Document Type: Article

References (47)

1. Mato JM, Corrales FJ, Lu SC, Avila MA. S-Adenosylmethionine: a control switch that regulates liver function. FASEB J. 2002; 16:15-26.
2. Nimni ME, Han B, Cordoba F. Are we getting enough sulfur in our diet? Nutr Metab (Lond). 2007; 4:24.
3. Brosnan JT, Brosnan ME. The sulfur-containing amino acids: an overview. J Nutr. 2006; 136 Suppl 6:S1636-40.
4. Prudova A, Bauman Z, Braun A, Vitvitsky V, Lu SC, Banerjee R. S-adenosylmethionine stabilizes cystathionine beta-synthase and modulates redox capacity. Proc Natl Acad Sci USA. 2006; 103:6489-94.
5. Gupta S, Kruger WD. Cystathionine beta-synthase deficiency causes fat loss in mice. PLoS ONE. 2011; 6:e27598.
6. Mudd SH, Levy HL, Skovby F. Disorders of transsulfuration. In: Scriver CR, Beaudet AL, Sly WS, Valle D, editors. The molecular and metabolic bases of inherited disease. New York: McGraw-Hill; 1995. p. 1279-327.
7. Elshorbagy AK, Nurk E, Gjesdal CG, Tell GS, Ueland PM, Nygard O, Tverdal A, Vollset SE, Refsum H. Homocysteine, cysteine, and body composition in the Hordaland Homocysteine Study: does cysteine link amino acid and lipid metabolism? Am J Clin Nutr. 2008; 88:738-46.
8. Elshorbagy AK, Valdivia-Garcia M, Graham IM, Palma Reis R, Sales Luis A, Smith AD, Refsum H. The association of fasting plasma sulfur-containing compounds with BMI, serum lipids and apolipoproteins. Nutr Metab Cardiovasc Dis. 2012; 22:1031-8.
9. Elshorbagy AK, Valdivia-Garcia M, Refsum H, Butte N. The association of cysteine with obesity, inflammatory cytokines and insulin resistance in Hispanic children and adolescents. PLoS ONE. 2012; 7:e44166.
10. Elshorbagy AK, Church C, Valdivia-Garcia M, Smith AD, Refsum H, Cox R. Dietary cystine level affects metabolic rate and glycaemic control in adult mice. J Nutr Biochem. 2012; 23:332-40.
11. Elshorbagy AK, Kozich V, Smith AD, Refsum H. Cysteine and obesity: consistency of the evidence across epidemiologic, animal and cellular studies. Curr Opin Clin Nutr Metab Care. 2012; 15:49-57.
12. Inoue-Choi M, Nelson HH, Robien K, Arning E, Bottiglieri T, Koh WP, Yuan JM. One-carbon metabolism nutrient status and plasma S-adenosyl-methionine concentrations in middle-aged and older Chinese in Singapore. Int J Mol Epidemiol Genet. 2012; 3:160-73.
13. van Driel LM, Eijkemans MJ, de Jonge R, de Vries JH, van Meurs JB, Steegers EA, Steegers-Theunissen RP. Body mass index is an important determinant of methylation biomarkers in women of reproductive ages. J Nutr. 2009; 139:2315-21.
14. Stead LM, Brosnan JT, Brosnan ME, Vance DE, Jacobs RL. Is it time to reevaluate methyl balance in humans? Am J Clin Nutr. 2006; 83:5-10.
15. Obeid R, Herrmann W. Homocysteine and lipids: S-adenosyl methionine as a key intermediate. FEBS Lett. 2009; 583:1215-25.
16. Cano A, Buque X, Martinez-Una M, Aurrekoetxea I, Menor A, Garcia-Rodriguez JL, Lu SC, Martinez-Chantar ML, Mato JM, Ochoa B, et al. Methionine adenosyltransferase 1A gene deletion disrupts hepatic very low-density lipoprotein assembly in mice. Hepatology. 2011; 54:1975-86.
17. Donohoe DR, Bultman SJ. Metaboloepigenetics: interrelationships between energy metabolism and epigenetic control of gene expression. J Cell Physiol. 2012; 227:3169-77.
18. Jiménez-Chillarón JC, Diaz R, Martinez D, Pentinat T, Ramon-Krauel M, Ribo S, Plosch T. The role of nutrition on epigenetic modifications and their implications on health. Biochimie. 2012; 94:2242-63.
