Fluorofenidone inhibits macrophage IL-1β production by suppressing inflammasome activity

International Immunopharmacology

Volumn 27, Issue 1, 2015, Pages 148-153

  Lu, Miaomiao ^a,b   Yang, Wenjun ^a   Peng, Zhangzhe ^a   Zhang, Jin ^a   Mei, Wenjuan ^a   Liu, Chunyan ^a   Tang, Juan ^a   Ma, Hong ^a   Yuan, Xiangning ^a   Meng, Jie ^a   Lv, Ben ^c   Liu, Jishi ^a   Hu, Gaoyun ^d   Tao, Lijian ^a,d  

^a CENTRAL SOUTH UNIVERSITY   (China)

^b JINZHOU MEDICAL UNIVERSITY   (China)

^c THE THIRD XIANGYA HOSPITAL OF CENTRAL SOUTH UNIVERSITY   (China)

^d CENTRAL SOUTH UNIVERSITY   (China)

Author keywords

Fluorofenidone; IL 1 ; Inflammasome

Indexed keywords

ANTIFIBROTIC AGENT; DIPYRONE; FLUOROFENIDONE; INFLAMMASOME; INTERLEUKIN 1BETA; INTERLEUKIN 1BETA CONVERTING ENZYME; UNCLASSIFIED DRUG; 5-METHYL-1-(3-FLUOROPHENYL)-2-(1H)-PYRIDONE; ADENOSINE TRIPHOSPHATE; ANTIINFLAMMATORY AGENT; BACTERIAL ANTIGEN; PYRIDONE DERIVATIVE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; DRUG EFFECT; DRUG MECHANISM; IN VITRO STUDY; IN VIVO STUDY; KIDNEY FIBROSIS; MACROPHAGE; MACROPHAGE ACTIVATION; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SALMONELLA ENTERICA SEROVAR TYPHIMURIUM; ANIMAL; BAGG ALBINO MOUSE; CELL CULTURE; DRUG EFFECTS; HUMAN; IMMUNOLOGY; IMMUNOSUPPRESSIVE TREATMENT; METABOLISM; NEPHRITIS, INTERSTITIAL; PERITONEUM MACROPHAGE; PROTEIN DEGRADATION;

ADENOSINE TRIPHOSPHATE; ANIMALS; ANTI-INFLAMMATORY AGENTS; ANTIGENS, BACTERIAL; CASPASE 1; CELLS, CULTURED; HUMANS; IMMUNOSUPPRESSION; INFLAMMASOMES; INTERLEUKIN-1BETA; MACROPHAGES, PERITONEAL; MALE; MICE; MICE, INBRED BALB C; NEPHRITIS, INTERSTITIAL; PROTEOLYSIS; PYRIDONES; SALMONELLA TYPHIMURIUM;

EID: 84929455799     PISSN: 15675769     EISSN: 18781705     Source Type: Journal    
DOI: 10.1016/j.intimp.2015.05.008     Document Type: Article

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