Fluorofenidone inhibits transforming growth factor-β1-induced cardiac myofibroblast differentiation

Pharmazie

Volumn 67, Issue 5, 2012, Pages 452-456

  Chen, Ling Xi ^a,b   Yang, Kan ^a   Sun, Ming ^b   Chen, Qiong ^b   Wang, Zhao He ^c   Hu, Gao Yun ^d   Tao, Li Jian ^b  

^a THE THIRD XIANGYA HOSPITAL OF CENTRAL SOUTH UNIVERSITY   (China)

^b CENTRAL SOUTH UNIVERSITY   (China)

^c Xiangya Hospital of Central South University ^*  (China)

^d CENTRAL SOUTH UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; 4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; ALPHA SMOOTH MUSCLE ACTIN; ANTIFIBROTIC AGENT; FIBRONECTIN; FLUOROFENIDONE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; PYRIDONE DERIVATIVE; TRANSFORMING GROWTH FACTOR BETA1; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CELL DIFFERENTIATION; CELL PROLIFERATION; DRUG EFFECT; DRUG MECHANISM; HEART MUSCLE CELL; MYOFIBROBLAST; NEWBORN; NONHUMAN; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; RAT; SIGNAL TRANSDUCTION;

ACTINS; ANIMALS; ANIMALS, NEWBORN; BLOTTING, WESTERN; CELL DIFFERENTIATION; CELL SEPARATION; CELLS, CULTURED; COLLAGEN; ENZYME INHIBITORS; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; FIBRONECTINS; FIBROSIS; FLAVONOIDS; INDICATORS AND REAGENTS; MITOGEN-ACTIVATED PROTEIN KINASES; MYOCARDIUM; MYOFIBROBLASTS; PHOSPHORYLATION; PYRIDONES; RATS; RATS, SPRAGUE-DAWLEY; TRANSFORMING GROWTH FACTOR BETA1;

EID: 84862311654     PISSN: 00317144     EISSN: None     Source Type: Journal    
DOI: 10.1691/ph.2012.1748     Document Type: Article

References (34)

