Histone deacetylase inhibitor treatment attenuates MAP kinase pathway activation and pulmonary inflammation following hemorrhagic shock in a rodent model

Journal of Surgical Research

Volumn 176, Issue 1, 2012, Pages 185-194

  Kochanek, Ashley R ^a   Fukudome, Eugene Y ^a   Li, Yongqing ^a   Smith, Eleanor J ^a   Liu, Baoling ^a   Velmahos, George C ^a   Demoya, Marc ^a   King, David ^a   Alam, Hasan B ^a  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

acute lung injury; hemorrhage; histone deacetylase inhibitors; inflammation; stress signals; valproic acid

Indexed keywords

HISTONE DEACETYLASE INHIBITOR; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE P38; MYELOPEROXIDASE; SODIUM CHLORIDE; VALPROIC ACID;

ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; ATTENUATION; BLEEDING; CONTROLLED STUDY; DISEASE MARKER; ENZYME ACTIVITY; HEMORRHAGIC SHOCK; HISTONE ACETYLATION; LUNG PARENCHYMA; MALE; NEUTROPHIL CHEMOTAXIS; NONHUMAN; PNEUMONIA; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; RAT; SIGNAL TRANSDUCTION; WESTERN BLOTTING;

ANIMALS; APOPTOSIS; DISEASE MODELS, ANIMAL; HISTONE DEACETYLASE INHIBITORS; LUNG; MALE; MITOGEN-ACTIVATED PROTEIN KINASE KINASES; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PEROXIDASE; PHOSPHORYLATION; PNEUMONIA; PROTO-ONCOGENE PROTEINS C-JUN; RATS; RATS, INBRED WKY; SHOCK, HEMORRHAGIC; SIGNAL TRANSDUCTION; VALPROIC ACID;

EID: 84862004824     PISSN: 00224804     EISSN: 10958673     Source Type: Journal    
DOI: 10.1016/j.jss.2011.06.007     Document Type: Article

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