19. Godfrey KM, Sheppard A, Gluckman PD, Lillycrop KA, Burdge GC, McLean C, Rodford J, Slater-Jefferies JL, Garratt E, Crozier SR, et al. Epigenetic gene promoter methylation at birth is associated with child's later adiposity. Diabetes. 2011; 60:1528-34.
20. Mooy JM, Grootenhuis PA, de Vries H, Valkenburg HA, Bouter LM, Kostense PJ, Heine RJ. Prevalence and determinants of glucose intolerance in a Dutch caucasian population. The Hoorn Study. Diabetes Care. 1995; 18:1270-3.
21. Snijder MB, Dekker JM, Visser M, Bouter LM, Stehouwer CD, Yudkin JS, Heine RJ, Nijpels G, Seidell JC. Trunk fat and leg fat have independent and opposite associations with fasting and postload glucose levels: The Hoorn study. Diabetes Care. 2004; 27:372-7.
22. Rose GA, Blackburn H. Cardiovascular survey methods. Monogr Ser World Health Organ. 1968; 56:1-188.
23. Arterial hypertension. Report of a WHO expert committee. World Health Organ Tech Rep Ser. 1978;(628):7-56.
24. Abbreviated Report of a WHO Consultation. Use of glycated haemoglobin (HbA1c) in the diagnosis of diabetes mellitus;2011 [cited 2013 Aug 8]. Available from: http://www.who.int/diabetes/publications/report-hba1c_2011.pdf.
25. Ocke MC, Buenode-Mesquita HB, Goddijn HE, Jansen A, Pols MA, van Staveren WA, Kromhout D. The Dutch EPIC food frequency questionnaire. I. Description of the questionnaire, and relative validity and reproducibility for food groups. Int J Epidemiol. 1997; 26 Suppl 1: S37-48.
26. Stichting Nederlands Voedingsstoffenbestand. Dutch food composition table (Nederlands voedingsstoffenbestand, NEVO Table). The Hague: Dutch Nutrition Center; 1996.
27. Struys EA, Jansen EE, de Meer K, Jakobs C. Determination of S-adenosylmethionine and S-adenosylhomocysteine in plasma and cerebrospinal fluid by stable-isotope dilution tandem mass spectrometry. Clin Chem. 2000; 46:1650-6.
28. Antoniades C, Shirodaria C, Leeson P, Baarholm OA, Van-Assche T, Cunnington C, Pillai R, Ratnatunga C, Tousoulis D, Stefanadis C, et al. MTHFR 677 C>T Polymorphism reveals functional importance for 5-mthyltetrahydrofolate, not homocysteine, in regulation of vascular redox state and endothelial function in human atherosclerosis. Circulation. 2009; 119:2507-15.
29. Junge W, Wilke B, Halabi A, Klein G. Determination of reference intervals for serum creatinine, creatinine excretion and creatinine clearance with an enzymatic and a modified Jaffe method. Clin Chim Acta. 2004; 344:137-48.
30. Becker A, Smulders YM, Teerlink T, Struys EA, de Meer K, Kostense PJ, Jakobs C, Dekker JM, Nijpels G, Heine RJ, et al. S-adenosylhomocysteine and the ratio of S-adenosylmethionine to S-adenosylhomocysteine are not related to folate, cobalamin and vitamin B6 concentrations. Eur J Clin Invest. 2003; 33:17-25.
31. Kwon do Y, Jung YS, Kim SJ, Park HK, Park JH, Kim YC. Impaired sulfur-amino acid metabolism and oxidative stress in nonalcoholic fatty liver are alleviated by betaine supplementation in rats. J Nutr. 2009; 139:63-8.
32. Kalhan SC, Edmison J, Marczewski S, Dasarathy S, Gruca LL, Bennett C, Duenas C, Lopez R. Methionine and protein metabolism in nonalcoholic steatohepatitis: evidence for lower rate of transmethylation of methionine. Clin Sci (Lond). 2011; 121:179-89.
33. Martinez-Uña M, Varela-Rey M, Cano A, Fernandez-Ares L, Beraza N, Aurrekoetxea I, Martinez-Arranz I, Garcia-Rodriguez JL, Buque X, Mestre D, et al. Excess S-adenosylmethionine reroutes phosphatidyl-ethanolamine towards phosphatidylcholine and triglyceride synthesis. Hepatology. Epub 2013 March 16.