1. Cleutjens JP, Kandala JC, Guarda E, Guntaka RV, Weber KT (1995) Regulation of collagen degradation in the rat myocardium after infarction. J Mol Cell Cardiol 27: 1281-1292.
2. Derynck R, Zhang YE (2003) Smad-dependent and Smad-independent pathways in TGF-beta family signalling. Nature 425: 577-584.
3. Ding Q, Gladson CL, Wu H, Hayasaka H, Olman MA (2008) Focal adhesion kinase (FAK)-related non-kinase inhibits myofibroblast differentiation through differential MAPK activation in a FAK-dependent manner. J Biol Chem 283: 26839-268449.
4. Doble BW, Chen Y, Bosc DG, Litchfield DW, Kardami E (1996) Fibroblast growth factor-2 decreases metabolic coupling and stimulates phosphorylation as well as masking of connexin43 epitopes in cardiac myocytes. Circ Res 79: 647-658.
5. Doble BW, Ping P, Kardami E (2000) The epsilon subtype of protein kinase C is required for cardiomyocyte connexin-43 phosphorylation. Circ Res 86: 293-301.
6. Engel ME, McDonnell MA, Law BK, Moses HL (1999) Interdependent SMAD and JNK signaling in transforming growth factor-beta-mediated transcription. J Biol Chem 274: 37413-37420.
7. English J, Pearson G, Wilsbacher J, Swantek J, Karandikar M, Xu S, Cobb MH (1999) New insights into the control of MAP kinase pathways. Exp Cell Res 253: 255-270.
8. Hautmann MB, Adam PJ, Owens GK (1999) Similarities and differences in smooth muscle alpha-actin induction by TGF-beta in smooth muscle versus non-smooth muscle cells. Arterioscler Thromb Vasc Biol 19: 2049-2058.
9. Jelaska A, Korn JH (2000) Role of apoptosis and transforming growth factor beta1 in fibroblast selection and activation in systemic sclerosis. Arthritis Rheum 43: 2230-2239.
10. Leslie KO, Taatjes DJ, Schwarz J, vonTurkovich M, Low RB (1991) Cardiac myofibroblasts express alpha smooth muscle actin during right ventricular pressure overload in the rabbit. Am J Pathol 139: 207-216.
11. Li BX, Tang YT, Wang W, Xie YY, Wang NS, Yuan QJ, Zhang FF, Peng ZZ, Hu GY, Tao LJ (2011) Fluorofenidone attenuates renal interstitial fibrosis in the rat model of obstructive nephropathy. Mol Cell Biochem 354: 263-273.
12. Li P, Wang D, Lucas J, Oparil S, Xing D, Cao X, Novak L, Renfrow MB, Chen YF (2008) Atrial natriuretic peptide inhibits transforming growth factor beta-induced Smad signaling and myofibroblast transformation in mouse cardiac fibroblasts. Circ Res 102: 185-192.
13. Lijnen PJ, Petrov VV, Fagard RH (2000) Induction of cardiac fibrosis by transforming growth factor-beta(1) Mol Genet Metab 71: 418-435.
14. Liu X, Sun SQ, Hassid A, Ostrom RS (2006) cAMP inhibits transforming growth factor-beta-stimulated collagen synthesis via inhibition of extracellular signal-regulated kinase 1/2 and Smad signaling in cardiac fibroblasts. Mol Pharmacol 70: 1992-2003.
15. Mauviel A (2005) Transforming growth factor-beta: a key mediator of fibrosis. Methods Mol Med 117: 69-80.
16. Mughal RS, Warburton P, O'Regan DJ, Ball SG, Turner NA, Porter KE (2009) Peroxisome proliferator-activated receptor gamma-independent effects of thiazolidinediones on human cardiac myofibroblast function. Clin Exp Pharmacol Physiol 36: 478-486.
17. Nakamura T, Matsumoto K, Mizuno S, Sawa Y, Matsuda H, Nakamura T (2005) Hepatocyte growth factor prevents tissue fibrosis, remodeling, and dysfunction in cardiomyopathic hamster hearts. Am J Physiol Heart Circ Physiol 288: H2131-H2139.
18. Ono K, Han J (2000) The p38 signal transduction pathway: activation and function. Cell Signal 12: 1-13.
19. Pearson G, Robinson F, Gibson BT,Xu BE, Karandikar M, Berman K, Cobb MH(2001) Mitogen-activated protein (MAP) kinase pathways: regulation and physiological functions. Endocr Rev 22: 153-183.
20. Peng ZZ, Hu GY, Shen H, Wang L, Ning WB, Xie YY, Wang NS, Li BX, Tang YT, Tao LJ (2009) Fluorofenidone attenuates collagen I and transforming growth factor-beta1 expression through a nicotinamide adenine dinucleotide phosphate oxidase-dependent way in NRK-52E cells. Nephrology 14: 565-572.
21. Peterson JT, Li H, Dillon L, Bryant JW (2000) Evolution of matrix metalloprotease and tissue inhibitor expression during heart failure progression in the infarcted rat. Cardiovasc Res 46: 307-315.
22. Petrov VV, Fagard RH, Lijnen PJ (2002) Stimulation of collagen production by transforming growth factor-beta1 during differentiation of cardiac fibroblasts to myofibroblasts. Hypertension 39: 258-263.
23. Petrov VV, van Pelt JF, Vermeesch JR, van Duppen VJ, Vekemans K, Fagard RH, Lijnen PJ (2008) TGF-beta1-induced cardiac myofibroblasts are non-proliferating functional cells carrying DNA damages. Exp Cell Res 314: 1480-1494.
24. Pokharel S, Rasoul S, Roks AJ, van Leeuwen RE, van Luyn MJ, Deelman LE, Smits JF Carretero O, van Gilst WH, Pinto YM (2002) N-acetyl-Ser-Asp-Lys-Pro inhibits phosphorylation of Smad2 in cardiac fibroblasts. Hypertension 40: 155-161.
25. Porter KE, Turner NA (2009) Cardiac fibroblasts: at the heart of myocardial remodeling. Pharmacol Ther 123: 255-278.
26. Porter KE, Turner NA, O'Regan DJ, Balmforth AJ, Ball SG (2004) Simvastatin reduces human atrial myofibroblast proliferation independently of cholesterol lowering via inhibition of RhoA. Cardiovasc Res 61: 745-755.
27. Santiago JJ, Dangerfield AL, Rattan SG, Bathe KL, Cunnington RH, Raizman JE, Bedosky KM, Freed D, Kardami E, Dixon IM (2010) Cardiac fibroblast to myofibroblast differentiation in vivo and in vitro: expression of focal adhesion components in neonatal and adult rat ventricular myofibroblasts. Dev Dyn 239: 1573-1584.
28. Sappino AP, Schurch W, Gabbiani G (1990) Differentiation repertoire of fibroblastic cells: expression of cytoskeletal proteins as marker of phenotypic modulations. Lab Invest 63: 144-161.
29. Tao LJ, Zhang J, Hu GY (2004) Effects of 1-(3-fluorophenyl)-5-methyl-2- (1H)-pyridone on renal fibroblast in rats. Zhong Nan Da Xue Xue Bao Yi Xue Ban 29: 139-141.
30. Thannickal VJ, Lee DY, White ES, Cui Z, Larios JM, Chacon R, Horowitz JC, Day RM, Thomas PE (2003) Myofibroblast Differentiation by Transforming Growth Factor-β1 Is Dependent on Cell Adhesion and Integrin Signaling via Focal Adhesion Kinase. J Biol Chem 278: 12384-12389.
31. Tomasek JJ, Gabbiani G, Hinz B, Chaponnier C, Brown RA (2002) Myofibroblasts and mechano-regulation of connective tissue remodelling. Nat Rev Mol Cell Biol 3: 349-363.
32. Virag JI, Murry CE (2003) Myofibroblast and endothelial cell proliferation during murine myocardial infarct repair. Am. J. Pathol 163: 2433-2440.
33. Wang L, Hu GM, Shen H, Peng ZZ, Ning WB, Tao LJ (2009) Fluorofenidone inhibits TGF-β1 induced CTGF via MAPK pathways in mouse mesangial cells. Pharmazie 64: 680-684.
34. Yu L, Hebert MC, Zhang YE (2002) TGF-beta receptor-activated p38 MAP kinase mediates Smad-independent TGF-beta responses. EMBO J 21: 3749-3759.