Regulatory T cell DNA methyltransferase inhibition accelerates resolution of lung inflammation

American Journal of Respiratory Cell and Molecular Biology

Volumn 52, Issue 5, 2015, Pages 641-652

  Singer, Benjamin D ^a   Mock, Jason R ^a   Aggarwal, Neil R ^a   Garibaldi, Brian T ^a   Sidhaye, Venkataramana K ^a   Florez, Marcus A ^a   Chau, Eric ^a   Gibbs, Kevin W ^a   Mandke, Pooja ^a   Tripathi, Ashutosh ^a   Yegnasubramanian, Srinivasan ^b   King, Landon S ^a   D'Alessio, Franco R ^a  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b JOHNS HOPKINS UNIVERSITY   (United States)

Author keywords

5 aza 2' deoxycytidine; Acute lung injury; DNA methylation; Epigenetics; Foxp3

Indexed keywords

CYTOTOXIC T LYMPHOCYTE ANTIGEN 4; DECITABINE; DIPHTHERIA TOXIN; DNA METHYLTRANSFERASE; INTERLEUKIN 2; TRANSCRIPTION FACTOR FOXP3; TRANSFORMING GROWTH FACTOR BETA; AZACITIDINE; ENZYME INHIBITOR; FORKHEAD TRANSCRIPTION FACTOR; FOXP3 PROTEIN, MOUSE; HOMEODOMAIN PROTEIN; LIPOPOLYSACCHARIDE; LIPOPOLYSACCHARIDE, E COLI O55-B5; RAG-1 PROTEIN;

ADOPTIVE TRANSFER; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CD4+ CD25 FOXP3+ REGULATORY T LYMPHOCYTE; CD4+ T LYMPHOCYTE; CONTROLLED STUDY; DEMETHYLATION; DNA METHYLATION; ENZYME INHIBITION; FLOW CYTOMETRY; LUNG INJURY; LYMPHOCYTE COUNT; LYMPHOCYTE CULTURE; MIXED LYMPHOCYTE REACTION; MOUSE; NEUTROPHIL COUNT; NONHUMAN; PHENOTYPE; PNEUMONIA; REGULATORY T LYMPHOCYTE; WEIGHT REDUCTION; ACUTE LUNG INJURY; ANALOGS AND DERIVATIVES; ANIMAL; ANTAGONISTS AND INHIBITORS; C57BL MOUSE; CELL CULTURE; CHEMICALLY INDUCED; DISEASE MODEL; DRUG EFFECTS; ENZYMOLOGY; GENETICS; IMMUNOLOGY; INFLUENZA A VIRUS (H1N1); KNOCKOUT MOUSE; LUNG; METABOLISM; NEUTROPHIL CHEMOTAXIS; TIME; TRANSPLANTATION; VIROLOGY;

MUS;

ACUTE LUNG INJURY; ADOPTIVE TRANSFER; ANIMALS; AZACITIDINE; CELLS, CULTURED; CHEMOTAXIS, LEUKOCYTE; DISEASE MODELS, ANIMAL; DNA MODIFICATION METHYLASES; ENZYME INHIBITORS; FORKHEAD TRANSCRIPTION FACTORS; HOMEODOMAIN PROTEINS; INFLUENZA A VIRUS, H1N1 SUBTYPE; LIPOPOLYSACCHARIDES; LUNG; MICE, INBRED C57BL; MICE, KNOCKOUT; PHENOTYPE; PNEUMONIA; T-LYMPHOCYTES, REGULATORY; TIME FACTORS;

EID: 84929468649     PISSN: 10441549     EISSN: 15354989     Source Type: Journal    
DOI: 10.1165/rcmb.2014-0327OC     Document Type: Article

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