34. She P, Van Horn C, Reid T, Hutson SM, Cooney RN, Lynch CJ. Obesity-related elevations in plasma leucine are associated with alterations in enzymes involved in branched-chain amino acid metabolism. Am J Physiol Endocrinol Metab. 2007; 293:E1552-63.
35. Williams KT, Schalinske KL. New insights into the regulation of methyl group and homocysteine metabolism. J Nutr. 2007; 137:311-4.
36. Corrales FJ, Perez-Mato I, Sanchez Del Pino MM, Ruiz F, Castro C, Garcia-Trevijano ER, Latasa U, Martinez-Chantar ML, Martinez-Cruz A, Avila MA, et al. Regulation of mammalian liver methionine adenosyl-transferase. J Nutr. 2002; 132 Suppl 8:S2377-81.
37. Sánchez-Gongora E, Pastorino JG, Alvarez L, Pajares MA, Garcia C, Vina JR, Mato JM, Farber JL. Increased sensitivity to oxidative injury in Chinese hamster ovary cells stably transfected with rat liver S-adenosyl-methionine synthetase cDNA. Biochem J. 1996; 319:767-73.
38. Chiang EP, Wang YC, Chen WW, Tang FY. Effects of insulin and glucose on cellular metabolic fluxes in homocysteine transsulfuration, remethylation, S-adenosylmethionine synthesis, and global deoxyribonucleic acid methylation. J Clin Endocrinol Metab. 2009; 94:1017-25.
39. Thomas A, Stevens AP, Klein MS, Hellerbrand C, Dettmer K, Gronwald W, Oefner PJ, Reinders J. Early changes in the liver-soluble proteome from mice fed a nonalcoholic steatohepatitis inducing diet. Proteomics. 2012; 12:1437-51.
40. Deminice R, da Silva RP, Lamarre SG, Brown C, Furey GN, McCarter SA, Jordao AA, Kelly KB, King-Jones K, Jacobs RL, et al. Creatine supplementation prevents the accumulation of fat in the livers of rats fed a high-fat diet. J Nutr. 2011; 141:1799-804.
41. Rubio-Aliaga I, Roos B, Sailer M, McLoughlin GA, Boekschoten MV, van Erk M, Bachmair EM, van Schothorst EM, Keijer J, Coort SL, et al. Alterations in hepatic one-carbon metabolism and related pathways following a high-fat dietary intervention. Physiol Genomics. 2011; 43:408-16.
42. Kirpich IA, Gobejishvili LN, Bon Homme M, Waigel S, Cave M, Arteel G, Barve SS, McClain CJ, Deaciuc IV. Integrated hepatic transcriptome and proteome analysis of mice with high-fat diet-induced nonalcoholic fatty liver disease. J Nutr Biochem. 2011; 22:38-45.
43. Shin OH, da Costa KA, Mar MH, Zeisel SH. Hepatic protein kinase C is not activated despite high intracellular 1,2-sn-diacylglycerol in obese Zucker rats. Biochim Biophys Acta. 1997; 1358:72-8.
44. Larsson SC, Giovannucci E, Wolk A. Methionine and vitamin B6 intake and risk of pancreatic cancer: a prospective study of Swedish women and men. Gastroenterology. 2007; 132:113-8.
45. Virtanen JK, Voutilainen S, Rissanen TH, Happonen P, Mursu J, Laukkanen JA, Poulsen H, Lakka TA, Salonen JT. High dietary methionine intake increases the risk of acute coronary events in middle-aged men. Nutr Metab Cardiovasc Dis. 2006; 16:113-20.
46. Bujnowski D, Xun P, Daviglus ML, Van Horn L, He K, Stamler J. Longitudinal association between animal and vegetable protein intake and obesity among men in the United States: the Chicago Western Electric Study. J Am Diet Assoc. 2011; 111:1150-5 el.
47. Elshorbagy AK, Valdivia-Garcia M, Mattocks DA, Plummer JD, Smith AD, Drevon CA, Refsum H, Perrone CE. Cysteine supplementation reverses methionine restriction effects on rat adiposity: significance of stearoyl-coenzyme A desaturase. J Lipid Res. 2011; 52:104-12.